JP2014524903A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014524903A5 JP2014524903A5 JP2014516148A JP2014516148A JP2014524903A5 JP 2014524903 A5 JP2014524903 A5 JP 2014524903A5 JP 2014516148 A JP2014516148 A JP 2014516148A JP 2014516148 A JP2014516148 A JP 2014516148A JP 2014524903 A5 JP2014524903 A5 JP 2014524903A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- pharmaceutical composition
- chimeric
- gpcr
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 25
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 25
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 230000003834 intracellular effect Effects 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 8
- 102100038300 Metabotropic glutamate receptor 6 Human genes 0.000 claims 7
- 108010038450 metabotropic glutamate receptor 6 Proteins 0.000 claims 7
- 230000002068 genetic effect Effects 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 230000004304 visual acuity Effects 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 210000001743 on-bipolar cell Anatomy 0.000 claims 5
- 230000009261 transgenic effect Effects 0.000 claims 5
- 239000013598 vector Substances 0.000 claims 5
- 102100025912 Melanopsin Human genes 0.000 claims 4
- 108010005417 melanopsin Proteins 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 101100122490 Drosophila melanogaster Galphaq gene Proteins 0.000 claims 2
- 108700028146 Genetic Enhancer Elements Proteins 0.000 claims 2
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 230000002186 photoactivation Effects 0.000 claims 2
- 230000002207 retinal effect Effects 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- 201000004569 Blindness Diseases 0.000 claims 1
- 241000252212 Danio rerio Species 0.000 claims 1
- 101000720986 Homo sapiens Melanopsin Proteins 0.000 claims 1
- 101000844510 Homo sapiens Transient receptor potential cation channel subfamily M member 1 Proteins 0.000 claims 1
- 102000010175 Opsin Human genes 0.000 claims 1
- 108050001704 Opsin Proteins 0.000 claims 1
- 239000002262 Schiff base Substances 0.000 claims 1
- 150000004753 Schiff bases Chemical class 0.000 claims 1
- 102000003617 TRPM1 Human genes 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 108091008695 photoreceptors Proteins 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 210000001116 retinal neuron Anatomy 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161500863P | 2011-06-24 | 2011-06-24 | |
| US61/500,863 | 2011-06-24 | ||
| PCT/CH2012/000138 WO2012174674A1 (en) | 2011-06-24 | 2012-06-22 | Light-sensitive chimeric gpcr protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524903A JP2014524903A (ja) | 2014-09-25 |
| JP2014524903A5 true JP2014524903A5 (https=) | 2017-11-02 |
| JP6240067B2 JP6240067B2 (ja) | 2017-11-29 |
Family
ID=46456289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014516148A Active JP6240067B2 (ja) | 2011-06-24 | 2012-06-22 | 光感受性キメラｇｐｃｒタンパク質 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10112984B2 (https=) |
| EP (2) | EP2723767B8 (https=) |
| JP (1) | JP6240067B2 (https=) |
| KR (1) | KR102008538B1 (https=) |
| CN (2) | CN107383184A (https=) |
| AU (1) | AU2012272505B2 (https=) |
| BR (2) | BR112013033028A8 (https=) |
| CA (1) | CA2840458C (https=) |
| DK (1) | DK3029063T3 (https=) |
| ES (1) | ES2766398T3 (https=) |
| HR (1) | HRP20200004T1 (https=) |
| HU (1) | HUE047074T2 (https=) |
| LT (1) | LT3029063T (https=) |
| PL (2) | PL2723767T3 (https=) |
| PT (1) | PT3029063T (https=) |
| RU (1) | RU2637367C2 (https=) |
| SI (1) | SI3029063T1 (https=) |
| WO (1) | WO2012174674A1 (https=) |
| ZA (1) | ZA201308824B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140087463A1 (en) * | 2012-09-25 | 2014-03-27 | The Washington University | Optical control of cell signaling |
| EP3007730A1 (en) * | 2013-06-11 | 2016-04-20 | Friedrich Miescher Institute for Biomedical Research | Retinal on bipolar cells-specific artificial promoter |
| GB201403260D0 (en) | 2014-02-25 | 2014-04-09 | Univ Manchester | Treatment of retinal degeneration using gene therapy |
| WO2018106369A2 (en) * | 2016-11-06 | 2018-06-14 | Nanoscope Technologies Llc | Optogenetic modulation by multi-characteristic opsins for vision restoration and other applications thereof |
| EP3318285A1 (en) * | 2016-11-08 | 2018-05-09 | Oxford University Innovation Limited | Treatment of eye disease |
| SG11202003778QA (en) | 2017-11-13 | 2020-05-28 | Univ California | Compositions and methods for enhancing visual function |
| JP7241090B2 (ja) * | 2018-01-02 | 2023-03-16 | シグニファイ ホールディング ビー ヴィ | 光メラノピックアクティビティインジケータ |
| CA3138642A1 (en) * | 2019-04-29 | 2020-11-05 | Confo Therapeutics N.V. | Screening methods and assays for use with transmembrane proteins, in particular with gpcrs |
| CN114729009A (zh) | 2019-10-31 | 2022-07-08 | 伯尔尼大学 | 用于眼部基因递送的aav载体变体 |
| PE20230093A1 (es) * | 2019-11-29 | 2023-01-16 | Univ Bern | Proteinas gpcr de opsinas quimericas |
| WO2021140205A1 (en) * | 2020-01-10 | 2021-07-15 | Confo Therapeutics N.V. | Methods for generating antibodies and antibody fragments and libraries comprising same |
| CN114762723A (zh) * | 2020-12-31 | 2022-07-19 | 吴伯骥 | HrpZpst蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用 |
| CN112675293A (zh) * | 2020-12-31 | 2021-04-20 | 吴伯骥 | HrpNEcb蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用 |
| JP2025519378A (ja) * | 2022-06-07 | 2025-06-26 | アドヴェラム バイオテクノロジーズ， インコーポレイテッド | 視覚回復のためのメラノプシンバリアント |
| CN118791624B (zh) | 2023-04-11 | 2026-04-03 | 苏州星明优健生物技术有限公司 | 用于治疗视网膜神经退行性疾病的新型gpcr嵌合视蛋白 |
| WO2025201567A1 (zh) * | 2024-09-23 | 2025-10-02 | 中眸医疗科技(武汉)有限公司 | 多种在on型双极细胞上高效靶定的启动子在基因治疗技术中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69637587D1 (de) * | 1995-07-26 | 2008-08-21 | Astrazeneca Ab | Chimäre rezeptoren und verfahren zur identifizieren verbindungen mit einem aktivität als metabotropischen glutamatrezeptoren sowie verwendung solcher verbindungen in der behandlung von neurologischer erkrankungen und neurologischenstörrungen |
| AU2003249318A1 (en) | 2002-07-18 | 2004-02-09 | The General Hospital Corp. | Method for augmenting vision in persons suffering from photoreceptor cell degeneration |
| GB0426196D0 (en) * | 2004-11-30 | 2004-12-29 | Imp College Innovations Ltd | Methods of treatment |
| EP2019588A4 (en) | 2006-05-04 | 2010-11-24 | Univ Wayne State | RESTORATION OF VISUAL RESPONSES BY IN VIVO ADMINISTRATION OF NUCLEIC ACIDS OF RHODOPSIN |
| EP1891976A1 (en) * | 2006-08-23 | 2008-02-27 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research | Use of light sensitive genes |
| US8178496B2 (en) * | 2007-12-21 | 2012-05-15 | The Regents Of The University Of California | Photoreactive regulator of glutamate receptor function and methods of use thereof |
| EP2910637A1 (en) * | 2008-05-20 | 2015-08-26 | University of Florida Research Foundation, Inc. | Vectors for delivery of light-sensitive proteins and methods of use |
| RU2374245C1 (ru) * | 2008-08-22 | 2009-11-27 | Андрей Александрович Иващенко | Лиганд с широким спектром одновременной рецепторной активности, фармацевтическая композиция, способ ее получения и лекарственное средство |
| NZ602416A (en) * | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
-
2012
- 2012-06-22 PL PL12731288T patent/PL2723767T3/pl unknown
- 2012-06-22 SI SI201231720T patent/SI3029063T1/sl unknown
- 2012-06-22 BR BR112013033028A patent/BR112013033028A8/pt not_active Application Discontinuation
- 2012-06-22 JP JP2014516148A patent/JP6240067B2/ja active Active
- 2012-06-22 PT PT152017133T patent/PT3029063T/pt unknown
- 2012-06-22 RU RU2014101708A patent/RU2637367C2/ru active
- 2012-06-22 LT LTEP15201713.3T patent/LT3029063T/lt unknown
- 2012-06-22 EP EP12731288.2A patent/EP2723767B8/en active Active
- 2012-06-22 EP EP15201713.3A patent/EP3029063B1/en active Active
- 2012-06-22 AU AU2012272505A patent/AU2012272505B2/en active Active
- 2012-06-22 BR BR122022007044-2A patent/BR122022007044B1/pt active IP Right Grant
- 2012-06-22 PL PL15201713T patent/PL3029063T3/pl unknown
- 2012-06-22 HU HUE15201713A patent/HUE047074T2/hu unknown
- 2012-06-22 WO PCT/CH2012/000138 patent/WO2012174674A1/en not_active Ceased
- 2012-06-22 CN CN201710294286.2A patent/CN107383184A/zh active Pending
- 2012-06-22 KR KR1020147000648A patent/KR102008538B1/ko active Active
- 2012-06-22 DK DK15201713.3T patent/DK3029063T3/da active
- 2012-06-22 ES ES15201713T patent/ES2766398T3/es active Active
- 2012-06-22 CN CN201280030926.4A patent/CN103814045B/zh active Active
- 2012-06-22 US US14/128,155 patent/US10112984B2/en active Active
- 2012-06-22 CA CA2840458A patent/CA2840458C/en active Active
-
2013
- 2013-11-22 ZA ZA2013/08824A patent/ZA201308824B/en unknown
-
2020
- 2020-01-03 HR HRP20200004TT patent/HRP20200004T1/hr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014524903A5 (https=) | ||
| RU2014101708A (ru) | Светочувствительный химерный белок gpcr | |
| ES3008567T3 (en) | Recombinant antibody molecule and its use for target cell restricted t cell activation | |
| ES2883633T3 (es) | Agentes terapéuticos | |
| Okada et al. | Activation of rhodopsin: new insights from structural and biochemical studies | |
| US10428149B2 (en) | Single-chain tumor necrosis factor (TNF) ligand family molecules, fusion proteins and derivatives thereof | |
| ES2613523T3 (es) | Antagonistas de ActRIIb y dosificación y usos de los mismos | |
| JP2020508068A5 (https=) | ||
| TW201141509A (en) | Modified binding proteins inhibiting the VEGF-A receptor interaction | |
| WO2010105573A1 (zh) | 抗血管新生融合蛋白 | |
| CN109715658B (zh) | 可溶性成纤维细胞生长因子受体3(sfgfr3)多肽及其用途 | |
| JP2015518479A5 (https=) | ||
| JP2016510755A5 (https=) | ||
| JP2017529059A5 (https=) | ||
| JP2020500885A5 (https=) | ||
| JP6757024B2 (ja) | 視覚機能再生剤又は視覚機能低下予防剤 | |
| AU2016232819B2 (en) | Compositions and methods for use of anion channel rhodopsins | |
| CA3162568A1 (en) | Chimeric opsin gpcr proteins | |
| JP2025123277A (ja) | キメラロドプシンをコードする核酸コンストラクト | |
| WO2020148913A1 (ja) | 網膜疾患の予防および進行抑制、視覚認知行動機能の改善、および視覚機能強化 | |
| KR102618373B1 (ko) | 키메라성 클로로톡신 수용체 | |
| CN103930439A (zh) | 基因工程生长因子变异体 | |
| CN109996817A (zh) | 扭转原肠胚形成多肽及其用途 | |
| JP7054143B2 (ja) | キメラ抗原受容体、及びその利用 | |
| WO2022192259A1 (en) | BIFUNCTIONAL HOMODIMERIC ANTI-PD-1 AND IL-15/IL-15Rα FUSION PROTEINS AND USES THEREOF |