AU2012272505B2 - Light-sensitive chimeric GPCR protein - Google Patents

Light-sensitive chimeric GPCR protein Download PDF

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Publication number
AU2012272505B2
AU2012272505B2 AU2012272505A AU2012272505A AU2012272505B2 AU 2012272505 B2 AU2012272505 B2 AU 2012272505B2 AU 2012272505 A AU2012272505 A AU 2012272505A AU 2012272505 A AU2012272505 A AU 2012272505A AU 2012272505 B2 AU2012272505 B2 AU 2012272505B2
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AU
Australia
Prior art keywords
mglur6
protein
light
gpcr
chimeric
Prior art date
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Active
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AU2012272505A
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English (en)
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AU2012272505A1 (en
Inventor
Sonja Kleinlogel
Michiel VAN WYK
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Novartis AG
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Novartis AG
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Assigned to Arctos Medical AG reassignment Arctos Medical AG Request to Amend Deed and Register Assignors: HAAG-STREIT MEDTECH AG
Assigned to NOVARTIS AG reassignment NOVARTIS AG Request for Assignment Assignors: Arctos Medical AG
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/40—Fish
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Environmental Sciences (AREA)
  • Animal Husbandry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biotechnology (AREA)
  • Vascular Medicine (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AU2012272505A 2011-06-24 2012-06-22 Light-sensitive chimeric GPCR protein Active AU2012272505B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161500863P 2011-06-24 2011-06-24
US61/500,863 2011-06-24
PCT/CH2012/000138 WO2012174674A1 (en) 2011-06-24 2012-06-22 Light-sensitive chimeric gpcr protein

Publications (2)

Publication Number Publication Date
AU2012272505A1 AU2012272505A1 (en) 2014-01-16
AU2012272505B2 true AU2012272505B2 (en) 2017-03-02

Family

ID=46456289

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2012272505A Active AU2012272505B2 (en) 2011-06-24 2012-06-22 Light-sensitive chimeric GPCR protein

Country Status (19)

Country Link
US (1) US10112984B2 (enExample)
EP (2) EP3029063B1 (enExample)
JP (1) JP6240067B2 (enExample)
KR (1) KR102008538B1 (enExample)
CN (2) CN103814045B (enExample)
AU (1) AU2012272505B2 (enExample)
BR (2) BR112013033028A8 (enExample)
CA (1) CA2840458C (enExample)
DK (1) DK3029063T3 (enExample)
ES (1) ES2766398T3 (enExample)
HR (1) HRP20200004T1 (enExample)
HU (1) HUE047074T2 (enExample)
LT (1) LT3029063T (enExample)
PL (2) PL3029063T3 (enExample)
PT (1) PT3029063T (enExample)
RU (1) RU2637367C2 (enExample)
SI (1) SI3029063T1 (enExample)
WO (1) WO2012174674A1 (enExample)
ZA (1) ZA201308824B (enExample)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20140087463A1 (en) * 2012-09-25 2014-03-27 The Washington University Optical control of cell signaling
US9862970B2 (en) 2013-06-11 2018-01-09 Friedrich Miescher Institute For Biomedical Research Retinal on bipolar cells-specific artificial promoter
GB201403260D0 (en) 2014-02-25 2014-04-09 Univ Manchester Treatment of retinal degeneration using gene therapy
EP3535282A4 (en) * 2016-11-06 2020-04-08 Nanoscope Technologies LLC OPTOGENETIC MODULATION BY OPSINS WITH MULTIPLE CHARACTERISTICS FOR RESTORATION OF VISION AND OTHER ASSOCIATED APPLICATIONS
EP3318285A1 (en) * 2016-11-08 2018-05-09 Oxford University Innovation Limited Treatment of eye disease
BR112020009329A2 (pt) * 2017-11-13 2020-10-13 The Regents Of The University Of California composições e métodos para melhorar a função visual
EP3735572A1 (en) * 2018-01-02 2020-11-11 Signify Holding B.V. Light melanopic activity indicator
CA3314168A1 (en) * 2019-04-29 2026-08-05 Confo Therapeutics N.V. Screening methods and assays for use with transmembrane proteins, in particular with gpcrs
CN114729009A (zh) 2019-10-31 2022-07-08 伯尔尼大学 用于眼部基因递送的aav载体变体
KR20220111294A (ko) * 2019-11-29 2022-08-09 유니버시태트 베른 키메라 옵신 gpcr 단백질
WO2021140205A1 (en) * 2020-01-10 2021-07-15 Confo Therapeutics N.V. Methods for generating antibodies and antibody fragments and libraries comprising same
CN112675293A (zh) * 2020-12-31 2021-04-20 吴伯骥 HrpNEcb蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用
CN114762723A (zh) * 2020-12-31 2022-07-19 吴伯骥 HrpZpst蛋白在识别激活多类受体和/或膜蛋白及其信号通路的制药中的应用
CA3252767A1 (en) * 2022-06-07 2023-12-14 Adverum Biotechnologies, Inc. VARIANTS OF MELANOPSINE FOR VISION RESTORATION
CN118791624B (zh) * 2023-04-11 2026-04-03 苏州星明优健生物技术有限公司 用于治疗视网膜神经退行性疾病的新型gpcr嵌合视蛋白
WO2026017073A1 (zh) * 2024-07-16 2026-01-22 北京脑科学与类脑研究所 一种光敏蛋白及其应用
CN120442622A (zh) * 2024-09-23 2025-08-08 中眸医疗科技(武汉)有限公司 多种在on型双极细胞上高效靶定的启动子在基因治疗技术中的应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997005252A2 (en) * 1995-07-26 1997-02-13 Nps Pharmaceuticals, Inc. Chimeric receptors and methods for identifying compounds active at metabotropic glutamate receptors and the use of such compounds in the treatment of neurological disorders and diseases
AU2003249318A1 (en) 2002-07-18 2004-02-09 The General Hospital Corp. Method for augmenting vision in persons suffering from photoreceptor cell degeneration
GB0426196D0 (en) 2004-11-30 2004-12-29 Imp College Innovations Ltd Methods of treatment
US8470790B2 (en) * 2006-05-04 2013-06-25 Wayne State University Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
EP1891976A1 (en) 2006-08-23 2008-02-27 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research Use of light sensitive genes
US8178496B2 (en) * 2007-12-21 2012-05-15 The Regents Of The University Of California Photoreactive regulator of glutamate receptor function and methods of use thereof
EP2910637A1 (en) * 2008-05-20 2015-08-26 University of Florida Research Foundation, Inc. Vectors for delivery of light-sensitive proteins and methods of use
RU2374245C1 (ru) * 2008-08-22 2009-11-27 Андрей Александрович Иващенко Лиганд с широким спектром одновременной рецепторной активности, фармацевтическая композиция, способ ее получения и лекарственное средство
NZ602416A (en) * 2008-11-14 2014-08-29 Univ Leland Stanford Junior Optically-based stimulation of target cells and modifications thereto

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YAMASHITA T. ET AL: "The second cytoplasmic loop of metabotropic glutamate receptor functions at the third loop position of rhodopsin" JOURNAL OF BIOCHEMISTRY, vol. 130, no. l, 2001 pages 149-155 *

Also Published As

Publication number Publication date
ZA201308824B (en) 2015-02-25
JP6240067B2 (ja) 2017-11-29
HUE047074T2 (hu) 2020-04-28
LT3029063T (lt) 2020-02-10
BR122022007044A8 (pt) 2022-11-01
CN103814045B (zh) 2017-05-31
US20140171376A1 (en) 2014-06-19
AU2012272505A1 (en) 2014-01-16
BR112013033028A2 (pt) 2017-01-31
CN103814045A (zh) 2014-05-21
EP2723767A1 (en) 2014-04-30
KR20140039281A (ko) 2014-04-01
CA2840458A1 (en) 2012-12-27
PL2723767T3 (pl) 2016-06-30
CA2840458C (en) 2020-09-22
BR112013033028A8 (pt) 2022-11-01
HRP20200004T1 (hr) 2020-05-15
BR122022007044B1 (pt) 2023-11-14
WO2012174674A1 (en) 2012-12-27
SI3029063T1 (sl) 2020-03-31
JP2014524903A (ja) 2014-09-25
US10112984B2 (en) 2018-10-30
RU2014101708A (ru) 2015-07-27
EP2723767B1 (en) 2016-01-06
RU2637367C2 (ru) 2017-12-04
EP2723767B8 (en) 2016-03-02
CN107383184A (zh) 2017-11-24
EP3029063A1 (en) 2016-06-08
ES2766398T3 (es) 2020-06-12
BR122022007044A2 (enExample) 2017-01-31
EP3029063B1 (en) 2019-10-16
PL3029063T3 (pl) 2020-05-18
PT3029063T (pt) 2020-01-22
DK3029063T3 (da) 2020-01-20
KR102008538B1 (ko) 2019-08-08

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Owner name: ARCTOS MEDICAL AG

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PC Assignment registered

Owner name: NOVARTIS AG

Free format text: FORMER OWNER(S): ARCTOS MEDICAL AG