JP4940438B2 - 疎水性薬物検出法 - Google Patents

疎水性薬物検出法 Download PDF

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Publication number
JP4940438B2
JP4940438B2 JP2010538187A JP2010538187A JP4940438B2 JP 4940438 B2 JP4940438 B2 JP 4940438B2 JP 2010538187 A JP2010538187 A JP 2010538187A JP 2010538187 A JP2010538187 A JP 2010538187A JP 4940438 B2 JP4940438 B2 JP 4940438B2
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Prior art keywords
hydrophobic drug
drug
medium
antibody
hydrophobic
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Japanese (ja)
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JP2011506973A5 (https=
JP2011506973A (ja
Inventor
ウェイ,ティエ・キュー
クレイグ,アラン
ポージー,エイミー
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シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G01N33/9493Immunosupressants
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/962Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/815Test for named compound or class of compounds
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/107497Preparation composition [e.g., lysing or precipitation, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/10Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/108331Preservative, buffer, anticoagulant or diluent
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25125Digestion or removing interfering materials
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2525Stabilizing or preserving
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25625Dilution

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
JP2010538187A 2007-12-14 2008-12-12 疎水性薬物検出法 Active JP4940438B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/956,603 US7910378B2 (en) 2007-12-14 2007-12-14 Methods for detection of hydrophobic drugs
US11/956,603 2007-12-14
PCT/US2008/086602 WO2009079374A1 (en) 2007-12-14 2008-12-12 Methods for detection of hydrophobic drugs

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012021160A Division JP5571108B2 (ja) 2007-12-14 2012-02-02 疎水性薬物検出法

Publications (3)

Publication Number Publication Date
JP2011506973A JP2011506973A (ja) 2011-03-03
JP2011506973A5 JP2011506973A5 (https=) 2012-01-26
JP4940438B2 true JP4940438B2 (ja) 2012-05-30

Family

ID=40753794

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010538187A Active JP4940438B2 (ja) 2007-12-14 2008-12-12 疎水性薬物検出法
JP2012021160A Active JP5571108B2 (ja) 2007-12-14 2012-02-02 疎水性薬物検出法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012021160A Active JP5571108B2 (ja) 2007-12-14 2012-02-02 疎水性薬物検出法

Country Status (5)

Country Link
US (3) US7910378B2 (https=)
EP (1) EP2217926B1 (https=)
JP (2) JP4940438B2 (https=)
ES (1) ES2605247T3 (https=)
WO (1) WO2009079374A1 (https=)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8563298B2 (en) 2010-10-22 2013-10-22 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
US8409807B2 (en) 2010-10-22 2013-04-02 T2 Biosystems, Inc. NMR systems and methods for the rapid detection of analytes
WO2012054639A2 (en) 2010-10-22 2012-04-26 T2 Biosystems, Inc. Nmr systems and methods for the rapid detection of analytes
US8586322B2 (en) 2012-03-07 2013-11-19 Siemens Healthcare Diagnostics, Inc Sandwich assay for immunosuppressant drugs
US9562271B2 (en) 2012-04-20 2017-02-07 T2 Biosystems, Inc. Compositions and methods for detection of Candida species
US9658218B2 (en) 2012-05-07 2017-05-23 Siemens Healthcare Diagnostics Inc. Determination of total analyte concentration
AR090964A1 (es) * 2012-05-09 2014-12-17 Novartis Ag Proceso para la elaboracion de undecapeptidos ciclicos
US9121859B2 (en) * 2012-12-04 2015-09-01 Siemens Healthcare Diagnostics Inc. Compounds and methods for determination of FKBP-binding immunosuppressant drugs
CN104749009B (zh) * 2015-03-30 2018-05-04 上海云泽生物科技有限公司 用于免疫分析的免疫抑制剂药物提取试剂
US10383860B2 (en) 2015-07-28 2019-08-20 Nippon Kayaku Kabushiki Kaisha Pharmaceutical composition comprising rapamycin or derivative thereof, and method for producing the same
WO2017127731A1 (en) 2016-01-21 2017-07-27 T2 Biosystems, Inc. Nmr methods and systems for the rapid detection of bacteria
EP3734271B1 (en) 2017-12-25 2026-04-15 Fujirebio Inc. Blood testing method for macrolide immunosuppressant
JP7143678B2 (ja) * 2018-08-24 2022-09-29 東ソー株式会社 標的細胞を検出する方法
JP7319362B2 (ja) * 2018-11-02 2023-08-01 シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレイテッド マクロフィリン結合医薬アッセイに使用するための結合競合剤およびその使用方法
CN120971716A (zh) * 2019-06-28 2025-11-18 美国西门子医学诊断股份有限公司 使用颗粒增强凝集检测的夹心免疫测定试剂及其生产和使用方法
US20210048436A1 (en) 2019-08-15 2021-02-18 Psychemedics Corporation Homogeneous enzyme immunoassay for keratinized structures
CN114964939B (zh) * 2021-12-20 2024-09-13 上海云泽生物科技有限公司 一种药物-蛋白解离组合物、含其的环孢霉素检测试剂盒及应用
US11977085B1 (en) 2023-09-05 2024-05-07 Elan Ehrlich Date rape drug detection device and method of using same
WO2026052704A1 (en) * 2024-09-05 2026-03-12 Roche Diagnostics Gmbh Extraction of macrocyclic analytes

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3817837A (en) 1971-05-14 1974-06-18 Syva Corp Enzyme amplification assay
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4233402A (en) 1978-04-05 1980-11-11 Syva Company Reagents and method employing channeling
US4275149A (en) 1978-11-24 1981-06-23 Syva Company Macromolecular environment control in specific receptor assays
US4318980A (en) 1978-04-10 1982-03-09 Miles Laboratories, Inc. Heterogenous specific binding assay employing a cycling reactant as label
US4661408A (en) 1986-03-18 1987-04-28 E.I. Du Pont De Nemours And Company Coated chromium dioxide particles
WO1989000446A1 (en) 1987-07-16 1989-01-26 E.I. Du Pont De Nemours And Company Affinity separating using immobilized flocculating reagents
US5089390A (en) 1987-09-04 1992-02-18 Syntex (U.S.A.) Inc. 2-methyl-4-hexene- and 2-methyl-4-heptene-1,2-diol derivatives
US5158871A (en) 1988-02-12 1992-10-27 University Of Connecticut Method of using magnetic particles for isolating, collecting and assaying diagnostic ligates
US5147529A (en) 1988-08-10 1992-09-15 E. I. Du Pont De Nemours And Company Method for automatically processing magnetic solid phase reagents
US5185243A (en) 1988-08-25 1993-02-09 Syntex (U.S.A.) Inc. Method for detection of specific nucleic acid sequences
US5151348A (en) 1988-12-23 1992-09-29 E. I. Du Pont De Nemours And Company Enzyme-linked immunoassay for measurement of cyclosporin a levels in whole blood samples
US5135863A (en) 1988-12-23 1992-08-04 Syntex (U.S.A.) Inc. Compositions and methods for determining the presence of amphetamines in a sample suspected of containing amphetamine and/or methamphetamine
US5101015A (en) 1989-04-10 1992-03-31 Abbott Laboratories Reagents for an amphetamine-class fluorescence polarization immunoassay
US5135875A (en) 1990-08-15 1992-08-04 Abbott Laboratories Protein precipitation reagent
DE69121844T2 (de) 1990-11-20 1997-01-23 Behringwerke Ag Immunotest für Cyclosporin
US5128103A (en) 1990-12-14 1992-07-07 E. I. Du Pont De Nemours And Company Apparatus for automatically processing magnetic solid phase reagents
US6777190B1 (en) 1991-04-10 2004-08-17 Biosite, Inc. Crosstalk inhibitors and their uses
US5340716A (en) 1991-06-20 1994-08-23 Snytex (U.S.A.) Inc. Assay method utilizing photoactivated chemiluminescent label
DE69228817T2 (de) 1991-07-26 1999-09-23 Dade Chemistry Systems Inc., Deerfield Signalerkennungspruefung in der anwesenheit von einem suspendierten festen träger
US6455288B1 (en) 1993-04-08 2002-09-24 Dade Behring Marburg Gmbh Homogeneous immunoassays using mutant glucose-6-phosphate dehydrogenases
WO1995006877A1 (en) 1993-09-03 1995-03-09 Behringwerke Ag Fluorescent oxygen channeling immunoassays
US6187547B1 (en) 1993-09-08 2001-02-13 Novartis Ag Assay kit
US5565326A (en) 1994-05-31 1996-10-15 Johnson & Johnson Clinical Diagnostics, Inc. Separation-free specific binding assays using anti-inhibitor antibodies
US6225073B1 (en) 1994-07-07 2001-05-01 Dade Behring Marburg Gmbh Immunoassay for mycophenolic acid
US5650288A (en) 1995-07-14 1997-07-22 Macfarlane; Gordon D. Immunophilin-bound immunosuppressant assay
EP0880705B1 (en) 1996-07-18 2003-06-18 Dade Behring Marburg GmbH Reagents for assays for mycophenolic acid
US6231982B1 (en) 1997-12-10 2001-05-15 Dade Behring Inc. Particle reagents having reduced matrix effects and containing an aldehyde-reactive functional group
AU751938B2 (en) 1998-05-15 2002-08-29 Sekisui Chemical Co., Ltd. Immunoassay reagents and immunoassay method
BR9804648A (pt) 1998-11-23 2000-05-30 Fundacao Oswaldo Cruz Monitorização da obediência do paciente ao tratamento e da biodisponibilidade de drogas pela desproteinização de fluidos corpóreos.
JP4504313B2 (ja) 2003-10-15 2010-07-14 株式会社リバース・プロテオミクス研究所 リガンド特異性の検定方法
US7186518B2 (en) * 2003-11-21 2007-03-06 Dade Behring Inc. Method and composition useful for determining FK 506
US7189582B2 (en) 2005-04-27 2007-03-13 Dade Behring Inc. Compositions and methods for detection of sirolimus
US7575875B2 (en) 2005-10-13 2009-08-18 Abbott Laboratories, Inc. Method of tacrolimus extraction and quantification using aqueous detergents
GB0606998D0 (en) * 2006-04-06 2006-05-17 Oxford Biosensors Ltd Lipoprotein sensor
US7914999B2 (en) 2006-12-29 2011-03-29 Abbott Laboratories Non-denaturing lysis reagent
US8288111B2 (en) * 2007-05-24 2012-10-16 Abbott Laboratories Immunoassays exhibiting reduced cross-reactivity with hydrophobic drug analyte metabolites

Also Published As

Publication number Publication date
WO2009079374A1 (en) 2009-06-25
EP2217926A4 (en) 2011-04-06
US8334104B2 (en) 2012-12-18
US20110136136A1 (en) 2011-06-09
JP2012112971A (ja) 2012-06-14
EP2217926A1 (en) 2010-08-18
JP5571108B2 (ja) 2014-08-13
ES2605247T3 (es) 2017-03-13
US20120064546A1 (en) 2012-03-15
US8071317B2 (en) 2011-12-06
US7910378B2 (en) 2011-03-22
JP2011506973A (ja) 2011-03-03
EP2217926B1 (en) 2016-10-05
US20090155929A1 (en) 2009-06-18

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