JP2014519036A5 - - Google Patents
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- Publication number
- JP2014519036A5 JP2014519036A5 JP2014512857A JP2014512857A JP2014519036A5 JP 2014519036 A5 JP2014519036 A5 JP 2014519036A5 JP 2014512857 A JP2014512857 A JP 2014512857A JP 2014512857 A JP2014512857 A JP 2014512857A JP 2014519036 A5 JP2014519036 A5 JP 2014519036A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- immunoassay
- carrier
- gemcitabine
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000003018 immunoassay Methods 0.000 claims 14
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 9
- 229960005277 gemcitabine Drugs 0.000 claims 9
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 8
- 239000000523 sample Substances 0.000 claims 7
- 125000003277 amino group Chemical group 0.000 claims 6
- 230000002163 immunogen Effects 0.000 claims 5
- UCKYOOZPSJFJIZ-FMDGEEDCSA-N (4r)-1-[(2r,3r,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-1,3-diazinan-2-one Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)N[C@H](O)CC1 UCKYOOZPSJFJIZ-FMDGEEDCSA-N 0.000 claims 4
- FIRDBEQIJQERSE-QPPQHZFASA-N 2',2'-Difluorodeoxyuridine Chemical compound FC1(F)[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 FIRDBEQIJQERSE-QPPQHZFASA-N 0.000 claims 4
- 125000000524 functional group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000002148 esters Chemical class 0.000 claims 3
- -1 imide ester Chemical class 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 229920000642 polymer Polymers 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- 125000002947 alkylene group Chemical group 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 230000009260 cross reactivity Effects 0.000 claims 2
- 229910052739 hydrogen Inorganic materials 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 239000001301 oxygen Substances 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 241000699670 Mus sp. Species 0.000 claims 1
- 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
- 241001494479 Pecora Species 0.000 claims 1
- 125000005907 alkyl ester group Chemical group 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 239000002105 nanoparticle Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 239000013610 patient sample Substances 0.000 claims 1
- 230000009257 reactivity Effects 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/114,218 US8426143B2 (en) | 2011-05-24 | 2011-05-24 | Gemcitabine immunoassay |
| US13/114,218 | 2011-05-24 | ||
| US13/160,370 US8946392B2 (en) | 2011-05-24 | 2011-06-14 | Gemcitabine immunoassay |
| US13/160,370 | 2011-06-14 | ||
| PCT/US2012/036723 WO2012161948A1 (en) | 2011-05-24 | 2012-05-07 | Gemcitabine immunoassay |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014519036A JP2014519036A (ja) | 2014-08-07 |
| JP2014519036A5 true JP2014519036A5 (https=) | 2015-07-09 |
Family
ID=47217602
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014512857A Pending JP2014519036A (ja) | 2011-05-24 | 2012-05-07 | ゲムシタビンイムノアッセイ |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8426143B2 (https=) |
| EP (1) | EP2715340A4 (https=) |
| JP (1) | JP2014519036A (https=) |
| CN (1) | CN103782167B (https=) |
| BR (1) | BR112013029974A2 (https=) |
| CA (1) | CA2836539A1 (https=) |
| WO (1) | WO2012161948A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8426143B2 (en) * | 2011-05-24 | 2013-04-23 | Saladax Biomedical Inc. | Gemcitabine immunoassay |
| DK3383406T3 (da) | 2015-12-03 | 2022-01-10 | Epidestiny Inc | Sammensætninger indeholdende decitabin, 5-azacytidin og tetrahydrouridin og anvendelser deraf |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2010200A (en) * | 1932-11-17 | 1935-08-06 | Internat Carbonic Engineering | Sealing device for pressure containers |
| US3996344A (en) | 1972-05-15 | 1976-12-07 | Biological Developments, Inc. | Phenethylamine antigenic conjugates, their preparation, antibodies and use |
| US4016146A (en) | 1974-12-10 | 1977-04-05 | Biological Developments, Inc. | Phenethylamine antigenic conjugates, their preparation, antibodies, and use |
| US4269511A (en) | 1979-02-15 | 1981-05-26 | Abbott Laboratories | Apparatus and method for measuring the magnitude of polarization of light |
| US4420568A (en) | 1980-07-30 | 1983-12-13 | Abbott Laboratories | Fluorescent polarization immunoassay utilizing substituted triazinylaminofluoresceins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5101015A (en) | 1989-04-10 | 1992-03-31 | Abbott Laboratories | Reagents for an amphetamine-class fluorescence polarization immunoassay |
| CA2096495C (en) | 1992-06-16 | 2002-07-09 | Kathy Palmer Ordonez | Dual analyte immunoassay |
| US7829064B2 (en) | 1999-05-10 | 2010-11-09 | Immunomedics, Inc. | Anti-CD74 immunoconjugates and methods |
| FR2836995B1 (fr) * | 2002-03-05 | 2006-09-22 | Centre Nat Rech Scient | Utilisation de derives de nucleosides comportant un groupement citrate pour la production d'anticorps ayant une affinite pour des nucleosides triphosphorylees et leurs applications |
| US7265096B2 (en) | 2002-11-04 | 2007-09-04 | Xenoport, Inc. | Gemcitabine prodrugs, pharmaceutical compositions and uses thereof |
| US20060177883A1 (en) | 2005-02-08 | 2006-08-10 | Saladax Biomedical Inc. | 5-Fluoro-uracil immunoassay |
| JP4896959B2 (ja) * | 2005-03-30 | 2012-03-14 | サラダックス バイオメディカル インク． | ドキソルビシン免疫測定法 |
| US8039220B2 (en) | 2008-09-17 | 2011-10-18 | Saladax Biomedical Inc. | Stabilized standards for busulfan immunoassay |
| KR101721865B1 (ko) | 2009-10-13 | 2017-04-03 | 렉산 파마슈티컬스, 인코포레이티드 | 항암제의 전달을 위한 폴리머 시스템 |
| US8426143B2 (en) * | 2011-05-24 | 2013-04-23 | Saladax Biomedical Inc. | Gemcitabine immunoassay |
-
2011
- 2011-05-24 US US13/114,218 patent/US8426143B2/en not_active Expired - Fee Related
- 2011-06-14 US US13/160,370 patent/US8946392B2/en active Active
-
2012
- 2012-05-07 BR BR112013029974A patent/BR112013029974A2/pt not_active IP Right Cessation
- 2012-05-07 CN CN201280036559.9A patent/CN103782167B/zh not_active Expired - Fee Related
- 2012-05-07 WO PCT/US2012/036723 patent/WO2012161948A1/en not_active Ceased
- 2012-05-07 CA CA 2836539 patent/CA2836539A1/en not_active Abandoned
- 2012-05-07 EP EP20120789833 patent/EP2715340A4/en not_active Withdrawn
- 2012-05-07 JP JP2014512857A patent/JP2014519036A/ja active Pending
-
2014
- 2014-12-19 US US14/576,877 patent/US20150104818A1/en not_active Abandoned
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