JP2014519524A5 - - Google Patents
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- JP2014519524A5 JP2014519524A5 JP2014515918A JP2014515918A JP2014519524A5 JP 2014519524 A5 JP2014519524 A5 JP 2014519524A5 JP 2014515918 A JP2014515918 A JP 2014515918A JP 2014515918 A JP2014515918 A JP 2014515918A JP 2014519524 A5 JP2014519524 A5 JP 2014519524A5
- Authority
- JP
- Japan
- Prior art keywords
- monoclonal antibody
- seq
- heavy chain
- amino acid
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000005614 monoclonal antibodies Human genes 0.000 claims 16
- 108010045030 monoclonal antibodies Proteins 0.000 claims 16
- 239000008194 pharmaceutical composition Substances 0.000 claims 9
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 201000004681 psoriasis Diseases 0.000 claims 5
- 102100014586 SELPLG Human genes 0.000 claims 4
- 101710023851 SELPLG Proteins 0.000 claims 4
- 238000002054 transplantation Methods 0.000 claims 4
- 200000000018 inflammatory disease Diseases 0.000 claims 3
- MTCFGRXMJLQNBG-UWTATZPHSA-N D-serine Chemical compound OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 claims 2
- 150000001413 amino acids Chemical class 0.000 claims 2
- 102000004965 antibodies Human genes 0.000 claims 2
- 108090001123 antibodies Proteins 0.000 claims 2
- 238000001802 infusion Methods 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- 206010002556 Ankylosing spondylitis Diseases 0.000 claims 1
- 206010003816 Autoimmune disease Diseases 0.000 claims 1
- 206010011401 Crohn's disease Diseases 0.000 claims 1
- 206010012455 Dermatitis exfoliative Diseases 0.000 claims 1
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 208000004526 Exfoliative Dermatitis Diseases 0.000 claims 1
- 206010018651 Graft versus host disease Diseases 0.000 claims 1
- 208000009329 Graft vs Host Disease Diseases 0.000 claims 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 1
- 210000004185 Liver Anatomy 0.000 claims 1
- 206010037162 Psoriatic arthropathy Diseases 0.000 claims 1
- 206010037575 Pustular psoriasis Diseases 0.000 claims 1
- 206010039073 Rheumatoid arthritis Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 201000009596 autoimmune hypersensitivity disease Diseases 0.000 claims 1
- 238000010322 bone marrow transplantation Methods 0.000 claims 1
- 230000001684 chronic Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 210000000056 organs Anatomy 0.000 claims 1
- 125000001116 prolino group Chemical group [H]OC(=O)C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 230000001185 psoriatic Effects 0.000 claims 1
- 201000001263 psoriatic arthritis Diseases 0.000 claims 1
- 230000000268 renotropic Effects 0.000 claims 1
- 210000001519 tissues Anatomy 0.000 claims 1
Claims (17)
- ヒトＰＳＧＬ−１に免疫特異的に結合するモノクローナル抗体であって、
（ｉ）配列番号３のアミノ酸配列を含む可変軽（「ＶＬ」）鎖領域；
（ｉｉ）配列番号４のアミノ酸配列を含む可変重（「ＶＨ」）鎖領域を含む重鎖；および
（ｉｉｉ）ＥＵインデックスの番号付けによる重鎖のアミノ酸２２８において、セリンからプロリンへの置換を含む、ヒトＩｇＧ４定常領域；
を含む、前記モノクローナル抗体。 - ヒトＰＳＧＬ−１に免疫特異的に結合するモノクローナル抗体であって、
（ｉ）配列番号１のアミノ酸配列を含む軽鎖；および
（ｉｉ）配列番号２のアミノ酸配列を含む重鎖；
を含む、前記モノクローナル抗体。 - ヒトＰＳＧＬ−１に免疫特異的に結合するモノクローナル抗体であって、
（ｉ）配列番号２からなる重鎖；および
（ｉｉ）配列番号１からなる軽鎖；
を含む、前記モノクローナル抗体。 - ヒトＰＳＧＬ−１に免疫特異的に結合し、かつ
（ｉ）配列番号８、９、および１０を含むＶＨ鎖領域；および
（ｉｉ）ＥＵインデックスの番号付けによる重鎖のアミノ酸２２８において、セリンからプロリンへのアミノ酸置換を含む、ヒトＩｇＧ４重鎖定常領域；
を含む重鎖を含む、モノクローナル抗体。 - モノクローナル抗体が、配列番号５、６、および７を含むＶＬ鎖領域を含む軽鎖をさらに含む、請求項４に記載のモノクローナル抗体。
- 抗体が精製されている、請求項１〜５のいずれか一項に記載のモノクローナル抗体。
- 請求項１〜６のいずれか一項に記載のモノクローナル抗体および薬学的に許容し得る担体を含む、医薬組成物。
- モノクローナル抗体が精製されている、請求項７に記載の医薬組成物。
- 配列番号２を含む、抗体重鎖。
- 請求項１〜６のいずれか一項に記載のモノクローナル抗体を含む第１容器を含む、キット。
- 請求項１〜６のいずれか一項に記載のモノクローナル抗体を含む、注入装置。
- 注入装置が注射器である、請求項１１に記載の注入装置。
- 治療有効量の請求項１〜６のいずれか一項に記載のモノクローナル抗体または請求項７もしくは８に記載の医薬組成物を含む、炎症性障害を処置するための医薬組成物。
- 炎症性障害が自己免疫疾患である、請求項１３に記載の医薬組成物。
- 炎症性障害が、乾癬、尋常性乾癬、慢性尋常性乾癬、滴状乾癬、逆位乾癬、膿疱性乾癬、乾癬性紅皮症、乾癬性関節炎、関節リウマチ、クローン病、強直性脊椎炎、または糖尿病である、請求項１３または１４に記載の医薬組成物。
- 治療有効量の請求項１〜６のいずれか一項に記載のモノクローナル抗体または請求項７もしくは８に記載の医薬組成物を含む、移植片対宿主病および移植拒絶反応を処置するための医薬組成物。
- 移植が、骨髄移植、肝移植、腎移植、または、任意の器官または組織の移植を含む、請求項１６に記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161496249P | 2011-06-13 | 2011-06-13 | |
| US61/496,249 | 2011-06-13 | ||
| PCT/US2012/042068 WO2012174001A1 (en) | 2011-06-13 | 2012-06-12 | Anti-psgl-1 antibodies and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014519524A JP2014519524A (ja) | 2014-08-14 |
| JP2014519524A5 true JP2014519524A5 (ja) | 2015-07-30 |
| JP6180408B2 JP6180408B2 (ja) | 2017-08-16 |
Family
ID=47357432
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014515918A Active JP6180408B2 (ja) | 2011-06-13 | 2012-06-12 | 抗ｐｓｇｌ−１抗体およびその使用 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US20130209449A9 (ja) |
| EP (2) | EP2718325A4 (ja) |
| JP (1) | JP6180408B2 (ja) |
| KR (1) | KR102103036B1 (ja) |
| CN (3) | CN108892726A (ja) |
| AU (1) | AU2012271845B2 (ja) |
| BR (1) | BR112013031892A2 (ja) |
| CA (1) | CA2838952C (ja) |
| CL (1) | CL2013003570A1 (ja) |
| CO (1) | CO6940376A2 (ja) |
| EC (1) | ECSP14013132A (ja) |
| IL (2) | IL229844B (ja) |
| MX (1) | MX358447B (ja) |
| NZ (1) | NZ619524A (ja) |
| RU (1) | RU2650817C2 (ja) |
| SG (1) | SG10201604767TA (ja) |
| TW (1) | TWI643872B (ja) |
| UA (1) | UA114712C2 (ja) |
| WO (1) | WO2012174001A1 (ja) |
| ZA (1) | ZA201400209B (ja) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7744888B2 (en) | 2001-08-03 | 2010-06-29 | Abgenomics Cooperatief U.A. | Methods of modulating T cell or natural killer cell activity with anti-P-selectin glycoprotein ligand 1 antibodies |
| US20040116333A1 (en) | 2001-08-03 | 2004-06-17 | Rong-Hwa Lin | Modulators of P-selectin glycoprotein ligand 1 |
| MY148646A (en) | 2004-05-10 | 2013-05-15 | Abgenomics Cooperatief Ua | Anti-psgl-1 antibodies |
| AR048840A1 (es) | 2004-05-11 | 2006-05-31 | Boehringer Ingelheim Int | Epitopes inductores de la muerte de las celulas t |
| CA2838952C (en) | 2011-06-13 | 2020-11-24 | Stefan Bassarab | Anti-psgl-1 antibodies and uses thereof |
| ES2877171T3 (es) * | 2014-07-08 | 2021-11-16 | Sanford Burnham Med Res Inst | Moduladores de PSGL-1 y usos de los mismos |
| RU2766000C2 (ru) * | 2016-01-08 | 2022-02-07 | АльтруБио Инк. | Четырехвалентные антитела к psgl-1 и их применения |
| WO2017214941A1 (zh) * | 2016-06-16 | 2017-12-21 | 毛侃琅 | 一种提升SelP基因表达水平的慢病毒载体及其应用 |
| KR102630011B1 (ko) | 2017-01-11 | 2024-01-26 | 브리스톨-마이어스 스큅 컴퍼니 | Psgl-1 길항제 및 그의 용도 |
| TWI788321B (zh) * | 2017-01-20 | 2023-01-01 | 美商健臻公司 | 骨靶向抗體 |
| EP3595720A4 (en) | 2017-03-14 | 2021-05-26 | Five Prime Therapeutics, Inc. | ANTIBODIES BINDING TO VISTA AT AN ACID PH |
| EP3824287A1 (en) | 2018-07-20 | 2021-05-26 | Pierre Fabre Médicament | Receptor for vista |
| CN113667015B (zh) * | 2021-08-20 | 2022-10-11 | 北京康特泊瑞生物医药科技股份公司 | 靶向psgl-1蛋白的抗体及其用途 |
| AU2022394559A1 (en) * | 2021-11-17 | 2024-05-09 | Altrubio Inc. | Methods of using anti-psgl-1 antibodies in combination with jak inhibitors to treat t-cell mediated inflammatory diseases or cancers |
| WO2024057232A1 (en) * | 2022-09-13 | 2024-03-21 | Tetherex Pharmaceuticals Corporation | Antibodies, compositions, and methods of treatment |
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-
2012
- 2012-06-12 CA CA2838952A patent/CA2838952C/en active Active
- 2012-06-12 EP EP12799966.2A patent/EP2718325A4/en not_active Ceased
- 2012-06-12 CN CN201810722769.2A patent/CN108892726A/zh active Pending
- 2012-06-12 NZ NZ619524A patent/NZ619524A/en unknown
- 2012-06-12 MX MX2013014814A patent/MX358447B/es active IP Right Grant
- 2012-06-12 WO PCT/US2012/042068 patent/WO2012174001A1/en active Application Filing
- 2012-06-12 SG SG10201604767TA patent/SG10201604767TA/en unknown
- 2012-06-12 CN CN202211394154.4A patent/CN116063522A/zh active Pending
- 2012-06-12 EP EP21168455.0A patent/EP3925978A1/en active Pending
- 2012-06-12 RU RU2013158083A patent/RU2650817C2/ru active
- 2012-06-12 KR KR1020147000603A patent/KR102103036B1/ko active IP Right Grant
- 2012-06-12 AU AU2012271845A patent/AU2012271845B2/en active Active
- 2012-06-12 UA UAA201314798A patent/UA114712C2/uk unknown
- 2012-06-12 US US13/494,398 patent/US20130209449A9/en not_active Abandoned
- 2012-06-12 JP JP2014515918A patent/JP6180408B2/ja active Active
- 2012-06-12 BR BR112013031892A patent/BR112013031892A2/pt not_active Application Discontinuation
- 2012-06-12 CN CN201280039482.0A patent/CN103732626A/zh active Pending
- 2012-06-13 TW TW101121146A patent/TWI643872B/zh active
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2013
- 2013-04-17 US US13/865,085 patent/US20130251708A1/en not_active Abandoned
- 2013-12-08 IL IL229844A patent/IL229844B/en unknown
- 2013-12-12 CL CL2013003570A patent/CL2013003570A1/es unknown
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2014
- 2014-01-09 ZA ZA2014/00209A patent/ZA201400209B/en unknown
- 2014-01-13 EC ECSP14013132 patent/ECSP14013132A/es unknown
- 2014-01-13 CO CO14004726A patent/CO6940376A2/es unknown
-
2021
- 2021-08-30 US US17/460,883 patent/US11897964B2/en active Active
- 2021-10-14 IL IL287270A patent/IL287270A/en unknown
-
2023
- 2023-12-26 US US18/396,607 patent/US20240124604A1/en active Pending
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