JP2013522589A5 - - Google Patents
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- Publication number
- JP2013522589A5 JP2013522589A5 JP2012556645A JP2012556645A JP2013522589A5 JP 2013522589 A5 JP2013522589 A5 JP 2013522589A5 JP 2012556645 A JP2012556645 A JP 2012556645A JP 2012556645 A JP2012556645 A JP 2012556645A JP 2013522589 A5 JP2013522589 A5 JP 2013522589A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cd11b
- lin
- level
- als
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 34
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 32
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 32
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 24
- 102100022338 Integrin alpha-M Human genes 0.000 claims 24
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 16
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 16
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 15
- 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 claims 12
- 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 claims 12
- 210000001744 T-lymphocyte Anatomy 0.000 claims 11
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 8
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 8
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 8
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 8
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 210000005259 peripheral blood Anatomy 0.000 claims 8
- 239000011886 peripheral blood Substances 0.000 claims 8
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 6
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 6
- 210000001185 bone marrow Anatomy 0.000 claims 6
- 210000004369 blood Anatomy 0.000 claims 5
- 239000008280 blood Substances 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 102100022749 Aminopeptidase N Human genes 0.000 claims 4
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 108010072051 Glatiramer Acetate Proteins 0.000 claims 2
- 102100026236 Interleukin-8 Human genes 0.000 claims 2
- 230000001413 cellular effect Effects 0.000 claims 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
- 210000001616 monocyte Anatomy 0.000 claims 2
- 230000000770 proinflammatory effect Effects 0.000 claims 2
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 claims 2
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 101001055222 Homo sapiens Interleukin-8 Proteins 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- SECKRCOLJRRGGV-UHFFFAOYSA-N Vardenafil Chemical compound CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 SECKRCOLJRRGGV-UHFFFAOYSA-N 0.000 claims 1
- FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 claims 1
- 210000002798 bone marrow cell Anatomy 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 229940038717 copaxone Drugs 0.000 claims 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 1
- 229960005277 gemcitabine Drugs 0.000 claims 1
- 229960003776 glatiramer acetate Drugs 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 229960003310 sildenafil Drugs 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 229960000835 tadalafil Drugs 0.000 claims 1
- IEHKWSGCTWLXFU-IIBYNOLFSA-N tadalafil Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C([C]4C=CC=CC4=N3)C[C@H]3N2C(=O)CN(C3=O)C)=C1 IEHKWSGCTWLXFU-IIBYNOLFSA-N 0.000 claims 1
- 229960002381 vardenafil Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31233510P | 2010-03-10 | 2010-03-10 | |
| US61/312,335 | 2010-03-10 | ||
| PCT/IL2011/000227 WO2011111043A1 (en) | 2010-03-10 | 2011-03-10 | Cellular blood markers for early diagnosis of als and for als progression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013522589A JP2013522589A (ja) | 2013-06-13 |
| JP2013522589A5 true JP2013522589A5 (https=) | 2014-04-24 |
| JP5904953B2 JP5904953B2 (ja) | 2016-04-20 |
Family
ID=43971347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012556645A Expired - Fee Related JP5904953B2 (ja) | 2010-03-10 | 2011-03-10 | Ａｌｓの早期診断およびａｌｓ進行のための細胞性血液マーカー |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20130230499A1 (https=) |
| EP (1) | EP2545381A1 (https=) |
| JP (1) | JP5904953B2 (https=) |
| CA (1) | CA2792471A1 (https=) |
| WO (1) | WO2011111043A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013144957A1 (en) | 2012-03-26 | 2013-10-03 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Cellular markers for diagnosis of alzheimer's disease and for alzheimer's disease progression |
| JP7012384B2 (ja) | 2017-06-27 | 2022-02-14 | ニューラクル サイエンス カンパニー リミテッド | 癌治療のための抗ｆａｍ１９ａ５抗体の用途 |
| AU2019264996A1 (en) * | 2018-05-10 | 2020-11-26 | The Methodist Hospital | Methods for prognosis and management of disease |
| DE102019121344A1 (de) * | 2019-08-07 | 2021-02-11 | ToposNomos Ltd. | Verfahren und Durchflusszytometer zum Untersuchen einer menschlichen oder tierischen Zellprobe sowie Computerprogrammprodukt |
| KR20240042044A (ko) | 2021-08-09 | 2024-04-01 | 뉴로퀘스트 엘티디 | 전임상 알츠하이머병을 검출하기 위한 조성물, 키트 및 방법 |
| EP4426295A1 (en) * | 2021-11-02 | 2024-09-11 | Tranquis Therapeutics, Inc. | Selection and treatment of subjects having a circulating myeloid cell inflammatory phenotype |
| JPWO2025058005A1 (https=) * | 2023-09-15 | 2025-03-20 | ||
| WO2025263405A1 (ja) * | 2024-06-18 | 2025-12-26 | 慶應義塾 | 筋萎縮性側索硬化症における判定、疾患修飾薬治療効果予測および判定、モニタリング、並びに層別化のためのバイオマーカーおよび方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5426028A (en) * | 1991-07-05 | 1995-06-20 | Rush-Presbyterian-St. Lukes Medical Center | Screening method for chronic immune dysfunction syndrome |
| US7410773B2 (en) * | 1995-02-02 | 2008-08-12 | Ghazi Jaswinder Dhoot | Method of preparing an undifferentiated cell |
| PT1248643E (pt) * | 2000-01-20 | 2005-10-31 | Yeda Res & Dev | Utilizacao de copolimero 1 e peptidos e polipeptidos congeneres e de celulas t tratadas co estes compostos para terapia neuroprotectora |
| US20020081635A1 (en) * | 2000-05-11 | 2002-06-27 | Thomas Terry E. | Novel antibody compositions for preparing enriched T cell preparations |
| CA2358061A1 (en) * | 2000-09-08 | 2002-03-08 | Stemcell Technologies Inc. | Novel antibody compositions for the negative selection of specific rat leukocyte subsets |
| US20030077576A1 (en) * | 2001-03-20 | 2003-04-24 | Joann Trial | Use of monoclonal antibodies and functional assays for prediction of risk of opportunistic infection |
| US7030126B2 (en) * | 2001-11-16 | 2006-04-18 | Als Therapy Development Foundation, Inc. | Use of polyamine analogs for amyotrophic lateral sclerosis |
| US7105183B2 (en) * | 2004-02-03 | 2006-09-12 | The Regents Of The University Of California | Chlorite in the treatment of neurodegenerative disease |
| JP5254017B2 (ja) * | 2005-09-12 | 2013-08-07 | カウンシル・オブ・サイエンティフィック・アンド・インダストリアル・リサーチ | ビピリジン化合物「セルロマイシンａ」、その誘導体および類似体の免疫抑制剤としての使用 |
| WO2007136157A1 (en) * | 2006-05-24 | 2007-11-29 | Hee Tae Kim | Compositions and methods for treating motor neuron diseases |
| WO2008036374A2 (en) * | 2006-09-21 | 2008-03-27 | Medistem Laboratories, Inc. | Allogeneic stem cell transplants in non-conditioned recipients |
| EP2073009A1 (en) * | 2007-12-19 | 2009-06-24 | Cell Med Research GMBH | Method for T, NK and NKT cells |
| US10114012B2 (en) * | 2008-10-31 | 2018-10-30 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and assays for detecting and quantifying pure subpopulations of white blood cells in immune system disorders |
| US20120225038A1 (en) * | 2009-01-28 | 2012-09-06 | Istituto Oncologico Veneto | Myeloid-derived suppressor cells generated in vitro |
-
2011
- 2011-03-10 US US13/583,790 patent/US20130230499A1/en not_active Abandoned
- 2011-03-10 WO PCT/IL2011/000227 patent/WO2011111043A1/en not_active Ceased
- 2011-03-10 EP EP11714845A patent/EP2545381A1/en not_active Withdrawn
- 2011-03-10 CA CA2792471A patent/CA2792471A1/en not_active Abandoned
- 2011-03-10 JP JP2012556645A patent/JP5904953B2/ja not_active Expired - Fee Related
-
2015
- 2015-04-02 US US14/677,123 patent/US20150209404A1/en not_active Abandoned
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