JP2014519900A5 - - Google Patents
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- JP2014519900A5 JP2014519900A5 JP2014511878A JP2014511878A JP2014519900A5 JP 2014519900 A5 JP2014519900 A5 JP 2014519900A5 JP 2014511878 A JP2014511878 A JP 2014511878A JP 2014511878 A JP2014511878 A JP 2014511878A JP 2014519900 A5 JP2014519900 A5 JP 2014519900A5
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- pharmaceutically active
- active compound
- exendin
- peptide
- here
- Prior art date
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- 150000001875 compounds Chemical class 0.000 description 6
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 3
- 208000004476 Acute Coronary Syndrome Diseases 0.000 description 2
- 208000002249 Diabetes Complications Diseases 0.000 description 2
- 206010012601 Diabetes mellitus Diseases 0.000 description 2
- 206010012689 Diabetic retinopathy Diseases 0.000 description 2
- HTQBXNHDCUEHJF-XWLPCZSASA-N Exendin-4 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)CNC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 HTQBXNHDCUEHJF-XWLPCZSASA-N 0.000 description 2
- 108010015174 exendin 3 Proteins 0.000 description 2
- LMHMJYMCGJNXRS-IOPUOMRJSA-N exendin-3 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)NCC(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CO)C(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@H](C)O)[C@H](C)O)C(C)C)C1=CC=CC=C1 LMHMJYMCGJNXRS-IOPUOMRJSA-N 0.000 description 2
- 101710038873 glc-1 Proteins 0.000 description 2
- 239000004026 insulin derivative Substances 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 229920000160 (ribonucleotides)n+m Polymers 0.000 description 1
- 206010002383 Angina pectoris Diseases 0.000 description 1
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 206010012655 Diabetic complications Diseases 0.000 description 1
- 101700024131 EXE4 Proteins 0.000 description 1
- 208000005189 Embolism Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229940088597 Hormone Drugs 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 208000002780 Macular Degeneration Diseases 0.000 description 1
- 208000010125 Myocardial Infarction Diseases 0.000 description 1
- 229920000272 Oligonucleotide Polymers 0.000 description 1
- 208000010378 Pulmonary Embolism Diseases 0.000 description 1
- 206010039073 Rheumatoid arthritis Diseases 0.000 description 1
- 208000003385 Rhinitis, Allergic, Seasonal Diseases 0.000 description 1
- 208000001435 Thromboembolism Diseases 0.000 description 1
- 210000003462 Veins Anatomy 0.000 description 1
- 102000004965 antibodies Human genes 0.000 description 1
- 108090001123 antibodies Proteins 0.000 description 1
- 201000001320 atherosclerosis Diseases 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229920003013 deoxyribonucleic acid Polymers 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drugs Drugs 0.000 description 1
- 229960001519 exenatide Drugs 0.000 description 1
- 150000004676 glycans Polymers 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 150000004804 polysaccharides Polymers 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 229960005486 vaccines Drugs 0.000 description 1
Description
本明細書で使用する用語「薬物」または「薬剤」は、少なくとも１つの薬学的に活性な化合物を含む医薬製剤を意味し、
ここで１実施態様において、薬学的に活性な化合物は、最大１５００Ｄａまでの分子量を有し、および／または、ペプチド、タンパク質、多糖類、ワクチン、ＤＮＡ、ＲＮＡ、酵素、抗体もしくはそのフラグメント、ホルモンもしくはオリゴヌクレオチド、または上述の薬学的に活性な化合物の混合物であり、
ここで、さらなる実施態様において、薬学的に活性な化合物は、糖尿病、または糖尿病性網膜症などの糖尿病関連の合併症、深部静脈または肺血栓塞栓症などの血栓塞栓症、急性冠症候群（ＡＣＳ）、狭心症、心筋梗塞、癌、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症および／または関節リウマチの処置および／または予防に有用であり、
ここで、さらなる実施態様において、薬学的に活性な化合物は、糖尿病または糖尿病性網膜症などの糖尿病に関連する合併症の処置および／または予防のための、少なくとも１つのペプチドを含み、
ここで、さらなる実施態様において、薬学的に活性な化合物は、少なくとも１つのヒトインスリンもしくはヒトインスリン類似体もしくは誘導体、グルカゴン様ペプチド（ＧＬＰ−１）もしくはその類似体もしくは誘導体、またはエキセンジン−３もしくはエキセンジン−４もしくはエキセンジン−３もしくはエキセンジン−４の類似体もしくは誘導体を含む。
ここで１実施態様において、薬学的に活性な化合物は、最大１５００Ｄａまでの分子量を有し、および／または、ペプチド、タンパク質、多糖類、ワクチン、ＤＮＡ、ＲＮＡ、酵素、抗体もしくはそのフラグメント、ホルモンもしくはオリゴヌクレオチド、または上述の薬学的に活性な化合物の混合物であり、
ここで、さらなる実施態様において、薬学的に活性な化合物は、糖尿病、または糖尿病性網膜症などの糖尿病関連の合併症、深部静脈または肺血栓塞栓症などの血栓塞栓症、急性冠症候群（ＡＣＳ）、狭心症、心筋梗塞、癌、黄斑変性症、炎症、枯草熱、アテローム性動脈硬化症および／または関節リウマチの処置および／または予防に有用であり、
ここで、さらなる実施態様において、薬学的に活性な化合物は、糖尿病または糖尿病性網膜症などの糖尿病に関連する合併症の処置および／または予防のための、少なくとも１つのペプチドを含み、
ここで、さらなる実施態様において、薬学的に活性な化合物は、少なくとも１つのヒトインスリンもしくはヒトインスリン類似体もしくは誘導体、グルカゴン様ペプチド（ＧＬＰ−１）もしくはその類似体もしくは誘導体、またはエキセンジン−３もしくはエキセンジン−４もしくはエキセンジン−３もしくはエキセンジン−４の類似体もしくは誘導体を含む。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11167531.0 | 2011-05-25 | ||
| EP11167531 | 2011-05-25 | ||
| PCT/EP2012/059747 WO2012160156A2 (en) | 2011-05-25 | 2012-05-24 | Medicament delivery device and method of controlling the device |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014519900A JP2014519900A (ja) | 2014-08-21 |
| JP2014519900A5 true JP2014519900A5 (ja) | 2015-07-02 |
| JP6180406B2 JP6180406B2 (ja) | 2017-08-16 |
Family
ID=44531765
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014511878A Active JP6180406B2 (ja) | 2011-05-25 | 2012-05-24 | 薬剤送達デバイスおよびこのデバイスを制御する方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9572932B2 (ja) |
| EP (1) | EP2714135B1 (ja) |
| JP (1) | JP6180406B2 (ja) |
| CN (1) | CN103687636B (ja) |
| BR (1) | BR112013029946A2 (ja) |
| CA (1) | CA2835527A1 (ja) |
| DK (1) | DK2714135T3 (ja) |
| IL (1) | IL229407A0 (ja) |
| WO (1) | WO2012160156A2 (ja) |
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| US10704944B2 (en) | 2014-09-14 | 2020-07-07 | Becton, Dickinson And Company | System and method for capturing dose information |
| US10971260B2 (en) | 2014-09-14 | 2021-04-06 | Becton, Dickinson And Company | System and method for capturing dose information |
| IL276435B (en) | 2015-03-10 | 2022-08-01 | Regeneron Pharma | System and method of piercing without contamination |
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| CN107683158B (zh) | 2015-06-04 | 2021-05-14 | 麦迪麦珀医疗工程有限公司 | 用于药物释放装置的筒插入 |
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| JP6924189B2 (ja) * | 2015-11-27 | 2021-08-25 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬剤注射デバイス |
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| US10455863B2 (en) | 2016-03-03 | 2019-10-29 | Altria Client Services Llc | Cartridge for electronic vaping device |
| US10433580B2 (en) | 2016-03-03 | 2019-10-08 | Altria Client Services Llc | Methods to add menthol, botanic materials, and/or non-botanic materials to a cartridge, and/or an electronic vaping device including the cartridge |
| US10368580B2 (en) | 2016-03-08 | 2019-08-06 | Altria Client Services Llc | Combined cartridge for electronic vaping device |
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| JP6882507B2 (ja) * | 2016-12-02 | 2021-06-02 | ブイエムアール・プロダクツ・リミテッド・ライアビリティ・カンパニーＶｍｒ Ｐｒｏｄｕｃｔｓ Ｌｌｃ | 混合式ヴェポライザ |
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-
2012
- 2012-05-24 JP JP2014511878A patent/JP6180406B2/ja active Active
- 2012-05-24 DK DK12724323.6T patent/DK2714135T3/da active
- 2012-05-24 EP EP12724323.6A patent/EP2714135B1/en active Active
- 2012-05-24 CN CN201280036341.3A patent/CN103687636B/zh active Active
- 2012-05-24 US US14/119,157 patent/US9572932B2/en active Active
- 2012-05-24 BR BR112013029946A patent/BR112013029946A2/pt not_active IP Right Cessation
- 2012-05-24 CA CA2835527A patent/CA2835527A1/en not_active Abandoned
- 2012-05-24 WO PCT/EP2012/059747 patent/WO2012160156A2/en active Application Filing
-
2013
- 2013-11-12 IL IL229407A patent/IL229407A0/en unknown
-
2017
- 2017-01-20 US US15/411,346 patent/US10213557B2/en active Active
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