JP2014521958A - 胸腔内液若しくは漿液と関連する腫瘍細胞の特徴づけによる癌の診断方法 - Google Patents

胸腔内液若しくは漿液と関連する腫瘍細胞の特徴づけによる癌の診断方法 Download PDF

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JP2014521958A
JP2014521958A JP2014523039A JP2014523039A JP2014521958A JP 2014521958 A JP2014521958 A JP 2014521958A JP 2014523039 A JP2014523039 A JP 2014523039A JP 2014523039 A JP2014523039 A JP 2014523039A JP 2014521958 A JP2014521958 A JP 2014521958A
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アルベルダ，ステイーブン・エム
シユエド，ダニエル
ラオ，ガラ・チヤンドラ
コネリー，マーク
フアウルク，ブラド
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ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア
ベリデツクス・エルエルシー
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants

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JP2014523039A 2011-07-28 2012-07-27 胸腔内液若しくは漿液と関連する腫瘍細胞の特徴づけによる癌の診断方法 Pending JP2014521958A (ja)

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US201161512576P 2011-07-28 2011-07-28
US61/512,576 2011-07-28
PCT/US2012/048452 WO2013016600A2 (en) 2011-07-28 2012-07-27 Methods and reagents for diagnosing conditions and characterization of tumor cells associated with serous fluids

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JP2014521958A true JP2014521958A (ja) 2014-08-28
JP2014521958A5 JP2014521958A5 (https=) 2015-09-03

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US (1) US20140295426A1 (https=)
EP (1) EP2737317A2 (https=)
JP (1) JP2014521958A (https=)
IL (1) IL230687A0 (https=)
TW (1) TW201312117A (https=)
WO (1) WO2013016600A2 (https=)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6238856B2 (ja) * 2014-08-25 2017-11-29 シスメックス株式会社 尿中異型細胞の分析方法、尿分析装置および体液中異型細胞の分析方法
WO2017054075A1 (en) * 2015-09-28 2017-04-06 The Governing Council Of The University Of Toronto Device for magnetic profiling of particles in a flow
US10696961B2 (en) 2017-12-01 2020-06-30 Global Life Sciences Solutions Usa Llc Magnetic cell isolation techniques
AU2018376657B2 (en) * 2017-12-01 2024-07-25 Global Life Sciences Solutions Usa Llc Methods for cell enrichment and isolation
WO2021119470A1 (en) * 2019-12-12 2021-06-17 University Of Miami Materials and methods for extracellular vesicle detection
US12159700B2 (en) 2020-04-22 2024-12-03 Iovance Biotherapeutics, Inc. Systems and methods for coordinating manufacturing of cells for patient-specific immunotherapy
EP4146794A1 (en) 2020-05-04 2023-03-15 Iovance Biotherapeutics, Inc. Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy
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US20230372397A1 (en) 2020-10-06 2023-11-23 Iovance Biotherapeutics, Inc. Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
WO2022076606A1 (en) 2020-10-06 2022-04-14 Iovance Biotherapeutics, Inc. Treatment of nsclc patients with tumor infiltrating lymphocyte therapies
TW202241468A (zh) 2020-12-11 2022-11-01 美商艾歐凡斯生物治療公司 用腫瘤浸潤性淋巴球療法與ｂｒａｆ抑制劑及／或ｍｅｋ抑制劑組合治療癌症患者
US20240123067A1 (en) 2020-12-17 2024-04-18 Iovance Biotherapeutics, Inc. Treatment of cancers with tumor infiltrating lymphocyte therapies
CA3202483A1 (en) 2020-12-17 2022-06-23 Maria Fardis Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors
TW202242085A (zh) 2020-12-31 2022-11-01 美商艾歐凡斯生物治療公司 供自動生產腫瘤浸潤淋巴球的裝置和方法
WO2022187741A2 (en) 2021-03-05 2022-09-09 Iovance Biotherapeutics, Inc. Tumor storage and cell culture compositions
WO2022198141A1 (en) 2021-03-19 2022-09-22 Iovance Biotherapeutics, Inc. Methods for tumor infiltrating lymphocyte (til) expansion related to cd39/cd69 selection and gene knockout in tils
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EP4326287A2 (en) 2021-04-19 2024-02-28 Iovance Biotherapeutics, Inc. Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies
WO2022245754A1 (en) 2021-05-17 2022-11-24 Iovance Biotherapeutics, Inc. Pd-1 gene-edited tumor infiltrating lymphocytes and uses of same in immunotherapy
US20240342285A1 (en) 2021-07-28 2024-10-17 Iovance Biotherapeutics, Inc. Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors
IL311333A (en) 2021-09-09 2024-05-01 Iovance Biotherapeutics Inc Processes for generating til products using pd-1 talen knockdown
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US20260008990A1 (en) 2022-07-06 2026-01-08 Iovance Biotherapeutics, Inc. Devices and processes for automated production of tumor infiltrating lymphocytes
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WO2025101484A1 (en) 2023-11-06 2025-05-15 Iovance Biotherapeutics, Inc. Treatment of endometrial cancers with tumor infiltrating lymphocyte therapies
WO2026035866A1 (en) 2024-08-07 2026-02-12 Iovance Biotherapeutics, Inc. Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with a lag-3 inhibitor and a pd-1 inhibitor
WO2026050217A2 (en) 2024-08-27 2026-03-05 Iovance Biotherapeutics, Inc. Engineered artificial antigen presenting cells and lipid nanoparticles for tumor infiltrating lymphocyte expansion

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63109793A (ja) * 1986-10-28 1988-05-14 Kyowa Hakko Kogyo Co Ltd 抗ヒト中皮細胞単クロ−ン性抗体
JPH09510779A (ja) * 1994-03-10 1997-10-28 フォドスタッド オイステイン 特定化あるいは混合した細胞母集団または混合細胞母集団を含む溶液内の特定標的細胞を検出する方法および装置
JP2008538509A (ja) * 2005-04-21 2008-10-30 カリフォルニア インスティチュート オブ テクノロジー パリレンメンブレンフィルターの使用
JP2009525478A (ja) * 2006-01-31 2009-07-09 ビオメリュー 癌、特に乳癌、甲状腺癌及び肺癌のインビトロ診断のためのＰｒｏＮＧＦアッセイのための方法とＰｒｏＮＧＦの治療的使用
JP2010501549A (ja) * 2006-08-23 2010-01-21 コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー 胆管癌治療用薬学的組成物、胆管癌の成長または浸潤抑制方法、および胆管癌の治療方法
WO2010102177A1 (en) * 2009-03-06 2010-09-10 Becton, Dickinson And Company Glycodelin monoclonal antibodies and methods for their use in the detection of ovarian cancer

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4939240A (en) 1983-03-04 1990-07-03 Health Research, Inc. Monoclonal antibodies to human breast carcinoma cells and their use in diagnosis and therapy
EP0491867B1 (en) 1989-09-15 1996-11-27 Genetic Systems Corporation Hybridoma ct43 producing a monoclonal antibody to a mucin epitope of colorectal cancer
DE69306803T2 (de) 1992-09-17 1997-05-15 Merck Patent Gmbh Kleinzelliger lungenkarzinom-spezifischer antikörper und antigenen
US6136182A (en) 1996-06-07 2000-10-24 Immunivest Corporation Magnetic devices and sample chambers for examination and manipulation of cells
US6790366B2 (en) 1996-06-07 2004-09-14 Immunivest Corporation Magnetic separation apparatus and methods
US6890426B2 (en) 1996-06-07 2005-05-10 Immunivest Corporation Magnetic separation apparatus and methods
EP0920627B1 (en) 1996-06-07 2004-05-12 Immunivest Corporation Magnetic separation employing external and internal gradients
US6660159B1 (en) 1996-06-07 2003-12-09 Immunivest Corporation Magnetic separation apparatus and methods
US7282350B2 (en) 1998-02-12 2007-10-16 Immunivest Corporation Labeled cell sets for use as functional controls in rare cell detection assays
WO1999041613A1 (en) 1998-02-12 1999-08-19 Immunivest Methods and reagents for the rapid and efficient isolation of circulating cancer cells
US6623982B1 (en) 1999-07-12 2003-09-23 Immunivest Corporation Increased separation efficiency via controlled aggregation of magnetic nanoparticles
DE60214827T2 (de) 2001-02-12 2007-03-29 Immunivest Corp., Wilmington Kassette als behälter eines probenexemplars für die optische analyse
EP1425294B2 (en) * 2001-08-23 2012-12-12 Veridex, LLC Analysis of circulating tumor cells, fragments, and debris
GB2424273B (en) * 2002-11-14 2007-06-27 Univ Nottingham Method for preparing tumour marker protein
US7666583B2 (en) * 2004-02-19 2010-02-23 Yale University Identification of cancer protein biomarkers using proteomic techniques
US20060024824A1 (en) * 2004-07-16 2006-02-02 Steven Woodside Magnetic cell separation method
US7846743B2 (en) * 2005-04-21 2010-12-07 California Institute Of Technology Uses of parylene membrane filters
EP2037265A1 (en) * 2007-09-17 2009-03-18 Adnagen AG Solid phase cell isolation and/or enrichment method

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63109793A (ja) * 1986-10-28 1988-05-14 Kyowa Hakko Kogyo Co Ltd 抗ヒト中皮細胞単クロ−ン性抗体
JPH09510779A (ja) * 1994-03-10 1997-10-28 フォドスタッド オイステイン 特定化あるいは混合した細胞母集団または混合細胞母集団を含む溶液内の特定標的細胞を検出する方法および装置
JP2008538509A (ja) * 2005-04-21 2008-10-30 カリフォルニア インスティチュート オブ テクノロジー パリレンメンブレンフィルターの使用
JP2009525478A (ja) * 2006-01-31 2009-07-09 ビオメリュー 癌、特に乳癌、甲状腺癌及び肺癌のインビトロ診断のためのＰｒｏＮＧＦアッセイのための方法とＰｒｏＮＧＦの治療的使用
JP2010501549A (ja) * 2006-08-23 2010-01-21 コリア リサーチ インスティテュート オブ バイオサイエンス アンド バイオテクノロジー 胆管癌治療用薬学的組成物、胆管癌の成長または浸潤抑制方法、および胆管癌の治療方法
WO2010102177A1 (en) * 2009-03-06 2010-09-10 Becton, Dickinson And Company Glycodelin monoclonal antibodies and methods for their use in the detection of ovarian cancer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ERIC KIELHORN: "USE OF MAGNETIC ENRICHMENT FOR DETECTION OF CARCINOMA CELLS IN FLUID SPECIMENS", CANCER, vol. V94 N1, JPN5015000886, 1 January 2002 (2002-01-01), pages 205 - 211, ISSN: 0003313015 *
MASAHIRO HORIKAWA, ONCOLOGY REPORTS, vol. V25 N5, JPN5015000877, 18 February 2011 (2011-02-18), pages 1413 - 1420, ISSN: 0003313016 *

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US20140295426A1 (en) 2014-10-02
WO2013016600A2 (en) 2013-01-31
IL230687A0 (en) 2014-03-31
TW201312117A (zh) 2013-03-16
WO2013016600A3 (en) 2013-04-18

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