CN109153993B - 检测胰腺高度异型增生 - Google Patents

检测胰腺高度异型增生 Download PDF

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CN109153993B
CN109153993B CN201780032351.2A CN201780032351A CN109153993B CN 109153993 B CN109153993 B CN 109153993B CN 201780032351 A CN201780032351 A CN 201780032351A CN 109153993 B CN109153993 B CN 109153993B
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methylation
dna
markers
sample
pancreatic
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CN109153993A (zh
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大卫·A·阿尔奎斯特
威廉·R·泰勒
约翰·B·基谢尔
特蕾西·C·亚卜
道格拉斯·W·马奥尼
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Mayo Clinic in Florida
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/112—Disease subtyping, staging or classification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
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  • Hospice & Palliative Care (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
CN201780032351.2A 2016-04-14 2017-04-13 检测胰腺高度异型增生 Active CN109153993B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310095425.4A CN116024334A (zh) 2016-04-14 2017-04-13 检测DMR试剂筛选IPMN-HGD、PanIN-3或PDAC的用途及试剂盒

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US201662322610P 2016-04-14 2016-04-14
US62/322,610 2016-04-14
PCT/US2017/027439 WO2017180886A1 (en) 2016-04-14 2017-04-13 Detecting pancreatic high-grade dysplasia

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CN109153993B true CN109153993B (zh) 2023-02-17

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CN202310095425.4A Pending CN116024334A (zh) 2016-04-14 2017-04-13 检测DMR试剂筛选IPMN-HGD、PanIN-3或PDAC的用途及试剂盒

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US (3) US11078543B2 (cg-RX-API-DMAC7.html)
EP (1) EP3443089A4 (cg-RX-API-DMAC7.html)
JP (3) JP7481804B2 (cg-RX-API-DMAC7.html)
KR (2) KR102506365B1 (cg-RX-API-DMAC7.html)
CN (2) CN109153993B (cg-RX-API-DMAC7.html)
AU (2) AU2017250663B2 (cg-RX-API-DMAC7.html)
CA (1) CA3020628A1 (cg-RX-API-DMAC7.html)
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CN107532124B (zh) 2015-03-27 2022-08-09 精密科学公司 检测食管疾病
CN109153993B (zh) * 2016-04-14 2023-02-17 梅约医学教育与研究基金会 检测胰腺高度异型增生
WO2018045322A1 (en) * 2016-09-02 2018-03-08 Mayo Foundation For Medical Education And Research Detecting hepatocellular carcinoma
EP3574110A4 (en) 2017-01-27 2021-01-13 Exact Sciences Development Company, LLC DETECTION OF COLUMN NEOPLASIA BY ANALYSIS OF METHYLATED DNA
US10975443B2 (en) 2017-11-30 2021-04-13 Mayo Foundation For Medical Education And Research Detecting breast cancer
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
JP7680365B2 (ja) * 2019-04-03 2025-05-20 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 血漿中の膵管腺癌の検出
EP3730941A1 (en) * 2019-04-23 2020-10-28 Institut Jean Paoli & Irène Calmettes Method for determining a reference tumor aggressiveness molecular gradient for a pancreatic ductal adenocarcinoma
WO2021020882A1 (ko) * 2019-07-29 2021-02-04 서울대학교병원 췌장암 진단용 바이오마커 및 이의 용도
CN112176419B (zh) * 2019-10-16 2022-03-22 中国医学科学院肿瘤医院 一种检测ctDNA中肿瘤特异基因的变异和甲基化的方法
AU2020374985A1 (en) 2019-10-31 2022-05-26 Exact Sciences Corporation Detecting ovarian cancer
AU2021268333A1 (en) * 2020-05-04 2022-11-24 Exact Sciences Corporation Detecting melanoma
AU2021268631A1 (en) * 2020-05-04 2023-01-05 Mayo Foundation For Medical Education And Research Detecting pancreatic neuroendocrine tumors
CN114250298B (zh) * 2020-09-23 2024-09-24 中国医学科学院北京协和医院 胰腺导管腺癌的dna甲基化标志物及其应用
CN112176057B (zh) * 2020-09-23 2023-11-10 中国人民解放军海军军医大学第一附属医院 利用CpG位点甲基化水平检测胰腺导管腺癌的标志物及其应用
JP7684545B2 (ja) * 2020-12-04 2025-05-28 学校法人順天堂 軽度認知障害の検出方法
CN117475360B (zh) * 2023-12-27 2024-03-26 南京纳实医学科技有限公司 基于改进型mlstm-fcn的音视频特点的生物特征提取与分析方法

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EP3443089A4 (en) 2020-04-22
CA3020628A1 (en) 2017-10-19
JP2024054246A (ja) 2024-04-16
JP2019520037A (ja) 2019-07-18
CN109153993A (zh) 2019-01-04
JP7443436B2 (ja) 2024-03-05
KR20180133497A (ko) 2018-12-14
KR20220044858A (ko) 2022-04-11
KR102506365B1 (ko) 2023-03-06
EP3443089A1 (en) 2019-02-20
US20250137067A1 (en) 2025-05-01
JP7481804B2 (ja) 2024-05-13
KR102380690B1 (ko) 2022-03-29
AU2023229554A1 (en) 2023-10-05
AU2017250663A1 (en) 2018-11-01
AU2023229554B2 (en) 2025-12-04
US20190161804A1 (en) 2019-05-30
CN116024334A (zh) 2023-04-28
US11078543B2 (en) 2021-08-03
US20210317538A1 (en) 2021-10-14
JP2022166247A (ja) 2022-11-01
WO2017180886A1 (en) 2017-10-19
AU2017250663B2 (en) 2023-06-15

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