GB2504888B - Anti-Nerve growth factor antibodies and methods of preparing and using the same - Google Patents

Anti-Nerve growth factor antibodies and methods of preparing and using the same

Info

Publication number
GB2504888B
GB2504888B GB1320050.6A GB201320050A GB2504888B GB 2504888 B GB2504888 B GB 2504888B GB 201320050 A GB201320050 A GB 201320050A GB 2504888 B GB2504888 B GB 2504888B
Authority
GB
United Kingdom
Prior art keywords
preparing
methods
same
growth factor
nerve growth
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
GB1320050.6A
Other languages
English (en)
Other versions
GB201320050D0 (en
GB2504888A (en
Inventor
David Gearing
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NVIP Pty Ltd
Original Assignee
NVIP Pty Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by NVIP Pty Ltd filed Critical NVIP Pty Ltd
Priority to GB1519606.6A priority Critical patent/GB2528811A/en
Publication of GB201320050D0 publication Critical patent/GB201320050D0/en
Publication of GB2504888A publication Critical patent/GB2504888A/en
Application granted granted Critical
Publication of GB2504888B publication Critical patent/GB2504888B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/467—Igs with modifications in the FR-residues only
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/74—Inducing cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Neurology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
GB1320050.6A 2011-05-06 2012-05-08 Anti-Nerve growth factor antibodies and methods of preparing and using the same Active GB2504888B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1519606.6A GB2528811A (en) 2011-05-06 2012-05-08 Anti-nerve growth factor antibodies and methods of preparing and using the same

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161483491P 2011-05-06 2011-05-06
US201161531439P 2011-09-06 2011-09-06
PCT/GB2012/051004 WO2012153123A1 (en) 2011-05-06 2012-05-08 Anti-nerve growth factor antibodies and methods of preparing and using the same

Publications (3)

Publication Number Publication Date
GB201320050D0 GB201320050D0 (en) 2013-12-25
GB2504888A GB2504888A (en) 2014-02-12
GB2504888B true GB2504888B (en) 2016-02-03

Family

ID=46168541

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1320050.6A Active GB2504888B (en) 2011-05-06 2012-05-08 Anti-Nerve growth factor antibodies and methods of preparing and using the same

Country Status (14)

Country Link
US (2) US20140170136A1 (cg-RX-API-DMAC7.html)
EP (2) EP3502136A1 (cg-RX-API-DMAC7.html)
JP (2) JP6181043B2 (cg-RX-API-DMAC7.html)
KR (1) KR101833465B1 (cg-RX-API-DMAC7.html)
CN (1) CN103764677A (cg-RX-API-DMAC7.html)
AU (1) AU2012252153B2 (cg-RX-API-DMAC7.html)
BR (1) BR112013028652A8 (cg-RX-API-DMAC7.html)
CA (1) CA2834983C (cg-RX-API-DMAC7.html)
ES (1) ES2704007T3 (cg-RX-API-DMAC7.html)
GB (1) GB2504888B (cg-RX-API-DMAC7.html)
MY (1) MY160884A (cg-RX-API-DMAC7.html)
RU (1) RU2640252C2 (cg-RX-API-DMAC7.html)
SG (2) SG10201500957QA (cg-RX-API-DMAC7.html)
WO (1) WO2012153123A1 (cg-RX-API-DMAC7.html)

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US9078878B2 (en) 2010-12-01 2015-07-14 Alderbio Holdings Llc Anti-NGF antibodies that selectively inhibit the association of NGF with TrkA, without affecting the association of NGF with p75
US11214610B2 (en) 2010-12-01 2022-01-04 H. Lundbeck A/S High-purity production of multi-subunit proteins such as antibodies in transformed microbes such as Pichia pastoris
MX359070B (es) 2010-12-01 2018-09-13 Alderbio Holdings Llc Composiciones anti-ngf y uso de las mismas.
US9067988B2 (en) 2010-12-01 2015-06-30 Alderbio Holdings Llc Methods of preventing or treating pain using anti-NGF antibodies
US9884909B2 (en) 2010-12-01 2018-02-06 Alderbio Holdings Llc Anti-NGF compositions and use thereof
US9539324B2 (en) 2010-12-01 2017-01-10 Alderbio Holdings, Llc Methods of preventing inflammation and treating pain using anti-NGF compositions
CN103764677A (zh) * 2011-05-06 2014-04-30 Nvip私人有限公司 抗神经生长因子抗体及其制备和使用方法
PT3083694T (pt) 2013-12-20 2024-02-01 Intervet Int Bv Anticorpos murinos caninizados anti-pd-1 canino
AU2015326996B2 (en) 2014-09-30 2021-05-20 Intervet International B.V. PD-L1 antibodies binding canine PD-L1
CN104910274B (zh) * 2015-02-12 2018-05-04 北京华安科创生物技术有限公司 抗人神经生长因子的中和性单克隆抗体12c11及其杂交瘤细胞株
CN104774265B (zh) * 2015-02-12 2018-05-04 北京华安科创生物技术有限公司 抗人神经生长因子的中和性单克隆抗体11f1及其杂交瘤细胞株
MX394954B (es) * 2015-05-22 2025-03-24 Astellas Pharma Inc Fragmento fab de anticuerpo anti-ngf humano novedoso.
US11091556B2 (en) 2015-12-18 2021-08-17 Intervet Inc. Caninized human antibodies to human IL-4R alpha
EP3390451B1 (en) 2015-12-18 2025-01-22 Intervet International B.V. Caninized human antibodies to human and canine il-4r alpha
US12297272B2 (en) 2017-08-15 2025-05-13 Eianco US inc. IgG Fc variants for veterinary use
GB2578867A (en) * 2018-10-09 2020-06-03 Genome Res Ltd Animal models and therapeutic molecules
FR3087107A1 (fr) 2018-10-15 2020-04-17 Avent Inc. Compositions, systèmes, kits et méthodes d'ablation neurale
EP4232096A4 (en) * 2020-10-22 2024-10-09 Scout Bio, Inc. Method of suppressing immune response to vector-delivered therapeutic protein
KR20240006586A (ko) 2021-05-12 2024-01-15 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 Rankl 및 ngf에 특이적으로 결합하는 항원 결합 분자, 및 이의 의학적 용도
WO2023034880A2 (en) 2021-08-31 2023-03-09 Scout Bio, Inc. Antigen-binding molecules and uses thereof
WO2025036564A1 (de) * 2023-08-17 2025-02-20 Gottfried Wilhelm Leibniz Universität Hannover (Luh) Nukleinsäuresequenz, vektor, screening-verfahren und verfahren zur herstellung von rekombinanten antikörpern

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EP2138512A1 (en) * 2003-12-24 2009-12-30 PanGenetics B.V. Humanized anti-NGF antibodies
WO2010027488A2 (en) * 2008-09-04 2010-03-11 Vet Therapeutics, Inc. Monoclonal antibodies
WO2012024650A2 (en) * 2010-08-19 2012-02-23 Abbott Laboratories Anti-ngf antibodies and their use

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COVACEUSZACH, S. ; CASSETTA, A. ; KONAREV, P.V. ; GONFLONI, S. ; RUDOLPH, R. ; SVERGUN, D.I. ; LAMBA, D. ; CATTANEO, A.: "Dissecting NGF Interactions with TrkA and p75 Receptors by Structural and Functional Studies of an Anti-NGF Neutralizing Antibody", JOURNAL OF MOLECULAR BIOLOGY, ACADEMIC PRESS, UNITED KINGDOM, vol. 381, no. 4, 12 September 2008 (2008-09-12), United Kingdom, pages 881 - 896, XP023611489, ISSN: 0022-2836, DOI: 10.1016/j.jmb.2008.06.008 *
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Also Published As

Publication number Publication date
KR101833465B1 (ko) 2018-02-28
JP6181043B2 (ja) 2017-08-16
US20140170136A1 (en) 2014-06-19
MY160884A (en) 2017-03-31
US20190276525A1 (en) 2019-09-12
GB201320050D0 (en) 2013-12-25
AU2012252153A1 (en) 2013-11-14
CA2834983C (en) 2020-11-17
CN103764677A (zh) 2014-04-30
JP2017123870A (ja) 2017-07-20
SG10201500957QA (en) 2015-04-29
KR20140041532A (ko) 2014-04-04
NZ617448A (en) 2015-01-30
EP2705056A1 (en) 2014-03-12
ES2704007T3 (es) 2019-03-13
RU2640252C2 (ru) 2017-12-27
EP3502136A1 (en) 2019-06-26
JP6526089B2 (ja) 2019-06-05
AU2012252153B2 (en) 2016-07-07
CA2834983A1 (en) 2012-11-15
RU2013154307A (ru) 2015-06-20
SG194795A1 (en) 2013-12-30
WO2012153123A1 (en) 2012-11-15
BR112013028652A2 (pt) 2016-11-29
AU2012252153A8 (en) 2013-12-19
EP2705056B1 (en) 2018-11-14
BR112013028652A8 (pt) 2017-12-26
GB2504888A (en) 2014-02-12
JP2014519318A (ja) 2014-08-14

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