JP2014524903A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014524903A5 JP2014524903A5 JP2014516148A JP2014516148A JP2014524903A5 JP 2014524903 A5 JP2014524903 A5 JP 2014524903A5 JP 2014516148 A JP2014516148 A JP 2014516148A JP 2014516148 A JP2014516148 A JP 2014516148A JP 2014524903 A5 JP2014524903 A5 JP 2014524903A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- pharmaceutical composition
- chimeric
- gpcr
- composition according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 claims 25
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 claims 25
- 239000008194 pharmaceutical composition Substances 0.000 claims 19
- 230000003834 intracellular effect Effects 0.000 claims 10
- 102000039446 nucleic acids Human genes 0.000 claims 10
- 108020004707 nucleic acids Proteins 0.000 claims 10
- 150000007523 nucleic acids Chemical class 0.000 claims 10
- 210000004027 cell Anatomy 0.000 claims 8
- 102100038300 Metabotropic glutamate receptor 6 Human genes 0.000 claims 7
- 108010038450 metabotropic glutamate receptor 6 Proteins 0.000 claims 7
- 230000002068 genetic effect Effects 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 230000004304 visual acuity Effects 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 210000001743 on-bipolar cell Anatomy 0.000 claims 5
- 230000009261 transgenic effect Effects 0.000 claims 5
- 239000013598 vector Substances 0.000 claims 5
- 102100025912 Melanopsin Human genes 0.000 claims 4
- 108010005417 melanopsin Proteins 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 3
- 238000006467 substitution reaction Methods 0.000 claims 3
- 238000002560 therapeutic procedure Methods 0.000 claims 3
- 101100122490 Drosophila melanogaster Galphaq gene Proteins 0.000 claims 2
- 108700028146 Genetic Enhancer Elements Proteins 0.000 claims 2
- 208000007014 Retinitis pigmentosa Diseases 0.000 claims 2
- 102000037865 fusion proteins Human genes 0.000 claims 2
- 108020001507 fusion proteins Proteins 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 230000002186 photoactivation Effects 0.000 claims 2
- 230000002207 retinal effect Effects 0.000 claims 2
- 230000011664 signaling Effects 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- 201000004569 Blindness Diseases 0.000 claims 1
- 241000252212 Danio rerio Species 0.000 claims 1
- 101000720986 Homo sapiens Melanopsin Proteins 0.000 claims 1
- 101000844510 Homo sapiens Transient receptor potential cation channel subfamily M member 1 Proteins 0.000 claims 1
- 102000010175 Opsin Human genes 0.000 claims 1
- 108050001704 Opsin Proteins 0.000 claims 1
- 239000002262 Schiff base Substances 0.000 claims 1
- 150000004753 Schiff bases Chemical class 0.000 claims 1
- 102000003617 TRPM1 Human genes 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000007850 degeneration Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 208000002780 macular degeneration Diseases 0.000 claims 1
- 108091008695 photoreceptors Proteins 0.000 claims 1
- 210000001525 retina Anatomy 0.000 claims 1
- 210000001116 retinal neuron Anatomy 0.000 claims 1
- 230000019491 signal transduction Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161500863P | 2011-06-24 | 2011-06-24 | |
| US61/500,863 | 2011-06-24 | ||
| PCT/CH2012/000138 WO2012174674A1 (en) | 2011-06-24 | 2012-06-22 | Light-sensitive chimeric gpcr protein |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524903A JP2014524903A (ja) | 2014-09-25 |
| JP2014524903A5 true JP2014524903A5 (enExample) | 2017-11-02 |
| JP6240067B2 JP6240067B2 (ja) | 2017-11-29 |
Family
ID=46456289
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014516148A Active JP6240067B2 (ja) | 2011-06-24 | 2012-06-22 | 光感受性キメラｇｐｃｒタンパク質 |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US10112984B2 (enExample) |
| EP (2) | EP2723767B8 (enExample) |
| JP (1) | JP6240067B2 (enExample) |
| KR (1) | KR102008538B1 (enExample) |
| CN (2) | CN107383184A (enExample) |
| AU (1) | AU2012272505B2 (enExample) |
| BR (2) | BR122022007044B1 (enExample) |
| CA (1) | CA2840458C (enExample) |
| DK (1) | DK3029063T3 (enExample) |
| ES (1) | ES2766398T3 (enExample) |
| HR (1) | HRP20200004T1 (enExample) |
| HU (1) | HUE047074T2 (enExample) |
| LT (1) | LT3029063T (enExample) |
| PL (2) | PL2723767T3 (enExample) |
| PT (1) | PT3029063T (enExample) |
| RU (1) | RU2637367C2 (enExample) |
| SI (1) | SI3029063T1 (enExample) |
| WO (1) | WO2012174674A1 (enExample) |
| ZA (1) | ZA201308824B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140087463A1 (en) * | 2012-09-25 | 2014-03-27 | The Washington University | Optical control of cell signaling |
| WO2014199299A1 (en) * | 2013-06-11 | 2014-12-18 | Friedrich Miescher Institute For Biomedical Research | Retinal on bipolar cells-specific artificial promoter |
| GB201403260D0 (en) | 2014-02-25 | 2014-04-09 | Univ Manchester | Treatment of retinal degeneration using gene therapy |
| WO2018106369A2 (en) * | 2016-11-06 | 2018-06-14 | Nanoscope Technologies Llc | Optogenetic modulation by multi-characteristic opsins for vision restoration and other applications thereof |
| EP3318285A1 (en) * | 2016-11-08 | 2018-05-09 | Oxford University Innovation Limited | Treatment of eye disease |
| WO2019094904A1 (en) * | 2017-11-13 | 2019-05-16 | The Regents Of The University Of California | Compositions and methods for enhancing visual function |
| WO2019134841A1 (en) * | 2018-01-02 | 2019-07-11 | Signify Holding B.V. | Light melanopic activity indicator |
| SG11202111980QA (en) * | 2019-04-29 | 2021-11-29 | Confo Therapeutics N V | Screening methods and assays for use with transmembrane proteins, in particular with gpcrs |
| WO2021105509A1 (en) * | 2019-11-29 | 2021-06-03 | Universität Bern | Chimeric opsin gpcr proteins |
| WO2021140205A1 (en) * | 2020-01-10 | 2021-07-15 | Confo Therapeutics N.V. | Methods for generating antibodies and antibody fragments and libraries comprising same |
| CN114762723A (zh) * | 2020-12-31 | 2022-07-19 | 吴伯骥 | HrpZpst蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用 |
| CN112675293A (zh) * | 2020-12-31 | 2021-04-20 | 吴伯骥 | HrpNEcb蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用 |
| KR20250022114A (ko) * | 2022-06-07 | 2025-02-14 | 애드베룸 바이오테크놀로지스, 인코포레이티드 | 시력 회복을 위한 멜라놉신 변이체 |
| CN118791624A (zh) * | 2023-04-11 | 2024-10-18 | 苏州星明优健生物技术有限公司 | 用于治疗视网膜神经退行性疾病的新型gpcr嵌合视蛋白 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH10507934A (ja) * | 1995-07-26 | 1998-08-04 | エヌピーエス・ファーマシウティカルズ・インコーポレイテッド | 代謝指向型グルタミン酸受容体に活性を示す化合物を同定するためのキメラ受容体および方法、ならびに神経学的障害および疾患の治療におけるそのような化合物の使用 |
| WO2004009022A2 (en) | 2002-07-18 | 2004-01-29 | The General Hospital Corp. | Method for augmenting vision in persons suffering from photoreceptor cell degeneration |
| GB0426196D0 (en) * | 2004-11-30 | 2004-12-29 | Imp College Innovations Ltd | Methods of treatment |
| US8470790B2 (en) | 2006-05-04 | 2013-06-25 | Wayne State University | Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids |
| EP1891976A1 (en) * | 2006-08-23 | 2008-02-27 | Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research | Use of light sensitive genes |
| US8178496B2 (en) * | 2007-12-21 | 2012-05-15 | The Regents Of The University Of California | Photoreactive regulator of glutamate receptor function and methods of use thereof |
| MX2010012592A (es) * | 2008-05-20 | 2011-05-05 | Eos Neuroscience Inc | Vectores para la administracion de proteinas sensibles a la luz y metodos de uso de las mismas. |
| RU2374245C1 (ru) * | 2008-08-22 | 2009-11-27 | Андрей Александрович Иващенко | Лиганд с широким спектром одновременной рецепторной активности, фармацевтическая композиция, способ ее получения и лекарственное средство |
| NZ602416A (en) * | 2008-11-14 | 2014-08-29 | Univ Leland Stanford Junior | Optically-based stimulation of target cells and modifications thereto |
-
2012
- 2012-06-22 EP EP12731288.2A patent/EP2723767B8/en active Active
- 2012-06-22 CA CA2840458A patent/CA2840458C/en active Active
- 2012-06-22 HU HUE15201713A patent/HUE047074T2/hu unknown
- 2012-06-22 LT LTEP15201713.3T patent/LT3029063T/lt unknown
- 2012-06-22 PL PL12731288T patent/PL2723767T3/pl unknown
- 2012-06-22 SI SI201231720T patent/SI3029063T1/sl unknown
- 2012-06-22 RU RU2014101708A patent/RU2637367C2/ru active
- 2012-06-22 WO PCT/CH2012/000138 patent/WO2012174674A1/en not_active Ceased
- 2012-06-22 PT PT152017133T patent/PT3029063T/pt unknown
- 2012-06-22 PL PL15201713T patent/PL3029063T3/pl unknown
- 2012-06-22 KR KR1020147000648A patent/KR102008538B1/ko active Active
- 2012-06-22 CN CN201710294286.2A patent/CN107383184A/zh active Pending
- 2012-06-22 JP JP2014516148A patent/JP6240067B2/ja active Active
- 2012-06-22 US US14/128,155 patent/US10112984B2/en active Active
- 2012-06-22 BR BR122022007044-2A patent/BR122022007044B1/pt active IP Right Grant
- 2012-06-22 BR BR112013033028A patent/BR112013033028A8/pt not_active Application Discontinuation
- 2012-06-22 EP EP15201713.3A patent/EP3029063B1/en active Active
- 2012-06-22 DK DK15201713.3T patent/DK3029063T3/da active
- 2012-06-22 ES ES15201713T patent/ES2766398T3/es active Active
- 2012-06-22 CN CN201280030926.4A patent/CN103814045B/zh active Active
- 2012-06-22 AU AU2012272505A patent/AU2012272505B2/en active Active
-
2013
- 2013-11-22 ZA ZA2013/08824A patent/ZA201308824B/en unknown
-
2020
- 2020-01-03 HR HRP20200004TT patent/HRP20200004T1/hr unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014524903A5 (enExample) | ||
| RU2014101708A (ru) | Светочувствительный химерный белок gpcr | |
| Okada et al. | Activation of rhodopsin: new insights from structural and biochemical studies | |
| ES2883633T3 (es) | Agentes terapéuticos | |
| US10428149B2 (en) | Single-chain tumor necrosis factor (TNF) ligand family molecules, fusion proteins and derivatives thereof | |
| ES2613523T3 (es) | Antagonistas de ActRIIb y dosificación y usos de los mismos | |
| JP2020508068A5 (enExample) | ||
| TW201141509A (en) | Modified binding proteins inhibiting the VEGF-A receptor interaction | |
| WO2010105573A1 (zh) | 抗血管新生融合蛋白 | |
| JP2015518479A5 (enExample) | ||
| JP2016510755A5 (enExample) | ||
| WO2013000234A1 (en) | A novel recomnimant bifunctional fusion protein and its preparation and use | |
| AU2016232819B2 (en) | Compositions and methods for use of anion channel rhodopsins | |
| JP6757024B2 (ja) | 視覚機能再生剤又は視覚機能低下予防剤 | |
| JP2025123277A (ja) | キメラロドプシンをコードする核酸コンストラクト | |
| WO2020148913A1 (ja) | 網膜疾患の予防および進行抑制、視覚認知行動機能の改善、および視覚機能強化 | |
| JP2014517690A5 (enExample) | ||
| CA3162568A1 (en) | Chimeric opsin gpcr proteins | |
| WO2018107134A1 (en) | Chimeric chlorotoxin receptors | |
| CN109996817A (zh) | 扭转原肠胚形成多肽及其用途 | |
| JP7054143B2 (ja) | キメラ抗原受容体、及びその利用 | |
| CN113817056B (zh) | 一种靶向cd70的单链抗体及其应用 | |
| EP3172325B1 (en) | Molecular constructs and uses thereof | |
| KR20250061742A (ko) | 광응답 변형 옵신 | |
| Abdulaev et al. | Grafting segments from the extracellular surface of CCR5 onto a bacteriorhodopsin transmembrane scaffold confers HIV-1 coreceptor activity |