JP2014518063A5 - - Google Patents
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- Publication number
- JP2014518063A5 JP2014518063A5 JP2014513625A JP2014513625A JP2014518063A5 JP 2014518063 A5 JP2014518063 A5 JP 2014518063A5 JP 2014513625 A JP2014513625 A JP 2014513625A JP 2014513625 A JP2014513625 A JP 2014513625A JP 2014518063 A5 JP2014518063 A5 JP 2014518063A5
- Authority
- JP
- Japan
- Prior art keywords
- crosslinker
- peptide
- modified
- igf
- lysosomal enzyme
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161490957P | 2011-05-27 | 2011-05-27 | |
| US61/490,957 | 2011-05-27 | ||
| PCT/US2012/039705 WO2012166653A2 (en) | 2011-05-27 | 2012-05-25 | Methods for coupling targeting peptides onto recombinant lysosomal enzymes for improved treatments of lysosomal storage diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017133655A Division JP2017225444A (ja) | 2011-05-27 | 2017-07-07 | リソソーム蓄積症の改善された治療のための組換えリソソーム酵素にターゲティングペプチドをカップリングするための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014518063A JP2014518063A (ja) | 2014-07-28 |
| JP2014518063A5 true JP2014518063A5 (https=) | 2018-02-15 |
| JP6300720B2 JP6300720B2 (ja) | 2018-03-28 |
Family
ID=47260229
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014513625A Active JP6300720B2 (ja) | 2011-05-27 | 2012-05-25 | リソソーム蓄積症の改善された治療のための組換えリソソーム酵素にターゲティングペプチドをカップリングするための方法 |
| JP2017133655A Pending JP2017225444A (ja) | 2011-05-27 | 2017-07-07 | リソソーム蓄積症の改善された治療のための組換えリソソーム酵素にターゲティングペプチドをカップリングするための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017133655A Pending JP2017225444A (ja) | 2011-05-27 | 2017-07-07 | リソソーム蓄積症の改善された治療のための組換えリソソーム酵素にターゲティングペプチドをカップリングするための方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US9545450B2 (https=) |
| EP (1) | EP2714752B1 (https=) |
| JP (2) | JP6300720B2 (https=) |
| KR (2) | KR101955054B1 (https=) |
| CN (2) | CN104160033B (https=) |
| BR (1) | BR112013030432A2 (https=) |
| CA (1) | CA2836318C (https=) |
| CY (1) | CY1120485T1 (https=) |
| DK (1) | DK2714752T3 (https=) |
| ES (1) | ES2660185T3 (https=) |
| HR (1) | HRP20180291T1 (https=) |
| HU (1) | HUE038172T2 (https=) |
| LT (1) | LT2714752T (https=) |
| NO (1) | NO2820016T3 (https=) |
| PL (1) | PL2714752T3 (https=) |
| PT (1) | PT2714752T (https=) |
| RS (1) | RS56913B1 (https=) |
| SI (1) | SI2714752T1 (https=) |
| SM (1) | SMT201800101T1 (https=) |
| TR (1) | TR201802230T4 (https=) |
| WO (1) | WO2012166653A2 (https=) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9925303B2 (en) | 2012-11-13 | 2018-03-27 | Edwards Lifesciences Corporation | Methods for cross-linking bioprosthetic tissue using bio-orthogonal binding pairs |
| CN105189742A (zh) * | 2013-03-15 | 2015-12-23 | 阿米库斯治疗学公司 | 化学交联剂 |
| JP6800752B2 (ja) * | 2014-04-04 | 2020-12-16 | ベスタロン コーポレイション | 人工的に活性化したペプチド |
| US10722559B2 (en) * | 2014-08-11 | 2020-07-28 | Shire Human Genetic Therapies, Inc. | Mannose-6-phosphate bearing peptides fused to lysosomal enzymes |
| WO2016054231A1 (en) * | 2014-09-30 | 2016-04-07 | Amicus Therapeutics, Inc. | Highly potent acid alpha-glucosidase with enhanced carbohydrates |
| CN104356238B (zh) * | 2014-10-15 | 2018-01-09 | 大连理工大学 | 一种重组蛋白a亲和配基的定点固定化方法 |
| KR102322182B1 (ko) * | 2015-03-11 | 2021-11-08 | 오웬스 코닝 인텔렉츄얼 캐피탈 엘엘씨 | 섬유성 재료로 머플러들을 충전하기 위한 방법들 및 시스템들 |
| AU2016349528A1 (en) | 2015-11-06 | 2018-05-17 | Biomarin Pharmaceutical Inc. | Cell-based assays for detection of antibodies or other factors that neutralize uptake of lysosomal enzymes |
| AU2016365834B2 (en) * | 2015-12-08 | 2023-09-28 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for internalizing enzymes |
| FI3635009T3 (fi) | 2017-06-07 | 2026-04-07 | Regeneron Pharma | Koostumuksia ja menetelmiä entsyymien internalisoimiseksi |
| BR112019026434A2 (pt) | 2017-06-14 | 2020-07-14 | Virometix Ag | peptídeos cíclicos para proteção contra vírus sincicial respiratório |
| AU2018345303B2 (en) | 2017-10-02 | 2025-09-18 | Denali Therapeutics Inc. | Fusion proteins comprising enzyme replacement therapy enzymes |
| JP7779653B2 (ja) | 2018-02-07 | 2025-12-03 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 治療用タンパク質送達のための方法および組成物 |
| WO2019173638A1 (en) * | 2018-03-08 | 2019-09-12 | California Institute Of Technology | Sample multiplexing for single-cell rna sequencing |
| KR20210005154A (ko) | 2018-04-30 | 2021-01-13 | 아미쿠스 세라퓨틱스, 인코포레이티드 | 유전자 요법 작제물 및 사용 방법 |
| EP3793591A1 (en) | 2018-05-17 | 2021-03-24 | Regeneron Pharmaceuticals, Inc. | Anti-cd63 antibodies, conjugates, and uses thereof |
| AR116624A1 (es) | 2018-10-10 | 2021-05-26 | Amicus Therapeutics Inc | Composiciones de polipéptidos estabilizados por enlaces disulfuro y métodos de uso |
| JP7703446B2 (ja) * | 2018-11-28 | 2025-07-07 | プロメガ コーポレイション | 反応性ペプチド標識付け |
| CN113301925A (zh) | 2018-12-19 | 2021-08-24 | 小利兰·斯坦福大学理事会 | 用于溶酶体靶向的双官能分子以及相关的组合物和方法 |
| EP3897708A1 (en) | 2018-12-20 | 2021-10-27 | Virometix AG | Lipopeptide building blocks and synthetic virus-like particles |
| CN114127275A (zh) * | 2019-04-30 | 2022-03-01 | 宾夕法尼亚州大学信托人 | 可用于治疗庞贝病的组合物 |
| CN110373405B (zh) * | 2019-07-24 | 2023-12-15 | 杭州恩和生物科技有限公司 | 一种接枝聚合物的生物酶及其制备方法和固定方法 |
| CN115087458A (zh) * | 2019-10-10 | 2022-09-20 | 阿米库斯治疗学公司 | 变体igf2构建体 |
| WO2022063990A1 (en) | 2020-09-28 | 2022-03-31 | Dbv Technologies | Particle comprising an rsv-f protein for use in rsv vaccination |
| TW202237850A (zh) | 2020-12-01 | 2022-10-01 | 賓州大學委員會 | 具有組織特異性靶向基序的新穎構成物及含有其之組成物 |
| AR125406A1 (es) | 2021-04-23 | 2023-07-12 | Univ Pennsylvania | Nuevas composiciones con motivos selectivos para el cerebro y composiciones que las contienen |
| US20240279360A1 (en) | 2021-06-23 | 2024-08-22 | Lycia Therapeutics, Inc. | Bifunctional compounds containing igf-2 polypeptides |
| AU2022310356A1 (en) | 2021-07-14 | 2024-01-25 | Lycia Therapeutics, Inc. | Asgpr cell surface receptor binding compounds and conjugates |
| WO2024130070A2 (en) | 2022-12-17 | 2024-06-20 | The Trustees Of The University Of Pennsylvania | Recombinant aav capsids with cardiac- and skeletal muscle- specific targeting motifs and uses thereof |
| KR20250135916A (ko) | 2022-12-17 | 2025-09-15 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | 심장 및 골격근 특이적 표적화 모티프를 갖는 재조합 aav 돌연변이체 벡터 및 이를 포함하는 조성물 |
| AR133098A1 (es) | 2023-06-29 | 2025-08-27 | Univ Pennsylvania | Aav mutante con motivos dirigidos al sistema nervioso central y composiciones que lo contienen |
| KR20260040241A (ko) | 2023-07-12 | 2026-03-24 | 비로메틱스 아게 | 폐렴구균 항원의 조성물 |
| WO2025106661A1 (en) | 2023-11-14 | 2025-05-22 | The Trustees Of The University Of Pennsylvania | Compositions with cardiac and skeletal musclespecific targeting motifs and uses thereof |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1118334A1 (en) | 2000-01-11 | 2001-07-25 | Aventis Behring Gesellschaft mit beschränkter Haftung | Method for the production of conjugates and uses thereof for the prevention and treatment of allergic reactions and autoimmune diseases |
| US7560424B2 (en) * | 2001-04-30 | 2009-07-14 | Zystor Therapeutics, Inc. | Targeted therapeutic proteins |
| US20030072761A1 (en) | 2001-10-16 | 2003-04-17 | Lebowitz Jonathan | Methods and compositions for targeting proteins across the blood brain barrier |
| US7355018B2 (en) | 2003-09-30 | 2008-04-08 | Regeneron Pharmaceuticals, Inc. | Modified IGF1 polypeptides with increased stability and potency |
| HRP20170698T1 (hr) * | 2008-05-07 | 2017-09-22 | Biomarin Pharmaceutical Inc. | Lizosomski usmjereni peptidi i njihove uporabe |
| EP3912643B8 (en) * | 2009-02-13 | 2023-08-23 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
-
2012
- 2012-05-25 LT LTEP12793015.4T patent/LT2714752T/lt unknown
- 2012-05-25 SM SM20180101T patent/SMT201800101T1/it unknown
- 2012-05-25 PL PL12793015T patent/PL2714752T3/pl unknown
- 2012-05-25 EP EP12793015.4A patent/EP2714752B1/en active Active
- 2012-05-25 SI SI201231229T patent/SI2714752T1/en unknown
- 2012-05-25 KR KR1020137034111A patent/KR101955054B1/ko not_active Expired - Fee Related
- 2012-05-25 US US14/122,858 patent/US9545450B2/en active Active
- 2012-05-25 BR BR112013030432A patent/BR112013030432A2/pt not_active Application Discontinuation
- 2012-05-25 PT PT127930154T patent/PT2714752T/pt unknown
- 2012-05-25 HR HRP20180291TT patent/HRP20180291T1/hr unknown
- 2012-05-25 TR TR2018/02230T patent/TR201802230T4/tr unknown
- 2012-05-25 ES ES12793015.4T patent/ES2660185T3/es active Active
- 2012-05-25 DK DK12793015.4T patent/DK2714752T3/en active
- 2012-05-25 CN CN201280037051.0A patent/CN104160033B/zh active Active
- 2012-05-25 CA CA2836318A patent/CA2836318C/en active Active
- 2012-05-25 WO PCT/US2012/039705 patent/WO2012166653A2/en not_active Ceased
- 2012-05-25 KR KR1020197005833A patent/KR20190022943A/ko not_active Ceased
- 2012-05-25 JP JP2014513625A patent/JP6300720B2/ja active Active
- 2012-05-25 CN CN201810440498.1A patent/CN108586621A/zh not_active Withdrawn
- 2012-05-25 HU HUE12793015A patent/HUE038172T2/hu unknown
- 2012-05-25 RS RS20180188A patent/RS56913B1/sr unknown
-
2013
- 2013-02-25 NO NO13708603A patent/NO2820016T3/no unknown
-
2016
- 2016-11-09 US US15/347,006 patent/US10660972B2/en active Active
-
2017
- 2017-07-07 JP JP2017133655A patent/JP2017225444A/ja active Pending
-
2018
- 2018-02-22 CY CY20181100212T patent/CY1120485T1/el unknown
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