JP2014518861A5 - - Google Patents
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- Publication number
- JP2014518861A5 JP2014518861A5 JP2014509868A JP2014509868A JP2014518861A5 JP 2014518861 A5 JP2014518861 A5 JP 2014518861A5 JP 2014509868 A JP2014509868 A JP 2014509868A JP 2014509868 A JP2014509868 A JP 2014509868A JP 2014518861 A5 JP2014518861 A5 JP 2014518861A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- probe
- group
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000523 sample Substances 0.000 claims 35
- 125000000217 alkyl group Chemical group 0.000 claims 30
- 125000003118 aryl group Chemical group 0.000 claims 30
- 239000012636 effector Substances 0.000 claims 23
- 230000008685 targeting Effects 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 10
- 150000001993 dienes Chemical class 0.000 claims 10
- 229910052757 nitrogen Inorganic materials 0.000 claims 7
- 125000006850 spacer group Chemical group 0.000 claims 7
- 229910052799 carbon Inorganic materials 0.000 claims 6
- URYYVOIYTNXXBN-OWOJBTEDSA-N trans-cyclooctene Chemical group C1CCC\C=C\CC1 URYYVOIYTNXXBN-OWOJBTEDSA-N 0.000 claims 6
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 230000008878 coupling Effects 0.000 claims 4
- 238000010168 coupling process Methods 0.000 claims 4
- 238000005859 coupling reaction Methods 0.000 claims 4
- 238000002059 diagnostic imaging Methods 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 3
- 238000005698 Diels-Alder reaction Methods 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical class N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- -1 NR′C where R ′ is H Chemical group 0.000 claims 2
- 150000001721 carbon Chemical class 0.000 claims 2
- 239000012216 imaging agent Substances 0.000 claims 2
- 238000003384 imaging method Methods 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 125000001424 substituent group Chemical group 0.000 claims 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims 1
- 238000002866 fluorescence resonance energy transfer Methods 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 230000003287 optical effect Effects 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 230000005298 paramagnetic effect Effects 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 238000002604 ultrasonography Methods 0.000 claims 1
- 0 *c1nnc(*)nn1 Chemical compound *c1nnc(*)nn1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11165267.3 | 2011-05-09 | ||
| EP11165267A EP2522369A1 (en) | 2011-05-09 | 2011-05-09 | Pretargeting kit, method and agents used therein |
| PCT/IB2012/052260 WO2012153254A1 (en) | 2011-05-09 | 2012-05-07 | Pretargeting kit for imaging or therapy comprising a trans - cyclooctene dienophile and a diene |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518861A JP2014518861A (ja) | 2014-08-07 |
| JP2014518861A5 true JP2014518861A5 (https=) | 2017-03-09 |
| JP6223962B2 JP6223962B2 (ja) | 2017-11-01 |
Family
ID=44484790
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014509868A Active JP6223962B2 (ja) | 2011-05-09 | 2012-05-07 | トランス−シクロオクテンジエノフィル及びジエンを有するイメージング又は治療用プレターゲティングキット |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9913921B2 (https=) |
| EP (2) | EP2522369A1 (https=) |
| JP (1) | JP6223962B2 (https=) |
| CN (1) | CN103648533B (https=) |
| AU (1) | AU2012252024B2 (https=) |
| CA (1) | CA2835298C (https=) |
| WO (1) | WO2012153254A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2836338C (en) * | 2011-05-16 | 2022-05-03 | Koninklijke Philips N.V. | Tetrazine derivatives used in bio-orthogonal drug activation |
| US20150359913A1 (en) * | 2013-01-25 | 2015-12-17 | Memorial Sloan-Kettering Cancer Center | Tetrazines/trans-cyclooctenes in solid phase synthesis of labeled peptides |
| ES2966631T3 (es) | 2013-06-19 | 2024-04-23 | Univ California | Estructuras químicas para el suministro localizado de agentes terapéuticos |
| CA2939265A1 (en) * | 2014-02-10 | 2015-08-13 | Mcmaster University | Targeted molecular imaging contrast agents |
| CN106659796B (zh) | 2014-03-14 | 2021-04-30 | 加利福尼亚大学董事会 | Tco缀合物和治疗剂递送方法 |
| US20170119892A1 (en) * | 2014-04-04 | 2017-05-04 | President And Fellows Of Harvard College | Refillable drug delivery devices and methods of use thereof |
| WO2016025480A1 (en) | 2014-08-11 | 2016-02-18 | The General Hospital Corporation | Cyclooctenes for bioorthogonol reactions |
| WO2016164565A1 (en) * | 2015-04-08 | 2016-10-13 | University Of Delaware | Trans-cycloheptenes and hetero-trans-cycloheptenes for bioorthogonal coupling |
| US11135309B2 (en) | 2015-08-14 | 2021-10-05 | The Regents Of The University Of California | Poly(vinyl alcohol) nanocarriers |
| WO2017044983A1 (en) * | 2015-09-10 | 2017-03-16 | Shasqi, Inc. | Bioorthogonal compositions |
| US11690825B2 (en) | 2016-03-09 | 2023-07-04 | Board Of Regents, The University Of Texas System | 20-HETE receptor (GPR75) antagonists and methods of use |
| WO2018004338A1 (en) | 2016-06-27 | 2018-01-04 | Tagworks Pharmaceuticals B.V. | Cleavable tetrazine used in bio-orthogonal drug activation |
| AU2018250312C1 (en) | 2017-04-07 | 2024-08-22 | Tambo, Inc. | Bioorthogonal compositions |
| US11560384B2 (en) | 2017-05-04 | 2023-01-24 | University Of Utah Research Foundation | Benzonorbornadiene derivatives and reactions thereof |
| CN107746367B (zh) * | 2017-11-07 | 2020-05-26 | 清华大学 | β-石竹烯衍生物及其制备方法与应用 |
| WO2019227490A1 (en) | 2018-06-01 | 2019-12-05 | Tayu Huaxia Biotech Medical Group Co., Ltd. | Compositions and methods for imaging |
| EP3826673A4 (en) * | 2018-07-26 | 2022-03-09 | Tayu Huaxia Biotech Medical Group Co., Ltd. | COMPOSITIONS AND METHODS FOR IMAGING |
| CR20210175A (es) | 2018-09-18 | 2021-06-01 | Nikang Therapeutics Inc | Derivados de anillo tricíclico condensado como inhibidores de la fosfatasa de homología a src 2 (shp2) |
| SG11202103393XA (en) * | 2018-10-10 | 2021-04-29 | Tambo Inc | Processes for preparing functionalized cyclooctenes |
| AU2020295308B2 (en) | 2019-06-17 | 2024-07-04 | Tagworks Pharmaceuticals B.V. | Agents for cleaving labels from biomolecules in vivo |
| CN110954514B (zh) * | 2019-12-02 | 2022-06-21 | 上海交通大学 | 适用于研究脂质体体内外分布的荧光示踪系统和方法 |
| CN116056765A (zh) | 2020-08-07 | 2023-05-02 | 坦伯公司 | 反式环辛烯生物正交剂及在癌症和免疫疗法中的用途 |
| WO2022038183A1 (en) | 2020-08-18 | 2022-02-24 | Rigshospitalet | Extracorporeal clearing traps based on inverse electron demand diels-alder cycloaddition for (pre)-targeted therapy and diagnostics |
| KR20230173150A (ko) | 2021-04-20 | 2023-12-26 | 테라파워, 엘엘씨 | Ac-225 생성용 티타니아 기반 발생기 |
| US20250135011A1 (en) * | 2021-12-08 | 2025-05-01 | European Molecular Biology Laboratory | Hydrophilic tetrazine-functionalized payloads for preparation of targeting conjugates |
| CN121127267A (zh) * | 2023-02-15 | 2025-12-12 | 泰克沃尔科斯制药有限公司 | 具有改进性质的四嗪 |
| CN118546131B (zh) * | 2024-05-10 | 2025-02-28 | 四川大学华西医院 | 四嗪聚集诱导发光探针前体、探针及其制备方法、应用 |
| CN119746111A (zh) * | 2024-12-04 | 2025-04-04 | 苏州大学 | 一种体内放射性标记降低肝脏辐射剂量的试剂及其应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3143578A (en) * | 1962-12-28 | 1964-08-04 | Union Carbide Corp | Preparation of tricyclo [8.2.1.02.9] trideca-5, 11-diene |
| US4741900A (en) | 1982-11-16 | 1988-05-03 | Cytogen Corporation | Antibody-metal ion complexes |
| US5326856A (en) | 1992-04-09 | 1994-07-05 | Cytogen Corporation | Bifunctional isothiocyanate derived thiocarbonyls as ligands for metal binding |
| US20030129191A1 (en) | 1992-12-23 | 2003-07-10 | Neorx Corporation | Pretargeting methods and compounds |
| ATE391713T1 (de) * | 2001-12-05 | 2008-04-15 | California Inst Of Techn | Enantioseletive umwandlung von alpha,beta- ungesättigten ketonen unter verwendung chiraler organischer katalysatoren |
| US8236949B2 (en) * | 2007-07-17 | 2012-08-07 | University Of Delaware | Tetrazine-based bio-orthogonal coupling reagents and methods |
| US8900549B2 (en) | 2008-10-31 | 2014-12-02 | The General Hospital Corporation | Compositions and methods for delivering a substance to a biological target |
| RU2011146362A (ru) | 2009-04-16 | 2013-05-27 | Конинклейке Филипс Электроникс Н.В. | Набор для предварительного таргетинга, способ и средства, используемые в нем |
| CN102395380B (zh) * | 2009-04-16 | 2015-05-20 | 皇家飞利浦电子股份有限公司 | 预靶向试剂盒、方法和其中使用的试剂 |
| EP2360167A1 (en) * | 2010-02-03 | 2011-08-24 | Deutsches Krebsforschungszentrum | Post-synthetic modification of nucleic acids by inverse Diels-Alder reaction |
| US10434197B2 (en) * | 2010-07-23 | 2019-10-08 | University Of Delaware | Tetrazine-trans-cyclooctene ligation for the rapid construction of radionuclide labeled probes |
| US9463256B2 (en) * | 2010-10-14 | 2016-10-11 | Koninklijke Philips N.V. | Pretargeting kit, method and agents used therein |
-
2011
- 2011-05-09 EP EP11165267A patent/EP2522369A1/en not_active Withdrawn
-
2012
- 2012-05-07 CN CN201280034134.4A patent/CN103648533B/zh not_active Expired - Fee Related
- 2012-05-07 JP JP2014509868A patent/JP6223962B2/ja active Active
- 2012-05-07 WO PCT/IB2012/052260 patent/WO2012153254A1/en not_active Ceased
- 2012-05-07 US US14/115,455 patent/US9913921B2/en active Active
- 2012-05-07 EP EP12724725.2A patent/EP2707035B1/en active Active
- 2012-05-07 CA CA2835298A patent/CA2835298C/en active Active
- 2012-05-07 AU AU2012252024A patent/AU2012252024B2/en active Active
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