JP2014519318A5 - - Google Patents
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- Publication number
- JP2014519318A5 JP2014519318A5 JP2014509819A JP2014509819A JP2014519318A5 JP 2014519318 A5 JP2014519318 A5 JP 2014519318A5 JP 2014509819 A JP2014509819 A JP 2014509819A JP 2014509819 A JP2014509819 A JP 2014509819A JP 2014519318 A5 JP2014519318 A5 JP 2014519318A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- seq
- acid sequence
- antibody
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000283073 Equus caballus Species 0.000 claims description 23
- 239000000427 antigen Substances 0.000 claims description 19
- 102000036639 antigens Human genes 0.000 claims description 19
- 108091007433 antigens Proteins 0.000 claims description 19
- 108010025020 Nerve Growth Factor Proteins 0.000 claims description 14
- 102000015336 Nerve Growth Factor Human genes 0.000 claims description 14
- 229940053128 nerve growth factor Drugs 0.000 claims description 14
- 125000000539 amino acid group Chemical group 0.000 claims description 13
- 241000283086 Equidae Species 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 7
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 238000006467 substitution reaction Methods 0.000 claims description 5
- 125000003275 alpha amino acid group Chemical group 0.000 claims 43
- 239000012634 fragment Substances 0.000 claims 16
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 8
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 4
- 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 4
- 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 4
- 108091008604 NGF receptors Proteins 0.000 claims 3
- 101150111783 NTRK1 gene Proteins 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 102000007339 Nerve Growth Factor Receptors Human genes 0.000 claims 3
- 102100035361 Cerebellar degeneration-related protein 2 Human genes 0.000 claims 2
- 101000737796 Homo sapiens Cerebellar degeneration-related protein 2 Proteins 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000012636 effector Substances 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical group COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 description 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 description 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161483491P | 2011-05-06 | 2011-05-06 | |
| US61/483,491 | 2011-05-06 | ||
| US201161531439P | 2011-09-06 | 2011-09-06 | |
| US61/531,439 | 2011-09-06 | ||
| PCT/GB2012/051004 WO2012153123A1 (en) | 2011-05-06 | 2012-05-08 | Anti-nerve growth factor antibodies and methods of preparing and using the same |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017075108A Division JP6526089B2 (ja) | 2011-05-06 | 2017-04-05 | 抗神経成長因子抗体ならびにそれを調製および使用する方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014519318A JP2014519318A (ja) | 2014-08-14 |
| JP2014519318A5 true JP2014519318A5 (cg-RX-API-DMAC7.html) | 2016-07-21 |
| JP6181043B2 JP6181043B2 (ja) | 2017-08-16 |
Family
ID=46168541
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014509819A Active JP6181043B2 (ja) | 2011-05-06 | 2012-05-08 | 抗神経成長因子抗体ならびにそれを調製および使用する方法 |
| JP2017075108A Active JP6526089B2 (ja) | 2011-05-06 | 2017-04-05 | 抗神経成長因子抗体ならびにそれを調製および使用する方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017075108A Active JP6526089B2 (ja) | 2011-05-06 | 2017-04-05 | 抗神経成長因子抗体ならびにそれを調製および使用する方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20140170136A1 (cg-RX-API-DMAC7.html) |
| EP (2) | EP3502136A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6181043B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101833465B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN103764677A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012252153B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112013028652A8 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2834983C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2704007T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB2504888B (cg-RX-API-DMAC7.html) |
| MY (1) | MY160884A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2640252C2 (cg-RX-API-DMAC7.html) |
| SG (2) | SG10201500957QA (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012153123A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11214610B2 (en) | 2010-12-01 | 2022-01-04 | H. Lundbeck A/S | High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris |
| US9067988B2 (en) | 2010-12-01 | 2015-06-30 | Alderbio Holdings Llc | Methods of preventing or treating pain using anti-NGF antibodies |
| US9884909B2 (en) | 2010-12-01 | 2018-02-06 | Alderbio Holdings Llc | Anti-NGF compositions and use thereof |
| NZ611076A (en) | 2010-12-01 | 2015-09-25 | Alderbio Holdings Llc | Anti-ngf compositions and use thereof |
| US9539324B2 (en) | 2010-12-01 | 2017-01-10 | Alderbio Holdings, Llc | Methods of preventing inflammation and treating pain using anti-NGF compositions |
| US9078878B2 (en) | 2010-12-01 | 2015-07-14 | Alderbio Holdings Llc | Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75 |
| WO2012153123A1 (en) * | 2011-05-06 | 2012-11-15 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of preparing and using the same |
| AU2014368449C1 (en) | 2013-12-20 | 2021-05-06 | Intervet International B.V. | Canine antibodies with modified CH2-CH3 sequences |
| CN107074952B (zh) | 2014-09-30 | 2021-04-09 | 英特维特国际股份有限公司 | 结合犬pd-l1的pd-l1抗体 |
| CN104774265B (zh) * | 2015-02-12 | 2018-05-04 | 北京华安科创生物技术有限公司 | 抗人神经生长因子的中和性单克隆抗体11f1及其杂交瘤细胞株 |
| CN104910274B (zh) * | 2015-02-12 | 2018-05-04 | 北京华安科创生物技术有限公司 | 抗人神经生长因子的中和性单克隆抗体12c11及其杂交瘤细胞株 |
| AR104721A1 (es) * | 2015-05-22 | 2017-08-09 | Astellas Pharma Inc | Fragmento fab anti-ngf humano |
| US11091556B2 (en) | 2015-12-18 | 2021-08-17 | Intervet Inc. | Caninized human antibodies to human IL-4R alpha |
| EP3390451B1 (en) | 2015-12-18 | 2025-01-22 | Intervet International B.V. | Caninized human antibodies to human and canine il-4r alpha |
| WO2019035010A1 (en) * | 2017-08-15 | 2019-02-21 | Kindred Biosciences, Inc. | IGG VARIANTS FOR VETERINARY USE |
| GB2578867A (en) * | 2018-10-09 | 2020-06-03 | Genome Res Ltd | Animal models and therapeutic molecules |
| FR3087107A1 (fr) | 2018-10-15 | 2020-04-17 | Avent Inc. | Compositions, systèmes, kits et méthodes d'ablation neurale |
| WO2022087153A1 (en) * | 2020-10-22 | 2022-04-28 | Scout Bio, Inc. | Method of suppressing immune response to vector-delivered therapeutic protein |
| KR20240006586A (ko) | 2021-05-12 | 2024-01-15 | 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 | Rankl 및 ngf에 특이적으로 결합하는 항원 결합 분자, 및 이의 의학적 용도 |
| CN118475612A (zh) | 2021-08-31 | 2024-08-09 | 斯科特生物公司 | 抗原结合分子及其用途 |
| WO2025036564A1 (de) * | 2023-08-17 | 2025-02-20 | Gottfried Wilhelm Leibniz Universität Hannover (Luh) | Nukleinsäuresequenz, vektor, screening-verfahren und verfahren zur herstellung von rekombinanten antikörpern |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| FI903489A0 (fi) | 1988-11-11 | 1990-07-10 | Medical Res Council | Ligander med en enda sektion, receptorer innehaollande naemnda ligander, foerfaranden foer deras framstaellning samt anvaendning av liganderna och receptorerna. |
| US6291158B1 (en) | 1989-05-16 | 2001-09-18 | Scripps Research Institute | Method for tapping the immunological repertoire |
| AU632843B2 (en) * | 1989-08-10 | 1993-01-14 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Cat-mouse heterohybridoma and gene fragment coding for constant region of feline immunoglobulin |
| CA2110799A1 (en) | 1991-06-14 | 1992-12-23 | Arnold H. Horwitz | Microbially-produced antibody fragments and their conjugates |
| DE69233745D1 (de) | 1991-12-02 | 2008-10-23 | Cambridge Antibody Tech | Herstellung von Autoantikörpern auf Phagenoberflächen ausgehend von Antikörpersegmentbibliotheken |
| SE9400088D0 (sv) | 1994-01-14 | 1994-01-14 | Kabi Pharmacia Ab | Bacterial receptor structures |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| ES2335861T3 (es) | 2000-09-08 | 2010-04-06 | Universitat Zurich | Grupos de proteinas repetitivas que comprenden modulos repetitivos. |
| US20030157561A1 (en) | 2001-11-19 | 2003-08-21 | Kolkman Joost A. | Combinatorial libraries of monomer domains |
| US20050053973A1 (en) | 2001-04-26 | 2005-03-10 | Avidia Research Institute | Novel proteins with targeted binding |
| ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
| DK2206728T3 (en) * | 2004-04-07 | 2018-04-23 | Rinat Neuroscience Corp | METHODS OF TREATING BONE CANCER PAIN BY SUBMITTING A NERVOUS FACTOR-ANTAGONISTIC ANTIBODY |
| ITRM20050290A1 (it) * | 2005-06-07 | 2006-12-08 | Lay Line Genomics Spa | Uso di molecole in grado di inibire il legame tra ngf e il suo recettore trka come analgesici ad effetto prolungato. |
| WO2007038619A2 (en) | 2005-09-27 | 2007-04-05 | Amunix, Inc. | Proteinaceous pharmaceuticals and uses thereof |
| WO2010027488A2 (en) * | 2008-09-04 | 2010-03-11 | Vet Therapeutics, Inc. | Monoclonal antibodies |
| NZ596839A (en) | 2009-05-04 | 2014-01-31 | Abbott Res Bv | Antibodies against nerve growth factor (ngf) with enhanced in vivo stability |
| BR112012022342A2 (pt) * | 2010-03-04 | 2017-02-14 | Vet Therapeutics Inc | anticorpos monoclonais dirigidos a cd52 |
| JP5911813B2 (ja) * | 2010-03-04 | 2016-04-27 | ベット・セラピューティクス・インコーポレイテッドＶｅｔ Ｔｈｅｒａｐｅｕｔｉｃｓ Ｉｎｃ． | Ｃｄ２０に対するモノクローナル抗体 |
| PT3333188T (pt) * | 2010-08-19 | 2022-03-28 | Zoetis Belgium S A | Anticorpos de anti-ngf e a sua utilização |
| WO2012153123A1 (en) * | 2011-05-06 | 2012-11-15 | Nvip Pty Ltd | Anti-nerve growth factor antibodies and methods of preparing and using the same |
-
2012
- 2012-05-08 WO PCT/GB2012/051004 patent/WO2012153123A1/en not_active Ceased
- 2012-05-08 GB GB1320050.6A patent/GB2504888B/en active Active
- 2012-05-08 SG SG10201500957QA patent/SG10201500957QA/en unknown
- 2012-05-08 US US14/115,772 patent/US20140170136A1/en not_active Abandoned
- 2012-05-08 JP JP2014509819A patent/JP6181043B2/ja active Active
- 2012-05-08 BR BR112013028652A patent/BR112013028652A8/pt not_active Application Discontinuation
- 2012-05-08 EP EP18205439.5A patent/EP3502136A1/en not_active Withdrawn
- 2012-05-08 CN CN201280033623.8A patent/CN103764677A/zh active Pending
- 2012-05-08 EP EP12723732.9A patent/EP2705056B1/en active Active
- 2012-05-08 RU RU2013154307A patent/RU2640252C2/ru not_active Application Discontinuation
- 2012-05-08 ES ES12723732T patent/ES2704007T3/es active Active
- 2012-05-08 AU AU2012252153A patent/AU2012252153B2/en active Active
- 2012-05-08 SG SG2013081914A patent/SG194795A1/en unknown
- 2012-05-08 MY MYPI2013702081A patent/MY160884A/en unknown
- 2012-05-08 CA CA2834983A patent/CA2834983C/en active Active
- 2012-05-08 KR KR1020137032545A patent/KR101833465B1/ko active Active
-
2017
- 2017-04-05 JP JP2017075108A patent/JP6526089B2/ja active Active
-
2018
- 2018-09-12 US US16/129,674 patent/US20190276525A1/en not_active Abandoned