DK3029063T3 - Lysfølsomt chimært GPCR-protein - Google Patents

Lysfølsomt chimært GPCR-protein Download PDF

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Publication number
DK3029063T3
DK3029063T3 DK15201713.3T DK15201713T DK3029063T3 DK 3029063 T3 DK3029063 T3 DK 3029063T3 DK 15201713 T DK15201713 T DK 15201713T DK 3029063 T3 DK3029063 T3 DK 3029063T3
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DK
Denmark
Prior art keywords
photosensitive
gpcr protein
chimeric gpcr
chimeric
protein
Prior art date
Application number
DK15201713.3T
Other languages
Danish (da)
English (en)
Inventor
Wyk Michiel Van
Sonja Kleinlogel
Original Assignee
Arctos Medical AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arctos Medical AG filed Critical Arctos Medical AG
Application granted granted Critical
Publication of DK3029063T3 publication Critical patent/DK3029063T3/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/40—Fish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Environmental Sciences (AREA)
  • Animal Husbandry (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DK15201713.3T 2011-06-24 2012-06-22 Lysfølsomt chimært GPCR-protein DK3029063T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161500863P 2011-06-24 2011-06-24
EP12731288.2A EP2723767B8 (en) 2011-06-24 2012-06-22 Light-sensitive chimeric gpcr protein

Publications (1)

Publication Number Publication Date
DK3029063T3 true DK3029063T3 (da) 2020-01-20

Family

ID=46456289

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15201713.3T DK3029063T3 (da) 2011-06-24 2012-06-22 Lysfølsomt chimært GPCR-protein

Country Status (19)

Country Link
US (1) US10112984B2 (https=)
EP (2) EP3029063B1 (https=)
JP (1) JP6240067B2 (https=)
KR (1) KR102008538B1 (https=)
CN (2) CN103814045B (https=)
AU (1) AU2012272505B2 (https=)
BR (2) BR112013033028A8 (https=)
CA (1) CA2840458C (https=)
DK (1) DK3029063T3 (https=)
ES (1) ES2766398T3 (https=)
HR (1) HRP20200004T1 (https=)
HU (1) HUE047074T2 (https=)
LT (1) LT3029063T (https=)
PL (2) PL2723767T3 (https=)
PT (1) PT3029063T (https=)
RU (1) RU2637367C2 (https=)
SI (1) SI3029063T1 (https=)
WO (1) WO2012174674A1 (https=)
ZA (1) ZA201308824B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140087463A1 (en) * 2012-09-25 2014-03-27 The Washington University Optical control of cell signaling
EP3007730A1 (en) 2013-06-11 2016-04-20 Friedrich Miescher Institute for Biomedical Research Retinal on bipolar cells-specific artificial promoter
GB201403260D0 (en) 2014-02-25 2014-04-09 Univ Manchester Treatment of retinal degeneration using gene therapy
JP6779546B2 (ja) * 2016-11-06 2020-11-04 ナノスコープ テクノロジーズ エルエルシーＮａｎｏｓｃｏｐｅ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｌｃ 視力回復のための多特性オプシンによる光遺伝学的調節及びその別の用途
EP3318285A1 (en) * 2016-11-08 2018-05-09 Oxford University Innovation Limited Treatment of eye disease
MX2020004643A (es) * 2017-11-13 2021-01-29 Univ California Composiciones y metodos para mejorar la funcion visual.
EP3735572A1 (en) * 2018-01-02 2020-11-11 Signify Holding B.V. Light melanopic activity indicator
WO2020221769A1 (en) 2019-04-29 2020-11-05 Confo Therapeutics N.V. Screening methods and assays for use with transmembrane proteins, in particular with gpcrs
CN114729009A (zh) 2019-10-31 2022-07-08 伯尔尼大学 用于眼部基因递送的aav载体变体
US20240174743A1 (en) * 2019-11-29 2024-05-30 Universität Bern Chimeric opsin gpcr proteins
WO2021140205A1 (en) * 2020-01-10 2021-07-15 Confo Therapeutics N.V. Methods for generating antibodies and antibody fragments and libraries comprising same
CN114762723A (zh) * 2020-12-31 2022-07-19 吴伯骥 HrpZpst蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用
CN112675293A (zh) * 2020-12-31 2021-04-20 吴伯骥 HrpNEcb蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用
JP2025519378A (ja) * 2022-06-07 2025-06-26 アドヴェラム バイオテクノロジーズ， インコーポレイテッド 視覚回復のためのメラノプシンバリアント
CN118791624B (zh) * 2023-04-11 2026-04-03 苏州星明优健生物技术有限公司 用于治疗视网膜神经退行性疾病的新型gpcr嵌合视蛋白
WO2026017073A1 (zh) * 2024-07-16 2026-01-22 北京脑科学与类脑研究所 一种光敏蛋白及其应用
CN120442622A (zh) * 2024-09-23 2025-08-08 中眸医疗科技(武汉)有限公司 多种在on型双极细胞上高效靶定的启动子在基因治疗技术中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2308779T3 (es) * 1995-07-26 2008-12-01 Astrazeneca Ab Receptores quimericos y metodos para identificar compuestos activos en los receptores de glutamato metabotropico y el uso de tales compuestos en el tratamiento de trastornos y enfermedades neurologicas.
WO2004009022A2 (en) 2002-07-18 2004-01-29 The General Hospital Corp. Method for augmenting vision in persons suffering from photoreceptor cell degeneration
GB0426196D0 (en) 2004-11-30 2004-12-29 Imp College Innovations Ltd Methods of treatment
CN101484005A (zh) 2006-05-04 2009-07-15 韦恩州立大学 通过向体内递送视紫红质核酸恢复视觉响应
EP1891976A1 (en) 2006-08-23 2008-02-27 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research Use of light sensitive genes
US8178496B2 (en) * 2007-12-21 2012-05-15 The Regents Of The University Of California Photoreactive regulator of glutamate receptor function and methods of use thereof
WO2010011404A2 (en) * 2008-05-20 2010-01-28 Eos Neuroscience, Inc. Vectors for delivery of light-sensitive proteins and methods of use
RU2374245C1 (ru) * 2008-08-22 2009-11-27 Андрей Александрович Иващенко Лиганд с широким спектром одновременной рецепторной активности, фармацевтическая композиция, способ ее получения и лекарственное средство
NZ602416A (en) * 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto

Also Published As

Publication number Publication date
KR20140039281A (ko) 2014-04-01
AU2012272505A1 (en) 2014-01-16
HRP20200004T1 (hr) 2020-05-15
CA2840458A1 (en) 2012-12-27
KR102008538B1 (ko) 2019-08-08
BR112013033028A8 (pt) 2022-11-01
BR122022007044B1 (pt) 2023-11-14
BR112013033028A2 (pt) 2017-01-31
JP6240067B2 (ja) 2017-11-29
EP3029063A1 (en) 2016-06-08
CA2840458C (en) 2020-09-22
CN103814045A (zh) 2014-05-21
WO2012174674A1 (en) 2012-12-27
BR122022007044A8 (pt) 2022-11-01
EP2723767A1 (en) 2014-04-30
EP2723767B8 (en) 2016-03-02
EP3029063B1 (en) 2019-10-16
RU2637367C2 (ru) 2017-12-04
PL2723767T3 (pl) 2016-06-30
CN107383184A (zh) 2017-11-24
ES2766398T3 (es) 2020-06-12
JP2014524903A (ja) 2014-09-25
AU2012272505B2 (en) 2017-03-02
RU2014101708A (ru) 2015-07-27
LT3029063T (lt) 2020-02-10
US20140171376A1 (en) 2014-06-19
US10112984B2 (en) 2018-10-30
PL3029063T3 (pl) 2020-05-18
ZA201308824B (en) 2015-02-25
EP2723767B1 (en) 2016-01-06
PT3029063T (pt) 2020-01-22
HUE047074T2 (hu) 2020-04-28
BR122022007044A2 (https=) 2017-01-31
CN103814045B (zh) 2017-05-31
SI3029063T1 (sl) 2020-03-31

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