JP2014512006A5 - - Google Patents
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- Publication number
- JP2014512006A5 JP2014512006A5 JP2014503276A JP2014503276A JP2014512006A5 JP 2014512006 A5 JP2014512006 A5 JP 2014512006A5 JP 2014503276 A JP2014503276 A JP 2014503276A JP 2014503276 A JP2014503276 A JP 2014503276A JP 2014512006 A5 JP2014512006 A5 JP 2014512006A5
- Authority
- JP
- Japan
- Prior art keywords
- cell
- measuring
- metabolic activity
- acidification profile
- volatile soluble
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 claims 28
- 210000004027 cell Anatomy 0.000 claims 22
- 230000020477 pH reduction Effects 0.000 claims 22
- 230000002503 metabolic effect Effects 0.000 claims 19
- 239000002207 metabolite Substances 0.000 claims 16
- 239000000523 sample Substances 0.000 claims 10
- 201000010099 disease Diseases 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 210000002865 immune cell Anatomy 0.000 claims 7
- 230000001717 pathogenic effect Effects 0.000 claims 7
- 230000036962 time dependent Effects 0.000 claims 6
- 230000028327 secretion Effects 0.000 claims 5
- 239000012472 biological sample Substances 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims 4
- 230000004936 stimulating effect Effects 0.000 claims 4
- 210000004698 lymphocyte Anatomy 0.000 claims 3
- 238000005259 measurement Methods 0.000 claims 3
- 239000008177 pharmaceutical agent Substances 0.000 claims 3
- 235000014655 lactic acid Nutrition 0.000 claims 2
- 239000004310 lactic acid Substances 0.000 claims 2
- 210000000265 leukocyte Anatomy 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 231100000252 nontoxic Toxicity 0.000 claims 1
- 230000003000 nontoxic effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161472213P | 2011-04-06 | 2011-04-06 | |
| US61/472,213 | 2011-04-06 | ||
| PCT/IL2012/050125 WO2012137207A1 (en) | 2011-04-06 | 2012-04-04 | Methods of monitoring and analyzing metabolic activity profiles diagnostic and therapeutic uses of same |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014512006A JP2014512006A (ja) | 2014-05-19 |
| JP2014512006A5 true JP2014512006A5 (https=) | 2015-05-14 |
| JP5990254B2 JP5990254B2 (ja) | 2016-09-07 |
Family
ID=46124593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014503276A Active JP5990254B2 (ja) | 2011-04-06 | 2012-04-04 | 代謝活性プロフィルのモニタリング方法および分析方法ならびにそれらの診断使用および治療使用 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US8728758B2 (https=) |
| EP (1) | EP2694962B1 (https=) |
| JP (1) | JP5990254B2 (https=) |
| KR (1) | KR102010600B1 (https=) |
| CN (1) | CN103518133B (https=) |
| AU (1) | AU2012240953B2 (https=) |
| BR (1) | BR112013025782B1 (https=) |
| CA (1) | CA2832031C (https=) |
| DK (1) | DK2694962T3 (https=) |
| ES (1) | ES2627154T3 (https=) |
| WO (1) | WO2012137207A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2832031C (en) | 2011-04-06 | 2019-09-17 | Ramot At Tel-Aviv University Ltd. | Methods of monitoring and analyzing metabolic activity profiles diagnostic and therapeutic uses of same |
| WO2015057713A1 (en) * | 2013-10-14 | 2015-04-23 | Case Western Reserve University | Metabolic analyzer for optimizing health and weight management |
| CN106164286A (zh) | 2013-10-22 | 2016-11-23 | 拉莫特特拉维夫大学有限公司 | 用于检测的方法和系统 |
| ITRM20130700A1 (it) * | 2013-12-19 | 2015-06-20 | Stichting Katholieke Univ | Metodo per il rilevamento di cellule tumorali circolanti |
| CN105303035A (zh) * | 2015-09-29 | 2016-02-03 | 上海新窝信息科技有限公司 | 一种健康监测方法及系统 |
| CA3007606A1 (en) | 2015-12-09 | 2017-06-15 | Ramot At Tel-Aviv University Ltd. | Method and system for sensing |
| JP2019526794A (ja) | 2016-08-22 | 2019-09-19 | ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッドＲａｍｏｔ Ａｔ Ｔｅｌ Ａｖｉｖ Ｕｎｉｖｅｒｓｉｔｙ Ｌｔｄ． | 生物検体の検出のための方法およびシステム |
| KR20190038660A (ko) | 2016-08-22 | 2019-04-08 | 라모트 앳 텔-아비브 유니버시티 리미티드 | 피하 센싱을 위한 방법 및 시스템 |
| US11619634B2 (en) * | 2017-08-21 | 2023-04-04 | Savicell Diagnostic Ltd. | Methods of diagnosing and treating lung cancer |
| CN110491511B (zh) * | 2019-07-24 | 2023-04-07 | 广州知汇云科技有限公司 | 一种基于围术期危险预警的多模型互补增强机器学习方法 |
| IT202000016429A1 (it) * | 2020-07-07 | 2022-01-07 | Univ Degli Studi Udine | Metodo per la valutazione dell’attivita’ metabolica di una cellula non-tumorale |
| WO2022109732A1 (en) * | 2020-11-26 | 2022-06-02 | 12535441 Canada Ltd. | Spectral diagnostic system |
| US20240358835A1 (en) * | 2021-08-17 | 2024-10-31 | Orgenesis Inc. | Tumor infiltrating lymphocytes with increased metabolic activity |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL154600B (nl) | 1971-02-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen. |
| NL154598B (nl) | 1970-11-10 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking. |
| NL154599B (nl) | 1970-12-28 | 1977-09-15 | Organon Nv | Werkwijze voor het aantonen en bepalen van specifiek bindende eiwitten en hun corresponderende bindbare stoffen, alsmede testverpakking. |
| US3901654A (en) | 1971-06-21 | 1975-08-26 | Biological Developments | Receptor assays of biologically active compounds employing biologically specific receptors |
| US3853987A (en) | 1971-09-01 | 1974-12-10 | W Dreyer | Immunological reagent and radioimmuno assay |
| US3867517A (en) | 1971-12-21 | 1975-02-18 | Abbott Lab | Direct radioimmunoassay for antigens and their antibodies |
| NL171930C (nl) | 1972-05-11 | 1983-06-01 | Akzo Nv | Werkwijze voor het aantonen en bepalen van haptenen, alsmede testverpakkingen. |
| US3850578A (en) | 1973-03-12 | 1974-11-26 | H Mcconnell | Process for assaying for biologically active molecules |
| US3935074A (en) | 1973-12-17 | 1976-01-27 | Syva Company | Antibody steric hindrance immunoassay with two antibodies |
| US3996345A (en) | 1974-08-12 | 1976-12-07 | Syva Company | Fluorescence quenching with immunological pairs in immunoassays |
| US4034074A (en) | 1974-09-19 | 1977-07-05 | The Board Of Trustees Of Leland Stanford Junior University | Universal reagent 2-site immunoradiometric assay using labelled anti (IgG) |
| US3984533A (en) | 1975-11-13 | 1976-10-05 | General Electric Company | Electrophoretic method of detecting antigen-antibody reaction |
| US4098876A (en) | 1976-10-26 | 1978-07-04 | Corning Glass Works | Reverse sandwich immunoassay |
| US4879219A (en) | 1980-09-19 | 1989-11-07 | General Hospital Corporation | Immunoassay utilizing monoclonal high affinity IgM antibodies |
| US5011771A (en) | 1984-04-12 | 1991-04-30 | The General Hospital Corporation | Multiepitopic immunometric assay |
| US4666828A (en) | 1984-08-15 | 1987-05-19 | The General Hospital Corporation | Test for Huntington's disease |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4801531A (en) | 1985-04-17 | 1989-01-31 | Biotechnology Research Partners, Ltd. | Apo AI/CIII genomic polymorphisms predictive of atherosclerosis |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| US5192659A (en) | 1989-08-25 | 1993-03-09 | Genetype Ag | Intron sequence analysis method for detection of adjacent and remote locus alleles as haplotypes |
| US5281521A (en) | 1992-07-20 | 1994-01-25 | The Trustees Of The University Of Pennsylvania | Modified avidin-biotin technique |
| US7713733B2 (en) * | 2001-08-06 | 2010-05-11 | Vanderbilt University | Device and methods for detecting the response of a plurality of cells to at least one analyte of interest |
| JP4625946B2 (ja) * | 2004-11-02 | 2011-02-02 | 国立大学法人 岡山大学 | ｐＨ測定装置及びｐＨ測定方法 |
| EP1736780A1 (en) | 2005-06-24 | 2006-12-27 | Eppendorf Array Technologies S.A. | Method and means for detecting and/or quantifying hierarchical molecular change of a cell in response to an external stimulus |
| WO2008018905A2 (en) * | 2006-01-17 | 2008-02-14 | Cellumen, Inc. | Method for predicting biological systems responses |
| CA2641954C (en) | 2006-03-06 | 2016-04-26 | Zetiq Technologies Ltd. | Methods and compositions for identifying a cell phenotype |
| WO2011000572A1 (de) | 2009-07-02 | 2011-01-06 | Patenthandel Portfoliofonds I Gmbh & Co. Kg | Verfahren und vorrichtung zum nachweis von biologischen langzeiteffekten in zellen |
| WO2011031803A1 (en) * | 2009-09-08 | 2011-03-17 | Nodality, Inc. | Analysis of cell networks |
| CA2832031C (en) | 2011-04-06 | 2019-09-17 | Ramot At Tel-Aviv University Ltd. | Methods of monitoring and analyzing metabolic activity profiles diagnostic and therapeutic uses of same |
-
2012
- 2012-04-04 CA CA2832031A patent/CA2832031C/en active Active
- 2012-04-04 AU AU2012240953A patent/AU2012240953B2/en active Active
- 2012-04-04 JP JP2014503276A patent/JP5990254B2/ja active Active
- 2012-04-04 CN CN201280022396.9A patent/CN103518133B/zh active Active
- 2012-04-04 WO PCT/IL2012/050125 patent/WO2012137207A1/en not_active Ceased
- 2012-04-04 KR KR1020137027588A patent/KR102010600B1/ko active Active
- 2012-04-04 BR BR112013025782-2A patent/BR112013025782B1/pt active IP Right Grant
- 2012-04-04 EP EP12721945.9A patent/EP2694962B1/en active Active
- 2012-04-04 ES ES12721945.9T patent/ES2627154T3/es active Active
- 2012-04-04 DK DK12721945.9T patent/DK2694962T3/en active
- 2012-04-04 US US13/817,543 patent/US8728758B2/en active Active
-
2014
- 2014-05-18 US US14/280,612 patent/US9784731B2/en active Active
-
2017
- 2017-10-04 US US15/724,299 patent/US20180038849A1/en not_active Abandoned
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