JP2019520037A5 - - Google Patents

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JP2019520037A5
JP2019520037A5 JP2018554339A JP2018554339A JP2019520037A5 JP 2019520037 A5 JP2019520037 A5 JP 2019520037A5 JP 2018554339 A JP2018554339 A JP 2018554339A JP 2018554339 A JP2018554339 A JP 2018554339A JP 2019520037 A5 JP2019520037 A5 JP 2019520037A5
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primers
seq
nos
methylation
sample
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JP2018554339A
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JP7481804B2 (ja
JP2019520037A (ja
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Priority claimed from PCT/US2017/027439 external-priority patent/WO2017180886A1/en
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Priority to JP2022131150A priority Critical patent/JP7443436B2/ja
Priority to JP2024017264A priority patent/JP2024054246A/ja
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JP2018554339A 2016-04-14 2017-04-13 高度膵異形成の検出 Active JP7481804B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2022131150A JP7443436B2 (ja) 2016-04-14 2022-08-19 高度膵異形成の検出
JP2024017264A JP2024054246A (ja) 2016-04-14 2024-02-07 高度膵異形成の検出

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662322610P 2016-04-14 2016-04-14
US62/322,610 2016-04-14
PCT/US2017/027439 WO2017180886A1 (en) 2016-04-14 2017-04-13 Detecting pancreatic high-grade dysplasia

Related Child Applications (2)

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JP2022131150A Division JP7443436B2 (ja) 2016-04-14 2022-08-19 高度膵異形成の検出
JP2024017264A Division JP2024054246A (ja) 2016-04-14 2024-02-07 高度膵異形成の検出

Publications (3)

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JP2019520037A JP2019520037A (ja) 2019-07-18
JP2019520037A5 true JP2019520037A5 (cg-RX-API-DMAC7.html) 2020-05-21
JP7481804B2 JP7481804B2 (ja) 2024-05-13

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JP2018554339A Active JP7481804B2 (ja) 2016-04-14 2017-04-13 高度膵異形成の検出
JP2022131150A Active JP7443436B2 (ja) 2016-04-14 2022-08-19 高度膵異形成の検出
JP2024017264A Pending JP2024054246A (ja) 2016-04-14 2024-02-07 高度膵異形成の検出

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JP2022131150A Active JP7443436B2 (ja) 2016-04-14 2022-08-19 高度膵異形成の検出
JP2024017264A Pending JP2024054246A (ja) 2016-04-14 2024-02-07 高度膵異形成の検出

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US (3) US11078543B2 (cg-RX-API-DMAC7.html)
EP (1) EP3443089A4 (cg-RX-API-DMAC7.html)
JP (3) JP7481804B2 (cg-RX-API-DMAC7.html)
KR (2) KR102506365B1 (cg-RX-API-DMAC7.html)
CN (2) CN109153993B (cg-RX-API-DMAC7.html)
AU (2) AU2017250663B2 (cg-RX-API-DMAC7.html)
CA (1) CA3020628A1 (cg-RX-API-DMAC7.html)
WO (1) WO2017180886A1 (cg-RX-API-DMAC7.html)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009102788A2 (en) 2008-02-15 2009-08-20 Mayo Foundation For Medical Education And Research Detecting neoplasm
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
WO2015153284A1 (en) 2014-03-31 2015-10-08 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasm
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
EP3274440A4 (en) 2015-03-27 2019-03-06 Exact Sciences Corporation Detecting esophageal disorders
AU2017250663B2 (en) * 2016-04-14 2023-06-15 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia
CN116064795A (zh) * 2016-09-02 2023-05-05 梅约医学教育与研究基金会 确定差异甲基化区域的甲基化状态的方法和试剂盒
EP3574110A4 (en) 2017-01-27 2021-01-13 Exact Sciences Development Company, LLC DETECTION OF COLUMN NEOPLASIA BY ANALYSIS OF METHYLATED DNA
CA3084584A1 (en) * 2017-11-30 2019-06-06 Mayo Foundation For Medical Education And Research Detecting breast cancer
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
CN113811622B (zh) * 2019-04-03 2024-09-17 梅约医学教育与研究基金会 在血浆中检测胰腺导管腺癌
EP3730941A1 (en) * 2019-04-23 2020-10-28 Institut Jean Paoli & Irène Calmettes Method for determining a reference tumor aggressiveness molecular gradient for a pancreatic ductal adenocarcinoma
US20220333206A1 (en) * 2019-07-29 2022-10-20 Seoul National University Hospital Biomarker for diagnosing pancreatic cancer, and use thereof
CN112176419B (zh) * 2019-10-16 2022-03-22 中国医学科学院肿瘤医院 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法
JP2022553575A (ja) 2019-10-31 2022-12-23 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 卵巣癌の検出
AU2021268631A1 (en) * 2020-05-04 2023-01-05 Mayo Foundation For Medical Education And Research Detecting pancreatic neuroendocrine tumors
US20230151433A1 (en) * 2020-05-04 2023-05-18 Mayo Foundation For Medical Education And Research Detecting melanoma
CN112176057B (zh) * 2020-09-23 2023-11-10 中国人民解放军海军军医大学第一附属医院 利用CpG位点甲基化水平检测胰腺导管腺癌的标志物及其应用
CN114250298B (zh) * 2020-09-23 2024-09-24 中国医学科学院北京协和医院 胰腺导管腺癌的dna甲基化标志物及其应用
JP7684545B2 (ja) * 2020-12-04 2025-05-28 学校法人順天堂 軽度認知障害の検出方法
CN117475360B (zh) * 2023-12-27 2024-03-26 南京纳实医学科技有限公司 基于改进型mlstm-fcn的音视频特点的生物特征提取与分析方法

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5541308A (en) 1986-11-24 1996-07-30 Gen-Probe Incorporated Nucleic acid probes for detection and/or quantitation of non-viral organisms
US5527676A (en) 1989-03-29 1996-06-18 The Johns Hopkins University Detection of loss of the wild-type P53 gene and kits therefor
US6800617B1 (en) 1989-03-29 2004-10-05 The Johns Hopkins University Methods for restoring wild-type p53 gene function
US6677312B1 (en) 1989-03-29 2004-01-13 The Johns Hopkins University Methods for restoring wild-type p53 gene function
US5362623A (en) 1991-06-14 1994-11-08 The John Hopkins University Sequence specific DNA binding by p53
US5352775A (en) 1991-01-16 1994-10-04 The Johns Hopkins Univ. APC gene and nucleic acid probes derived therefrom
US6235470B1 (en) 1993-11-12 2001-05-22 The Johns Hopkins University School Of Medicine Detection of neoplasia by analysis of saliva
US5670325A (en) 1996-08-14 1997-09-23 Exact Laboratories, Inc. Method for the detection of clonal populations of transformed cells in a genomically heterogeneous cellular sample
US5741650A (en) 1996-01-30 1998-04-21 Exact Laboratories, Inc. Methods for detecting colon cancer from stool samples
US5891651A (en) 1996-03-29 1999-04-06 Mayo Foundation For Medical Education And Research Methods of recovering colorectal epithelial cells or fragments thereof from stool
US5786146A (en) 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
US5928870A (en) 1997-06-16 1999-07-27 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
US5952178A (en) 1996-08-14 1999-09-14 Exact Laboratories Methods for disease diagnosis from stool samples
US6020137A (en) 1996-08-14 2000-02-01 Exact Laboratories, Inc. Methods for the detection of loss of heterozygosity
AU7829398A (en) 1997-06-09 1998-12-30 University Of Southern California A cancer diagnostic method based upon dna methylation differences
US7700324B1 (en) 1998-11-03 2010-04-20 The Johns Hopkins University School Of Medicine Methylated CpG island amplification (MCA)
US6335193B1 (en) 1999-04-15 2002-01-01 Padmanabhan P Nair Isolated colonocytes
ATE458831T1 (de) 1999-12-07 2010-03-15 Exact Sciences Corp Verfahren zum nachweis von lungenneoplasmen in fäkalen proben
EP1297185A2 (en) 2000-06-30 2003-04-02 Epigenomics AG Diagnosis of diseases associated with signal transduction
IL154663A0 (en) 2000-09-01 2003-09-17 Epigenomics Ag Method for determining the degree of methylation of defined cytosines in genomic dna in the sequence context 5'-cpg-3'
WO2002070742A1 (en) * 2001-03-01 2002-09-12 Epigenomics Ag Method for the development of gene panels for diagnostic and therapeutic purposes based on the expression and methylatoin status of the genes
US7432050B2 (en) 2001-10-05 2008-10-07 Case Western Reserve University Methods and compositions for detecting colon cancers
CA2478592A1 (en) 2002-03-07 2003-09-18 The Johns Hopkins University School Of Medicine Genomic screen for epigenetically silenced genes associated with cancer
CA2519456A1 (en) * 2003-03-17 2004-09-30 Michael G. Goggins Aberrantly methylated genes in pancreatic cancer
JP4781267B2 (ja) 2003-08-14 2011-09-28 ケース ウエスタン リザーブ ユニバーシティ 大腸癌を検出する方法及び組成物
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
US20080039413A1 (en) 2003-10-21 2008-02-14 Morris David W Novel compositions and methods in cancer
SI3296407T1 (sl) 2004-03-02 2019-09-30 The Johns Hopkins University Mutacije gena PIK3CA pri rakih pri ljudeh
US8114587B2 (en) 2005-06-23 2012-02-14 Ambergen, Inc. Methods for the detection of colorectal cancer
US7851154B2 (en) 2005-07-22 2010-12-14 Simon Daniel Spivack GC tag-modified bisulfite genomic DNA sequencing for continuous methylation spectra
JP4490382B2 (ja) 2006-02-28 2010-06-23 富士フイルム株式会社 感熱転写受像シートおよびその製造方法
WO2007116417A1 (en) 2006-04-07 2007-10-18 Silvia Sabbioni Novel dna methylation markers useful for the diagnosis of neoplastic diseases
WO2007140319A1 (en) 2006-05-26 2007-12-06 Meltzer Stephen J Methylated promoters as biomarkers of colon cancer
GB0700374D0 (en) 2007-01-09 2007-02-14 Oncomethylome Sciences S A NDRG family methylation markers
US20080213870A1 (en) 2007-03-01 2008-09-04 Sean Wuxiong Cao Methods for obtaining modified DNA from a biological specimen
CN101353695B (zh) 2007-07-23 2013-05-01 上海市肿瘤研究所 尿沉淀dna甲基化谱式分析诊断膀胱癌的方法和试剂盒
WO2009102788A2 (en) 2008-02-15 2009-08-20 Mayo Foundation For Medical Education And Research Detecting neoplasm
US8962247B2 (en) * 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
WO2010062914A1 (en) 2008-11-26 2010-06-03 The Johns Hopkins University Methods for identifying cancer risk
US20110318738A1 (en) 2008-12-23 2011-12-29 University Of Utah Research Foundation Identification and regulation of a novel dna demethylase system
EP2233590A1 (en) 2009-01-28 2010-09-29 AIT Austrian Institute of Technology GmbH Methylation assay
EP2394170B1 (en) 2009-02-03 2015-04-01 MDxHealth SA Methods of detecting colorectal cancer
WO2010113529A1 (ja) 2009-04-03 2010-10-07 国立大学法人山口大学 大腸腫瘍の検出方法
US20120164110A1 (en) 2009-10-14 2012-06-28 Feinberg Andrew P Differentially methylated regions of reprogrammed induced pluripotent stem cells, method and compositions thereof
US8709736B2 (en) 2010-07-09 2014-04-29 Medical Research Council Biomarker for Barrett's Oesophagus
AU2011230633B2 (en) 2010-03-26 2015-01-22 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal neoplasm
US20130012410A1 (en) 2010-03-29 2013-01-10 Mayo Foundation For Medical Education And Research Methods and materials for detecting colorectal cancer and adenoma
US9957570B2 (en) 2010-10-04 2018-05-01 The Johns Hopkins University DNA hypermethylation diagnostic biomarkers for colorectal cancer
US8916344B2 (en) 2010-11-15 2014-12-23 Exact Sciences Corporation Methylation assay
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
US8715937B2 (en) 2010-11-15 2014-05-06 Exact Sciences Corporation Mutation detection assay
EP2655664A2 (en) 2010-12-21 2013-10-30 Sloan-Kettering Institute for Cancer Research Epigenomic markers of cancer metastasis
US10144971B2 (en) 2011-01-04 2018-12-04 The Johns Hopkins University Genes frequently altered in pancreatic neuroendocrine tumors
WO2012125721A2 (en) 2011-03-14 2012-09-20 Mayo Foundation For Medical Education And Research Methods and materials for using the contents of phagocytes to detect neoplasms
US8980107B2 (en) 2011-05-12 2015-03-17 Exact Sciences Corporation Spin filter
EP3231877B1 (en) 2011-05-12 2019-12-04 Exact Sciences Corporation Isolation of nucleic acids
US8808990B2 (en) 2011-05-12 2014-08-19 Exact Sciences Corporation Serial isolation of multiple DNA targets from stool
US8993341B2 (en) 2011-05-12 2015-03-31 Exact Sciences Corporation Removal of PCR inhibitors
WO2012167145A2 (en) 2011-06-01 2012-12-06 University Of Southern California Genome-scale analysis of aberrant dna methylation in colorectal cancer
WO2012174256A2 (en) 2011-06-17 2012-12-20 The Regents Of The University Of Michigan Dna methylation profiles in cancer
WO2012175562A2 (en) 2011-06-21 2012-12-27 University Of Tartu Methylation and microrna markers of early-stage non-small cell lung cancer
US9575073B2 (en) 2011-10-10 2017-02-21 Rutgers, The State University Of New Jersey Detection of high-risk intraductal papillary mucinous neoplasm and pancreatic adenocarcinoma
WO2013081188A1 (ja) 2011-11-30 2013-06-06 独立行政法人国立がん研究センター 誘導悪性幹細胞
US20150126374A1 (en) 2012-02-28 2015-05-07 The Johns Hopkins University Hypermethylated gene markers for head and neck cancer
WO2013138044A1 (en) 2012-03-15 2013-09-19 Mayo Foundation For Medical Education And Research Methods and materials for noninvasive detection of colorectal neoplasia associated with inflammatory bowel disease
EP2698436A1 (en) * 2012-08-14 2014-02-19 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Colorectal cancer markers
EP2900835B1 (en) 2012-09-27 2025-04-30 Population Bio, Inc. Method for screening and treating developmental disorders
US9506116B2 (en) * 2013-03-14 2016-11-29 Mayo Foundation For Medical Education And Research Detecting neoplasm
JP6369857B2 (ja) 2013-05-29 2018-08-08 シスメックス株式会社 肝細胞癌に関する情報の取得方法、ならびに肝細胞癌に関する情報を取得するためのマーカーおよびキット
AU2014274276A1 (en) 2013-05-31 2015-12-03 Onconova Therapeutics, Inc. Methods and compositions for predicting therapeutic efficacy of kinase inhibitors in patients with myelodysplastic syndrome or related disorders
WO2015153284A1 (en) 2014-03-31 2015-10-08 Mayo Foundation For Medical Education And Research Detecting colorectal neoplasm
US20160010081A1 (en) * 2014-07-11 2016-01-14 Exact Sciences Corporation Systems, methods and kits for extracting nucleic acid from digestive fluid
US10184154B2 (en) * 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
EP3034624A1 (en) 2014-12-18 2016-06-22 Hospital Clínic de Barcelona Method for the prognosis of hepatocellular carcinoma
EP3274440A4 (en) * 2015-03-27 2019-03-06 Exact Sciences Corporation Detecting esophageal disorders
JP6877704B2 (ja) * 2015-11-16 2021-05-26 公立大学法人名古屋市立大学 膵臓癌の検出のための方法及びキット
AU2017250663B2 (en) * 2016-04-14 2023-06-15 Mayo Foundation For Medical Education And Research Detecting pancreatic high-grade dysplasia

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