JP2014520807A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014520807A5 JP2014520807A5 JP2014519091A JP2014519091A JP2014520807A5 JP 2014520807 A5 JP2014520807 A5 JP 2014520807A5 JP 2014519091 A JP2014519091 A JP 2014519091A JP 2014519091 A JP2014519091 A JP 2014519091A JP 2014520807 A5 JP2014520807 A5 JP 2014520807A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- polypeptide
- epitope
- composition
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims description 164
- 102000036639 antigens Human genes 0.000 claims description 164
- 108091007433 antigens Proteins 0.000 claims description 164
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 110
- 229920001184 polypeptide Polymers 0.000 claims description 98
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 98
- 239000000203 mixture Substances 0.000 claims description 97
- 230000002163 immunogen Effects 0.000 claims description 41
- 244000052769 pathogen Species 0.000 claims description 27
- 230000001717 pathogenic effect Effects 0.000 claims description 27
- 230000037452 priming Effects 0.000 claims description 26
- 230000003612 virological effect Effects 0.000 claims description 22
- 241000701022 Cytomegalovirus Species 0.000 claims description 18
- 125000002091 cationic group Chemical group 0.000 claims description 18
- 241000700605 Viruses Species 0.000 claims description 14
- 239000007908 nanoemulsion Substances 0.000 claims description 13
- 230000004927 fusion Effects 0.000 claims description 12
- 239000002502 liposome Substances 0.000 claims description 12
- 239000011859 microparticle Substances 0.000 claims description 12
- 239000004005 microsphere Substances 0.000 claims description 12
- 239000002077 nanosphere Substances 0.000 claims description 12
- 239000000277 virosome Substances 0.000 claims description 12
- -1 Cationic lipid Chemical class 0.000 claims description 11
- 239000002671 adjuvant Substances 0.000 claims description 10
- 239000007764 o/w emulsion Substances 0.000 claims description 10
- 239000007762 w/o emulsion Substances 0.000 claims description 10
- 230000004936 stimulating effect Effects 0.000 claims description 8
- 239000003937 drug carrier Substances 0.000 claims description 7
- 239000003981 vehicle Substances 0.000 claims description 7
- 241000710929 Alphavirus Species 0.000 claims description 6
- 208000035473 Communicable disease Diseases 0.000 claims description 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 6
- 230000028993 immune response Effects 0.000 claims description 6
- 208000015181 infectious disease Diseases 0.000 claims description 6
- 125000003729 nucleotide group Chemical group 0.000 claims description 6
- 239000012528 membrane Substances 0.000 claims description 5
- 230000003308 immunostimulating effect Effects 0.000 claims description 4
- 230000001939 inductive effect Effects 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 230000002265 prevention Effects 0.000 claims description 3
- 230000005847 immunogenicity Effects 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 15
- 229940127557 pharmaceutical product Drugs 0.000 claims 15
- 239000003814 drug Substances 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 4
- 239000002356 single layer Substances 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229940126601 medicinal product Drugs 0.000 claims 2
- 208000019802 Sexually transmitted disease Diseases 0.000 claims 1
- 238000011081 inoculation Methods 0.000 claims 1
- 230000004044 response Effects 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 description 28
- 239000000839 emulsion Substances 0.000 description 4
- 239000002691 unilamellar liposome Substances 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161505105P | 2011-07-06 | 2011-07-06 | |
| US61/505,105 | 2011-07-06 | ||
| PCT/US2012/045854 WO2013006842A2 (en) | 2011-07-06 | 2012-07-06 | Immunogenic compositions and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016210783A Division JP2017025103A (ja) | 2011-07-06 | 2016-10-27 | 免疫原性組成物およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014520807A JP2014520807A (ja) | 2014-08-25 |
| JP2014520807A5 true JP2014520807A5 (enrdf_load_stackoverflow) | 2015-08-20 |
Family
ID=46513884
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014519091A Pending JP2014520807A (ja) | 2011-07-06 | 2012-07-06 | 免疫原性組成物およびその使用 |
| JP2016210783A Pending JP2017025103A (ja) | 2011-07-06 | 2016-10-27 | 免疫原性組成物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016210783A Pending JP2017025103A (ja) | 2011-07-06 | 2016-10-27 | 免疫原性組成物およびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US11058762B2 (enrdf_load_stackoverflow) |
| EP (2) | EP2729168A2 (enrdf_load_stackoverflow) |
| JP (2) | JP2014520807A (enrdf_load_stackoverflow) |
| CA (1) | CA2841047A1 (enrdf_load_stackoverflow) |
| WO (1) | WO2013006842A2 (enrdf_load_stackoverflow) |
Families Citing this family (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11446374B2 (en) | 2008-12-09 | 2022-09-20 | Novavax, Inc. | Modified RSV F proteins and methods of their use |
| CN102307591B (zh) | 2008-12-09 | 2016-08-03 | 诺瓦瓦克斯股份有限公司 | 修饰的rsv f蛋白及其使用方法 |
| JP5940064B2 (ja) | 2010-07-06 | 2016-06-29 | ノバルティス アーゲー | 低用量のｒｎａを用いた大型哺乳動物の免疫化 |
| CN103153284B (zh) | 2010-07-06 | 2015-11-25 | 诺华股份有限公司 | 含有其pKa值有利于RNA递送的脂质的脂质体 |
| ES2646669T3 (es) | 2010-07-06 | 2017-12-14 | Glaxosmithkline Biologicals Sa | Procedimientos de aumento de una respuesta inmunitaria mediante el suministro de ARN |
| WO2012019168A2 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| LT4066856T (lt) | 2010-08-31 | 2023-01-25 | Glaxosmithkline Biologicals Sa | Pegilintos liposomos, skirtos imunogeną koduojančios rnr pristatymui |
| WO2012045075A1 (en) | 2010-10-01 | 2012-04-05 | Jason Schrum | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| CA2814386C (en) | 2010-10-11 | 2019-08-20 | Novartis Ag | Antigen delivery platforms |
| AU2012236099A1 (en) | 2011-03-31 | 2013-10-03 | Moderna Therapeutics, Inc. | Delivery and formulation of engineered nucleic acids |
| ES2911653T3 (es) | 2011-06-08 | 2022-05-20 | Translate Bio Inc | Composiciones de nanopartículas lipídicas y métodos para el suministro de ARNm |
| ES2656050T3 (es) | 2011-07-06 | 2018-02-22 | Glaxosmithkline Biologicals Sa | Composiciones de combinación inmunogénica y usos de las mismas |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| SI3682905T1 (sl) | 2011-10-03 | 2022-04-29 | Modernatx, Inc. | Modificirani nukleozidi, nukleotidi in nukleinske kisline ter njihove uporabe |
| BR112014008694A2 (pt) * | 2011-10-11 | 2017-06-20 | Novartis Ag | moléculas de ácido nucleico policistrônico recombinante |
| US9040397B2 (en) * | 2011-10-21 | 2015-05-26 | LGS Innovations LLC | Method of making graphene layers, and articles made thereby |
| EP4144378A1 (en) | 2011-12-16 | 2023-03-08 | ModernaTX, Inc. | Modified nucleoside, nucleotide, and nucleic acid compositions |
| CA2868996A1 (en) | 2012-04-02 | 2013-10-10 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| EP2869842A1 (en) * | 2012-07-06 | 2015-05-13 | Novartis AG | Immunogenic compositions and uses thereof |
| EP2869843B1 (en) * | 2012-07-06 | 2019-08-07 | GlaxoSmithKline Biologicals SA | Complexes of cytomegalovirus proteins |
| US9512456B2 (en) | 2012-08-14 | 2016-12-06 | Modernatx, Inc. | Enzymes and polymerases for the synthesis of RNA |
| PL2922554T3 (pl) | 2012-11-26 | 2022-06-20 | Modernatx, Inc. | Na zmodyfikowany na końcach |
| JP2016506416A (ja) | 2013-01-10 | 2016-03-03 | ノバルティス アーゲー | インフルエンザウイルス免疫原性組成物およびその使用 |
| EP2968391A1 (en) | 2013-03-13 | 2016-01-20 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| EP2971010B1 (en) | 2013-03-14 | 2020-06-10 | ModernaTX, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| CN105980401A (zh) | 2013-10-03 | 2016-09-28 | 现代治疗公司 | 编码低密度脂蛋白受体的多核苷酸 |
| SMT202200158T1 (it) | 2014-04-23 | 2022-05-12 | Modernatx Inc | Vaccini ad acidi nucleici |
| RU2016147987A (ru) * | 2014-05-08 | 2018-06-13 | Пфайзер Инк. | Средства и способы лечения cmv |
| BR112016028816A8 (pt) * | 2014-06-13 | 2021-07-20 | Glaxosmithkline Biologicals Sa | combinação imunogênica, método para obter uma resposta imunológica específica, uso de uma combinação imunogênica, e, regime de vacinação para prevenção, redução ou tratamento de infecção por vírus sincicial respiratório |
| JP2017524357A (ja) | 2014-07-16 | 2017-08-31 | モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． | キメラポリヌクレオチド |
| AU2016264027A1 (en) | 2015-05-15 | 2017-08-31 | Curevac Ag | Prime-boost regimens involving administration of at least one mRNA construct |
| CA2988654A1 (en) * | 2015-06-12 | 2016-12-15 | Glaxosmithkline Biologicals S.A. | Adenovirus polynucleotides and polypeptides |
| WO2017015463A2 (en) | 2015-07-21 | 2017-01-26 | Modernatx, Inc. | Infectious disease vaccines |
| US11364292B2 (en) | 2015-07-21 | 2022-06-21 | Modernatx, Inc. | CHIKV RNA vaccines |
| BR112018004242A2 (pt) | 2015-09-03 | 2018-09-25 | Novavax Inc | composições de vacina que possuem estabilidade e imunogenicidade aumentadas |
| PL3350157T3 (pl) | 2015-09-17 | 2022-05-16 | Modernatx, Inc. | Związki i kompozycje do dostarczania wewnątrzkomórkowego środków terapeutycznych |
| JP6990176B2 (ja) | 2015-10-05 | 2022-02-03 | モデルナティエックス インコーポレイテッド | メッセンジャーリボ核酸薬物の治療投与のための方法 |
| CA3002922A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| WO2017070624A1 (en) | 2015-10-22 | 2017-04-27 | Modernatx, Inc. | Tropical disease vaccines |
| US20180289792A1 (en) | 2015-10-22 | 2018-10-11 | ModernaTX. Inc. | Sexually transmitted disease vaccines |
| AU2016342371B2 (en) | 2015-10-22 | 2023-05-11 | Modernatx, Inc. | Nucleic acid vaccines for varicella zoster virus (VZV) |
| DK3386484T3 (da) | 2015-12-10 | 2022-07-04 | Modernatx Inc | Sammensætninger og fremgangsmåder til afgivelse af terapeutiske midler |
| CA3007297A1 (en) | 2015-12-22 | 2017-06-29 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
| WO2017123652A1 (en) | 2016-01-11 | 2017-07-20 | Verndari, Inc. | Microneedle compositions and methods of using same |
| US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| US12128113B2 (en) | 2016-05-18 | 2024-10-29 | Modernatx, Inc. | Polynucleotides encoding JAGGED1 for the treatment of Alagille syndrome |
| EP3528821A4 (en) | 2016-10-21 | 2020-07-01 | ModernaTX, Inc. | HUMAN CYTOMEGALOVIRUS VACCINE |
| US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| WO2018089851A2 (en) | 2016-11-11 | 2018-05-17 | Modernatx, Inc. | Influenza vaccine |
| US11103578B2 (en) | 2016-12-08 | 2021-08-31 | Modernatx, Inc. | Respiratory virus nucleic acid vaccines |
| WO2018170245A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Broad spectrum influenza virus vaccine |
| WO2018170322A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Crystal forms of amino lipids |
| US11045540B2 (en) | 2017-03-15 | 2021-06-29 | Modernatx, Inc. | Varicella zoster virus (VZV) vaccine |
| WO2018170306A1 (en) | 2017-03-15 | 2018-09-20 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| MA47787A (fr) * | 2017-03-15 | 2020-01-22 | Modernatx Inc | Vaccin contre le virus respiratoire syncytial |
| US11752206B2 (en) | 2017-03-15 | 2023-09-12 | Modernatx, Inc. | Herpes simplex virus vaccine |
| US11969506B2 (en) | 2017-03-15 | 2024-04-30 | Modernatx, Inc. | Lipid nanoparticle formulation |
| EP3600396A4 (en) * | 2017-03-30 | 2021-01-13 | The Government of the United States of America as represented by the Secretary of the Army | VACCINE COMPOSITION OF NUCLEIC ACID INCLUDING A LIPIDIC FORMULATION, AND PROCESS FOR INCREASING THE EFFECTIVENESS OF NUCLEIC ACID VACCINES |
| KR20200003390A (ko) | 2017-05-08 | 2020-01-09 | 그릿스톤 온콜로지, 인코포레이티드 | 알파바이러스 신생항원 벡터 |
| WO2018232120A1 (en) | 2017-06-14 | 2018-12-20 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of agents |
| MA49421A (fr) | 2017-06-15 | 2020-04-22 | Modernatx Inc | Formulations d'arn |
| CN111148509A (zh) | 2017-07-24 | 2020-05-12 | 诺瓦瓦克斯股份有限公司 | 治疗呼吸系统疾病的方法和组合物 |
| EP3658179A1 (en) * | 2017-07-28 | 2020-06-03 | Janssen Vaccines & Prevention B.V. | Methods and compositions for heterologous reprna immunizations |
| WO2019036008A1 (en) | 2017-08-16 | 2019-02-21 | Acuitas Therapeutics, Inc. | LIPIDS FOR USE IN LIPID NANOPARTICULAR FORMULATIONS |
| EP3675817A1 (en) | 2017-08-31 | 2020-07-08 | Modernatx, Inc. | Methods of making lipid nanoparticles |
| WO2019052975A1 (en) * | 2017-09-13 | 2019-03-21 | Sanofi Pasteur | IMMUNOGENIC COMPOSITION AGAINST HUMAN CYTOMEGALOVIRUS |
| EP3681514A4 (en) | 2017-09-14 | 2021-07-14 | ModernaTX, Inc. | RNA VACZINE AGAINST ZIKA VIRUS |
| EP3728291A1 (en) | 2017-12-20 | 2020-10-28 | GlaxoSmithKline Biologicals S.A. | Epstein-barr virus antigen constructs |
| CN118955721A (zh) | 2018-01-04 | 2024-11-15 | 伊科尼克治疗公司 | 抗组织因子抗体、抗体-药物缀合物及相关方法 |
| EP3746090A4 (en) | 2018-01-29 | 2021-11-17 | ModernaTX, Inc. | RSV RNA VACCINES |
| SG11202009206QA (en) | 2018-03-19 | 2020-10-29 | Novavax Inc | Multivalent influenza nanoparticle vaccines |
| EP3836963A2 (en) | 2018-08-17 | 2021-06-23 | GlaxoSmithKline Biologicals S.A. | Immunogenic compositions and uses thereof |
| MA53650A (fr) | 2018-09-19 | 2021-07-28 | Modernatx Inc | Lipides peg et leurs utilisations |
| CA3113436A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| MA53652A (fr) | 2018-09-19 | 2021-07-28 | Modernatx Inc | Lipides peg de haute pureté et leurs utilisations |
| CN113271926A (zh) | 2018-09-20 | 2021-08-17 | 摩登纳特斯有限公司 | 脂质纳米颗粒的制备及其施用方法 |
| US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| TWI852977B (zh) | 2019-01-10 | 2024-08-21 | 美商健生生物科技公司 | 前列腺新抗原及其用途 |
| US11351242B1 (en) | 2019-02-12 | 2022-06-07 | Modernatx, Inc. | HMPV/hPIV3 mRNA vaccine composition |
| US11717548B2 (en) * | 2019-03-08 | 2023-08-08 | Massachusetts Institute Of Technology | Synthetic oncolytic LNP-replicon RNA and uses for cancer immunotherapy |
| MA55321A (fr) | 2019-03-15 | 2022-01-19 | Modernatx Inc | Vaccins à base d'arn contre le vih |
| US12214027B2 (en) | 2019-03-29 | 2025-02-04 | Intervet Inc. | Stabilisation of live mollicutes bacteria in a liquid composition |
| AU2020282369A1 (en) | 2019-05-30 | 2022-01-20 | Seattle Project Corp. | Modified adenoviruses |
| CA3143632A1 (en) | 2019-06-20 | 2020-12-24 | Janssen Sciences Ireland Unlimited Company | Self-replicating rna molecules for hepatitis b virus (hbv) vaccines and uses thereof |
| BR112022004759A2 (pt) | 2019-09-19 | 2022-06-21 | Modernatx Inc | Composições e compostos lipídicos com cauda ramificada para entrega intracelular de agentes terapêuticos |
| WO2021099906A1 (en) | 2019-11-18 | 2021-05-27 | Janssen Biotech, Inc. | Vaccines based on mutant calr and jak2 and their uses |
| WO2021183564A1 (en) | 2020-03-09 | 2021-09-16 | Arcturus Therapeutics, Inc. | Compositions and methods for inducing immune responses |
| CA3174187A1 (en) * | 2020-04-01 | 2021-10-07 | University Of Florida Research Foundation, Incorporated | Multilamellar rna nanoparticle vaccine against sars-cov-2 |
| KR20230009489A (ko) | 2020-05-11 | 2023-01-17 | 얀센 파마슈티칼즈, 인코포레이티드 | 안정화된 코로나 바이러스 스파이크 단백질을 암호화하는 rna 레플리콘 |
| AU2021275213A1 (en) * | 2020-05-20 | 2023-02-02 | Flagship Pioneering Innovations Vi, Llc | Immunogenic compositions and uses thereof |
| US11857622B2 (en) | 2020-06-21 | 2024-01-02 | Pfizer Inc. | Human cytomegalovirus GB polypeptide |
| US12295997B2 (en) | 2020-07-06 | 2025-05-13 | Janssen Biotech, Inc. | Prostate neoantigens and their uses |
| CA3187258A1 (en) | 2020-08-06 | 2022-02-10 | Karin Jooss | Multiepitope vaccine cassettes |
| MX2023001853A (es) | 2020-08-14 | 2023-07-07 | Arcturus Therapeutics Inc | Método de liofilización de nanopartículas lípidicas. |
| US11406703B2 (en) | 2020-08-25 | 2022-08-09 | Modernatx, Inc. | Human cytomegalovirus vaccine |
| WO2022103927A1 (en) * | 2020-11-12 | 2022-05-19 | Shape Biopharmaceuticals Inc. | Immunogenic compositions for coronaviruses |
| EP4267593A2 (en) * | 2020-12-23 | 2023-11-01 | GlaxoSmithKline Biologicals SA | Self-amplifying messenger rna |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
| US12129223B2 (en) | 2021-12-16 | 2024-10-29 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| US12115217B2 (en) | 2022-11-18 | 2024-10-15 | Trustees Of Boston University | Self-replicating RNA and uses thereof |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4186745A (en) | 1976-07-30 | 1980-02-05 | Kauzlarich James J | Porous catheters |
| US4500707A (en) | 1980-02-29 | 1985-02-19 | University Patents, Inc. | Nucleosides useful in the preparation of polynucleotides |
| US5132418A (en) | 1980-02-29 | 1992-07-21 | University Patents, Inc. | Process for preparing polynucleotides |
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US4973679A (en) | 1981-03-27 | 1990-11-27 | University Patents, Inc. | Process for oligonucleo tide synthesis using phosphormidite intermediates |
| US4668777A (en) | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
| US4373071A (en) | 1981-04-30 | 1983-02-08 | City Of Hope Research Institute | Solid-phase synthesis of polynucleotides |
| SE8205892D0 (sv) | 1982-10-18 | 1982-10-18 | Bror Morein | Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin |
| IL73534A (en) | 1983-11-18 | 1990-12-23 | Riker Laboratories Inc | 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds |
| US6090406A (en) | 1984-04-12 | 2000-07-18 | The Liposome Company, Inc. | Potentiation of immune responses with liposomal adjuvants |
| US5916588A (en) | 1984-04-12 | 1999-06-29 | The Liposome Company, Inc. | Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| US5036006A (en) | 1984-11-13 | 1991-07-30 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| ATE171185T1 (de) | 1985-03-15 | 1998-10-15 | Antivirals Inc | Immunotestmittel für polynukleotid und verfahren |
| US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| US5153319A (en) | 1986-03-31 | 1992-10-06 | University Patents, Inc. | Process for preparing polynucleotides |
| US6048729A (en) | 1987-05-01 | 2000-04-11 | Transkaryotic Therapies, Inc. | In vivo protein production and delivery system for gene therapy |
| US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| JPH0731857B2 (ja) | 1988-02-19 | 1995-04-10 | 三洋電機株式会社 | 磁気記録再生装置におけるリール台駆動装置 |
| AU627226B2 (en) | 1988-08-25 | 1992-08-20 | Liposome Company, Inc., The | Influenza vaccine and novel adjuvants |
| US5238944A (en) | 1988-12-15 | 1993-08-24 | Riker Laboratories, Inc. | Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine |
| US5262530A (en) | 1988-12-21 | 1993-11-16 | Applied Biosystems, Inc. | Automated system for polynucleotide synthesis and purification |
| US5047524A (en) | 1988-12-21 | 1991-09-10 | Applied Biosystems, Inc. | Automated system for polynucleotide synthesis and purification |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US4929624A (en) | 1989-03-23 | 1990-05-29 | Minnesota Mining And Manufacturing Company | Olefinic 1H-imidazo(4,5-c)quinolin-4-amines |
| WO1990014837A1 (en) | 1989-05-25 | 1990-12-13 | Chiron Corporation | Adjuvant formulation comprising a submicron oil droplet emulsion |
| US5674192A (en) | 1990-12-28 | 1997-10-07 | Boston Scientific Corporation | Drug delivery |
| US5389640A (en) | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| US5268376A (en) | 1991-09-04 | 1993-12-07 | Minnesota Mining And Manufacturing Company | 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
| US6054288A (en) | 1991-11-05 | 2000-04-25 | Transkaryotic Therapies, Inc. | In vivo protein production and delivery system for gene therapy |
| PT101031B (pt) | 1991-11-05 | 2002-07-31 | Transkaryotic Therapies Inc | Processo para o fornecimento de proteinas por terapia genetica |
| US5266575A (en) | 1991-11-06 | 1993-11-30 | Minnesota Mining And Manufacturing Company | 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines |
| US5340740A (en) | 1992-05-15 | 1994-08-23 | North Carolina State University | Method of producing an avian embryonic stem cell culture and the avian embryonic stem cell culture produced by the process |
| US5395937A (en) | 1993-01-29 | 1995-03-07 | Minnesota Mining And Manufacturing Company | Process for preparing quinoline amines |
| BR9405957A (pt) | 1993-03-23 | 1995-12-12 | Smithkline Beecham Biolog | Composições de vacina contendo lipidio A deacilatado 3-0 monofosforil |
| US5352784A (en) | 1993-07-15 | 1994-10-04 | Minnesota Mining And Manufacturing Company | Fused cycloalkylimidazopyridines |
| CZ288182B6 (en) | 1993-07-15 | 2001-05-16 | Minnesota Mining & Mfg | Imidazo[4,5-c]pyridine-4-amines and pharmaceutical preparations based thereon |
| US5397307A (en) | 1993-12-07 | 1995-03-14 | Schneider (Usa) Inc. | Drug delivery PTCA catheter and method for drug delivery |
| GB9326174D0 (en) | 1993-12-22 | 1994-02-23 | Biocine Sclavo | Mucosal adjuvant |
| JP3403233B2 (ja) | 1994-01-20 | 2003-05-06 | テルモ株式会社 | バルーンカテーテル |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| AUPM873294A0 (en) | 1994-10-12 | 1994-11-03 | Csl Limited | Saponin preparations and use thereof in iscoms |
| FR2726003B1 (fr) | 1994-10-21 | 2002-10-18 | Agronomique Inst Nat Rech | Milieu de culture de cellules embryonnaires totipotentes aviaires, procede de culture de ces cellules, et cellules embryonnaires totipotentes aviaires |
| AU3876695A (en) | 1994-11-17 | 1996-06-17 | Imperial College Of Science, Technology And Medicine | Internalisation of dna, using conjugates of poly-l-lysine and an integrin receptor ligand |
| US6071890A (en) | 1994-12-09 | 2000-06-06 | Genzyme Corporation | Organ-specific targeting of cationic amphiphile/DNA complexes for gene therapy |
| US5482936A (en) | 1995-01-12 | 1996-01-09 | Minnesota Mining And Manufacturing Company | Imidazo[4,5-C]quinoline amines |
| UA56132C2 (uk) | 1995-04-25 | 2003-05-15 | Смітклайн Бічем Байолоджікалс С.А. | Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини |
| US5700642A (en) | 1995-05-22 | 1997-12-23 | Sri International | Oligonucleotide sizing using immobilized cleavable primers |
| CA2244110A1 (en) | 1996-02-12 | 1997-08-14 | Cobra Therapeutics Limited | Novel methods of vaccination and vaccines thereof comprising a nucleic acid encoding a first epitope and a peptide containing a second epitope |
| DE69841122D1 (de) | 1997-03-10 | 2009-10-15 | Coley Pharm Gmbh | Verwendung von nicht-methyliertem CpG Dinukleotid in Kombination mit Aluminium als Adjuvantien |
| US6818222B1 (en) | 1997-03-21 | 2004-11-16 | Chiron Corporation | Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants |
| US6090619A (en) | 1997-09-08 | 2000-07-18 | University Of Florida | Materials and methods for intracellular delivery of biologically active molecules |
| EP0980280B1 (en) | 1997-10-01 | 2005-02-09 | Medtronic Ave, Inc. | Drug delivery and gene therapy delivery system |
| GB9725084D0 (en) | 1997-11-28 | 1998-01-28 | Medeva Europ Ltd | Vaccine compositions |
| GB9726555D0 (en) | 1997-12-16 | 1998-02-11 | Smithkline Beecham Plc | Vaccine |
| IL138000A0 (en) | 1998-04-09 | 2001-10-31 | Smithkline Beecham Biolog | Adjuvant compositions |
| US6562798B1 (en) | 1998-06-05 | 2003-05-13 | Dynavax Technologies Corp. | Immunostimulatory oligonucleotides with modified bases and methods of use thereof |
| GB9817052D0 (en) | 1998-08-05 | 1998-09-30 | Smithkline Beecham Biolog | Vaccine |
| DE69935606T9 (de) | 1998-10-16 | 2021-03-11 | Glaxosmithkline Biologicals S.A. | Adjuvanzsysteme und impfstoffe |
| IL148671A0 (en) | 1999-09-24 | 2002-09-12 | Smithkline Beecham Biolog | Adjuvant comprising a polyxyethylene alkyl ether or ester and at least one nonionic surfactant |
| PL355163A1 (en) | 1999-09-24 | 2004-04-05 | Smithkline Beecham Biologicals S.A. | Use of combination of polyoxyethylene sorbitan ester and octoxynol as adjuvant and its use in vaccines |
| WO2001095935A1 (en) | 2000-01-20 | 2001-12-20 | Ottawa Health Research Institute | Immunostimulatory nucleic acids for inducing a th2 immune response |
| US7318928B2 (en) | 2000-08-01 | 2008-01-15 | The Johns Hopkins University | Molecular vaccine linking intercellular spreading protein to an antigen |
| AU9475001A (en) | 2000-09-26 | 2002-04-08 | Hybridon Inc | Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes |
| AU2002347404A1 (en) | 2001-09-14 | 2003-04-01 | Cytos Biotechnology Ag | In vivo activation of antigen presenting cells for enhancement of immune responses induced by virus like particles |
| WO2003024481A2 (en) | 2001-09-14 | 2003-03-27 | Cytos Biotechnology Ag | Packaging of immunostimulatory substances into virus-like particles: method of preparation and use |
| WO2003035836A2 (en) | 2001-10-24 | 2003-05-01 | Hybridon Inc. | Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends |
| FR2832423B1 (fr) | 2001-11-22 | 2004-10-08 | Vivalis | Systeme d'expression de proteines exogenes dans un systeme aviaire |
| FR2836924B1 (fr) | 2002-03-08 | 2005-01-14 | Vivalis | Lignees de cellules aviaires utiles pour la production de substances d'interet |
| WO2004004758A1 (en) | 2002-07-05 | 2004-01-15 | Lipoxen Technologies Limited | Method to enhance an immune response of nucleic acid vaccination |
| ATE471335T1 (de) | 2002-12-23 | 2010-07-15 | Vical Inc | Impfstoffe gegen infektionen mit dem humanen zytomegalivirus auf grundlage von codonoptimierten polynukleotiden |
| CA2511646A1 (en) | 2002-12-27 | 2004-07-22 | Chiron Corporation | Thiosemicarbazones as anti-virals and immunopotentiators |
| ES2391770T3 (es) | 2003-01-21 | 2012-11-29 | Novartis Vaccines And Diagnostics, Inc. | Uso de compuestos de triptantrina para la potenciación inmune |
| DE602004021260D1 (de) * | 2003-07-11 | 2009-07-09 | Alphavax Inc | Cytomegalovirusimpfstoffe, die auf dem alphavirus basieren |
| EP1528101A1 (en) | 2003-11-03 | 2005-05-04 | ProBioGen AG | Immortalized avian cell lines for virus production |
| US20060024670A1 (en) | 2004-05-18 | 2006-02-02 | Luke Catherine J | Influenza virus vaccine composition and methods of use |
| US7862829B2 (en) | 2004-07-09 | 2011-01-04 | University Of North Carolina At Chapel Hill | Viral adjuvants |
| GB2421025A (en) | 2004-12-09 | 2006-06-14 | Oxxon Therapeutics Ltd | HSV vaccination vectors |
| US20090162395A1 (en) | 2007-09-26 | 2009-06-25 | Crowe Jr James E | Vaccine for rsv and mpv |
| WO2009074861A2 (en) | 2007-12-10 | 2009-06-18 | Powderject Research Limited | Improved vaccine |
| PL2222710T3 (pl) | 2007-12-24 | 2017-01-31 | Id Biomedical Corporation Of Quebec | Rekombinowane antygeny rsv |
| AU2009222105B2 (en) | 2008-03-03 | 2012-05-17 | Novartis Ag | Compounds and compositions as TLR activity modulators |
| WO2009132206A1 (en) | 2008-04-25 | 2009-10-29 | Liquidia Technologies, Inc. | Compositions and methods for intracellular delivery and release of cargo |
| WO2009156852A1 (en) | 2008-06-25 | 2009-12-30 | Novartis Ag | Rapid responses to delayed booster immunisations |
| US20110177122A1 (en) | 2008-09-26 | 2011-07-21 | The United States Of America, As Represented By The Secretary, Dept. Of Health & Human Services | Dna prime/activated vaccine boost immunization to influenza virus |
| WO2011005799A2 (en) * | 2009-07-06 | 2011-01-13 | Novartis Ag | Self replicating rna molecules and uses thereof |
| JP5829210B2 (ja) | 2009-07-15 | 2015-12-09 | ノバルティス アーゲー | Ｒｓｖｆタンパク質組成物およびそれを作製するための方法 |
| JP5721729B2 (ja) | 2009-11-04 | 2015-05-20 | マリーナ バイオテック，インコーポレイテッド | 活性産生送達分子 |
| SG10201407996PA (en) | 2009-12-23 | 2015-01-29 | Novartis Ag | Lipids, lipid compositions, and methods of using them |
| BR112012025364A2 (pt) | 2010-04-07 | 2015-09-22 | Novartis Ag | método para geração de partícula semelhante a vírus de parvovírus b19 |
| JP5940064B2 (ja) | 2010-07-06 | 2016-06-29 | ノバルティス アーゲー | 低用量のｒｎａを用いた大型哺乳動物の免疫化 |
| PT2611467T (pt) * | 2010-08-31 | 2022-08-01 | Glaxosmithkline Biologicals Sa | Lipossomas pequenos para entrega de arn que codifica um imunogénio |
| US11730804B1 (en) * | 2022-04-13 | 2023-08-22 | Replicate Bioscience, Inc. | Compositions and methods for the prevention and treatment of rabies virus infection |
-
2012
- 2012-07-06 EP EP12735421.5A patent/EP2729168A2/en not_active Withdrawn
- 2012-07-06 EP EP18209088.6A patent/EP3508219A1/en active Pending
- 2012-07-06 WO PCT/US2012/045854 patent/WO2013006842A2/en active Application Filing
- 2012-07-06 JP JP2014519091A patent/JP2014520807A/ja active Pending
- 2012-07-06 US US14/130,869 patent/US11058762B2/en active Active
- 2012-07-06 CA CA2841047A patent/CA2841047A1/en not_active Abandoned
-
2016
- 2016-10-27 JP JP2016210783A patent/JP2017025103A/ja active Pending
-
2021
- 2021-05-26 US US17/330,826 patent/US20210290755A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014520807A5 (enrdf_load_stackoverflow) | ||
| JP2014522842A5 (enrdf_load_stackoverflow) | ||
| Foged | Subunit vaccines of the future: the need for safe, customized and optimized particulate delivery systems | |
| JP2015522580A5 (enrdf_load_stackoverflow) | ||
| Cui et al. | Topical immunization using nanoengineered genetic vaccines | |
| Malyala et al. | Enhancing the therapeutic efficacy of CpG oligonucleotides using biodegradable microparticles | |
| García et al. | An overview of adjuvant formulations and delivery systems | |
| Jabbal-Gill | Nasal vaccine innovation | |
| van Riet et al. | Combatting infectious diseases; nanotechnology as a platform for rational vaccine design | |
| Uddin et al. | Overview and future potential of fast dissolving buccal films as drug delivery system for vaccines | |
| Shahiwala et al. | Nanocarriers for systemic and mucosal vaccine delivery | |
| Kersten et al. | Antigen delivery systems | |
| Zurbriggen | Immunostimulating reconstituted influenza virosomes | |
| Noh et al. | Polymer nanomicelles for efficient mucus delivery and antigen-specific high mucosal immunity. | |
| Yadav et al. | Nanovaccines formulation and applications-a review | |
| Beg et al. | Colloidal drug delivery systems in vaccine delivery | |
| Xiang et al. | Promising particle-based vaccines in cancer therapy | |
| Huang et al. | Research progress on emulsion vaccine adjuvants | |
| US20200054571A1 (en) | Formulation for protection through controlled release of microparticles containing recombinant outer membrane vesicles | |
| von Hoegen | Synthetic biomimetic supra molecular Biovector™(SMBV™) particles for nasal vaccine delivery | |
| Goetz et al. | Vaccine adjuvants for infectious disease in the clinic | |
| Amirnasr et al. | Immunization against HTLV-I with chitosan and tri-methylchitosan nanoparticles loaded with recombinant env23 and env13 antigens of envelope protein gp46 | |
| O’Hagan | New generation vaccine adjuvants | |
| Zeng et al. | In-depth review of delivery carriers associated with vaccine adjuvants: current status and future perspectives | |
| Glück et al. | Novel approaches in the development of immunopotentiating reconstituted influenza virosomes as efficient antigen carrier systems |