PL2723767T3 - Światłoczułe chimerowe białko GPCR - Google Patents

Światłoczułe chimerowe białko GPCR

Info

Publication number
PL2723767T3
PL2723767T3 PL12731288T PL12731288T PL2723767T3 PL 2723767 T3 PL2723767 T3 PL 2723767T3 PL 12731288 T PL12731288 T PL 12731288T PL 12731288 T PL12731288 T PL 12731288T PL 2723767 T3 PL2723767 T3 PL 2723767T3
Authority
PL
Poland
Prior art keywords
light
gpcr protein
chimeric gpcr
sensitive chimeric
sensitive
Prior art date
Application number
PL12731288T
Other languages
English (en)
Polish (pl)
Inventor
Wyk Michiel Van
Sonja Kleinlogel
Original Assignee
Haag Streit Medtech Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Haag Streit Medtech Ag filed Critical Haag Streit Medtech Ag
Publication of PL2723767T3 publication Critical patent/PL2723767T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/40—Fish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Environmental Sciences (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biotechnology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PL12731288T 2011-06-24 2012-06-22 Światłoczułe chimerowe białko GPCR PL2723767T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161500863P 2011-06-24 2011-06-24
PCT/CH2012/000138 WO2012174674A1 (en) 2011-06-24 2012-06-22 Light-sensitive chimeric gpcr protein
EP12731288.2A EP2723767B8 (en) 2011-06-24 2012-06-22 Light-sensitive chimeric gpcr protein

Publications (1)

Publication Number Publication Date
PL2723767T3 true PL2723767T3 (pl) 2016-06-30

Family

ID=46456289

Family Applications (2)

Application Number Title Priority Date Filing Date
PL12731288T PL2723767T3 (pl) 2011-06-24 2012-06-22 Światłoczułe chimerowe białko GPCR
PL15201713T PL3029063T3 (pl) 2011-06-24 2012-06-22 Wrażliwe na światło chimeryczne białko GPCR

Family Applications After (1)

Application Number Title Priority Date Filing Date
PL15201713T PL3029063T3 (pl) 2011-06-24 2012-06-22 Wrażliwe na światło chimeryczne białko GPCR

Country Status (19)

Country Link
US (1) US10112984B2 (enExample)
EP (2) EP2723767B8 (enExample)
JP (1) JP6240067B2 (enExample)
KR (1) KR102008538B1 (enExample)
CN (2) CN107383184A (enExample)
AU (1) AU2012272505B2 (enExample)
BR (2) BR122022007044B1 (enExample)
CA (1) CA2840458C (enExample)
DK (1) DK3029063T3 (enExample)
ES (1) ES2766398T3 (enExample)
HR (1) HRP20200004T1 (enExample)
HU (1) HUE047074T2 (enExample)
LT (1) LT3029063T (enExample)
PL (2) PL2723767T3 (enExample)
PT (1) PT3029063T (enExample)
RU (1) RU2637367C2 (enExample)
SI (1) SI3029063T1 (enExample)
WO (1) WO2012174674A1 (enExample)
ZA (1) ZA201308824B (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140087463A1 (en) * 2012-09-25 2014-03-27 The Washington University Optical control of cell signaling
WO2014199299A1 (en) * 2013-06-11 2014-12-18 Friedrich Miescher Institute For Biomedical Research Retinal on bipolar cells-specific artificial promoter
GB201403260D0 (en) 2014-02-25 2014-04-09 Univ Manchester Treatment of retinal degeneration using gene therapy
WO2018106369A2 (en) * 2016-11-06 2018-06-14 Nanoscope Technologies Llc Optogenetic modulation by multi-characteristic opsins for vision restoration and other applications thereof
EP3318285A1 (en) * 2016-11-08 2018-05-09 Oxford University Innovation Limited Treatment of eye disease
WO2019094904A1 (en) * 2017-11-13 2019-05-16 The Regents Of The University Of California Compositions and methods for enhancing visual function
WO2019134841A1 (en) * 2018-01-02 2019-07-11 Signify Holding B.V. Light melanopic activity indicator
SG11202111980QA (en) * 2019-04-29 2021-11-29 Confo Therapeutics N V Screening methods and assays for use with transmembrane proteins, in particular with gpcrs
WO2021105509A1 (en) * 2019-11-29 2021-06-03 Universität Bern Chimeric opsin gpcr proteins
WO2021140205A1 (en) * 2020-01-10 2021-07-15 Confo Therapeutics N.V. Methods for generating antibodies and antibody fragments and libraries comprising same
CN114762723A (zh) * 2020-12-31 2022-07-19 吴伯骥 HrpZpst蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用
CN112675293A (zh) * 2020-12-31 2021-04-20 吴伯骥 HrpNEcb蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用
KR20250022114A (ko) * 2022-06-07 2025-02-14 애드베룸 바이오테크놀로지스, 인코포레이티드 시력 회복을 위한 멜라놉신 변이체
CN118791624A (zh) * 2023-04-11 2024-10-18 苏州星明优健生物技术有限公司 用于治疗视网膜神经退行性疾病的新型gpcr嵌合视蛋白

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH10507934A (ja) * 1995-07-26 1998-08-04 エヌピーエス・ファーマシウティカルズ・インコーポレイテッド 代謝指向型グルタミン酸受容体に活性を示す化合物を同定するためのキメラ受容体および方法、ならびに神経学的障害および疾患の治療におけるそのような化合物の使用
WO2004009022A2 (en) 2002-07-18 2004-01-29 The General Hospital Corp. Method for augmenting vision in persons suffering from photoreceptor cell degeneration
GB0426196D0 (en) * 2004-11-30 2004-12-29 Imp College Innovations Ltd Methods of treatment
US8470790B2 (en) 2006-05-04 2013-06-25 Wayne State University Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
EP1891976A1 (en) * 2006-08-23 2008-02-27 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research Use of light sensitive genes
US8178496B2 (en) * 2007-12-21 2012-05-15 The Regents Of The University Of California Photoreactive regulator of glutamate receptor function and methods of use thereof
MX2010012592A (es) * 2008-05-20 2011-05-05 Eos Neuroscience Inc Vectores para la administracion de proteinas sensibles a la luz y metodos de uso de las mismas.
RU2374245C1 (ru) * 2008-08-22 2009-11-27 Андрей Александрович Иващенко Лиганд с широким спектром одновременной рецепторной активности, фармацевтическая композиция, способ ее получения и лекарственное средство
NZ602416A (en) * 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto

Also Published As

Publication number Publication date
KR102008538B1 (ko) 2019-08-08
WO2012174674A1 (en) 2012-12-27
PL3029063T3 (pl) 2020-05-18
CN107383184A (zh) 2017-11-24
CA2840458A1 (en) 2012-12-27
EP2723767B8 (en) 2016-03-02
KR20140039281A (ko) 2014-04-01
JP6240067B2 (ja) 2017-11-29
CA2840458C (en) 2020-09-22
CN103814045A (zh) 2014-05-21
JP2014524903A (ja) 2014-09-25
PT3029063T (pt) 2020-01-22
BR112013033028A2 (pt) 2017-01-31
BR112013033028A8 (pt) 2022-11-01
DK3029063T3 (da) 2020-01-20
AU2012272505A1 (en) 2014-01-16
ES2766398T3 (es) 2020-06-12
AU2012272505B2 (en) 2017-03-02
BR122022007044B1 (pt) 2023-11-14
RU2637367C2 (ru) 2017-12-04
EP3029063A1 (en) 2016-06-08
US10112984B2 (en) 2018-10-30
BR122022007044A8 (pt) 2022-11-01
US20140171376A1 (en) 2014-06-19
SI3029063T1 (sl) 2020-03-31
EP3029063B1 (en) 2019-10-16
HRP20200004T1 (hr) 2020-05-15
HUE047074T2 (hu) 2020-04-28
LT3029063T (lt) 2020-02-10
BR122022007044A2 (enExample) 2017-01-31
RU2014101708A (ru) 2015-07-27
EP2723767A1 (en) 2014-04-30
EP2723767B1 (en) 2016-01-06
CN103814045B (zh) 2017-05-31
ZA201308824B (en) 2015-02-25

Similar Documents

Publication Publication Date Title
HRP20200004T1 (hr) Fotosenzitivan kimerni protein gpcr
IL259826A (en) Anti-alphabetatisiar antibody
GB201103955D0 (en) Antibodies
GB201112056D0 (en) Antibodies
ZA201309174B (en) Polypeptides
ZA201307983B (en) Anti-b7-h3 antibody
PL2726363T3 (pl) Składana łódź
EP2751136A4 (en) NATRIURETIC POLYPEPTIDES
GB201111183D0 (en) Peptide
TWI563004B (en) Anti-hxcr1 antibody
GB201115910D0 (en) Peptides
EP2714074A4 (en) ANTIBODIES AGAINST EMR1
GB201106130D0 (en) Polypeptide
GB201112849D0 (en) Polypeptide
GB201112985D0 (en) Polypeptide
GB201103169D0 (en) Protein expression
GB201118688D0 (en) Collapsible covered frame
HUP1100282A2 (en) Protein factor
GB201115014D0 (en) Peptides
HUE047406T2 (hu) Polipeptidek
ZA201207058B (en) An attachemnt element
GB201107189D0 (en) Fusion proteins
GB201114701D0 (en) Fusion proteins
GB201206080D0 (en) Collapsible frame construction