JP2011506973A5 - - Google Patents
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- Publication number
- JP2011506973A5 JP2011506973A5 JP2010538187A JP2010538187A JP2011506973A5 JP 2011506973 A5 JP2011506973 A5 JP 2011506973A5 JP 2010538187 A JP2010538187 A JP 2010538187A JP 2010538187 A JP2010538187 A JP 2010538187A JP 2011506973 A5 JP2011506973 A5 JP 2011506973A5
- Authority
- JP
- Japan
- Prior art keywords
- hydrophobic drug
- medium
- antibody
- bioavailability
- solubilizer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims description 12
- 229940079593 drug Drugs 0.000 claims 19
- 239000003814 drug Substances 0.000 claims 19
- 230000002209 hydrophobic effect Effects 0.000 claims 19
- 239000002904 solvent Substances 0.000 claims 6
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 claims 3
- 239000002207 metabolite Substances 0.000 claims 3
- 229920005862 polyol Polymers 0.000 claims 3
- ARXJGSRGQADJSQ-UHFFFAOYSA-N 1-methoxypropan-2-ol Chemical compound COCC(C)O ARXJGSRGQADJSQ-UHFFFAOYSA-N 0.000 claims 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 150000003077 polyols Chemical class 0.000 claims 2
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 claims 2
- 150000005690 diesters Chemical class 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 239000003219 hemolytic agent Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 229960003444 immunosuppressant agent Drugs 0.000 claims 1
- 230000001861 immunosuppressant effect Effects 0.000 claims 1
- 239000003018 immunosuppressive agent Substances 0.000 claims 1
- 230000002934 lysing effect Effects 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims 1
- 150000005691 triesters Chemical class 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000012491 analyte Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000021615 conjugation Effects 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 239000003446 ligand Substances 0.000 description 1
- 125000005647 linker group Chemical group 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/956,603 US7910378B2 (en) | 2007-12-14 | 2007-12-14 | Methods for detection of hydrophobic drugs |
| US11/956,603 | 2007-12-14 | ||
| PCT/US2008/086602 WO2009079374A1 (en) | 2007-12-14 | 2008-12-12 | Methods for detection of hydrophobic drugs |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012021160A Division JP5571108B2 (ja) | 2007-12-14 | 2012-02-02 | 疎水性薬物検出法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011506973A JP2011506973A (ja) | 2011-03-03 |
| JP2011506973A5 true JP2011506973A5 (https=) | 2012-01-26 |
| JP4940438B2 JP4940438B2 (ja) | 2012-05-30 |
Family
ID=40753794
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010538187A Active JP4940438B2 (ja) | 2007-12-14 | 2008-12-12 | 疎水性薬物検出法 |
| JP2012021160A Active JP5571108B2 (ja) | 2007-12-14 | 2012-02-02 | 疎水性薬物検出法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012021160A Active JP5571108B2 (ja) | 2007-12-14 | 2012-02-02 | 疎水性薬物検出法 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US7910378B2 (https=) |
| EP (1) | EP2217926B1 (https=) |
| JP (2) | JP4940438B2 (https=) |
| ES (1) | ES2605247T3 (https=) |
| WO (1) | WO2009079374A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8563298B2 (en) | 2010-10-22 | 2013-10-22 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| US8409807B2 (en) | 2010-10-22 | 2013-04-02 | T2 Biosystems, Inc. | NMR systems and methods for the rapid detection of analytes |
| WO2012054639A2 (en) | 2010-10-22 | 2012-04-26 | T2 Biosystems, Inc. | Nmr systems and methods for the rapid detection of analytes |
| US8586322B2 (en) | 2012-03-07 | 2013-11-19 | Siemens Healthcare Diagnostics, Inc | Sandwich assay for immunosuppressant drugs |
| US9562271B2 (en) | 2012-04-20 | 2017-02-07 | T2 Biosystems, Inc. | Compositions and methods for detection of Candida species |
| US9658218B2 (en) | 2012-05-07 | 2017-05-23 | Siemens Healthcare Diagnostics Inc. | Determination of total analyte concentration |
| AR090964A1 (es) * | 2012-05-09 | 2014-12-17 | Novartis Ag | Proceso para la elaboracion de undecapeptidos ciclicos |
| US9121859B2 (en) * | 2012-12-04 | 2015-09-01 | Siemens Healthcare Diagnostics Inc. | Compounds and methods for determination of FKBP-binding immunosuppressant drugs |
| CN104749009B (zh) * | 2015-03-30 | 2018-05-04 | 上海云泽生物科技有限公司 | 用于免疫分析的免疫抑制剂药物提取试剂 |
| US10383860B2 (en) | 2015-07-28 | 2019-08-20 | Nippon Kayaku Kabushiki Kaisha | Pharmaceutical composition comprising rapamycin or derivative thereof, and method for producing the same |
| WO2017127731A1 (en) | 2016-01-21 | 2017-07-27 | T2 Biosystems, Inc. | Nmr methods and systems for the rapid detection of bacteria |
| EP3734271B1 (en) | 2017-12-25 | 2026-04-15 | Fujirebio Inc. | Blood testing method for macrolide immunosuppressant |
| JP7143678B2 (ja) * | 2018-08-24 | 2022-09-29 | 東ソー株式会社 | 標的細胞を検出する方法 |
| JP7319362B2 (ja) * | 2018-11-02 | 2023-08-01 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド | マクロフィリン結合医薬アッセイに使用するための結合競合剤およびその使用方法 |
| CN120971716A (zh) * | 2019-06-28 | 2025-11-18 | 美国西门子医学诊断股份有限公司 | 使用颗粒增强凝集检测的夹心免疫测定试剂及其生产和使用方法 |
| US20210048436A1 (en) | 2019-08-15 | 2021-02-18 | Psychemedics Corporation | Homogeneous enzyme immunoassay for keratinized structures |
| CN114964939B (zh) * | 2021-12-20 | 2024-09-13 | 上海云泽生物科技有限公司 | 一种药物-蛋白解离组合物、含其的环孢霉素检测试剂盒及应用 |
| US11977085B1 (en) | 2023-09-05 | 2024-05-07 | Elan Ehrlich | Date rape drug detection device and method of using same |
| WO2026052704A1 (en) * | 2024-09-05 | 2026-03-12 | Roche Diagnostics Gmbh | Extraction of macrocyclic analytes |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3817837A (en) | 1971-05-14 | 1974-06-18 | Syva Corp | Enzyme amplification assay |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4233402A (en) | 1978-04-05 | 1980-11-11 | Syva Company | Reagents and method employing channeling |
| US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
| US4318980A (en) | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
| US4661408A (en) | 1986-03-18 | 1987-04-28 | E.I. Du Pont De Nemours And Company | Coated chromium dioxide particles |
| WO1989000446A1 (en) | 1987-07-16 | 1989-01-26 | E.I. Du Pont De Nemours And Company | Affinity separating using immobilized flocculating reagents |
| US5089390A (en) | 1987-09-04 | 1992-02-18 | Syntex (U.S.A.) Inc. | 2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivatives |
| US5158871A (en) | 1988-02-12 | 1992-10-27 | University Of Connecticut | Method of using magnetic particles for isolating, collecting and assaying diagnostic ligates |
| US5147529A (en) | 1988-08-10 | 1992-09-15 | E. I. Du Pont De Nemours And Company | Method for automatically processing magnetic solid phase reagents |
| US5185243A (en) | 1988-08-25 | 1993-02-09 | Syntex (U.S.A.) Inc. | Method for detection of specific nucleic acid sequences |
| US5151348A (en) | 1988-12-23 | 1992-09-29 | E. I. Du Pont De Nemours And Company | Enzyme-linked immunoassay for measurement of cyclosporin a levels in whole blood samples |
| US5135863A (en) | 1988-12-23 | 1992-08-04 | Syntex (U.S.A.) Inc. | Compositions and methods for determining the presence of amphetamines in a sample suspected of containing amphetamine and/or methamphetamine |
| US5101015A (en) | 1989-04-10 | 1992-03-31 | Abbott Laboratories | Reagents for an amphetamine-class fluorescence polarization immunoassay |
| US5135875A (en) | 1990-08-15 | 1992-08-04 | Abbott Laboratories | Protein precipitation reagent |
| DE69121844T2 (de) | 1990-11-20 | 1997-01-23 | Behringwerke Ag | Immunotest für Cyclosporin |
| US5128103A (en) | 1990-12-14 | 1992-07-07 | E. I. Du Pont De Nemours And Company | Apparatus for automatically processing magnetic solid phase reagents |
| US6777190B1 (en) | 1991-04-10 | 2004-08-17 | Biosite, Inc. | Crosstalk inhibitors and their uses |
| US5340716A (en) | 1991-06-20 | 1994-08-23 | Snytex (U.S.A.) Inc. | Assay method utilizing photoactivated chemiluminescent label |
| DE69228817T2 (de) | 1991-07-26 | 1999-09-23 | Dade Chemistry Systems Inc., Deerfield | Signalerkennungspruefung in der anwesenheit von einem suspendierten festen träger |
| US6455288B1 (en) | 1993-04-08 | 2002-09-24 | Dade Behring Marburg Gmbh | Homogeneous immunoassays using mutant glucose-6-phosphate dehydrogenases |
| WO1995006877A1 (en) | 1993-09-03 | 1995-03-09 | Behringwerke Ag | Fluorescent oxygen channeling immunoassays |
| US6187547B1 (en) | 1993-09-08 | 2001-02-13 | Novartis Ag | Assay kit |
| US5565326A (en) | 1994-05-31 | 1996-10-15 | Johnson & Johnson Clinical Diagnostics, Inc. | Separation-free specific binding assays using anti-inhibitor antibodies |
| US6225073B1 (en) | 1994-07-07 | 2001-05-01 | Dade Behring Marburg Gmbh | Immunoassay for mycophenolic acid |
| US5650288A (en) | 1995-07-14 | 1997-07-22 | Macfarlane; Gordon D. | Immunophilin-bound immunosuppressant assay |
| EP0880705B1 (en) | 1996-07-18 | 2003-06-18 | Dade Behring Marburg GmbH | Reagents for assays for mycophenolic acid |
| US6231982B1 (en) | 1997-12-10 | 2001-05-15 | Dade Behring Inc. | Particle reagents having reduced matrix effects and containing an aldehyde-reactive functional group |
| AU751938B2 (en) | 1998-05-15 | 2002-08-29 | Sekisui Chemical Co., Ltd. | Immunoassay reagents and immunoassay method |
| BR9804648A (pt) | 1998-11-23 | 2000-05-30 | Fundacao Oswaldo Cruz | Monitorização da obediência do paciente ao tratamento e da biodisponibilidade de drogas pela desproteinização de fluidos corpóreos. |
| JP4504313B2 (ja) | 2003-10-15 | 2010-07-14 | 株式会社リバース・プロテオミクス研究所 | リガンド特異性の検定方法 |
| US7186518B2 (en) * | 2003-11-21 | 2007-03-06 | Dade Behring Inc. | Method and composition useful for determining FK 506 |
| US7189582B2 (en) | 2005-04-27 | 2007-03-13 | Dade Behring Inc. | Compositions and methods for detection of sirolimus |
| US7575875B2 (en) | 2005-10-13 | 2009-08-18 | Abbott Laboratories, Inc. | Method of tacrolimus extraction and quantification using aqueous detergents |
| GB0606998D0 (en) * | 2006-04-06 | 2006-05-17 | Oxford Biosensors Ltd | Lipoprotein sensor |
| US7914999B2 (en) | 2006-12-29 | 2011-03-29 | Abbott Laboratories | Non-denaturing lysis reagent |
| US8288111B2 (en) * | 2007-05-24 | 2012-10-16 | Abbott Laboratories | Immunoassays exhibiting reduced cross-reactivity with hydrophobic drug analyte metabolites |
-
2007
- 2007-12-14 US US11/956,603 patent/US7910378B2/en active Active
-
2008
- 2008-12-12 WO PCT/US2008/086602 patent/WO2009079374A1/en not_active Ceased
- 2008-12-12 EP EP08862673.4A patent/EP2217926B1/en active Active
- 2008-12-12 JP JP2010538187A patent/JP4940438B2/ja active Active
- 2008-12-12 ES ES08862673.4T patent/ES2605247T3/es active Active
-
2011
- 2011-02-14 US US13/026,756 patent/US8071317B2/en active Active
- 2011-10-27 US US13/282,957 patent/US8334104B2/en active Active
-
2012
- 2012-02-02 JP JP2012021160A patent/JP5571108B2/ja active Active
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