JP2014519832A5 - - Google Patents

Download PDF

Info

Publication number
JP2014519832A5
JP2014519832A5 JP2014516354A JP2014516354A JP2014519832A5 JP 2014519832 A5 JP2014519832 A5 JP 2014519832A5 JP 2014516354 A JP2014516354 A JP 2014516354A JP 2014516354 A JP2014516354 A JP 2014516354A JP 2014519832 A5 JP2014519832 A5 JP 2014519832A5
Authority
JP
Japan
Prior art keywords
range
chir
cells
concentration
activin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2014516354A
Other languages
English (en)
Japanese (ja)
Other versions
JP6312591B2 (ja
JP2014519832A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2012/062013 external-priority patent/WO2012175633A1/en
Publication of JP2014519832A publication Critical patent/JP2014519832A/ja
Publication of JP2014519832A5 publication Critical patent/JP2014519832A5/ja
Application granted granted Critical
Publication of JP6312591B2 publication Critical patent/JP6312591B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2014516354A 2011-06-21 2012-06-21 多能性幹細胞からの胚体内胚葉の効率的な誘導 Active JP6312591B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11170713.9 2011-06-21
EP11170713 2011-06-21
US201161501351P 2011-06-27 2011-06-27
US61/501,351 2011-06-27
PCT/EP2012/062013 WO2012175633A1 (en) 2011-06-21 2012-06-21 Efficient induction of definitive endoderm from pluripotent stem cells

Publications (3)

Publication Number Publication Date
JP2014519832A JP2014519832A (ja) 2014-08-21
JP2014519832A5 true JP2014519832A5 (enExample) 2015-08-06
JP6312591B2 JP6312591B2 (ja) 2018-04-18

Family

ID=47422055

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014516354A Active JP6312591B2 (ja) 2011-06-21 2012-06-21 多能性幹細胞からの胚体内胚葉の効率的な誘導

Country Status (6)

Country Link
US (3) US20140234963A1 (enExample)
EP (1) EP2723852B1 (enExample)
JP (1) JP6312591B2 (enExample)
CN (2) CN108220224A (enExample)
ES (1) ES2902650T3 (enExample)
WO (1) WO2012175633A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6312591B2 (ja) 2011-06-21 2018-04-18 ノヴォ ノルディスク アー/エス 多能性幹細胞からの胚体内胚葉の効率的な誘導
US20150247123A1 (en) 2012-09-03 2015-09-03 Novo Nordisk A/S Generation of pancreatic endoderm from Pluripotent Stem cells using small molecules
GB201317869D0 (en) * 2013-10-09 2013-11-20 Cambridge Entpr Ltd In vitro production of foregut stem cells
JP7123802B2 (ja) 2016-02-24 2022-08-23 ノヴォ ノルディスク アー/エス ヒト多能性幹細胞由来内分泌前駆細胞からの機能的ベータ細胞の産生
US20190071645A1 (en) * 2017-09-07 2019-03-07 Sergio Mora Efficient differentiation of human stem cells to definitive endoderm
JP7389020B2 (ja) 2017-09-11 2023-11-29 ノヴォ ノルディスク アー/エス 幹細胞からインビトロで誘導されたnkx6.1およびc-ペプチド共発現細胞の濃縮
EP3790956A4 (en) 2018-05-11 2022-03-16 Cornell University METHOD FOR INDUCING DIFFERENTIATION OF HUMAN PLURIPOTENT STEM CELLS INTO MONOHORMONAL CELLS
WO2020043292A1 (en) 2018-08-30 2020-03-05 Novo Nordisk A/S Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors
WO2020207998A1 (en) 2019-04-08 2020-10-15 Novo Nordisk A/S Generation of pancreatic endoderm from stem cell derived definitive endoderm
US20220389378A1 (en) 2019-11-22 2022-12-08 Novo Nordisk A/S Spin-aggregated neural microspheres and the application thereof
WO2022043518A1 (en) 2020-08-28 2022-03-03 Novo Nordisk A/S Method for screening in vitro population of stem cell derived beta like cells and novel markers thereof
JP2025520898A (ja) 2022-07-06 2025-07-03 ノヴォ ノルディスク アー/エス 幹細胞の膵臓内分泌細胞への分化
WO2024151541A1 (en) 2023-01-09 2024-07-18 Sana Biotechnology, Inc. Type-1 diabetes autoimmune mouse
WO2024243236A2 (en) 2023-05-22 2024-11-28 Sana Biotechnology, Inc. Methods of delivery of islet cells and related methods
WO2025093467A1 (en) 2023-10-31 2025-05-08 Novo Nordisk A/S Methods for preventing unwanted cells arising during differentiation of human pluripotent stem cells
EP4491712A1 (en) 2024-03-20 2025-01-15 Novo Nordisk A/S Method for detecting contaminant cells in a stem cell derived cell population

Family Cites Families (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5523226A (en) * 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
WO1999065897A1 (en) 1998-06-19 1999-12-23 Chiron Corporation Inhibitors of glycogen synthase kinase 3
WO2002092756A2 (en) 2001-05-15 2002-11-21 Rappaport Family Institute For Research In The Medical Sciences Insulin producing cells derived from human embryonic stem cells
CN101240262A (zh) 2001-12-07 2008-08-13 杰龙公司 源自人胚胎干细胞的胰岛细胞
IL162663A0 (en) 2001-12-28 2005-11-20 Cellartis Ab A method for the establishment of apluripotent human blastocyst-derived stem cell line
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
MX2009009225A (es) * 2003-12-23 2009-09-28 Cythera Inc Endodermo definitivo.
EP1740612B1 (en) 2004-04-27 2019-08-07 Viacyte, Inc. Pdx1 expressing endoderm
AU2006301549B2 (en) 2005-10-07 2013-02-14 Cellartis Ab A method for obtaining a xeno-free hBS cell line
SG170068A1 (en) 2006-03-02 2011-04-29 Cythera Inc Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
GB0615327D0 (en) 2006-03-30 2006-09-13 Univ Edinburgh Culture medium containing kinase inhibitors and uses thereof
ES2725601T3 (es) 2006-04-28 2019-09-25 Lifescan Inc Diferenciación de células madre embriónicas humanas
US8741643B2 (en) * 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
AU2007254766A1 (en) 2006-06-02 2007-12-13 University Of Georgia Research Foundation, Inc. Pancreatic and liver endoderm cells and tissue by differentiation of definitive endoderm cells obtained from human embryonic stems
CA2676044C (en) * 2007-01-30 2019-10-22 University Of Georgia Research Foundation, Inc. Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc)
EP2148569B1 (en) 2007-04-23 2014-07-16 Stowers Institute for Medical Research Methods and compositions for hematopoeitic stem cell self-renewal
US9080145B2 (en) * 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
KR101555824B1 (ko) 2007-07-18 2015-09-25 라이프스캔, 인코포레이티드 인간 배아 줄기 세포의 분화
WO2009013254A1 (en) 2007-07-20 2009-01-29 Cellartis Ab A novel population of hepatocytes derived via definitive endoderm (de-hep) from human blastocysts stem cells
MX2010001335A (es) * 2007-07-31 2010-06-02 Lifescan Inc Diferenciacion de celulas madre embrionarias humanas.
EP2185691B1 (en) 2007-07-31 2018-03-14 Lifescan, Inc. Pluripotent stem cell differentiation by using human feeder cells
EP2195417A1 (en) * 2007-08-24 2010-06-16 University Court of the University of Edinburgh Regionalised endoderm cells and uses thereof
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
US7939322B2 (en) 2008-04-24 2011-05-10 Centocor Ortho Biotech Inc. Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm
CA2723820A1 (en) 2008-05-09 2009-11-12 Vistagen Therapeutics, Inc. Pancreatic endocrine progenitor cells derived from pluripotent stem cells
DK2993226T3 (da) * 2008-06-03 2021-02-22 Viacyte Inc Vækstfaktorer til fremstilling af en definitiv endoderm
US20090298178A1 (en) * 2008-06-03 2009-12-03 D Amour Kevin Allen Growth factors for production of definitive endoderm
US20110091971A1 (en) 2008-06-30 2011-04-21 Janet Davis Differentiation of Pluripotent Stem Cells
MX2011000125A (es) 2008-06-30 2011-02-25 Centocor Ortho Biotech Inc Diferenciacion de celulas madre pluripotentes.
US20100028307A1 (en) 2008-07-31 2010-02-04 O'neil John J Pluripotent stem cell differentiation
US8278105B2 (en) * 2008-09-09 2012-10-02 University Of Southern California Induction, propagation and isolation of liver progenitor cells
CN101684454B (zh) * 2008-09-25 2012-08-15 中国科学院上海生命科学研究院 一种定型内胚层细胞的制备和分离方法
ES2727950T3 (es) 2008-10-31 2019-10-21 Janssen Biotech Inc Diferenciación de células madre embrionarias humanas en linaje endocrino pancreático
PL2346988T3 (pl) 2008-10-31 2017-10-31 Janssen Biotech Inc Różnicowanie ludzkich zarodkowych komórek macierzystych do linii endokrynnej trzustki
JP2012508584A (ja) 2008-11-14 2012-04-12 ヴィアサイト,インコーポレイテッド ヒト多能性幹細胞由来膵臓細胞のカプセル化
WO2010091241A2 (en) 2009-02-06 2010-08-12 President And Fellows Of Harvard College Compositions and methods for promoting the generation of definitive endoderm
EP3904505A1 (en) 2009-04-22 2021-11-03 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
CN102812122A (zh) 2009-05-27 2012-12-05 索尔克生物学研究院 基因矫正的无疾病的诱导的多能干细胞的产生
SG177481A1 (en) 2009-07-20 2012-02-28 Janssen Biotech Inc Differentiation of human embryonic stem cells
WO2011011302A2 (en) 2009-07-20 2011-01-27 Centocor Ortho Biotech Inc. Differentiation of human embryonic stem cells
CA2784415C (en) 2009-12-23 2019-06-18 Jean Xu Differentiation of human embryonic stem cells
KR101764404B1 (ko) 2009-12-23 2017-08-03 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
JP5762979B2 (ja) 2009-12-29 2015-08-12 武田薬品工業株式会社 膵ホルモン産生細胞の製造法
PH12012501686A1 (en) 2010-03-01 2020-10-19 Janssen Biotech Inc Methods for purifying cells derived from pluripotent stem cells
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
JP6050225B2 (ja) 2010-05-12 2016-12-21 ヤンセン バイオテツク,インコーポレーテツド ヒト胚性幹細胞の分化
US9085757B2 (en) 2010-06-17 2015-07-21 Regents Of The University Of Minnesota Production of insulin producing cells
AU2011289379A1 (en) 2010-08-12 2013-02-07 Janssen Biotech, Inc. Treatment of diabetes with pancreatic endocrine precursor cells
EP3372672A1 (en) 2010-08-31 2018-09-12 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
MX355077B (es) 2010-08-31 2018-04-03 Janssen Biotech Inc Diferenciacion de celulas madre embrionarias humanas.
US9062292B2 (en) 2010-09-13 2015-06-23 Enzo Life Sciences Inc. Mutant T7 polymerases
WO2012070014A2 (en) 2010-11-26 2012-05-31 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Identification of novel cell surface markers for pancreatic progenitor cells and definite endodermal cells
AU2010365057B2 (en) 2010-12-08 2016-12-22 Viacyte, Inc. Agents and methods for inhibiting human pluripotent stem cell growth
JP5922147B2 (ja) 2010-12-15 2016-05-24 カディマステム リミテッド 多能性幹細胞に由来するインスリン産生細胞
JP6312591B2 (ja) 2011-06-21 2018-04-18 ノヴォ ノルディスク アー/エス 多能性幹細胞からの胚体内胚葉の効率的な誘導

Similar Documents

Publication Publication Date Title
JP2014519832A5 (enExample)
JP2019004912A5 (enExample)
MY157524A (en) Culturing embryonic stem cells, embryonic stem-like cells, or induced pluripotent stem cells with a muc1 or muc1* ligand
IL307568A (en) Photoreceptors and photoreceptor progenitors produced from pluripotent stem cells
WO2010147395A3 (en) Medium composition comprising neuropeptide y for the generation, maintenance, prologned undifferentiated growth of pluripotent stem cells and method of culturing pluripotent stem cell using the same
WO2015054526A3 (en) Methods of mammalian retinal stem cell production and applications
IL252607B (en) Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
BR112015019950A2 (pt) Método para gerar linhagem de células-tronco embrionárias (es) de rato, e, cultura in vitro
EP2408903A4 (en) PLURIPOTENTE AND MULTIPOTENTE CELL CULTURE ON MICROWAVES
SG195299A1 (en) Expansion of stem cells in hollow fiber bioreactors
HK1217110A1 (zh) 在空氣-液體界面處培養人胚胎幹細胞以用於分化成胰腺內分泌細胞
WO2014153115A3 (en) Compositions and methods for reprogramming hematopoietic stem cell lineages
RU2018108090A (ru) Суспендирование и кластеризация плюрипотентных клеток человека с целью их дифференцировки в панкреатические эндокринные клетки
BR112014026308A2 (pt) composições de cultura celular e métodos para produção de polipeptídeos
WO2015065524A3 (en) Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells
BR112013001089A2 (pt) composição de meio de cultura e método para cultivar células tronco mesenquimais derivadas de âmnio
WO2012003479A3 (en) Methods for culturing undifferentiated cells using sustained release compositions
MX2015004027A (es) Composiciones y metodos para producir glucoproteinas.
EP2582792A4 (en) HEART OF CARDIOMYOCYTES WITH DIALYSATED SERUM
WO2012126013A3 (en) Method for making pluripotent stem cells
MY184796A (en) Method for manufacturing ciliary marginal zone-like structure
BR112016030723B8 (pt) Meios de cultura de células, método para indução da morte celular de células-tronco indiferenciadas e métodos para seleção de cardiomiócitos
MX354771B (es) Metodo para cultivar algas.
JP2015213495A5 (enExample)
WO2014027176A3 (en) Stem cell culture method