RU2637367C2 - Светочувствительный химерный белок gpcr - Google Patents

Светочувствительный химерный белок gpcr Download PDF

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Publication number
RU2637367C2
RU2637367C2 RU2014101708A RU2014101708A RU2637367C2 RU 2637367 C2 RU2637367 C2 RU 2637367C2 RU 2014101708 A RU2014101708 A RU 2014101708A RU 2014101708 A RU2014101708 A RU 2014101708A RU 2637367 C2 RU2637367 C2 RU 2637367C2
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protein
gpcr
mglur6
chimeric
cells
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RU2014101708A
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English (en)
Russian (ru)
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RU2014101708A (ru
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ВИК Михиль ФАН
Зонья КЛАЙНЛОГЕЛЬ
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Хаг-Штрайт Медтех Аг
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/40—Fish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Environmental Sciences (AREA)
  • Animal Husbandry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
RU2014101708A 2011-06-24 2012-06-22 Светочувствительный химерный белок gpcr RU2637367C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161500863P 2011-06-24 2011-06-24
US61/500,863 2011-06-24
PCT/CH2012/000138 WO2012174674A1 (en) 2011-06-24 2012-06-22 Light-sensitive chimeric gpcr protein

Publications (2)

Publication Number Publication Date
RU2014101708A RU2014101708A (ru) 2015-07-27
RU2637367C2 true RU2637367C2 (ru) 2017-12-04

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RU2014101708A RU2637367C2 (ru) 2011-06-24 2012-06-22 Светочувствительный химерный белок gpcr

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US (1) US10112984B2 (enExample)
EP (2) EP3029063B1 (enExample)
JP (1) JP6240067B2 (enExample)
KR (1) KR102008538B1 (enExample)
CN (2) CN103814045B (enExample)
AU (1) AU2012272505B2 (enExample)
BR (2) BR112013033028A8 (enExample)
CA (1) CA2840458C (enExample)
DK (1) DK3029063T3 (enExample)
ES (1) ES2766398T3 (enExample)
HR (1) HRP20200004T1 (enExample)
HU (1) HUE047074T2 (enExample)
LT (1) LT3029063T (enExample)
PL (2) PL3029063T3 (enExample)
PT (1) PT3029063T (enExample)
RU (1) RU2637367C2 (enExample)
SI (1) SI3029063T1 (enExample)
WO (1) WO2012174674A1 (enExample)
ZA (1) ZA201308824B (enExample)

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US20140087463A1 (en) * 2012-09-25 2014-03-27 The Washington University Optical control of cell signaling
US9862970B2 (en) 2013-06-11 2018-01-09 Friedrich Miescher Institute For Biomedical Research Retinal on bipolar cells-specific artificial promoter
GB201403260D0 (en) 2014-02-25 2014-04-09 Univ Manchester Treatment of retinal degeneration using gene therapy
EP3535282A4 (en) * 2016-11-06 2020-04-08 Nanoscope Technologies LLC OPTOGENETIC MODULATION BY OPSINS WITH MULTIPLE CHARACTERISTICS FOR RESTORATION OF VISION AND OTHER ASSOCIATED APPLICATIONS
EP3318285A1 (en) * 2016-11-08 2018-05-09 Oxford University Innovation Limited Treatment of eye disease
BR112020009329A2 (pt) * 2017-11-13 2020-10-13 The Regents Of The University Of California composições e métodos para melhorar a função visual
EP3735572A1 (en) * 2018-01-02 2020-11-11 Signify Holding B.V. Light melanopic activity indicator
CA3314168A1 (en) * 2019-04-29 2026-08-05 Confo Therapeutics N.V. Screening methods and assays for use with transmembrane proteins, in particular with gpcrs
CN114729009A (zh) 2019-10-31 2022-07-08 伯尔尼大学 用于眼部基因递送的aav载体变体
KR20220111294A (ko) * 2019-11-29 2022-08-09 유니버시태트 베른 키메라 옵신 gpcr 단백질
WO2021140205A1 (en) * 2020-01-10 2021-07-15 Confo Therapeutics N.V. Methods for generating antibodies and antibody fragments and libraries comprising same
CN112675293A (zh) * 2020-12-31 2021-04-20 吴伯骥 HrpNEcb蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用
CN114762723A (zh) * 2020-12-31 2022-07-19 吴伯骥 HrpZpst蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用
CA3252767A1 (en) * 2022-06-07 2023-12-14 Adverum Biotechnologies, Inc. VARIANTS OF MELANOPSINE FOR VISION RESTORATION
CN118791624B (zh) * 2023-04-11 2026-04-03 苏州星明优健生物技术有限公司 用于治疗视网膜神经退行性疾病的新型gpcr嵌合视蛋白
WO2026017073A1 (zh) * 2024-07-16 2026-01-22 北京脑科学与类脑研究所 一种光敏蛋白及其应用
CN120442622A (zh) * 2024-09-23 2025-08-08 中眸医疗科技(武汉)有限公司 多种在on型双极细胞上高效靶定的启动子在基因治疗技术中的应用

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WO2006059081A2 (en) * 2004-11-30 2006-06-08 Imperial Innovations Limited Methods of treatment using melanopsin
EA018788B1 (ru) * 2008-08-22 2013-10-30 Андрей Александрович ИВАЩЕНКО Лиганд с широким спектром фармакологической активности и его применение

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WO1997005252A2 (en) * 1995-07-26 1997-02-13 Nps Pharmaceuticals, Inc. Chimeric receptors and methods for identifying compounds active at metabotropic glutamate receptors and the use of such compounds in the treatment of neurological disorders and diseases
AU2003249318A1 (en) 2002-07-18 2004-02-09 The General Hospital Corp. Method for augmenting vision in persons suffering from photoreceptor cell degeneration
US8470790B2 (en) * 2006-05-04 2013-06-25 Wayne State University Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
EP1891976A1 (en) 2006-08-23 2008-02-27 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research Use of light sensitive genes
US8178496B2 (en) * 2007-12-21 2012-05-15 The Regents Of The University Of California Photoreactive regulator of glutamate receptor function and methods of use thereof
EP2910637A1 (en) * 2008-05-20 2015-08-26 University of Florida Research Foundation, Inc. Vectors for delivery of light-sensitive proteins and methods of use
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WO2006059081A2 (en) * 2004-11-30 2006-06-08 Imperial Innovations Limited Methods of treatment using melanopsin
EA018788B1 (ru) * 2008-08-22 2013-10-30 Андрей Александрович ИВАЩЕНКО Лиганд с широким спектром фармакологической активности и его применение

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YAMASHITA T. The second cytoplasmic loop of metabotropic glutamate receptor functions at the third loop position of rhodopsin, J. Biochem., 2001, v.130, is.1, p.149-155. *

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Publication number Publication date
ZA201308824B (en) 2015-02-25
JP6240067B2 (ja) 2017-11-29
HUE047074T2 (hu) 2020-04-28
LT3029063T (lt) 2020-02-10
BR122022007044A8 (pt) 2022-11-01
CN103814045B (zh) 2017-05-31
US20140171376A1 (en) 2014-06-19
AU2012272505A1 (en) 2014-01-16
BR112013033028A2 (pt) 2017-01-31
CN103814045A (zh) 2014-05-21
EP2723767A1 (en) 2014-04-30
KR20140039281A (ko) 2014-04-01
CA2840458A1 (en) 2012-12-27
PL2723767T3 (pl) 2016-06-30
CA2840458C (en) 2020-09-22
BR112013033028A8 (pt) 2022-11-01
HRP20200004T1 (hr) 2020-05-15
BR122022007044B1 (pt) 2023-11-14
WO2012174674A1 (en) 2012-12-27
SI3029063T1 (sl) 2020-03-31
JP2014524903A (ja) 2014-09-25
US10112984B2 (en) 2018-10-30
AU2012272505B2 (en) 2017-03-02
RU2014101708A (ru) 2015-07-27
EP2723767B1 (en) 2016-01-06
EP2723767B8 (en) 2016-03-02
CN107383184A (zh) 2017-11-24
EP3029063A1 (en) 2016-06-08
ES2766398T3 (es) 2020-06-12
BR122022007044A2 (enExample) 2017-01-31
EP3029063B1 (en) 2019-10-16
PL3029063T3 (pl) 2020-05-18
PT3029063T (pt) 2020-01-22
DK3029063T3 (da) 2020-01-20
KR102008538B1 (ko) 2019-08-08

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