JP2015511721A5 - - Google Patents
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- Publication number
- JP2015511721A5 JP2015511721A5 JP2015502555A JP2015502555A JP2015511721A5 JP 2015511721 A5 JP2015511721 A5 JP 2015511721A5 JP 2015502555 A JP2015502555 A JP 2015502555A JP 2015502555 A JP2015502555 A JP 2015502555A JP 2015511721 A5 JP2015511721 A5 JP 2015511721A5
- Authority
- JP
- Japan
- Prior art keywords
- level
- cells
- blood sample
- cd11b
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 31
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 19
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 19
- 238000000034 method Methods 0.000 claims 17
- 210000001744 T-lymphocyte Anatomy 0.000 claims 14
- 210000004369 blood Anatomy 0.000 claims 12
- 239000008280 blood Substances 0.000 claims 12
- 210000002074 inflammatory monocyte Anatomy 0.000 claims 12
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 10
- 102100022338 Integrin alpha-M Human genes 0.000 claims 10
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 9
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 9
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 9
- 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 claims 8
- 208000024827 Alzheimer disease Diseases 0.000 claims 8
- 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 claims 8
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 3
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 3
- 210000005259 peripheral blood Anatomy 0.000 claims 3
- 239000011886 peripheral blood Substances 0.000 claims 3
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 2
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 2
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 2
- 210000001185 bone marrow Anatomy 0.000 claims 2
- 230000001413 cellular effect Effects 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 102100022749 Aminopeptidase N Human genes 0.000 claims 1
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261615465P | 2012-03-26 | 2012-03-26 | |
| US61/615,465 | 2012-03-26 | ||
| PCT/IL2013/050277 WO2013144957A1 (en) | 2012-03-26 | 2013-03-21 | Cellular markers for diagnosis of alzheimer's disease and for alzheimer's disease progression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015511721A JP2015511721A (ja) | 2015-04-20 |
| JP2015511721A5 true JP2015511721A5 (https=) | 2016-05-12 |
| JP6276252B2 JP6276252B2 (ja) | 2018-02-07 |
Family
ID=49258360
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015502555A Active JP6276252B2 (ja) | 2012-03-26 | 2013-03-21 | アルツハイマー病の診断のための細胞マーカーおよびアルツハイマー病の進行の細胞マーカー |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20150057176A1 (https=) |
| EP (1) | EP2831584B1 (https=) |
| JP (1) | JP6276252B2 (https=) |
| KR (1) | KR20140145173A (https=) |
| CN (1) | CN104471394B (https=) |
| AU (1) | AU2013239070A1 (https=) |
| CA (1) | CA2907909A1 (https=) |
| ES (1) | ES2819174T3 (https=) |
| IL (1) | IL234779A (https=) |
| WO (1) | WO2013144957A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6312302B2 (ja) * | 2014-01-06 | 2018-04-18 | 公益財団法人ヒューマンサイエンス振興財団 | 脳梗塞の診断マーカー |
| CN111201030B (zh) | 2017-07-25 | 2024-11-01 | 真和制药有限公司 | 通过阻断tim-3和其配体的相互作用治疗癌症 |
| JP6499342B2 (ja) * | 2018-03-19 | 2019-04-10 | 隆樹 日和佐 | 脳梗塞の診断マーカー |
| WO2020160156A2 (en) | 2019-01-30 | 2020-08-06 | Immutics, Inc. | Anti-gal3 antibodies and uses thereof |
| US20220170908A1 (en) * | 2019-03-26 | 2022-06-02 | Anton Wyss-Coray | Compositions and methods for characterizing and treating alzheimers disease |
| WO2021072650A1 (zh) * | 2019-10-15 | 2021-04-22 | 湖南乾康科技有限公司 | 中间型单核细胞在制备诊断和预测ad药物中的应用 |
| EP4157338A4 (en) | 2020-05-26 | 2024-11-13 | TrueBinding, Inc. | METHOD FOR TREATING INFLAMMATORY DISEASES BY GALECTIN-3 BLOCKING |
| CN112562867A (zh) * | 2021-02-22 | 2021-03-26 | 天津迈德新医药科技有限公司 | 一种预测极早期hiv感染风险的装置、存储介质和电子装置 |
| CN118103710A (zh) | 2021-08-09 | 2024-05-28 | 安元有限公司 | 用于检测临床前阿兹海默氏病的组合物、试剂盒和方法 |
| EP4426295A1 (en) * | 2021-11-02 | 2024-09-11 | Tranquis Therapeutics, Inc. | Selection and treatment of subjects having a circulating myeloid cell inflammatory phenotype |
| KR102745500B1 (ko) * | 2022-09-02 | 2024-12-23 | 한양대학교 에리카산학협력단 | 혈액 대사체를 이용한 치매 스크리닝 장치 및 방법 |
| CN116270741B (zh) * | 2023-02-28 | 2025-10-24 | 东莞市东南部中心医院 | 骨髓源性抑制细胞在制备治疗阿兹海默症药物或试剂中的应用 |
| CN117122612B (zh) * | 2023-07-07 | 2024-08-27 | 河络新图生物科技(上海)有限公司 | 外周血单个核细胞在制备治疗/预防阿尔茨海默病的药物中的用途 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4328050B2 (ja) * | 2000-01-20 | 2009-09-09 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | 神経保護療法のためのコポリマー１、関連ペプチド及びポリペプチドならびにそれらによって処理されたｔ細胞の使用 |
| US20020137108A1 (en) * | 2000-11-08 | 2002-09-26 | Michael Mullan | CD45 isoform alteration in CD4+ T cells as a potential diagnostic marker in alzheimer's disease |
| US7351686B2 (en) * | 2001-12-06 | 2008-04-01 | Yeda Research And Development Co. Ltd. | Method for neuronal protection in amyotrophic lateral sclerosis by a vaccine comprising Copolymer-1 or Copolymer-1 related peptides |
| CN100591761C (zh) * | 2004-08-19 | 2010-02-24 | 加的夫大学学院咨询有限公司 | 呈递抗原的人γδT细胞的制备和在免疫治疗中的用途 |
| JP5771525B2 (ja) * | 2008-09-18 | 2015-09-02 | セダーズ−シナイ メディカル センター | アルツハイマー病を検出するための光学的方法 |
| WO2011111043A1 (en) | 2010-03-10 | 2011-09-15 | Yeda Research And Development Co. Ltd | Cellular blood markers for early diagnosis of als and for als progression |
-
2013
- 2013-03-21 WO PCT/IL2013/050277 patent/WO2013144957A1/en not_active Ceased
- 2013-03-21 US US14/388,369 patent/US20150057176A1/en not_active Abandoned
- 2013-03-21 EP EP13767635.9A patent/EP2831584B1/en active Active
- 2013-03-21 CN CN201380027520.5A patent/CN104471394B/zh active Active
- 2013-03-21 JP JP2015502555A patent/JP6276252B2/ja active Active
- 2013-03-21 AU AU2013239070A patent/AU2013239070A1/en not_active Abandoned
- 2013-03-21 ES ES13767635T patent/ES2819174T3/es active Active
- 2013-03-21 CA CA2907909A patent/CA2907909A1/en not_active Abandoned
- 2013-03-21 KR KR1020147029916A patent/KR20140145173A/ko not_active Withdrawn
-
2014
- 2014-09-22 IL IL234779A patent/IL234779A/en active IP Right Grant
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