BR112013033028A8 - Composições farmacêuticas e proteína de gpcr quimérica, molécula de ácido nucleico, e vetor - Google Patents
Composições farmacêuticas e proteína de gpcr quimérica, molécula de ácido nucleico, e vetorInfo
- Publication number
- BR112013033028A8 BR112013033028A8 BR112013033028A BR112013033028A BR112013033028A8 BR 112013033028 A8 BR112013033028 A8 BR 112013033028A8 BR 112013033028 A BR112013033028 A BR 112013033028A BR 112013033028 A BR112013033028 A BR 112013033028A BR 112013033028 A8 BR112013033028 A8 BR 112013033028A8
- Authority
- BR
- Brazil
- Prior art keywords
- light
- gpcr
- protein
- sensitive
- chimeric
- Prior art date
Links
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 title abstract 10
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 title abstract 10
- 102000039446 nucleic acids Human genes 0.000 title 1
- 108020004707 nucleic acids Proteins 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 4
- 108090000623 proteins and genes Proteins 0.000 abstract 4
- 230000008878 coupling Effects 0.000 abstract 2
- 238000010168 coupling process Methods 0.000 abstract 2
- 238000005859 coupling reaction Methods 0.000 abstract 2
- 201000004569 Blindness Diseases 0.000 abstract 1
- 102100022758 Glutamate receptor ionotropic, kainate 2 Human genes 0.000 abstract 1
- 101710112360 Glutamate receptor ionotropic, kainate 2 Proteins 0.000 abstract 1
- 101000720986 Homo sapiens Melanopsin Proteins 0.000 abstract 1
- 102100025912 Melanopsin Human genes 0.000 abstract 1
- 206010034960 Photophobia Diseases 0.000 abstract 1
- 210000000170 cell membrane Anatomy 0.000 abstract 1
- 210000003986 cell retinal photoreceptor Anatomy 0.000 abstract 1
- 230000007850 degeneration Effects 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 102000037865 fusion proteins Human genes 0.000 abstract 1
- 108020001507 fusion proteins Proteins 0.000 abstract 1
- 230000031146 intracellular signal transduction Effects 0.000 abstract 1
- 208000013469 light sensitivity Diseases 0.000 abstract 1
- 238000013160 medical therapy Methods 0.000 abstract 1
- 108010005417 melanopsin Proteins 0.000 abstract 1
- 210000001743 on-bipolar cell Anatomy 0.000 abstract 1
- 210000001525 retina Anatomy 0.000 abstract 1
- 230000019491 signal transduction Effects 0.000 abstract 1
- 230000004393 visual impairment Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/40—Fish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Environmental Sciences (AREA)
- Urology & Nephrology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Biotechnology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR122022007044-2A BR122022007044B1 (pt) | 2011-06-24 | 2012-06-22 | Composições farmacêuticas que compreendem uma proteína de gpcr quimérica, proteína de gpcr quimérica, molécula de ácido nucleico, e vetor |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161500863P | 2011-06-24 | 2011-06-24 | |
| PCT/CH2012/000138 WO2012174674A1 (en) | 2011-06-24 | 2012-06-22 | Light-sensitive chimeric gpcr protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112013033028A2 BR112013033028A2 (pt) | 2017-01-31 |
| BR112013033028A8 true BR112013033028A8 (pt) | 2022-11-01 |
Family
ID=46456289
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013033028A BR112013033028A8 (pt) | 2011-06-24 | 2012-06-22 | Composições farmacêuticas e proteína de gpcr quimérica, molécula de ácido nucleico, e vetor |
| BR122022007044-2A BR122022007044B1 (pt) | 2011-06-24 | 2012-06-22 | Composições farmacêuticas que compreendem uma proteína de gpcr quimérica, proteína de gpcr quimérica, molécula de ácido nucleico, e vetor |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122022007044-2A BR122022007044B1 (pt) | 2011-06-24 | 2012-06-22 | Composições farmacêuticas que compreendem uma proteína de gpcr quimérica, proteína de gpcr quimérica, molécula de ácido nucleico, e vetor |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10112984B2 (https=) |
| EP (2) | EP2723767B8 (https=) |
| JP (1) | JP6240067B2 (https=) |
| KR (1) | KR102008538B1 (https=) |
| CN (2) | CN107383184A (https=) |
| AU (1) | AU2012272505B2 (https=) |
| BR (2) | BR112013033028A8 (https=) |
| CA (1) | CA2840458C (https=) |
| DK (1) | DK3029063T3 (https=) |
| ES (1) | ES2766398T3 (https=) |
| HR (1) | HRP20200004T1 (https=) |
| HU (1) | HUE047074T2 (https=) |
| LT (1) | LT3029063T (https=) |
| PL (2) | PL2723767T3 (https=) |
| PT (1) | PT3029063T (https=) |
| RU (1) | RU2637367C2 (https=) |
| SI (1) | SI3029063T1 (https=) |
| WO (1) | WO2012174674A1 (https=) |
| ZA (1) | ZA201308824B (https=) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140087463A1 (en) * | 2012-09-25 | 2014-03-27 | The Washington University | Optical control of cell signaling |
| EP3007730A1 (en) * | 2013-06-11 | 2016-04-20 | Friedrich Miescher Institute for Biomedical Research | Retinal on bipolar cells-specific artificial promoter |
| GB201403260D0 (en) | 2014-02-25 | 2014-04-09 | Univ Manchester | Treatment of retinal degeneration using gene therapy |
| WO2018106369A2 (en) * | 2016-11-06 | 2018-06-14 | Nanoscope Technologies Llc | Optogenetic modulation by multi-characteristic opsins for vision restoration and other applications thereof |
| EP3318285A1 (en) * | 2016-11-08 | 2018-05-09 | Oxford University Innovation Limited | Treatment of eye disease |
| SG11202003778QA (en) | 2017-11-13 | 2020-05-28 | Univ California | Compositions and methods for enhancing visual function |
| JP7241090B2 (ja) * | 2018-01-02 | 2023-03-16 | シグニファイ ホールディング ビー ヴィ | 光メラノピックアクティビティインジケータ |
| CA3138642A1 (en) * | 2019-04-29 | 2020-11-05 | Confo Therapeutics N.V. | Screening methods and assays for use with transmembrane proteins, in particular with gpcrs |
| CN114729009A (zh) | 2019-10-31 | 2022-07-08 | 伯尔尼大学 | 用于眼部基因递送的aav载体变体 |
| PE20230093A1 (es) * | 2019-11-29 | 2023-01-16 | Univ Bern | Proteinas gpcr de opsinas quimericas |
| WO2021140205A1 (en) * | 2020-01-10 | 2021-07-15 | Confo Therapeutics N.V. | Methods for generating antibodies and antibody fragments and libraries comprising same |
| CN114762723A (zh) * | 2020-12-31 | 2022-07-19 | 吴伯骥 | HrpZpst蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用 |
| CN112675293A (zh) * | 2020-12-31 | 2021-04-20 | 吴伯骥 | HrpNEcb蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用 |
| JP2025519378A (ja) * | 2022-06-07 | 2025-06-26 | アドヴェラム バイオテクノロジーズ， インコーポレイテッド | 視覚回復のためのメラノプシンバリアント |
| CN118791624B (zh) | 2023-04-11 | 2026-04-03 | 苏州星明优健生物技术有限公司 | 用于治疗视网膜神经退行性疾病的新型gpcr嵌合视蛋白 |
| WO2025201567A1 (zh) * | 2024-09-23 | 2025-10-02 | 中眸医疗科技(武汉)有限公司 | 多种在on型双极细胞上高效靶定的启动子在基因治疗技术中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE69637587D1 (de) * | 1995-07-26 | 2008-08-21 | Astrazeneca Ab | Chimäre rezeptoren und verfahren zur identifizieren verbindungen mit einem aktivität als metabotropischen glutamatrezeptoren sowie verwendung solcher verbindungen in der behandlung von neurologischer erkrankungen und neurologischenstörrungen |
| AU2003249318A1 (en) | 2002-07-18 | 2004-02-09 | The General Hospital Corp. | Method for augmenting vision in persons suffering from photoreceptor cell degeneration |
| GB0426196D0 (en) * | 2004-11-30 | 2004-12-29 | Imp College Innovations Ltd | Methods of treatment |
| EP2019588A4 (en) | 2006-05-04 | 2010-11-24 | Univ Wayne State | RESTORATION OF VISUAL RESPONSES BY IN VIVO ADMINISTRATION OF NUCLEIC ACIDS OF RHODOPSIN |
| EP1891976A1 (en) * | 2006-08-23 | 2008-02-27 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research | Use of light sensitive genes |
| US8178496B2 (en) * | 2007-12-21 | 2012-05-15 | The Regents Of The University Of California | Photoreactive regulator of glutamate receptor function and methods of use thereof |
| EP2910637A1 (en) * | 2008-05-20 | 2015-08-26 | University of Florida Research Foundation, Inc. | Vectors for delivery of light-sensitive proteins and methods of use |
| RU2374245C1 (ru) * | 2008-08-22 | 2009-11-27 | Андрей Александрович Иващенко | Лиганд с широким спектром одновременной рецепторной активности, фармацевтическая композиция, способ ее получения и лекарственное средство |
| NZ602416A (en) * | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
-
2012
- 2012-06-22 PL PL12731288T patent/PL2723767T3/pl unknown
- 2012-06-22 SI SI201231720T patent/SI3029063T1/sl unknown
- 2012-06-22 BR BR112013033028A patent/BR112013033028A8/pt not_active Application Discontinuation
- 2012-06-22 JP JP2014516148A patent/JP6240067B2/ja active Active
- 2012-06-22 PT PT152017133T patent/PT3029063T/pt unknown
- 2012-06-22 RU RU2014101708A patent/RU2637367C2/ru active
- 2012-06-22 LT LTEP15201713.3T patent/LT3029063T/lt unknown
- 2012-06-22 EP EP12731288.2A patent/EP2723767B8/en active Active
- 2012-06-22 EP EP15201713.3A patent/EP3029063B1/en active Active
- 2012-06-22 AU AU2012272505A patent/AU2012272505B2/en active Active
- 2012-06-22 BR BR122022007044-2A patent/BR122022007044B1/pt active IP Right Grant
- 2012-06-22 PL PL15201713T patent/PL3029063T3/pl unknown
- 2012-06-22 HU HUE15201713A patent/HUE047074T2/hu unknown
- 2012-06-22 WO PCT/CH2012/000138 patent/WO2012174674A1/en not_active Ceased
- 2012-06-22 CN CN201710294286.2A patent/CN107383184A/zh active Pending
- 2012-06-22 KR KR1020147000648A patent/KR102008538B1/ko active Active
- 2012-06-22 DK DK15201713.3T patent/DK3029063T3/da active
- 2012-06-22 ES ES15201713T patent/ES2766398T3/es active Active
- 2012-06-22 CN CN201280030926.4A patent/CN103814045B/zh active Active
- 2012-06-22 US US14/128,155 patent/US10112984B2/en active Active
- 2012-06-22 CA CA2840458A patent/CA2840458C/en active Active
-
2013
- 2013-11-22 ZA ZA2013/08824A patent/ZA201308824B/en unknown
-
2020
- 2020-01-03 HR HRP20200004TT patent/HRP20200004T1/hr unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS. |
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| B25G | Requested change of headquarter approved |
Owner name: HAAG-STREIT MEDTECH AG (CH) |
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| B25D | Requested change of name of applicant approved |
Owner name: ARCTOS MEDICAL AG (CH) |
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| B25G | Requested change of headquarter approved |
Owner name: ARCTOS MEDICAL AG (CH) |
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| B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B25A | Requested transfer of rights approved |
Owner name: NOVARTIS AG (CH) |
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| B12B | Appeal against refusal [chapter 12.2 patent gazette] |