JP2014524903A5 - - Google Patents
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- Publication number
- JP2014524903A5 JP2014524903A5 JP2014516148A JP2014516148A JP2014524903A5 JP 2014524903 A5 JP2014524903 A5 JP 2014524903A5 JP 2014516148 A JP2014516148 A JP 2014516148A JP 2014516148 A JP2014516148 A JP 2014516148A JP 2014524903 A5 JP2014524903 A5 JP 2014524903A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- pharmaceutical composition
- chimeric
- gpcr
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 25
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 25
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 230000003834 intracellular effect Effects 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 8
- 102100038300 Metabotropic glutamate receptor 6 Human genes 0.000 claims 7
- 108010038450 metabotropic glutamate receptor 6 Proteins 0.000 claims 7
- 230000002068 genetic effect Effects 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 230000004304 visual acuity Effects 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 210000001743 on-bipolar cell Anatomy 0.000 claims 5
- 230000009261 transgenic effect Effects 0.000 claims 5
- 239000013598 vector Substances 0.000 claims 5
- 102100025912 Melanopsin Human genes 0.000 claims 4
- 108010005417 melanopsin Proteins 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 101100122490 Drosophila melanogaster Galphaq gene Proteins 0.000 claims 2
- 108700028146 Genetic Enhancer Elements Proteins 0.000 claims 2
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 230000002186 photoactivation Effects 0.000 claims 2
- 230000002207 retinal effect Effects 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- 201000004569 Blindness Diseases 0.000 claims 1
- 241000252212 Danio rerio Species 0.000 claims 1
- 101000720986 Homo sapiens Melanopsin Proteins 0.000 claims 1
- 101000844510 Homo sapiens Transient receptor potential cation channel subfamily M member 1 Proteins 0.000 claims 1
- 102000010175 Opsin Human genes 0.000 claims 1
- 108050001704 Opsin Proteins 0.000 claims 1
- 239000002262 Schiff base Substances 0.000 claims 1
- 150000004753 Schiff bases Chemical class 0.000 claims 1
- 102000003617 TRPM1 Human genes 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 108091008695 photoreceptors Proteins 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 210000001116 retinal neuron Anatomy 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161500863P | 2011-06-24 | 2011-06-24 | |
| US61/500,863 | 2011-06-24 | ||
| PCT/CH2012/000138 WO2012174674A1 (en) | 2011-06-24 | 2012-06-22 | Light-sensitive chimeric gpcr protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524903A JP2014524903A (ja) | 2014-09-25 |
| JP2014524903A5 true JP2014524903A5 (https=) | 2017-11-02 |
| JP6240067B2 JP6240067B2 (ja) | 2017-11-29 |
Family
ID=46456289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014516148A Active JP6240067B2 (ja) | 2011-06-24 | 2012-06-22 | 光感受性キメラｇｐｃｒタンパク質 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10112984B2 (https=) |
| EP (2) | EP3029063B1 (https=) |
| JP (1) | JP6240067B2 (https=) |
| KR (1) | KR102008538B1 (https=) |
| CN (2) | CN103814045B (https=) |
| AU (1) | AU2012272505B2 (https=) |
| BR (2) | BR112013033028A8 (https=) |
| CA (1) | CA2840458C (https=) |
| DK (1) | DK3029063T3 (https=) |
| ES (1) | ES2766398T3 (https=) |
| HR (1) | HRP20200004T1 (https=) |
| HU (1) | HUE047074T2 (https=) |
| LT (1) | LT3029063T (https=) |
| PL (2) | PL2723767T3 (https=) |
| PT (1) | PT3029063T (https=) |
| RU (1) | RU2637367C2 (https=) |
| SI (1) | SI3029063T1 (https=) |
| WO (1) | WO2012174674A1 (https=) |
| ZA (1) | ZA201308824B (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140087463A1 (en) * | 2012-09-25 | 2014-03-27 | The Washington University | Optical control of cell signaling |
| EP3007730A1 (en) | 2013-06-11 | 2016-04-20 | Friedrich Miescher Institute for Biomedical Research | Retinal on bipolar cells-specific artificial promoter |
| GB201403260D0 (en) | 2014-02-25 | 2014-04-09 | Univ Manchester | Treatment of retinal degeneration using gene therapy |
| JP6779546B2 (ja) * | 2016-11-06 | 2020-11-04 | ナノスコープ テクノロジーズ エルエルシーＮａｎｏｓｃｏｐｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｌｃ | 視力回復のための多特性オプシンによる光遺伝学的調節及びその別の用途 |
| EP3318285A1 (en) * | 2016-11-08 | 2018-05-09 | Oxford University Innovation Limited | Treatment of eye disease |
| MX2020004643A (es) * | 2017-11-13 | 2021-01-29 | Univ California | Composiciones y metodos para mejorar la funcion visual. |
| EP3735572A1 (en) * | 2018-01-02 | 2020-11-11 | Signify Holding B.V. | Light melanopic activity indicator |
| WO2020221769A1 (en) | 2019-04-29 | 2020-11-05 | Confo Therapeutics N.V. | Screening methods and assays for use with transmembrane proteins, in particular with gpcrs |
| CN114729009A (zh) | 2019-10-31 | 2022-07-08 | 伯尔尼大学 | 用于眼部基因递送的aav载体变体 |
| US20240174743A1 (en) * | 2019-11-29 | 2024-05-30 | Universität Bern | Chimeric opsin gpcr proteins |
| WO2021140205A1 (en) * | 2020-01-10 | 2021-07-15 | Confo Therapeutics N.V. | Methods for generating antibodies and antibody fragments and libraries comprising same |
| CN114762723A (zh) * | 2020-12-31 | 2022-07-19 | 吴伯骥 | HrpZpst蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用 |
| CN112675293A (zh) * | 2020-12-31 | 2021-04-20 | 吴伯骥 | HrpNEcb蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用 |
| JP2025519378A (ja) * | 2022-06-07 | 2025-06-26 | アドヴェラム バイオテクノロジーズ， インコーポレイテッド | 視覚回復のためのメラノプシンバリアント |
| CN118791624B (zh) * | 2023-04-11 | 2026-04-03 | 苏州星明优健生物技术有限公司 | 用于治疗视网膜神经退行性疾病的新型gpcr嵌合视蛋白 |
| WO2026017073A1 (zh) * | 2024-07-16 | 2026-01-22 | 北京脑科学与类脑研究所 | 一种光敏蛋白及其应用 |
| CN120442622A (zh) * | 2024-09-23 | 2025-08-08 | 中眸医疗科技(武汉)有限公司 | 多种在on型双极细胞上高效靶定的启动子在基因治疗技术中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2308779T3 (es) * | 1995-07-26 | 2008-12-01 | Astrazeneca Ab | Receptores quimericos y metodos para identificar compuestos activos en los receptores de glutamato metabotropico y el uso de tales compuestos en el tratamiento de trastornos y enfermedades neurologicas. |
| WO2004009022A2 (en) | 2002-07-18 | 2004-01-29 | The General Hospital Corp. | Method for augmenting vision in persons suffering from photoreceptor cell degeneration |
| GB0426196D0 (en) | 2004-11-30 | 2004-12-29 | Imp College Innovations Ltd | Methods of treatment |
| CN101484005A (zh) | 2006-05-04 | 2009-07-15 | 韦恩州立大学 | 通过向体内递送视紫红质核酸恢复视觉响应 |
| EP1891976A1 (en) | 2006-08-23 | 2008-02-27 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research | Use of light sensitive genes |
| US8178496B2 (en) * | 2007-12-21 | 2012-05-15 | The Regents Of The University Of California | Photoreactive regulator of glutamate receptor function and methods of use thereof |
| WO2010011404A2 (en) * | 2008-05-20 | 2010-01-28 | Eos Neuroscience, Inc. | Vectors for delivery of light-sensitive proteins and methods of use |
| RU2374245C1 (ru) * | 2008-08-22 | 2009-11-27 | Андрей Александрович Иващенко | Лиганд с широким спектром одновременной рецепторной активности, фармацевтическая композиция, способ ее получения и лекарственное средство |
| NZ602416A (en) * | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
-
2012
- 2012-06-22 EP EP15201713.3A patent/EP3029063B1/en active Active
- 2012-06-22 WO PCT/CH2012/000138 patent/WO2012174674A1/en not_active Ceased
- 2012-06-22 KR KR1020147000648A patent/KR102008538B1/ko active Active
- 2012-06-22 RU RU2014101708A patent/RU2637367C2/ru active
- 2012-06-22 HU HUE15201713A patent/HUE047074T2/hu unknown
- 2012-06-22 LT LTEP15201713.3T patent/LT3029063T/lt unknown
- 2012-06-22 CN CN201280030926.4A patent/CN103814045B/zh active Active
- 2012-06-22 DK DK15201713.3T patent/DK3029063T3/da active
- 2012-06-22 CA CA2840458A patent/CA2840458C/en active Active
- 2012-06-22 PL PL12731288T patent/PL2723767T3/pl unknown
- 2012-06-22 BR BR112013033028A patent/BR112013033028A8/pt not_active Application Discontinuation
- 2012-06-22 EP EP12731288.2A patent/EP2723767B8/en active Active
- 2012-06-22 PL PL15201713T patent/PL3029063T3/pl unknown
- 2012-06-22 ES ES15201713T patent/ES2766398T3/es active Active
- 2012-06-22 AU AU2012272505A patent/AU2012272505B2/en active Active
- 2012-06-22 BR BR122022007044-2A patent/BR122022007044B1/pt active IP Right Grant
- 2012-06-22 PT PT152017133T patent/PT3029063T/pt unknown
- 2012-06-22 CN CN201710294286.2A patent/CN107383184A/zh active Pending
- 2012-06-22 JP JP2014516148A patent/JP6240067B2/ja active Active
- 2012-06-22 SI SI201231720T patent/SI3029063T1/sl unknown
- 2012-06-22 US US14/128,155 patent/US10112984B2/en active Active
-
2013
- 2013-11-22 ZA ZA2013/08824A patent/ZA201308824B/en unknown
-
2020
- 2020-01-03 HR HRP20200004TT patent/HRP20200004T1/hr unknown
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