JP2014519806A5 - - Google Patents

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Publication number
JP2014519806A5
JP2014519806A5 JP2014506610A JP2014506610A JP2014519806A5 JP 2014519806 A5 JP2014519806 A5 JP 2014519806A5 JP 2014506610 A JP2014506610 A JP 2014506610A JP 2014506610 A JP2014506610 A JP 2014506610A JP 2014519806 A5 JP2014519806 A5 JP 2014519806A5
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JP
Japan
Prior art keywords
strand
target
mirna
strands
nucleoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014506610A
Other languages
English (en)
Japanese (ja)
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JP2014519806A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/034595 external-priority patent/WO2012145729A2/en
Publication of JP2014519806A publication Critical patent/JP2014519806A/ja
Publication of JP2014519806A5 publication Critical patent/JP2014519806A5/ja
Pending legal-status Critical Current

Links

JP2014506610A 2011-04-20 2012-04-20 細胞内で自己会合し、ＲＮＡｉ活性を産生する組成物を使用した遺伝子発現を調節するための方法および成分 Pending JP2014519806A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161477283P 2011-04-20 2011-04-20
US201161477291P 2011-04-20 2011-04-20
US61/477,291 2011-04-20
US61/477,283 2011-04-20
US201161477875P 2011-04-21 2011-04-21
US61/477,875 2011-04-21
PCT/US2012/034595 WO2012145729A2 (en) 2011-04-20 2012-04-20 Methods and compositions for modulating gene expression using components that self assemble in cells and produce rnai activity

Publications (2)

Publication Number Publication Date
JP2014519806A JP2014519806A (ja) 2014-08-21
JP2014519806A5 true JP2014519806A5 (https=) 2015-07-30

Family

ID=47042197

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014506610A Pending JP2014519806A (ja) 2011-04-20 2012-04-20 細胞内で自己会合し、ＲＮＡｉ活性を産生する組成物を使用した遺伝子発現を調節するための方法および成分

Country Status (10)

Country Link
US (2) US20150038549A1 (https=)
EP (1) EP2699271A4 (https=)
JP (1) JP2014519806A (https=)
CN (1) CN104271740A (https=)
AU (1) AU2012245188A1 (https=)
BR (1) BR112013027070A2 (https=)
CA (1) CA2871089A1 (https=)
IL (1) IL228951A0 (https=)
RU (1) RU2013151301A (https=)
WO (1) WO2012145729A2 (https=)

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ES2697249T3 (es) * 2013-03-11 2019-01-22 Fond Telethon miR-204 y miR-211 y usos de los mismos
CN105264092B (zh) * 2013-03-15 2019-02-22 得克萨斯州大学系统董事会 用于诊断和疗法的外来体中的miRNA生物发生
WO2015106128A2 (en) * 2014-01-09 2015-07-16 Alnylam Pharmaceuticals, Inc. MODIFIED RNAi AGENTS
WO2015168661A1 (en) * 2014-05-01 2015-11-05 Smith Larry J METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT
PT3166607T (pt) 2014-07-11 2022-12-07 Gilead Sciences Inc Moduladores de receptores de tipo toll para o tratamento do vih
SG11201701402QA (en) * 2014-08-27 2017-03-30 Peptimed Inc Anti-tumor compositions and methods
CN108135921B (zh) 2015-07-22 2023-10-17 波涛生命科学有限公司 寡核苷酸组合物及其方法
HK1257270A1 (zh) 2015-09-15 2019-10-18 Gilead Sciences, Inc. 用於治疗hiv的toll样受体(tlr)调节剂
EP4065716A4 (en) * 2019-11-26 2024-06-12 City of Hope MICRORNA AS A THERAPEUTIC
US20250297258A1 (en) * 2021-07-07 2025-09-25 Ractigen Therapeutics Oligonucleotide-based delivery vehicle for oligonucleotides agents and methods of use thereof
WO2024098061A2 (en) 2022-11-04 2024-05-10 Genkardia Inc. Oligonucleotide-based therapeutics targeting cyclin d2 for the treatment of heart failure
WO2024108217A1 (en) 2022-11-18 2024-05-23 Genkardia Inc. Methods and compositions for preventing, treating, or reversing cardiac diastolic dysfunction

Family Cites Families (22)

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Publication number Priority date Publication date Assignee Title
US20050119212A1 (en) 2001-05-18 2005-06-02 Sirna Therapeutics, Inc. RNA interference mediated inhibition of FAS and FASL gene expression using short interfering nucleic acid (siNA)
US7407943B2 (en) 2001-08-01 2008-08-05 Isis Pharmaceuticals, Inc. Antisense modulation of apolipoprotein B expression
EP2213737B1 (en) 2002-02-01 2012-11-07 Life Technologies Corporation Double-stranded oligonucleotides
US20040014957A1 (en) * 2002-05-24 2004-01-22 Anne Eldrup Oligonucleotides having modified nucleoside units
US6841675B1 (en) 2002-06-13 2005-01-11 The Regents Of The University Of California Piperazine-based nucleic acid analogs
WO2005042719A2 (en) 2003-10-30 2005-05-12 The Cbr Institute For Biomedical Research, Inc. Methods for treating and preventing ischemia-reperfusion injury using rna interfering agents
WO2005074966A1 (en) 2004-02-06 2005-08-18 Adelaide Research & Innovation Pty. Ltd. A method of modulating cellular uptake and molecules useful for same
WO2005079533A2 (en) * 2004-02-17 2005-09-01 University Of Massachusetts Methods and compositions for mediating gene silencing
US20050260755A1 (en) * 2004-04-06 2005-11-24 Isis Pharmaceuticals, Inc. Sequential delivery of oligomeric compounds
PL1786472T3 (pl) 2004-08-10 2013-06-28 Kastle Therapeutics Llc Antysensowna modulacja ekspresji apolipoproteiny B
US7528118B2 (en) 2004-09-24 2009-05-05 Alnylam Pharmaceuticals, Inc. RNAi modulation of ApoB and uses thereof
AU2005288522B2 (en) 2004-09-28 2012-06-28 Quark Pharmaceuticals, Inc. Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases
CA2587411A1 (en) 2004-11-17 2006-05-26 Protiva Biotherapeutics, Inc. Sirna silencing of apolipoprotein b
CN101517407A (zh) 2005-09-07 2009-08-26 纽约州州立大学研究基金会 用于研究动脉粥样硬化损害的动物模型
US7910566B2 (en) 2006-03-09 2011-03-22 Quark Pharmaceuticals Inc. Prevention and treatment of acute renal failure and other kidney diseases by inhibition of p53 by siRNA
EP2023940B1 (en) 2006-05-05 2011-06-22 Isis Pharmaceuticals, Inc. Compounds and methods for modulating expression of sglt2
ES2874149T3 (es) 2006-05-11 2021-11-04 Alnylam Pharmaceuticals Inc Composiciones y métodos para inhibir la expresión del gen PCSK9
WO2008033285A2 (en) 2006-09-15 2008-03-20 The Trustees Of Culumbia University In The City Of New York Delivery of double-stranded rna into the central nervous system
CN101679979A (zh) 2007-03-24 2010-03-24 基酶有限公司 施用与人载脂蛋白b互补的反义寡核苷酸
AR066984A1 (es) 2007-06-15 2009-09-23 Novartis Ag Inhibicion de la expresion de la subunidad alfa del canal epitelial de sodio (enac) por medio de arni (arn de interferencia)
WO2010105096A2 (en) * 2009-03-11 2010-09-16 University Of Massachusetts Modulation of human cytomegalovirus replication by micro-rna 132 (mir132), micro-rna 145 (mir145) and micro-rna 212 (mir212)
US20130079382A1 (en) * 2009-10-12 2013-03-28 Larry J. Smith Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro

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