JP2014518552A5 - - Google Patents
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- Publication number
- JP2014518552A5 JP2014518552A5 JP2014505586A JP2014505586A JP2014518552A5 JP 2014518552 A5 JP2014518552 A5 JP 2014518552A5 JP 2014505586 A JP2014505586 A JP 2014505586A JP 2014505586 A JP2014505586 A JP 2014505586A JP 2014518552 A5 JP2014518552 A5 JP 2014518552A5
- Authority
- JP
- Japan
- Prior art keywords
- phenoxy
- ethyl
- methylsulfonyl
- fluoro
- disorder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 14
- OYFWJMHZQZMCIM-UHFFFAOYSA-N n-phenoxyethanamine Chemical class CCNOC1=CC=CC=C1 OYFWJMHZQZMCIM-UHFFFAOYSA-N 0.000 claims 12
- 150000001204 N-oxides Chemical class 0.000 claims 11
- 239000000203 mixture Substances 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 208000035475 disorder Diseases 0.000 claims 8
- -1 2 -cyclopropyl Chemical group 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 208000012661 Dyskinesia Diseases 0.000 claims 5
- 201000000980 schizophrenia Diseases 0.000 claims 5
- WTDRDQBEARUVNC-LURJTMIESA-N L-DOPA Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-LURJTMIESA-N 0.000 claims 4
- WTDRDQBEARUVNC-UHFFFAOYSA-N L-Dopa Natural products OC(=O)C(N)CC1=CC=C(O)C(O)=C1 WTDRDQBEARUVNC-UHFFFAOYSA-N 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- 208000024827 Alzheimer disease Diseases 0.000 claims 3
- 206010012289 Dementia Diseases 0.000 claims 3
- 208000023105 Huntington disease Diseases 0.000 claims 3
- 208000028017 Psychotic disease Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 2
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
- 208000020925 Bipolar disease Diseases 0.000 claims 2
- 208000014094 Dystonic disease Diseases 0.000 claims 2
- 208000030814 Eating disease Diseases 0.000 claims 2
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 2
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 2
- 208000018737 Parkinson disease Diseases 0.000 claims 2
- 206010034010 Parkinsonism Diseases 0.000 claims 2
- 206010043118 Tardive Dyskinesia Diseases 0.000 claims 2
- 208000000323 Tourette Syndrome Diseases 0.000 claims 2
- 208000016620 Tourette disease Diseases 0.000 claims 2
- 208000029560 autism spectrum disease Diseases 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
- 235000014632 disordered eating Nutrition 0.000 claims 2
- 208000010118 dystonia Diseases 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 239000001257 hydrogen Substances 0.000 claims 2
- BHCSEBZPESSXOJ-UHFFFAOYSA-N n-[2-(3-fluoro-5-methylsulfonylphenoxy)ethyl]butan-1-amine Chemical compound CCCCNCCOC1=CC(F)=CC(S(C)(=O)=O)=C1 BHCSEBZPESSXOJ-UHFFFAOYSA-N 0.000 claims 2
- OSBPYFBXSLJHCR-UHFFFAOYSA-N n-[2-(3-fluoro-5-methylsulfonylphenoxy)ethyl]propan-1-amine Chemical compound CCCNCCOC1=CC(F)=CC(S(C)(=O)=O)=C1 OSBPYFBXSLJHCR-UHFFFAOYSA-N 0.000 claims 2
- BQEQVMXYMOVUTM-UHFFFAOYSA-N n-ethyl-2-(3-fluoro-5-methylsulfonylphenoxy)ethanamine Chemical compound CCNCCOC1=CC(F)=CC(S(C)(=O)=O)=C1 BQEQVMXYMOVUTM-UHFFFAOYSA-N 0.000 claims 2
- 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
- XBIWYCHIWQDRHO-UHFFFAOYSA-N 1-(3-fluoro-5-methylsulfonylphenoxy)-n-propylpropan-2-amine Chemical compound CCCNC(C)COC1=CC(F)=CC(S(C)(=O)=O)=C1 XBIWYCHIWQDRHO-UHFFFAOYSA-N 0.000 claims 1
- ULYYLRLQSVQDKI-UHFFFAOYSA-N 1-[2-(3-fluoro-5-methylsulfonylphenoxy)ethyl]azetidine Chemical compound CS(=O)(=O)C1=CC(F)=CC(OCCN2CCC2)=C1 ULYYLRLQSVQDKI-UHFFFAOYSA-N 0.000 claims 1
- QPJKPHFTNUZUON-UHFFFAOYSA-N 1-[2-(3-fluoro-5-methylsulfonylphenoxy)ethyl]piperidine Chemical compound CS(=O)(=O)C1=CC(F)=CC(OCCN2CCCCC2)=C1 QPJKPHFTNUZUON-UHFFFAOYSA-N 0.000 claims 1
- DLKVQLABRDFMNP-UHFFFAOYSA-N 2-(3-fluoro-5-methylsulfonylphenoxy)-n-propylpropan-1-amine Chemical compound CCCNCC(C)OC1=CC(F)=CC(S(C)(=O)=O)=C1 DLKVQLABRDFMNP-UHFFFAOYSA-N 0.000 claims 1
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 206010020852 Hypertonia Diseases 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 208000019022 Mood disease Diseases 0.000 claims 1
- 208000016285 Movement disease Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 208000005793 Restless legs syndrome Diseases 0.000 claims 1
- 206010044565 Tremor Diseases 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 206010008129 cerebral palsy Diseases 0.000 claims 1
- HFXKQSZZZPGLKQ-UHFFFAOYSA-N cyclopentamine Chemical compound CNC(C)CC1CCCC1 HFXKQSZZZPGLKQ-UHFFFAOYSA-N 0.000 claims 1
- 229960003263 cyclopentamine Drugs 0.000 claims 1
- 230000010249 dopaminergic function Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000002545 drug psychosis Diseases 0.000 claims 1
- 208000035474 group of disease Diseases 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- RFWUHUYECRPDDQ-UHFFFAOYSA-N n,n-diethyl-2-(3-fluoro-5-methylsulfonylphenoxy)ethanamine Chemical compound CCN(CC)CCOC1=CC(F)=CC(S(C)(=O)=O)=C1 RFWUHUYECRPDDQ-UHFFFAOYSA-N 0.000 claims 1
- BHOCMEYROOUQKX-UHFFFAOYSA-N n-(cyclopropylmethyl)-2-(3-fluoro-5-methylsulfonylphenoxy)ethanamine Chemical compound CS(=O)(=O)C1=CC(F)=CC(OCCNCC2CC2)=C1 BHOCMEYROOUQKX-UHFFFAOYSA-N 0.000 claims 1
- DUYQHEGMZVGKEE-UHFFFAOYSA-N n-[2-(3-chloro-5-methylsulfonylphenoxy)ethyl]propan-1-amine Chemical compound CCCNCCOC1=CC(Cl)=CC(S(C)(=O)=O)=C1 DUYQHEGMZVGKEE-UHFFFAOYSA-N 0.000 claims 1
- AWBCNMJTPXEZIZ-UHFFFAOYSA-N n-[2-(3-fluoro-5-methylsulfonylphenoxy)ethyl]-2-methylbutan-2-amine Chemical compound CCC(C)(C)NCCOC1=CC(F)=CC(S(C)(=O)=O)=C1 AWBCNMJTPXEZIZ-UHFFFAOYSA-N 0.000 claims 1
- SRCFIFBVUFTTSZ-UHFFFAOYSA-N n-[2-(3-fluoro-5-methylsulfonylphenoxy)ethyl]-2-methylpropan-1-amine Chemical compound CC(C)CNCCOC1=CC(F)=CC(S(C)(=O)=O)=C1 SRCFIFBVUFTTSZ-UHFFFAOYSA-N 0.000 claims 1
- XZOYYKQMPMTMBE-UHFFFAOYSA-N n-[2-(3-fluoro-5-methylsulfonylphenoxy)ethyl]-n-methylpropan-1-amine Chemical compound CCCN(C)CCOC1=CC(F)=CC(S(C)(=O)=O)=C1 XZOYYKQMPMTMBE-UHFFFAOYSA-N 0.000 claims 1
- LDGSLDGDBLBRDR-UHFFFAOYSA-N n-[2-(3-fluoro-5-methylsulfonylphenoxy)ethyl]butan-2-amine Chemical compound CCC(C)NCCOC1=CC(F)=CC(S(C)(=O)=O)=C1 LDGSLDGDBLBRDR-UHFFFAOYSA-N 0.000 claims 1
- ODFVMTOLMMHTSY-UHFFFAOYSA-N n-[2-(3-fluoro-5-methylsulfonylphenoxy)ethyl]propan-2-amine Chemical compound CC(C)NCCOC1=CC(F)=CC(S(C)(=O)=O)=C1 ODFVMTOLMMHTSY-UHFFFAOYSA-N 0.000 claims 1
- 201000003631 narcolepsy Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000012201 sexual and gender identity disease Diseases 0.000 claims 1
- 208000015891 sexual disease Diseases 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161476810P | 2011-04-19 | 2011-04-19 | |
| US61/476,810 | 2011-04-19 | ||
| DKPA201170187 | 2011-04-19 | ||
| DKPA201170187 | 2011-04-19 | ||
| DKPA201170495 | 2011-09-06 | ||
| DKPA201170495 | 2011-09-06 | ||
| PCT/EP2012/056959 WO2012143337A1 (en) | 2011-04-19 | 2012-04-17 | Novel modulators of cortical dopaminergic- and nmda-receptor-mediated glutamatergic neurotransmission |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518552A JP2014518552A (ja) | 2014-07-31 |
| JP2014518552A5 true JP2014518552A5 (enExample) | 2015-04-16 |
| JP5876140B2 JP5876140B2 (ja) | 2016-03-02 |
Family
ID=47041067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014505586A Active JP5876140B2 (ja) | 2011-04-19 | 2012-04-17 | 皮質のドーパミン作動性及びｎｍｄａ受容体介在のグルタミン酸作動性神経伝達の新規なモジュレータ |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US9006227B2 (enExample) |
| EP (1) | EP2699543B1 (enExample) |
| JP (1) | JP5876140B2 (enExample) |
| KR (1) | KR101964406B1 (enExample) |
| CN (1) | CN103476746B (enExample) |
| AU (1) | AU2012244867C1 (enExample) |
| CA (1) | CA2832874C (enExample) |
| DK (1) | DK2699543T3 (enExample) |
| ES (1) | ES2566634T3 (enExample) |
| IL (1) | IL228705A (enExample) |
| MX (1) | MX341847B (enExample) |
| PL (1) | PL2699543T3 (enExample) |
| RU (1) | RU2593500C2 (enExample) |
| SG (1) | SG193992A1 (enExample) |
| WO (1) | WO2012143337A1 (enExample) |
| ZA (1) | ZA201307227B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6789681B2 (ja) * | 2016-06-10 | 2020-11-25 | スリーエム イノベイティブ プロパティズ カンパニー | グラフィックフィルム、ライセンスプレート、及びグラフィックフィルムの製造方法 |
| US12275694B2 (en) * | 2019-05-24 | 2025-04-15 | Irl 790 Ab | Pharmaceutically acceptable salts of [2-(3-fluoro-5-methane-sulfonylphenoxy)ethyl](propyl)amine and uses thereof |
| US20230147129A1 (en) | 2020-03-27 | 2023-05-11 | Som Innovation Biotech, S.A. | Compounds for use in the treatment of synucleinopathies |
| JP2023548429A (ja) | 2020-11-10 | 2023-11-16 | インテグレイティブ・リサーチ・ラボラトリーズ・スウェーデン・アーベー | パーキンソン病、特にｌ－ｄｏｐａ誘発性ジスキネジアのための医薬品に対する感作の予防または軽減における使用のための［２－（３－フルオロ－５－メタンスルホニルフェノキシ）エチル］（プロピル）アミン（メスドペタム） |
| WO2024042540A1 (en) * | 2022-08-24 | 2024-02-29 | Alkem Laboratories Limited | Mesdopetam compositions |
| CA3268423A1 (en) | 2022-09-21 | 2024-03-28 | Assia Chemical Industries Ltd. | Solid state forms of mesdopetam and salts thereof |
| GB202312055D0 (en) | 2023-08-07 | 2023-09-20 | Ipsen Biopharm Ltd | Pharmaceutical compositions |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS51123821A (en) | 1975-04-18 | 1976-10-28 | Nippon Kayaku Co Ltd | An algicide and protective agent |
| IL87181A (en) * | 1987-08-07 | 1993-08-18 | Sanofi Sa | Aminoalkoxyphenyl derivatives, their preparation and pharmaceutical and veterinary compositions containing them |
| GB8823405D0 (en) * | 1988-10-05 | 1988-11-09 | Erba Carlo Spa | Aryloxy-arythio-heteraryloxy-heteroarylthio-alkenylene derivatives of amines |
| ES2169102T3 (es) * | 1994-10-14 | 2002-07-01 | Merck Patent Gmbh | (r)-(-)-2-(5-(4-fluorfenil)-3-piridilmetilaminometil)-cromano como agente activo sobre el sistema nervioso central. |
| DOP2001000189A (es) * | 2000-06-30 | 2002-03-30 | Pfizer Prod Inc | Benzofenonas y sulfonas como inhibidores de la captación de glicina |
| GB0428235D0 (en) * | 2004-12-23 | 2005-01-26 | Glaxo Group Ltd | Novel compounds |
| JP2006193494A (ja) | 2005-01-17 | 2006-07-27 | Dainippon Ink & Chem Inc | ４級アンモニウム系化合物を有効成分とする心臓疾患治療剤 |
| WO2007063789A1 (ja) * | 2005-11-29 | 2007-06-07 | Kissei Pharmaceutical Co., Ltd. | 新規なカテコール誘導体、それを含有する医薬組成物およびそれらの用途 |
| WO2007072041A1 (en) * | 2005-12-23 | 2007-06-28 | Astex Therapeutics Limited | Therapeutic compounds |
| AU2007218086A1 (en) * | 2006-02-15 | 2007-08-30 | M's Science Corporation | Piperazine derivatives |
| WO2009133110A1 (en) | 2008-04-29 | 2009-11-05 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Modulators of dopamine neurotransmission |
| JP2011519839A (ja) | 2008-04-29 | 2011-07-14 | エヌエスエイビー、フィリアル アヴ ノイロサーチ スウェーデン エービー、スヴェーリエ | ドーパミン神経伝達のモジュレーター |
| MX2010011724A (es) | 2008-04-29 | 2010-11-30 | Nsab Af Neurosearch Sweden Ab | Moduladores de neurotransmision de dopamina. |
-
2012
- 2012-04-17 US US14/112,080 patent/US9006227B2/en active Active
- 2012-04-17 PL PL12714704.9T patent/PL2699543T3/pl unknown
- 2012-04-17 SG SG2013072871A patent/SG193992A1/en unknown
- 2012-04-17 MX MX2013012025A patent/MX341847B/es active IP Right Grant
- 2012-04-17 AU AU2012244867A patent/AU2012244867C1/en active Active
- 2012-04-17 DK DK12714704.9T patent/DK2699543T3/en active
- 2012-04-17 ES ES12714704.9T patent/ES2566634T3/es active Active
- 2012-04-17 RU RU2013147917/04A patent/RU2593500C2/ru active
- 2012-04-17 WO PCT/EP2012/056959 patent/WO2012143337A1/en not_active Ceased
- 2012-04-17 EP EP12714704.9A patent/EP2699543B1/en active Active
- 2012-04-17 CA CA2832874A patent/CA2832874C/en active Active
- 2012-04-17 JP JP2014505586A patent/JP5876140B2/ja active Active
- 2012-04-17 CN CN201280019006.2A patent/CN103476746B/zh active Active
- 2012-04-17 KR KR1020137030198A patent/KR101964406B1/ko active Active
-
2013
- 2013-10-03 ZA ZA2013/07227A patent/ZA201307227B/en unknown
- 2013-10-03 IL IL228705A patent/IL228705A/en active IP Right Grant
-
2015
- 2015-01-23 US US14/603,661 patent/US9120728B2/en active Active
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