JP2014519310A5 - - Google Patents
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- JP2014519310A5 JP2014519310A5 JP2013552632A JP2013552632A JP2014519310A5 JP 2014519310 A5 JP2014519310 A5 JP 2014519310A5 JP 2013552632 A JP2013552632 A JP 2013552632A JP 2013552632 A JP2013552632 A JP 2013552632A JP 2014519310 A5 JP2014519310 A5 JP 2014519310A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- cpg
- loci
- adenoma
- cancer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108020004707 nucleic acids Proteins 0.000 claims 21
- 150000007523 nucleic acids Chemical class 0.000 claims 21
- 102000039446 nucleic acids Human genes 0.000 claims 21
- 238000000034 method Methods 0.000 claims 19
- 230000011987 methylation Effects 0.000 claims 14
- 238000007069 methylation reaction Methods 0.000 claims 14
- 208000003200 Adenoma Diseases 0.000 claims 13
- 206010001233 Adenoma benign Diseases 0.000 claims 13
- 206010028980 Neoplasm Diseases 0.000 claims 13
- 201000011510 cancer Diseases 0.000 claims 13
- 238000003556 assay Methods 0.000 claims 12
- 239000003550 marker Substances 0.000 claims 11
- 238000001514 detection method Methods 0.000 claims 4
- 238000003776 cleavage reaction Methods 0.000 claims 3
- 230000007017 scission Effects 0.000 claims 3
- 102100024504 Bone morphogenetic protein 3 Human genes 0.000 claims 2
- 101000762375 Homo sapiens Bone morphogenetic protein 3 Proteins 0.000 claims 2
- 101000938422 Homo sapiens Eyes absent homolog 4 Proteins 0.000 claims 2
- 101000835083 Homo sapiens Tissue factor pathway inhibitor 2 Proteins 0.000 claims 2
- 102000012060 Septin 9 Human genes 0.000 claims 2
- 108050002584 Septin 9 Proteins 0.000 claims 2
- 102100026134 Tissue factor pathway inhibitor 2 Human genes 0.000 claims 2
- 102000013127 Vimentin Human genes 0.000 claims 2
- 108010065472 Vimentin Proteins 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 238000010252 digital analysis Methods 0.000 claims 2
- 238000012163 sequencing technique Methods 0.000 claims 2
- 210000005048 vimentin Anatomy 0.000 claims 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 102100033356 Lecithin retinol acyltransferase Human genes 0.000 claims 1
- 101710163270 Nuclease Proteins 0.000 claims 1
- 230000003321 amplification Effects 0.000 claims 1
- 230000002596 correlated effect Effects 0.000 claims 1
- 230000000875 corresponding effect Effects 0.000 claims 1
- 238000007847 digital PCR Methods 0.000 claims 1
- 108010084957 lecithin-retinol acyltransferase Proteins 0.000 claims 1
- 238000003199 nucleic acid amplification method Methods 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 239000011541 reaction mixture Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161438649P | 2011-02-02 | 2011-02-02 | |
| US61/438,649 | 2011-02-02 | ||
| PCT/US2012/023646 WO2012106525A2 (en) | 2011-02-02 | 2012-02-02 | Digital sequence analysis of dna methylation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014519310A JP2014519310A (ja) | 2014-08-14 |
| JP2014519310A5 true JP2014519310A5 (OSRAM) | 2015-02-05 |
Family
ID=46577813
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013552632A Pending JP2014519310A (ja) | 2011-02-02 | 2012-02-02 | Ｄｎａメチル化のデジタル配列分析 |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US9637792B2 (OSRAM) |
| EP (3) | EP3795699B1 (OSRAM) |
| JP (1) | JP2014519310A (OSRAM) |
| CN (2) | CN103703173A (OSRAM) |
| AU (1) | AU2012212127B2 (OSRAM) |
| CA (1) | CA2826696C (OSRAM) |
| ES (2) | ES2686309T3 (OSRAM) |
| WO (1) | WO2012106525A2 (OSRAM) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2255198A4 (en) | 2008-02-15 | 2011-05-25 | Mayo Foundation | DETECTION OF NEOPLASM |
| US8361720B2 (en) | 2010-11-15 | 2013-01-29 | Exact Sciences Corporation | Real time cleavage assay |
| JP2014519310A (ja) | 2011-02-02 | 2014-08-14 | エクザクト サイエンシーズ コーポレイション | Ｄｎａメチル化のデジタル配列分析 |
| CN105579590A (zh) * | 2012-08-31 | 2016-05-11 | 赖鸿政 | 一种癌症筛检的方法 |
| EP2899272B1 (en) * | 2012-09-19 | 2018-08-15 | Sysmex Corporation | Method and use for obtaining information about colorectal cancer |
| JP6325667B2 (ja) * | 2013-10-21 | 2018-05-16 | キム・ソンチョン | オリゴヌクレオチドを用いた生体分子分析方法及び装置 |
| WO2015066695A1 (en) | 2013-11-04 | 2015-05-07 | Exact Sciences Corporation | Multiple-control calibrators for dna quantitation |
| US10138524B2 (en) | 2013-12-19 | 2018-11-27 | Exact Sciences Development Company, Llc | Synthetic nucleic acid control molecules |
| WO2015153284A1 (en) | 2014-03-31 | 2015-10-08 | Mayo Foundation For Medical Education And Research | Detecting colorectal neoplasm |
| US10184154B2 (en) | 2014-09-26 | 2019-01-22 | Mayo Foundation For Medical Education And Research | Detecting cholangiocarcinoma |
| WO2016160454A1 (en) | 2015-03-27 | 2016-10-06 | Exact Sciences Corporation | Detecting esophageal disorders |
| CA3002196C (en) | 2015-10-30 | 2024-05-14 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay and isolation and detection of dna from plasma |
| CN105603061A (zh) * | 2015-12-11 | 2016-05-25 | 宁云山 | 一种基于数字PCR技术检测人Septin 9基因甲基化的方法及所用探针与引物及其试剂盒 |
| DE102015226843B3 (de) * | 2015-12-30 | 2017-04-27 | Technische Universität Dresden | Verfahren und Mittel zur Diagnostik von Tumoren |
| WO2017201400A1 (en) * | 2016-05-19 | 2017-11-23 | The Regents Of The University Of California | Determination of cell types in mixtures using targeted bisulfite sequencing |
| KR102892245B1 (ko) | 2017-01-27 | 2025-11-27 | 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 | 메틸화된 dna 분석에 의한 결장 신조직형성의 검출 |
| CN110770354B (zh) | 2017-04-19 | 2024-03-19 | 鹍远基因公司 | 用于文库构建和序列分析的组合物和方法 |
| WO2019108626A1 (en) | 2017-11-30 | 2019-06-06 | Mayo Foundation For Medical Education And Research | Detecting breast cancer |
| US10648025B2 (en) | 2017-12-13 | 2020-05-12 | Exact Sciences Development Company, Llc | Multiplex amplification detection assay II |
| WO2019178277A1 (en) | 2018-03-13 | 2019-09-19 | Grail, Inc. | Anomalous fragment detection and classification |
| CN108676878B (zh) * | 2018-05-23 | 2019-12-17 | 杭州诺辉健康科技有限公司 | 检测ndrg4基因甲基化位点的产品在制备结直肠癌早期检测的产品的用途 |
| WO2020132572A1 (en) | 2018-12-21 | 2020-06-25 | Grail, Inc. | Source of origin deconvolution based on methylation fragments in cell-free-dna samples |
| CA3154354A1 (en) | 2019-10-31 | 2021-05-06 | William R. Taylor | Detecting ovarian cancer |
| CA3169488A1 (en) * | 2020-02-28 | 2021-09-02 | Collin MELTON | Identifying methylation patterns that discriminate or indicate a cancer condition |
| CN112195243A (zh) * | 2020-09-22 | 2021-01-08 | 北京华大吉比爱生物技术有限公司 | 一种检测多基因甲基化的试剂盒及其应用 |
| CN114561464A (zh) * | 2021-12-20 | 2022-05-31 | 上海锐翌生物科技有限公司 | 用于进展期腺瘤诊断、检测或筛查的引物探针组及试剂盒 |
| CN114317775B (zh) * | 2022-01-12 | 2023-06-30 | 中国人民解放军军事科学院军事医学研究院 | 一种NCOA4的RNA m6A修饰作为γ射线辐射标志物的应用 |
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| JP2014519310A (ja) | 2011-02-02 | 2014-08-14 | エクザクト サイエンシーズ コーポレイション | Ｄｎａメチル化のデジタル配列分析 |
-
2012
- 2012-02-02 JP JP2013552632A patent/JP2014519310A/ja active Pending
- 2012-02-02 AU AU2012212127A patent/AU2012212127B2/en active Active
- 2012-02-02 WO PCT/US2012/023646 patent/WO2012106525A2/en not_active Ceased
- 2012-02-02 EP EP20193533.5A patent/EP3795699B1/en active Active
- 2012-02-02 ES ES12742758.1T patent/ES2686309T3/es active Active
- 2012-02-02 CN CN201280016745.6A patent/CN103703173A/zh active Pending
- 2012-02-02 US US13/364,978 patent/US9637792B2/en active Active
- 2012-02-02 EP EP18179746.5A patent/EP3441479B1/en active Active
- 2012-02-02 CN CN201910145167.XA patent/CN110129436A/zh active Pending
- 2012-02-02 EP EP12742758.1A patent/EP2670893B1/en active Active
- 2012-02-02 CA CA2826696A patent/CA2826696C/en active Active
- 2012-02-02 ES ES18179746T patent/ES2829198T3/es active Active
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2016
- 2016-09-28 US US15/278,697 patent/US10519510B2/en active Active
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2019
- 2019-10-28 US US16/665,738 patent/US10870893B2/en active Active
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2020
- 2020-11-23 US US17/101,904 patent/US11952633B2/en active Active
-
2024
- 2024-04-05 US US18/628,011 patent/US20240368702A1/en active Pending
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