JP2014518232A - ソラフェニブを含有する眼科用局所医薬組成物 - Google Patents
ソラフェニブを含有する眼科用局所医薬組成物 Download PDFInfo
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- JP2014518232A JP2014518232A JP2014517657A JP2014517657A JP2014518232A JP 2014518232 A JP2014518232 A JP 2014518232A JP 2014517657 A JP2014517657 A JP 2014517657A JP 2014517657 A JP2014517657 A JP 2014517657A JP 2014518232 A JP2014518232 A JP 2014518232A
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- pharmaceutically acceptable
- eye
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- sorafenib
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/255—Esters, e.g. nitroglycerine, selenocyanates of sulfoxy acids or sulfur analogues thereof
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
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| EP11171715.3 | 2011-06-28 | ||
| EP11171715 | 2011-06-28 | ||
| EP12161989.4 | 2012-03-29 | ||
| EP12161989 | 2012-03-29 | ||
| PCT/EP2012/062354 WO2013000909A1 (en) | 2011-06-28 | 2012-06-26 | Topical ophthalmological pharmaceutical composition containing sorafenib |
Publications (2)
| Publication Number | Publication Date |
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| JP2014518232A true JP2014518232A (ja) | 2014-07-28 |
| JP2014518232A5 JP2014518232A5 (enExample) | 2014-09-04 |
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| JP2014517657A Ceased JP2014518232A (ja) | 2011-06-28 | 2012-06-26 | ソラフェニブを含有する眼科用局所医薬組成物 |
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| Country | Link |
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| US (1) | US20140235678A1 (enExample) |
| EP (1) | EP2726057A1 (enExample) |
| JP (1) | JP2014518232A (enExample) |
| CN (1) | CN103764118A (enExample) |
| CA (1) | CA2840491A1 (enExample) |
| WO (1) | WO2013000909A1 (enExample) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017530989A (ja) * | 2014-10-09 | 2017-10-19 | ディストレット テクノロジーコ シシリア ミクロ エ ナノ システミ エス．シー．エー．アール．エル． | 眼疾患を治療するためのシリビニンおよび他の有効成分を送達するためのナノ構造製剤 |
| JP2019516769A (ja) * | 2016-05-25 | 2019-06-20 | 参天製薬株式会社 | 持続性浮腫を伴う滲出性加齢黄斑変性の処置のためのシロリムスの使用 |
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| AU2005289100B2 (en) | 2004-09-29 | 2011-11-03 | Bayer Healthcare Llc | Thermodynamically stable form of bay 43-9006 tosylate |
| DE602006017188D1 (de) | 2005-03-07 | 2010-11-11 | Bayer Schering Pharma Ag | Pharmazeutische zusammensetzung mit einem omega-carboxyaryl-substituierten diphenylharnstoff zur behandlung von krebs |
| AR081060A1 (es) | 2010-04-15 | 2012-06-06 | Bayer Schering Pharma Ag | Procedimiento para preparar 4-{4-[({[4-cloro-3-(trifluorometil)fenil]amino}carbonil)amino]-3-fluorofenoxi}-n-metilpiridin-2-carboxamida |
| US9206423B2 (en) * | 2012-12-30 | 2015-12-08 | The Regents Of The University Of California | Methods of modulating compliance of the trabecular meshwork |
| US8901144B2 (en) | 2013-02-07 | 2014-12-02 | Scifluor Life Sciences, Llc | Fluorinated 3-(2-oxo-3-(3-arylpropyl)imidazolidin-1-yl)-3-arylpropanoic acid derivatives |
| EP3266782B1 (en) | 2013-02-07 | 2019-10-30 | SciFluor Life Sciences, Inc. | Fluorinated integrin antagonists |
| US11136625B2 (en) | 2013-08-28 | 2021-10-05 | Crown Bioscience, Inc. (Taicang) | Gene expression signatures predictive of subject response to a multi-kinase inhibitor and methods of using the same |
| EP3925959A1 (en) | 2015-02-19 | 2021-12-22 | OcuTerra Therapeutics, Inc. | Fluorinated derivatives of 3-(2-oxo-3-(3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl)imidazolidin-1-yl)propanoic acid and uses thereof |
| ES2584534B1 (es) * | 2015-03-27 | 2017-03-13 | Retinset, S.L. | Formulación tópica oftálmica de bosentan |
| US20160324836A1 (en) * | 2015-05-05 | 2016-11-10 | pSivida US.Inc. | Injectable depot formulations |
| CN108135737B (zh) | 2015-06-06 | 2021-11-05 | 拨云生物医药科技(广州)有限公司 | 用于治疗翼状胬肉的组合物和方法 |
| TWI664965B (zh) | 2015-06-22 | 2019-07-11 | 新源生物科技股份有限公司 | 酪胺酸激酶抑制劑之眼用調配物、其使用方法、及其製備方法 |
| BR112018074450A2 (pt) | 2016-06-02 | 2019-03-19 | Cloudbreak Therapeutics, Llc | composições e métodos para a utilização de nintedanib para melhorar o sucesso da cirurgia do glaucoma |
| ES3074517T3 (en) | 2019-12-17 | 2026-07-21 | Merck Sharp & Dohme Llc | 4-(3,4-dihydroisoquinolin-2(1h)-yl)-3-hydroxypiperidine derivatives as prmt5 inhibitors for the treatment of cancer and sickle cell disease |
| CN114288242B (zh) * | 2022-01-14 | 2023-05-23 | 中国药科大学 | 一种索拉非尼纳米混悬滴眼液及其制备方法 |
| AU2025217596A1 (en) | 2024-02-05 | 2026-08-13 | Sun Pharmaceutical Industries Limited | Ophthalmic compositions of tyrosine kinase inhibitors and their uses |
| CN117982434A (zh) * | 2024-02-22 | 2024-05-07 | 中国药科大学 | 一种治疗湿性年龄相关性黄斑病变的对甲苯磺酸索拉非尼聚乳酸微球 |
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| AU2005289100B2 (en) | 2004-09-29 | 2011-11-03 | Bayer Healthcare Llc | Thermodynamically stable form of bay 43-9006 tosylate |
| SI1885336T1 (sl) | 2005-05-10 | 2009-08-31 | Alcon Inc | Suspenzijske formulacije, ki obsegajo aktivno sestavino, poloksamerni ali meroksapolni surfaktant in glikol, in njihova uporaba za pripravo zdravila za zdravljenje oftalmičnih motenj |
| WO2006133411A1 (en) | 2005-06-08 | 2006-12-14 | Targegen, Inc. | Methods and compositions for the treatment of ocular disorders |
| EP1968594B1 (en) | 2005-11-29 | 2010-09-29 | GlaxoSmithKline LLC | Treatment of ocular neovascular disorders such as macular degeneration, angiod streaks, uveitis and macular edema |
| JP2009519266A (ja) * | 2005-12-15 | 2009-05-14 | バイエル・ヘルスケア・アクチェンゲゼルシャフト | 炎症性の皮膚、眼および／または耳疾患を処置するためのジアリールウレア類 |
| WO2007076358A1 (en) | 2005-12-23 | 2007-07-05 | Alcon, Inc. | PHARMACEUTICAL FORMULATION FOR DELIVERY OF RECEPTOR TYROSINE KINASE INHIBITING (RTKi) COMPOUNDS TO THE EYE |
| WO2008027341A2 (en) | 2006-08-30 | 2008-03-06 | Merck & Co., Inc. | Topical ophthalmic formulations |
| JP2012525415A (ja) | 2009-05-01 | 2012-10-22 | オプソテツク・コーポレイシヨン | 眼科疾患を処置または予防するための方法 |
| JP2012533562A (ja) | 2009-07-16 | 2012-12-27 | グラクソ ウェルカム マニュファクチュアリング ピーティーイー リミテッド | 治療法 |
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- 2012-06-26 CA CA2840491A patent/CA2840491A1/en not_active Abandoned
- 2012-06-26 US US14/129,557 patent/US20140235678A1/en not_active Abandoned
- 2012-06-26 JP JP2014517657A patent/JP2014518232A/ja not_active Ceased
- 2012-06-26 CN CN201280031848.XA patent/CN103764118A/zh active Pending
- 2012-06-26 WO PCT/EP2012/062354 patent/WO2013000909A1/en not_active Ceased
- 2012-06-26 EP EP12730512.6A patent/EP2726057A1/en not_active Withdrawn
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| WO2010015672A1 (en) * | 2008-08-08 | 2010-02-11 | S.I.F.I. Societa' Industria Farmaceutica Italiana S.P.A. | Ophthalmic pharmaceutical compositions comprising sorafenib for the treatment of neoangiogenic pathologies of the eye |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017530989A (ja) * | 2014-10-09 | 2017-10-19 | ディストレット テクノロジーコ シシリア ミクロ エ ナノ システミ エス．シー．エー．アール．エル． | 眼疾患を治療するためのシリビニンおよび他の有効成分を送達するためのナノ構造製剤 |
| US11253526B2 (en) | 2014-10-09 | 2022-02-22 | Distretto Tecnologico Sicilia Micro E Nano Sistemi S.C.A.R.L. | Nanostructured formulations for the delivery of silibinin and other active ingredients for treating ocular diseases |
| US11266659B2 (en) | 2014-10-09 | 2022-03-08 | Distretto Tecnologico Sicilia Micro E Nano Sistemi S.C.A.R.L. | Nanostructured formulations for the delivery of silibinin and other active ingredients for treating ocular diseases |
| US11633356B2 (en) | 2014-10-09 | 2023-04-25 | Distretto Tecnologico Sicilia Micro E Nano Sistemi S.C.A.R.L. | Nanostructured formulations for the delivery of silibinin and other active ingredients for treating ocular diseases |
| JP2019516769A (ja) * | 2016-05-25 | 2019-06-20 | 参天製薬株式会社 | 持続性浮腫を伴う滲出性加齢黄斑変性の処置のためのシロリムスの使用 |
| US11400080B2 (en) | 2016-05-25 | 2022-08-02 | Santen Pharmaceutical Co., Ltd. | Use of sirolimus to treat exudative age-related macular degeneration with persistent edema |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103764118A (zh) | 2014-04-30 |
| WO2013000909A1 (en) | 2013-01-03 |
| CA2840491A1 (en) | 2013-01-03 |
| US20140235678A1 (en) | 2014-08-21 |
| EP2726057A1 (en) | 2014-05-07 |
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