JP2014524747A5 - - Google Patents
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- JP2014524747A5 JP2014524747A5 JP2014520591A JP2014520591A JP2014524747A5 JP 2014524747 A5 JP2014524747 A5 JP 2014524747A5 JP 2014520591 A JP2014520591 A JP 2014520591A JP 2014520591 A JP2014520591 A JP 2014520591A JP 2014524747 A5 JP2014524747 A5 JP 2014524747A5
- Authority
- JP
- Japan
- Prior art keywords
- concentration
- factor
- collection
- detergent
- ctab
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
- 239000003599 detergent Substances 0.000 description 14
- 241000700605 Viruses Species 0.000 description 9
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 8
- 239000007788 liquid Substances 0.000 description 8
- 230000009467 reduction Effects 0.000 description 8
- 125000002091 cationic group Chemical group 0.000 description 7
- 238000011084 recovery Methods 0.000 description 7
- 239000000427 antigen Substances 0.000 description 4
- 102000036639 antigens Human genes 0.000 description 4
- 108091007433 antigens Proteins 0.000 description 4
- 230000007928 solubilization Effects 0.000 description 4
- 238000005063 solubilization Methods 0.000 description 4
- 229920001429 chelating resin Polymers 0.000 description 3
- 238000005352 clarification Methods 0.000 description 3
- 238000010790 dilution Methods 0.000 description 3
- 239000012895 dilution Substances 0.000 description 3
- 238000011038 discontinuous diafiltration by volume reduction Methods 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 3
- 229920000053 polysorbate 80 Polymers 0.000 description 3
- 101710084021 Large envelope protein Proteins 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 238000009295 crossflow filtration Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000011027 product recovery Methods 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161509630P | 2011-07-20 | 2011-07-20 | |
| EP11174660 | 2011-07-20 | ||
| EP11174660.8 | 2011-07-20 | ||
| US61/509,630 | 2011-07-20 | ||
| PCT/EP2012/063045 WO2013010797A1 (en) | 2011-07-20 | 2012-07-04 | Process for producing viral antigen and vaccines |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014524747A JP2014524747A (ja) | 2014-09-25 |
| JP2014524747A5 true JP2014524747A5 (cg-RX-API-DMAC7.html) | 2016-11-04 |
| JP6275641B2 JP6275641B2 (ja) | 2018-02-07 |
Family
ID=45094875
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014520591A Expired - Fee Related JP6275641B2 (ja) | 2011-07-20 | 2012-07-04 | ウイルス抗原およびワクチンの製造方法 |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2734619B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6275641B2 (cg-RX-API-DMAC7.html) |
| KR (2) | KR20140038530A (cg-RX-API-DMAC7.html) |
| CN (1) | CN103827296B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012286098C1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112014001049A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2841604C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2653197T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2014000753A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2565827C2 (cg-RX-API-DMAC7.html) |
| TW (1) | TW201311896A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2013010797A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109568573A (zh) * | 2014-12-12 | 2019-04-05 | 普莱柯生物工程股份有限公司 | 疫苗组合物及其制备方法和应用 |
| WO2019121846A1 (en) | 2017-12-19 | 2019-06-27 | CSL Behring Lengnau AG | Protein purification and virus inactivation with alkyl glycosides |
| JP7360594B2 (ja) * | 2017-12-28 | 2023-10-13 | 共立製薬株式会社 | ワクチン製剤、並びに魚類のイリドウイルス感染症予防方法 |
| US11690907B2 (en) | 2018-06-12 | 2023-07-04 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| US11529413B2 (en) | 2018-06-12 | 2022-12-20 | Kbio Holdings Limited | Virus and antigen purification and conjugation |
| US11696948B2 (en) | 2018-06-12 | 2023-07-11 | Kbio Holdings Limited | Vaccines formed by virus and antigen conjugation |
| BR112020025250A2 (pt) | 2018-06-12 | 2021-03-09 | Kentucky Bioprocessing, Inc. | Purificação e conjugação de vírus e antígeno |
| CN112384615A (zh) * | 2018-07-04 | 2021-02-19 | 普罗拜奥根股份公司 | 用于纯化包膜病毒的方法 |
| US12123028B2 (en) | 2018-11-15 | 2024-10-22 | Bayer Healthcare Llc | Viral inactivation methods for continuous manufacturing of antibodies |
| RU2710239C1 (ru) * | 2019-06-14 | 2019-12-25 | Федеральное государственное унитарное предприятие "Санкт-Петербургский научно-исследовательский институт вакцин и сывороток и предприятие по производству бактерийных препаратов" Федерального медико-биологического агентства | Способ получения антигена или антигенов для производства противогриппозной вакцины и вакцина на его основе |
| KR20220098370A (ko) * | 2019-11-07 | 2022-07-12 | 세퀴러스 유케이 리미티드 | 감소된 입자 크기를 가지는 바이러스 백신을 제조하기 위한 조성물 및 방법 |
| KR102546626B1 (ko) * | 2020-04-29 | 2023-06-21 | 에스케이바이오사이언스(주) | 인플루엔자 바이러스 항원 정제 조건 신속 확인 시험 |
| US20230212230A1 (en) * | 2020-04-29 | 2023-07-06 | Sk Bioscience Co., Ltd. | Influenza virus production method using single-use culture process system and rapid confirmation test of influenza virus antigen purification condition |
| CN112309502B (zh) * | 2020-10-14 | 2024-09-20 | 深圳市新合生物医疗科技有限公司 | 一种计算肿瘤新抗原负荷的方法及系统 |
| JP2023141423A (ja) * | 2022-03-24 | 2023-10-05 | 国立大学法人 東京大学 | ウイルスの精製方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4140762A (en) * | 1974-01-14 | 1979-02-20 | Sandoz Ltd. | Influenza sub-unit vaccine |
| US4240762A (en) * | 1979-03-12 | 1980-12-23 | Johnston Pump Company | Seal-aligning rigid coupling assembly |
| SE8405493D0 (sv) * | 1984-11-01 | 1984-11-01 | Bror Morein | Immunogent komplex samt sett for framstellning derav och anvendning derav som immunstimulerande medel |
| KR101190932B1 (ko) * | 2003-02-25 | 2012-10-16 | 메디뮨 엘엘씨 | 인플루엔자 백신 조성물의 제조 방법 |
| RU2283139C1 (ru) * | 2005-03-21 | 2006-09-10 | Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации | Способ получения антигенов для вакцины против вирусов гриппа |
| EP1982727A1 (en) * | 2007-04-17 | 2008-10-22 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Method for purification of viral proteins |
| SI2192917T1 (sl) * | 2007-08-28 | 2014-05-30 | Baxter International Inc. | Postopek za proizvodnjo virusnih cepiv |
| AU2009227674C1 (en) * | 2008-03-18 | 2015-01-29 | Seqirus UK Limited | Improvements in preparation of influenza virus vaccine antigens |
| KR20110074563A (ko) * | 2008-09-24 | 2011-06-30 | 메디뮨 엘엘씨 | 바이러스의 정제 방법 |
| US8202726B2 (en) * | 2008-09-24 | 2012-06-19 | Medimmune, Llc | Methods for cultivating cells, propagating and purifying viruses |
| GB0918830D0 (en) * | 2009-10-27 | 2009-12-09 | Glaxosmithkline Biolog Niederl | Process |
-
2012
- 2012-07-04 ES ES12734892.8T patent/ES2653197T3/es active Active
- 2012-07-04 BR BR112014001049A patent/BR112014001049A2/pt not_active IP Right Cessation
- 2012-07-04 MX MX2014000753A patent/MX2014000753A/es not_active Application Discontinuation
- 2012-07-04 KR KR1020147001348A patent/KR20140038530A/ko not_active Ceased
- 2012-07-04 CA CA2841604A patent/CA2841604C/en not_active Expired - Fee Related
- 2012-07-04 KR KR1020167020663A patent/KR20160096215A/ko not_active Withdrawn
- 2012-07-04 EP EP12734892.8A patent/EP2734619B1/en active Active
- 2012-07-04 JP JP2014520591A patent/JP6275641B2/ja not_active Expired - Fee Related
- 2012-07-04 WO PCT/EP2012/063045 patent/WO2013010797A1/en not_active Ceased
- 2012-07-04 AU AU2012286098A patent/AU2012286098C1/en not_active Ceased
- 2012-07-04 RU RU2014101484/10A patent/RU2565827C2/ru not_active IP Right Cessation
- 2012-07-04 CN CN201280035724.9A patent/CN103827296B/zh not_active Expired - Fee Related
- 2012-07-19 TW TW101126141A patent/TW201311896A/zh unknown
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