KR102008538B1 - 감광성 키메라 gpcr 단백질 - Google Patents

감광성 키메라 gpcr 단백질 Download PDF

Info

Publication number
KR102008538B1
KR102008538B1 KR1020147000648A KR20147000648A KR102008538B1 KR 102008538 B1 KR102008538 B1 KR 102008538B1 KR 1020147000648 A KR1020147000648 A KR 1020147000648A KR 20147000648 A KR20147000648 A KR 20147000648A KR 102008538 B1 KR102008538 B1 KR 102008538B1
Authority
KR
South Korea
Prior art keywords
protein
chimeric
mglur6
gpcr
ala
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020147000648A
Other languages
English (en)
Korean (ko)
Other versions
KR20140039281A (ko
Inventor
미히엘 반 빅
소냐 클라인로겔
Original Assignee
아크토스 메디컬 아게
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 아크토스 메디컬 아게 filed Critical 아크토스 메디컬 아게
Publication of KR20140039281A publication Critical patent/KR20140039281A/ko
Application granted granted Critical
Publication of KR102008538B1 publication Critical patent/KR102008538B1/ko
Assigned to 노파르티스 아게 reassignment 노파르티스 아게 권리의 전부이전등록 Assignors: 아크토스 메디컬 아게
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/40—Fish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Environmental Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020147000648A 2011-06-24 2012-06-22 감광성 키메라 gpcr 단백질 Active KR102008538B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161500863P 2011-06-24 2011-06-24
US61/500,863 2011-06-24
PCT/CH2012/000138 WO2012174674A1 (en) 2011-06-24 2012-06-22 Light-sensitive chimeric gpcr protein

Publications (2)

Publication Number Publication Date
KR20140039281A KR20140039281A (ko) 2014-04-01
KR102008538B1 true KR102008538B1 (ko) 2019-08-08

Family

ID=46456289

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147000648A Active KR102008538B1 (ko) 2011-06-24 2012-06-22 감광성 키메라 gpcr 단백질

Country Status (19)

Country Link
US (1) US10112984B2 (https=)
EP (2) EP2723767B8 (https=)
JP (1) JP6240067B2 (https=)
KR (1) KR102008538B1 (https=)
CN (2) CN107383184A (https=)
AU (1) AU2012272505B2 (https=)
BR (2) BR112013033028A8 (https=)
CA (1) CA2840458C (https=)
DK (1) DK3029063T3 (https=)
ES (1) ES2766398T3 (https=)
HR (1) HRP20200004T1 (https=)
HU (1) HUE047074T2 (https=)
LT (1) LT3029063T (https=)
PL (2) PL2723767T3 (https=)
PT (1) PT3029063T (https=)
RU (1) RU2637367C2 (https=)
SI (1) SI3029063T1 (https=)
WO (1) WO2012174674A1 (https=)
ZA (1) ZA201308824B (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140087463A1 (en) * 2012-09-25 2014-03-27 The Washington University Optical control of cell signaling
EP3007730A1 (en) * 2013-06-11 2016-04-20 Friedrich Miescher Institute for Biomedical Research Retinal on bipolar cells-specific artificial promoter
GB201403260D0 (en) 2014-02-25 2014-04-09 Univ Manchester Treatment of retinal degeneration using gene therapy
WO2018106369A2 (en) * 2016-11-06 2018-06-14 Nanoscope Technologies Llc Optogenetic modulation by multi-characteristic opsins for vision restoration and other applications thereof
EP3318285A1 (en) * 2016-11-08 2018-05-09 Oxford University Innovation Limited Treatment of eye disease
SG11202003778QA (en) 2017-11-13 2020-05-28 Univ California Compositions and methods for enhancing visual function
JP7241090B2 (ja) * 2018-01-02 2023-03-16 シグニファイ ホールディング ビー ヴィ 光メラノピックアクティビティインジケータ
CA3138642A1 (en) * 2019-04-29 2020-11-05 Confo Therapeutics N.V. Screening methods and assays for use with transmembrane proteins, in particular with gpcrs
CN114729009A (zh) 2019-10-31 2022-07-08 伯尔尼大学 用于眼部基因递送的aav载体变体
PE20230093A1 (es) * 2019-11-29 2023-01-16 Univ Bern Proteinas gpcr de opsinas quimericas
WO2021140205A1 (en) * 2020-01-10 2021-07-15 Confo Therapeutics N.V. Methods for generating antibodies and antibody fragments and libraries comprising same
CN114762723A (zh) * 2020-12-31 2022-07-19 吴伯骥 HrpZpst蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用
CN112675293A (zh) * 2020-12-31 2021-04-20 吴伯骥 HrpNEcb蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用
JP2025519378A (ja) * 2022-06-07 2025-06-26 アドヴェラム バイオテクノロジーズ， インコーポレイテッド 視覚回復のためのメラノプシンバリアント
CN118791624B (zh) 2023-04-11 2026-04-03 苏州星明优健生物技术有限公司 用于治疗视网膜神经退行性疾病的新型gpcr嵌合视蛋白
WO2025201567A1 (zh) * 2024-09-23 2025-10-02 中眸医疗科技(武汉)有限公司 多种在on型双极细胞上高效靶定的启动子在基因治疗技术中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69637587D1 (de) * 1995-07-26 2008-08-21 Astrazeneca Ab Chimäre rezeptoren und verfahren zur identifizieren verbindungen mit einem aktivität als metabotropischen glutamatrezeptoren sowie verwendung solcher verbindungen in der behandlung von neurologischer erkrankungen und neurologischenstörrungen
AU2003249318A1 (en) 2002-07-18 2004-02-09 The General Hospital Corp. Method for augmenting vision in persons suffering from photoreceptor cell degeneration
GB0426196D0 (en) * 2004-11-30 2004-12-29 Imp College Innovations Ltd Methods of treatment
EP2019588A4 (en) 2006-05-04 2010-11-24 Univ Wayne State RESTORATION OF VISUAL RESPONSES BY IN VIVO ADMINISTRATION OF NUCLEIC ACIDS OF RHODOPSIN
EP1891976A1 (en) * 2006-08-23 2008-02-27 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research Use of light sensitive genes
US8178496B2 (en) * 2007-12-21 2012-05-15 The Regents Of The University Of California Photoreactive regulator of glutamate receptor function and methods of use thereof
EP2910637A1 (en) * 2008-05-20 2015-08-26 University of Florida Research Foundation, Inc. Vectors for delivery of light-sensitive proteins and methods of use
RU2374245C1 (ru) * 2008-08-22 2009-11-27 Андрей Александрович Иващенко Лиганд с широким спектром одновременной рецепторной активности, фармацевтическая композиция, способ ее получения и лекарственное средство
NZ602416A (en) * 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
Duvoisin R.M. 등, Cellscience reviews, Vol.2, No.2, pp.1-18 (2005.)*
J.M. Kim 등, Biochemistry, Vol.44, pp.2284-2292 (2005.)*
R. Hermann 등, Neuroscience Lettes, Vol.376, pp.76-80 (2005.)*
R.D. Airan 등, Nature, Vol.458, pp.1025-1029 (2009.04.23.)*
Yamashita Takahiro 등, J. Biochem., Vol.130, No.1, pp.149-155 (2001.07.01.)

Also Published As

Publication number Publication date
CA2840458A1 (en) 2012-12-27
JP2014524903A (ja) 2014-09-25
HRP20200004T1 (hr) 2020-05-15
CA2840458C (en) 2020-09-22
RU2637367C2 (ru) 2017-12-04
US20140171376A1 (en) 2014-06-19
PL2723767T3 (pl) 2016-06-30
EP2723767A1 (en) 2014-04-30
EP2723767B8 (en) 2016-03-02
CN103814045B (zh) 2017-05-31
PL3029063T3 (pl) 2020-05-18
EP3029063B1 (en) 2019-10-16
CN103814045A (zh) 2014-05-21
EP3029063A1 (en) 2016-06-08
ES2766398T3 (es) 2020-06-12
BR122022007044A8 (pt) 2022-11-01
PT3029063T (pt) 2020-01-22
AU2012272505B2 (en) 2017-03-02
EP2723767B1 (en) 2016-01-06
KR20140039281A (ko) 2014-04-01
BR112013033028A2 (pt) 2017-01-31
WO2012174674A1 (en) 2012-12-27
BR112013033028A8 (pt) 2022-11-01
SI3029063T1 (sl) 2020-03-31
CN107383184A (zh) 2017-11-24
ZA201308824B (en) 2015-02-25
BR122022007044B1 (pt) 2023-11-14
BR122022007044A2 (https=) 2017-01-31
JP6240067B2 (ja) 2017-11-29
US10112984B2 (en) 2018-10-30
LT3029063T (lt) 2020-02-10
HUE047074T2 (hu) 2020-04-28
DK3029063T3 (da) 2020-01-20
RU2014101708A (ru) 2015-07-27
AU2012272505A1 (en) 2014-01-16

Similar Documents

Publication Publication Date Title
KR102008538B1 (ko) 감광성 키메라 gpcr 단백질
US12343408B2 (en) AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
US8470790B2 (en) Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
AU2017239601B2 (en) Identification of Channelopsin-2 (Chop2) mutations and methods of use
EP2968476B1 (en) A plasmin for use in enhancing delivery of therapeutic compounds to the eyes or for improving vision
MX2010012592A (es) Vectores para la administracion de proteinas sensibles a la luz y metodos de uso de las mismas.
CN110267972A (zh) 由多特征视蛋白进行的用于视力恢复的光学调制以及其其他应用
CN118791624B (zh) 用于治疗视网膜神经退行性疾病的新型gpcr嵌合视蛋白
JP7846932B2 (ja) 改変チャネルロドプシン
Tomita et al. 26 Strategies for Restoring Vision by Transducing a Channelrhodopsin Gene into Retinal Ganglion Cells

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20140109

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20170613

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20180822

Patent event code: PE09021S01D

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

Patent event code: PE07011S01D

Comment text: Decision to Grant Registration

Patent event date: 20190523

GRNT Written decision to grant
PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20190801

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20190801

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
FPAY Annual fee payment

Payment date: 20220728

Year of fee payment: 4

PR1001 Payment of annual fee

Payment date: 20220728

Start annual number: 4

End annual number: 4

PR1001 Payment of annual fee

Payment date: 20240729

Start annual number: 6

End annual number: 6