JP2014519310A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014519310A5 JP2014519310A5 JP2013552632A JP2013552632A JP2014519310A5 JP 2014519310 A5 JP2014519310 A5 JP 2014519310A5 JP 2013552632 A JP2013552632 A JP 2013552632A JP 2013552632 A JP2013552632 A JP 2013552632A JP 2014519310 A5 JP2014519310 A5 JP 2014519310A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- cpg
- loci
- adenoma
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108020004707 nucleic acids Proteins 0.000 claims 21
- 150000007523 nucleic acids Chemical class 0.000 claims 21
- 102000039446 nucleic acids Human genes 0.000 claims 21
- 238000000034 method Methods 0.000 claims 19
- 230000011987 methylation Effects 0.000 claims 14
- 238000007069 methylation reaction Methods 0.000 claims 14
- 208000003200 Adenoma Diseases 0.000 claims 13
- 206010001233 Adenoma benign Diseases 0.000 claims 13
- 206010028980 Neoplasm Diseases 0.000 claims 13
- 201000011510 cancer Diseases 0.000 claims 13
- 238000003556 assay Methods 0.000 claims 12
- 239000003550 marker Substances 0.000 claims 11
- 238000001514 detection method Methods 0.000 claims 4
- 238000003776 cleavage reaction Methods 0.000 claims 3
- 230000007017 scission Effects 0.000 claims 3
- 102100024504 Bone morphogenetic protein 3 Human genes 0.000 claims 2
- 101000762375 Homo sapiens Bone morphogenetic protein 3 Proteins 0.000 claims 2
- 101000938422 Homo sapiens Eyes absent homolog 4 Proteins 0.000 claims 2
- 101000835083 Homo sapiens Tissue factor pathway inhibitor 2 Proteins 0.000 claims 2
- 102000012060 Septin 9 Human genes 0.000 claims 2
- 108050002584 Septin 9 Proteins 0.000 claims 2
- 102100026134 Tissue factor pathway inhibitor 2 Human genes 0.000 claims 2
- 102000013127 Vimentin Human genes 0.000 claims 2
- 108010065472 Vimentin Proteins 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 238000010252 digital analysis Methods 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 210000005048 vimentin Anatomy 0.000 claims 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102100033356 Lecithin retinol acyltransferase Human genes 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 230000002596 correlated effect Effects 0.000 claims 1
- 230000000875 corresponding effect Effects 0.000 claims 1
- 238000007847 digital PCR Methods 0.000 claims 1
- 108010084957 lecithin-retinol acyltransferase Proteins 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161438649P | 2011-02-02 | 2011-02-02 | |
| US61/438,649 | 2011-02-02 | ||
| PCT/US2012/023646 WO2012106525A2 (en) | 2011-02-02 | 2012-02-02 | Digital sequence analysis of dna methylation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014519310A JP2014519310A (ja) | 2014-08-14 |
| JP2014519310A5 true JP2014519310A5 (cg-RX-API-DMAC7.html) | 2015-02-05 |
Family
ID=46577813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013552632A Pending JP2014519310A (ja) | 2011-02-02 | 2012-02-02 | Ｄｎａメチル化のデジタル配列分析 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US9637792B2 (cg-RX-API-DMAC7.html) |
| EP (3) | EP2670893B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2014519310A (cg-RX-API-DMAC7.html) |
| CN (2) | CN110129436A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2012212127B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2826696C (cg-RX-API-DMAC7.html) |
| ES (2) | ES2829198T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012106525A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009102788A2 (en) | 2008-02-15 | 2009-08-20 | Mayo Foundation For Medical Education And Research | Detecting neoplasm |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| AU2012212127B2 (en) | 2011-02-02 | 2016-06-02 | Exact Sciences Corporation | Digital sequence analysis of DNA methylation |
| JP2015526096A (ja) * | 2012-08-31 | 2015-09-10 | 国防医学院Ｎａｔｉｏｎａｌ Ｄｅｆｅｎｓｅ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ | 癌のスクリーニング方法 |
| WO2014046197A1 (ja) * | 2012-09-19 | 2014-03-27 | シスメックス株式会社 | 大腸癌に関する情報の取得方法、ならびに大腸癌に関する情報を取得するためのマーカーおよびキット |
| WO2015060609A2 (ko) * | 2013-10-21 | 2015-04-30 | 주식회사 바이오이즈 | 올리고뉴클레오타이드를 이용한 생체분자의 분석방법 및 장치 |
| WO2015066695A1 (en) | 2013-11-04 | 2015-05-07 | Exact Sciences Corporation | Multiple-control calibrators for dna quantitation |
| US10138524B2 (en) | 2013-12-19 | 2018-11-27 | Exact Sciences Development Company, Llc | Synthetic nucleic acid control molecules |
| WO2015153284A1 (en) | 2014-03-31 | 2015-10-08 | Mayo Foundation For Medical Education And Research | Detecting colorectal neoplasm |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| EP3274440A4 (en) | 2015-03-27 | 2019-03-06 | Exact Sciences Corporation | Detecting esophageal disorders |
| US10704081B2 (en) | 2015-10-30 | 2020-07-07 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay |
| CN105603061A (zh) * | 2015-12-11 | 2016-05-25 | 宁云山 | 一种基于数字PCR技术检测人Septin 9基因甲基化的方法及所用探针与引物及其试剂盒 |
| DE102015226843B3 (de) * | 2015-12-30 | 2017-04-27 | Technische Universität Dresden | Verfahren und Mittel zur Diagnostik von Tumoren |
| WO2017201400A1 (en) * | 2016-05-19 | 2017-11-23 | The Regents Of The University Of California | Determination of cell types in mixtures using targeted bisulfite sequencing |
| EP3574110A4 (en) | 2017-01-27 | 2021-01-13 | Exact Sciences Development Company, LLC | DETECTION OF COLUMN NEOPLASIA BY ANALYSIS OF METHYLATED DNA |
| SG10202111266VA (en) | 2017-04-19 | 2021-11-29 | Singlera Genomics Inc | Compositions and methods for library construction and sequence analysis |
| CA3084584A1 (en) | 2017-11-30 | 2019-06-06 | Mayo Foundation For Medical Education And Research | Detecting breast cancer |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| TW202434742A (zh) | 2018-03-13 | 2024-09-01 | 美商格瑞爾有限責任公司 | 異常片段偵測及分類 |
| CN108676878B (zh) * | 2018-05-23 | 2019-12-17 | 杭州诺辉健康科技有限公司 | 检测ndrg4基因甲基化位点的产品在制备结直肠癌早期检测的产品的用途 |
| US12234514B2 (en) | 2018-12-21 | 2025-02-25 | Grail, Inc. | Source of origin deconvolution based on methylation fragments in cell-free DNA samples |
| JP2022553575A (ja) | 2019-10-31 | 2022-12-23 | マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ | 卵巣癌の検出 |
| CN115443507A (zh) * | 2020-02-28 | 2022-12-06 | 格里尔公司 | 鉴定可鉴别或指示癌症病状的甲基化模式 |
| CN112195243A (zh) * | 2020-09-22 | 2021-01-08 | 北京华大吉比爱生物技术有限公司 | 一种检测多基因甲基化的试剂盒及其应用 |
| CN114561464A (zh) * | 2021-12-20 | 2022-05-31 | 上海锐翌生物科技有限公司 | 用于进展期腺瘤诊断、检测或筛查的引物探针组及试剂盒 |
| CN114317775B (zh) * | 2022-01-12 | 2023-06-30 | 中国人民解放军军事科学院军事医学研究院 | 一种NCOA4的RNA m6A修饰作为γ射线辐射标志物的应用 |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US563961A (en) | 1896-07-14 | Alfred john keys | ||
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US5288609A (en) | 1984-04-27 | 1994-02-22 | Enzo Diagnostics, Inc. | Capture sandwich hybridization method and composition |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US5011769A (en) | 1985-12-05 | 1991-04-30 | Meiogenics U.S. Limited Partnership | Methods for detecting nucleic acid sequences |
| US5124246A (en) | 1987-10-15 | 1992-06-23 | Chiron Corporation | Nucleic acid multimers and amplified nucleic acid hybridization assays using same |
| US5359100A (en) | 1987-10-15 | 1994-10-25 | Chiron Corporation | Bifunctional blocked phosphoramidites useful in making nucleic acid mutimers |
| US5403711A (en) | 1987-11-30 | 1995-04-04 | University Of Iowa Research Foundation | Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| US5639611A (en) | 1988-12-12 | 1997-06-17 | City Of Hope | Allele specific polymerase chain reaction |
| US6800617B1 (en) | 1989-03-29 | 2004-10-05 | The Johns Hopkins University | Methods for restoring wild-type p53 gene function |
| US5362623A (en) | 1991-06-14 | 1994-11-08 | The John Hopkins University | Sequence specific DNA binding by p53 |
| US6677312B1 (en) | 1989-03-29 | 2004-01-13 | The Johns Hopkins University | Methods for restoring wild-type p53 gene function |
| US5527676A (en) | 1989-03-29 | 1996-06-18 | The Johns Hopkins University | Detection of loss of the wild-type P53 gene and kits therefor |
| CA2036946C (en) | 1990-04-06 | 2001-10-16 | Kenneth V. Deugau | Indexing linkers |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| US5849481A (en) | 1990-07-27 | 1998-12-15 | Chiron Corporation | Nucleic acid hybridization assays employing large comb-type branched polynucleotides |
| US5352775A (en) | 1991-01-16 | 1994-10-04 | The Johns Hopkins Univ. | APC gene and nucleic acid probes derived therefrom |
| US5994069A (en) | 1996-01-24 | 1999-11-30 | Third Wave Technologies, Inc. | Detection of nucleic acids by multiple sequential invasive cleavages |
| US5846717A (en) | 1996-01-24 | 1998-12-08 | Third Wave Technologies, Inc. | Detection of nucleic acid sequences by invader-directed cleavage |
| US6872816B1 (en) | 1996-01-24 | 2005-03-29 | Third Wave Technologies, Inc. | Nucleic acid detection kits |
| US5338671A (en) | 1992-10-07 | 1994-08-16 | Eastman Kodak Company | DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody |
| WO1995014106A2 (en) | 1993-11-17 | 1995-05-26 | Id Biomedical Corporation | Cycling probe cleavage detection of nucleic acid sequences |
| US5851770A (en) | 1994-04-25 | 1998-12-22 | Variagenics, Inc. | Detection of mismatches by resolvase cleavage using a magnetic bead support |
| JPH09512428A (ja) | 1994-04-25 | 1997-12-16 | アビテック ディアゴノスティックス インク | リゾルベース開裂による突然変異の検出 |
| DE69528670T2 (de) | 1994-12-23 | 2004-03-11 | Dade Behring Inc., Deerfield | Nachweis von nukleinsäuren durch nuklease-katalysierte produktbildung |
| US5882867A (en) | 1995-06-07 | 1999-03-16 | Dade Behring Marburg Gmbh | Detection of nucleic acids by formation of template-dependent product |
| US5773258A (en) | 1995-08-25 | 1998-06-30 | Roche Molecular Systems, Inc. | Nucleic acid amplification using a reversibly inactivated thermostable enzyme |
| US5854033A (en) | 1995-11-21 | 1998-12-29 | Yale University | Rolling circle replication reporter systems |
| US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
| CA2239683A1 (en) | 1995-12-22 | 1997-07-03 | Dade Behring Marburg Gmbh | Homogeneous amplification and detection of nucleic acids |
| US5985557A (en) | 1996-01-24 | 1999-11-16 | Third Wave Technologies, Inc. | Invasive cleavage of nucleic acids |
| US5741650A (en) | 1996-01-30 | 1998-04-21 | Exact Laboratories, Inc. | Methods for detecting colon cancer from stool samples |
| WO1997039008A1 (en) | 1996-04-12 | 1997-10-23 | The Public Health Research Institute Of The City Of New York, Inc. | Detection probes, kits and assays |
| US5786146A (en) | 1996-06-03 | 1998-07-28 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US6017704A (en) | 1996-06-03 | 2000-01-25 | The Johns Hopkins University School Of Medicine | Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids |
| US5952178A (en) | 1996-08-14 | 1999-09-14 | Exact Laboratories | Methods for disease diagnosis from stool samples |
| US6096273A (en) | 1996-11-05 | 2000-08-01 | Clinical Micro Sensors | Electrodes linked via conductive oligomers to nucleic acids |
| US6143496A (en) | 1997-04-17 | 2000-11-07 | Cytonix Corporation | Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly |
| US6013459A (en) | 1997-06-12 | 2000-01-11 | Clinical Micro Sensors, Inc. | Detection of analytes using reorganization energy |
| US6268136B1 (en) | 1997-06-16 | 2001-07-31 | Exact Science Corporation | Methods for stool sample preparation |
| US6063573A (en) | 1998-01-27 | 2000-05-16 | Clinical Micro Sensors, Inc. | Cycling probe technology using electron transfer detection |
| ATE224458T1 (de) | 1998-02-04 | 2002-10-15 | Variagenics Inc | Techniken zu detektion von fehlpaarungen |
| US6235502B1 (en) | 1998-09-18 | 2001-05-22 | Molecular Staging Inc. | Methods for selectively isolating DNA using rolling circle amplification |
| US6440706B1 (en) | 1999-08-02 | 2002-08-27 | Johns Hopkins University | Digital amplification |
| ATE376067T1 (de) | 2000-02-04 | 2007-11-15 | Qiagen Gmbh | Nukleinsäure-isolierung aus stuhlproben und anderen biologischen materialien, die reich an inhibitoren sind |
| US7611869B2 (en) * | 2000-02-07 | 2009-11-03 | Illumina, Inc. | Multiplexed methylation detection methods |
| US7432050B2 (en) | 2001-10-05 | 2008-10-07 | Case Western Reserve University | Methods and compositions for detecting colon cancers |
| JP4381142B2 (ja) * | 2001-11-16 | 2009-12-09 | ザ ジョーンズ ホプキンス ユニバーシティー スクール オブ メディシン | 前立腺癌の検出法 |
| US20030215842A1 (en) * | 2002-01-30 | 2003-11-20 | Epigenomics Ag | Method for the analysis of cytosine methylation patterns |
| EP1340818A1 (en) * | 2002-02-27 | 2003-09-03 | Epigenomics AG | Method and nucleic acids for the analysis of a colon cell proliferative disorder |
| EP2339025B1 (en) * | 2002-06-26 | 2013-10-09 | Cold Spring Harbor Laboratory | Methods for determining the methylation profiles |
| US7662594B2 (en) | 2002-09-20 | 2010-02-16 | New England Biolabs, Inc. | Helicase-dependent amplification of RNA |
| JP4781267B2 (ja) | 2003-08-14 | 2011-09-28 | ケース ウエスタン リザーブ ユニバーシティ | 大腸癌を検出する方法及び組成物 |
| AU2004270220B2 (en) | 2003-09-05 | 2009-03-05 | The Chinese University Of Hong Kong | Method for non-invasive prenatal diagnosis |
| US20070059753A1 (en) * | 2005-09-15 | 2007-03-15 | Tatiana Vener | Detecting gene methylation |
| EP2385143B1 (en) | 2006-02-02 | 2016-07-13 | The Board of Trustees of the Leland Stanford Junior University | Non-invasive fetal genetic screening by digital analysis |
| US20100092981A1 (en) * | 2006-04-03 | 2010-04-15 | Genzyme Corporation | Methods of detecting hypermethylation |
| EP2099931A4 (en) * | 2006-12-19 | 2010-11-24 | Cornell Res Foundation Inc | USE OF LECITHIN: RETINOL-ACYLTRANSFERASE GENEPROMOTERMETHYLATION IN THE EVALUATION OF A PERSON'S CANCER STATUS |
| GB0700374D0 (en) * | 2007-01-09 | 2007-02-14 | Oncomethylome Sciences S A | NDRG family methylation markers |
| US9290803B2 (en) | 2007-04-12 | 2016-03-22 | University Of Southern California | DNA methylation analysis by digital bisulfite genomic sequencing and digital methylight |
| KR101419980B1 (ko) | 2008-03-15 | 2014-07-15 | 홀로직, 인크. | 증폭 반응 도중에 핵산 분자를 분석하기 위한 조성물 및 방법 |
| US8609327B2 (en) * | 2008-07-10 | 2013-12-17 | International Business Machines Corporation | Forming sub-lithographic patterns using double exposure |
| US20100124747A1 (en) * | 2008-11-03 | 2010-05-20 | University Of Southern California | Compositions and methods for diagnosis or prognosis of testicular cancer |
| US20100273164A1 (en) | 2009-03-24 | 2010-10-28 | President And Fellows Of Harvard College | Targeted and Whole-Genome Technologies to Profile DNA Cytosine Methylation |
| US20120164638A1 (en) * | 2009-04-06 | 2012-06-28 | Case Western Reserve University | Digital Quantification of DNA Methylation |
| US8916344B2 (en) * | 2010-11-15 | 2014-12-23 | Exact Sciences Corporation | Methylation assay |
| AU2012212127B2 (en) | 2011-02-02 | 2016-06-02 | Exact Sciences Corporation | Digital sequence analysis of DNA methylation |
-
2012
- 2012-02-02 AU AU2012212127A patent/AU2012212127B2/en active Active
- 2012-02-02 CN CN201910145167.XA patent/CN110129436A/zh active Pending
- 2012-02-02 CA CA2826696A patent/CA2826696C/en active Active
- 2012-02-02 CN CN201280016745.6A patent/CN103703173A/zh active Pending
- 2012-02-02 JP JP2013552632A patent/JP2014519310A/ja active Pending
- 2012-02-02 US US13/364,978 patent/US9637792B2/en active Active
- 2012-02-02 ES ES18179746T patent/ES2829198T3/es active Active
- 2012-02-02 WO PCT/US2012/023646 patent/WO2012106525A2/en not_active Ceased
- 2012-02-02 ES ES12742758.1T patent/ES2686309T3/es active Active
- 2012-02-02 EP EP12742758.1A patent/EP2670893B1/en active Active
- 2012-02-02 EP EP20193533.5A patent/EP3795699B1/en active Active
- 2012-02-02 EP EP18179746.5A patent/EP3441479B1/en active Active
-
2016
- 2016-09-28 US US15/278,697 patent/US10519510B2/en active Active
-
2019
- 2019-10-28 US US16/665,738 patent/US10870893B2/en active Active
-
2020
- 2020-11-23 US US17/101,904 patent/US11952633B2/en active Active
-
2024
- 2024-04-05 US US18/628,011 patent/US20240368702A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014519310A5 (cg-RX-API-DMAC7.html) | ||
| JP2020506680A5 (cg-RX-API-DMAC7.html) | ||
| JP2019528704A5 (cg-RX-API-DMAC7.html) | ||
| JP2024123233A5 (cg-RX-API-DMAC7.html) | ||
| Van Loo et al. | Single cell analysis of cancer genomes | |
| JP2023025184A5 (ja) | メチル化ｄｎａの分析による腫瘍の検出 | |
| JP2025041764A5 (cg-RX-API-DMAC7.html) | ||
| AU2012212127B2 (en) | Digital sequence analysis of DNA methylation | |
| JP2021503943A5 (cg-RX-API-DMAC7.html) | ||
| JP2008506407A5 (cg-RX-API-DMAC7.html) | ||
| Wang et al. | Characterization of microRNA expression profiles in blood and saliva using the Ion Personal Genome Machine® System (Ion PGM™ System) | |
| US20180143198A1 (en) | Method for detecting differentially methylated cpg islands associated with abnormal state of human body | |
| JP2014519319A5 (cg-RX-API-DMAC7.html) | ||
| JP2014073134A5 (ja) | 標的増幅及びシークエンシングを使用した非侵襲的な胎児遺伝子型スクリーニング | |
| WO2018087129A1 (en) | Colorectal cancer methylation markers | |
| JP2015091262A5 (cg-RX-API-DMAC7.html) | ||
| CN111032881A (zh) | 核酸的精确和大规模平行定量 | |
| RU2019138698A (ru) | Способы и композиции для днк-профилирования | |
| CA2873585A1 (en) | Method for increasing accuracy in quantitative detection of polynucleotides | |
| WO2007133831A3 (en) | High throughput genome sequencing on dna arrays | |
| JP2014507164A5 (cg-RX-API-DMAC7.html) | ||
| WO2007130519A3 (en) | Viral nucleic acid microarray and method of use | |
| WO2008070144A3 (en) | Imprinted genes and disease | |
| EP3180441B1 (en) | Method of estimating the amount of a methylated locus in a sample | |
| JP2009533066A5 (cg-RX-API-DMAC7.html) |