JP2014519806A - 細胞内で自己会合し、RNAi活性を産生する組成物を使用した遺伝子発現を調節するための方法および成分 - Google Patents
細胞内で自己会合し、RNAi活性を産生する組成物を使用した遺伝子発現を調節するための方法および成分 Download PDFInfo
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- JP2014519806A JP2014519806A JP2014506610A JP2014506610A JP2014519806A JP 2014519806 A JP2014519806 A JP 2014519806A JP 2014506610 A JP2014506610 A JP 2014506610A JP 2014506610 A JP2014506610 A JP 2014506610A JP 2014519806 A JP2014519806 A JP 2014519806A
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C12N15/09—Recombinant DNA-technology
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
- C12N2310/141—MicroRNAs, miRNAs
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2320/00—Applications; Uses
- C12N2320/50—Methods for regulating/modulating their activity
- C12N2320/52—Methods for regulating/modulating their activity modulating the physical stability, e.g. GC-content
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- Health & Medical Sciences (AREA)
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- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
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- Microbiology (AREA)
- Plant Pathology (AREA)
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- Oncology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
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- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161477283P | 2011-04-20 | 2011-04-20 | |
| US201161477291P | 2011-04-20 | 2011-04-20 | |
| US61/477,291 | 2011-04-20 | ||
| US61/477,283 | 2011-04-20 | ||
| US201161477875P | 2011-04-21 | 2011-04-21 | |
| US61/477,875 | 2011-04-21 | ||
| PCT/US2012/034595 WO2012145729A2 (en) | 2011-04-20 | 2012-04-20 | Methods and compositions for modulating gene expression using components that self assemble in cells and produce rnai activity |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014519806A true JP2014519806A (ja) | 2014-08-21 |
| JP2014519806A5 JP2014519806A5 (https=) | 2015-07-30 |
Family
ID=47042197
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014506610A Pending JP2014519806A (ja) | 2011-04-20 | 2012-04-20 | 細胞内で自己会合し、RNAi活性を産生する組成物を使用した遺伝子発現を調節するための方法および成分 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20150038549A1 (https=) |
| EP (1) | EP2699271A4 (https=) |
| JP (1) | JP2014519806A (https=) |
| CN (1) | CN104271740A (https=) |
| AU (1) | AU2012245188A1 (https=) |
| BR (1) | BR112013027070A2 (https=) |
| CA (1) | CA2871089A1 (https=) |
| IL (1) | IL228951A0 (https=) |
| RU (1) | RU2013151301A (https=) |
| WO (1) | WO2012145729A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018524013A (ja) * | 2015-07-22 | 2018-08-30 | ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. | オリゴヌクレオチド組成物およびその方法 |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2697249T3 (es) * | 2013-03-11 | 2019-01-22 | Fond Telethon | miR-204 y miR-211 y usos de los mismos |
| CN105264092B (zh) * | 2013-03-15 | 2019-02-22 | 得克萨斯州大学系统董事会 | 用于诊断和疗法的外来体中的miRNA生物发生 |
| WO2015106128A2 (en) * | 2014-01-09 | 2015-07-16 | Alnylam Pharmaceuticals, Inc. | MODIFIED RNAi AGENTS |
| WO2015168661A1 (en) * | 2014-05-01 | 2015-11-05 | Smith Larry J | METHODS AND MODIFICATIONS THAT PRODUCE ssRNAi COMPOUNDS WITH ENHANCED ACTIVITY, POTENCY AND DURATION OF EFFECT |
| PT3166607T (pt) | 2014-07-11 | 2022-12-07 | Gilead Sciences Inc | Moduladores de receptores de tipo toll para o tratamento do vih |
| SG11201701402QA (en) * | 2014-08-27 | 2017-03-30 | Peptimed Inc | Anti-tumor compositions and methods |
| HK1257270A1 (zh) | 2015-09-15 | 2019-10-18 | Gilead Sciences, Inc. | 用於治疗hiv的toll样受体(tlr)调节剂 |
| EP4065716A4 (en) * | 2019-11-26 | 2024-06-12 | City of Hope | MICRORNA AS A THERAPEUTIC |
| US20250297258A1 (en) * | 2021-07-07 | 2025-09-25 | Ractigen Therapeutics | Oligonucleotide-based delivery vehicle for oligonucleotides agents and methods of use thereof |
| WO2024098061A2 (en) | 2022-11-04 | 2024-05-10 | Genkardia Inc. | Oligonucleotide-based therapeutics targeting cyclin d2 for the treatment of heart failure |
| WO2024108217A1 (en) | 2022-11-18 | 2024-05-23 | Genkardia Inc. | Methods and compositions for preventing, treating, or reversing cardiac diastolic dysfunction |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060069050A1 (en) * | 2004-02-17 | 2006-03-30 | University Of Massachusetts | Methods and compositions for mediating gene silencing |
| WO2010105096A2 (en) * | 2009-03-11 | 2010-09-16 | University Of Massachusetts | Modulation of human cytomegalovirus replication by micro-rna 132 (mir132), micro-rna 145 (mir145) and micro-rna 212 (mir212) |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050119212A1 (en) | 2001-05-18 | 2005-06-02 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of FAS and FASL gene expression using short interfering nucleic acid (siNA) |
| US7407943B2 (en) | 2001-08-01 | 2008-08-05 | Isis Pharmaceuticals, Inc. | Antisense modulation of apolipoprotein B expression |
| EP2213737B1 (en) | 2002-02-01 | 2012-11-07 | Life Technologies Corporation | Double-stranded oligonucleotides |
| US20040014957A1 (en) * | 2002-05-24 | 2004-01-22 | Anne Eldrup | Oligonucleotides having modified nucleoside units |
| US6841675B1 (en) | 2002-06-13 | 2005-01-11 | The Regents Of The University Of California | Piperazine-based nucleic acid analogs |
| WO2005042719A2 (en) | 2003-10-30 | 2005-05-12 | The Cbr Institute For Biomedical Research, Inc. | Methods for treating and preventing ischemia-reperfusion injury using rna interfering agents |
| WO2005074966A1 (en) | 2004-02-06 | 2005-08-18 | Adelaide Research & Innovation Pty. Ltd. | A method of modulating cellular uptake and molecules useful for same |
| US20050260755A1 (en) * | 2004-04-06 | 2005-11-24 | Isis Pharmaceuticals, Inc. | Sequential delivery of oligomeric compounds |
| PL1786472T3 (pl) | 2004-08-10 | 2013-06-28 | Kastle Therapeutics Llc | Antysensowna modulacja ekspresji apolipoproteiny B |
| US7528118B2 (en) | 2004-09-24 | 2009-05-05 | Alnylam Pharmaceuticals, Inc. | RNAi modulation of ApoB and uses thereof |
| AU2005288522B2 (en) | 2004-09-28 | 2012-06-28 | Quark Pharmaceuticals, Inc. | Oligoribonucleotides and methods of use thereof for treatment of alopecia, acute renal failure and other diseases |
| CA2587411A1 (en) | 2004-11-17 | 2006-05-26 | Protiva Biotherapeutics, Inc. | Sirna silencing of apolipoprotein b |
| CN101517407A (zh) | 2005-09-07 | 2009-08-26 | 纽约州州立大学研究基金会 | 用于研究动脉粥样硬化损害的动物模型 |
| US7910566B2 (en) | 2006-03-09 | 2011-03-22 | Quark Pharmaceuticals Inc. | Prevention and treatment of acute renal failure and other kidney diseases by inhibition of p53 by siRNA |
| EP2023940B1 (en) | 2006-05-05 | 2011-06-22 | Isis Pharmaceuticals, Inc. | Compounds and methods for modulating expression of sglt2 |
| ES2874149T3 (es) | 2006-05-11 | 2021-11-04 | Alnylam Pharmaceuticals Inc | Composiciones y métodos para inhibir la expresión del gen PCSK9 |
| WO2008033285A2 (en) | 2006-09-15 | 2008-03-20 | The Trustees Of Culumbia University In The City Of New York | Delivery of double-stranded rna into the central nervous system |
| CN101679979A (zh) | 2007-03-24 | 2010-03-24 | 基酶有限公司 | 施用与人载脂蛋白b互补的反义寡核苷酸 |
| AR066984A1 (es) | 2007-06-15 | 2009-09-23 | Novartis Ag | Inhibicion de la expresion de la subunidad alfa del canal epitelial de sodio (enac) por medio de arni (arn de interferencia) |
| US20130079382A1 (en) * | 2009-10-12 | 2013-03-28 | Larry J. Smith | Methods and Compositions for Modulating Gene Expression Using Oligonucleotide Based Drugs Administered in vivo or in vitro |
-
2012
- 2012-04-20 RU RU2013151301/10A patent/RU2013151301A/ru not_active Application Discontinuation
- 2012-04-20 BR BR112013027070A patent/BR112013027070A2/pt not_active IP Right Cessation
- 2012-04-20 CN CN201280029769.5A patent/CN104271740A/zh active Pending
- 2012-04-20 CA CA2871089A patent/CA2871089A1/en not_active Abandoned
- 2012-04-20 JP JP2014506610A patent/JP2014519806A/ja active Pending
- 2012-04-20 WO PCT/US2012/034595 patent/WO2012145729A2/en not_active Ceased
- 2012-04-20 US US14/113,093 patent/US20150038549A1/en not_active Abandoned
- 2012-04-20 AU AU2012245188A patent/AU2012245188A1/en not_active Abandoned
- 2012-04-20 EP EP12774523.0A patent/EP2699271A4/en not_active Withdrawn
-
2013
- 2013-10-17 IL IL228951A patent/IL228951A0/en unknown
-
2016
- 2016-04-07 US US15/093,711 patent/US20160272972A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060069050A1 (en) * | 2004-02-17 | 2006-03-30 | University Of Massachusetts | Methods and compositions for mediating gene silencing |
| WO2010105096A2 (en) * | 2009-03-11 | 2010-09-16 | University Of Massachusetts | Modulation of human cytomegalovirus replication by micro-rna 132 (mir132), micro-rna 145 (mir145) and micro-rna 212 (mir212) |
Non-Patent Citations (3)
| Title |
|---|
| JPN6016008354; SOUTSCHEK J. et al.: Nature 432(2004), p.173-178 * |
| JPN6016008356; HALL AH et al.: Nucleic Acids Res. 34(9)(2006), p.2773-2781 * |
| JPN6016008358; UI-TEI K. et al.: Nucleic Acids Res. 36(22)(2008), p.7100-7109,supplemental information * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018524013A (ja) * | 2015-07-22 | 2018-08-30 | ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. | オリゴヌクレオチド組成物およびその方法 |
| JP2022000023A (ja) * | 2015-07-22 | 2022-01-04 | ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. | オリゴヌクレオチド組成物およびその方法 |
| JP7441816B2 (ja) | 2015-07-22 | 2024-03-01 | ウェイブ ライフ サイエンシズ リミテッド | オリゴヌクレオチド組成物およびその方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| NZ617944A (en) | 2016-01-29 |
| WO2012145729A3 (en) | 2014-05-01 |
| IL228951A0 (en) | 2013-12-31 |
| EP2699271A4 (en) | 2015-10-07 |
| CN104271740A (zh) | 2015-01-07 |
| AU2012245188A1 (en) | 2013-12-05 |
| CA2871089A1 (en) | 2012-10-26 |
| US20150038549A1 (en) | 2015-02-05 |
| US20160272972A1 (en) | 2016-09-22 |
| WO2012145729A2 (en) | 2012-10-26 |
| EP2699271A2 (en) | 2014-02-26 |
| RU2013151301A (ru) | 2015-05-27 |
| BR112013027070A2 (pt) | 2019-09-24 |
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