JP2008534927A5 - - Google Patents

Info

Publication number

JP2008534927A5

JP2008534927A5 JP2008503065A JP2008503065A JP2008534927A5 JP 2008534927 A5 JP2008534927 A5 JP 2008534927A5 JP 2008503065 A JP2008503065 A JP 2008503065A JP 2008503065 A JP2008503065 A JP 2008503065A JP 2008534927 A5 JP2008534927 A5 JP 2008534927A5

Authority

JP

Japan

Prior art keywords

general formula

antibody

compound

carrier

immunoassay

Prior art date

2006-03-20

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 238000003018 immunoassay Methods 0.000 claims 27
• 150000001875 compounds Chemical class 0.000 claims 22
• 230000002163 immunogen Effects 0.000 claims 14
• 239000003446 ligand Substances 0.000 claims 13
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 7
• 229960003668 docetaxel Drugs 0.000 claims 7
• 239000000203 mixture Substances 0.000 claims 6
• 229920000642 polymer Polymers 0.000 claims 6
• 239000000523 sample Substances 0.000 claims 6
• 229920000768 polyamine Polymers 0.000 claims 5
• 239000003153 chemical reaction reagent Substances 0.000 claims 3
• 150000002148 esters Chemical class 0.000 claims 3
• 125000005647 linker group Chemical group 0.000 claims 3
• 239000007787 solid Substances 0.000 claims 3
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
• 125000000524 functional group Chemical group 0.000 claims 2
• 229910052739 hydrogen Inorganic materials 0.000 claims 2
• 239000001257 hydrogen Substances 0.000 claims 2
• -1 imide ester Chemical class 0.000 claims 2
• 229910052760 oxygen Inorganic materials 0.000 claims 2
• 239000001301 oxygen Substances 0.000 claims 2
• 229910052717 sulfur Inorganic materials 0.000 claims 2
• 239000011593 sulfur Substances 0.000 claims 2
• 241000283973 Oryctolagus cuniculus Species 0.000 claims 1
• 229930012538 Paclitaxel Natural products 0.000 claims 1
• 125000005907 alkyl ester group Chemical group 0.000 claims 1
• 125000002947 alkylene group Chemical group 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 125000004432 carbon atom Chemical group C* 0.000 claims 1
• 238000001514 detection method Methods 0.000 claims 1
• 239000010419 fine particle Substances 0.000 claims 1
• 125000004430 oxygen atom Chemical group O* 0.000 claims 1
• 229960001592 paclitaxel Drugs 0.000 claims 1
• 239000013610 patient sample Substances 0.000 claims 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
• 0 BO[C@](C(C1(C)C)=C(C)CC[C@]1(CC(*OC(C)=O)(C1C(C2)OC1)[C@@]1(C)C2OC)O)C1=O Chemical compound BO[C@](C(C1(C)C)=C(C)CC[C@]1(CC(*OC(C)=O)(C1C(C2)OC1)[C@@]1(C)C2OC)O)C1=O 0.000 description 1
• SSCMXMLNUJOBJC-NFJWQWPMSA-N CC(C)(C)OC(NC([C@H](C(O)=O)O)[IH]c1ccccc1)=O Chemical compound CC(C)(C)OC(NC([C@H](C(O)=O)O)[IH]c1ccccc1)=O SSCMXMLNUJOBJC-NFJWQWPMSA-N 0.000 description 1
• QPJVMBTYPHYUOC-UHFFFAOYSA-N COC(c1ccccc1)=O Chemical compound COC(c1ccccc1)=O QPJVMBTYPHYUOC-UHFFFAOYSA-N 0.000 description 1