JP2013522589A5 - - Google Patents
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- Publication number
- JP2013522589A5 JP2013522589A5 JP2012556645A JP2012556645A JP2013522589A5 JP 2013522589 A5 JP2013522589 A5 JP 2013522589A5 JP 2012556645 A JP2012556645 A JP 2012556645A JP 2012556645 A JP2012556645 A JP 2012556645A JP 2013522589 A5 JP2013522589 A5 JP 2013522589A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- cd11b
- lin
- level
- als
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 34
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 32
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 32
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 24
- 102100022338 Integrin alpha-M Human genes 0.000 claims 24
- 101000934338 Homo sapiens Myeloid cell surface antigen CD33 Proteins 0.000 claims 16
- 102100025243 Myeloid cell surface antigen CD33 Human genes 0.000 claims 16
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 15
- 102100035248 Alpha-(1,3)-fucosyltransferase 4 Human genes 0.000 claims 12
- 101001022185 Homo sapiens Alpha-(1,3)-fucosyltransferase 4 Proteins 0.000 claims 12
- 210000001744 T-lymphocyte Anatomy 0.000 claims 11
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 8
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 8
- 101000917858 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-A Proteins 0.000 claims 8
- 101000917839 Homo sapiens Low affinity immunoglobulin gamma Fc region receptor III-B Proteins 0.000 claims 8
- 102100029185 Low affinity immunoglobulin gamma Fc region receptor III-B Human genes 0.000 claims 8
- 238000000034 method Methods 0.000 claims 8
- 210000005259 peripheral blood Anatomy 0.000 claims 8
- 239000011886 peripheral blood Substances 0.000 claims 8
- 102000006354 HLA-DR Antigens Human genes 0.000 claims 6
- 108010058597 HLA-DR Antigens Proteins 0.000 claims 6
- 210000001185 bone marrow Anatomy 0.000 claims 6
- 210000004369 blood Anatomy 0.000 claims 5
- 239000008280 blood Substances 0.000 claims 5
- 239000003795 chemical substances by application Substances 0.000 claims 5
- 102100022749 Aminopeptidase N Human genes 0.000 claims 4
- 101000757160 Homo sapiens Aminopeptidase N Proteins 0.000 claims 4
- 229940079593 drug Drugs 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 108010072051 Glatiramer Acetate Proteins 0.000 claims 2
- 102100026236 Interleukin-8 Human genes 0.000 claims 2
- 230000001413 cellular effect Effects 0.000 claims 2
- 210000001175 cerebrospinal fluid Anatomy 0.000 claims 2
- 210000001616 monocyte Anatomy 0.000 claims 2
- 230000000770 proinflammatory effect Effects 0.000 claims 2
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 claims 2
- 102000019034 Chemokines Human genes 0.000 claims 1
- 108010012236 Chemokines Proteins 0.000 claims 1
- 101001055222 Homo sapiens Interleukin-8 Proteins 0.000 claims 1
- 108090001007 Interleukin-8 Proteins 0.000 claims 1
- SECKRCOLJRRGGV-UHFFFAOYSA-N Vardenafil Chemical compound CCCC1=NC(C)=C(C(N=2)=O)N1NC=2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(CC)CC1 SECKRCOLJRRGGV-UHFFFAOYSA-N 0.000 claims 1
- FHEAIOHRHQGZPC-KIWGSFCNSA-N acetic acid;(2s)-2-amino-3-(4-hydroxyphenyl)propanoic acid;(2s)-2-aminopentanedioic acid;(2s)-2-aminopropanoic acid;(2s)-2,6-diaminohexanoic acid Chemical compound CC(O)=O.C[C@H](N)C(O)=O.NCCCC[C@H](N)C(O)=O.OC(=O)[C@@H](N)CCC(O)=O.OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 FHEAIOHRHQGZPC-KIWGSFCNSA-N 0.000 claims 1
- 210000002798 bone marrow cell Anatomy 0.000 claims 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 1
- 229940038717 copaxone Drugs 0.000 claims 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 1
- 229960005277 gemcitabine Drugs 0.000 claims 1
- 229960003776 glatiramer acetate Drugs 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 238000005259 measurement Methods 0.000 claims 1
- 229960003310 sildenafil Drugs 0.000 claims 1
- 210000000278 spinal cord Anatomy 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 229960000835 tadalafil Drugs 0.000 claims 1
- IEHKWSGCTWLXFU-IIBYNOLFSA-N tadalafil Chemical compound C1=C2OCOC2=CC([C@@H]2C3=C([C]4C=CC=CC4=N3)C[C@H]3N2C(=O)CN(C3=O)C)=C1 IEHKWSGCTWLXFU-IIBYNOLFSA-N 0.000 claims 1
- 229960002381 vardenafil Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31233510P | 2010-03-10 | 2010-03-10 | |
| US61/312,335 | 2010-03-10 | ||
| PCT/IL2011/000227 WO2011111043A1 (en) | 2010-03-10 | 2011-03-10 | Cellular blood markers for early diagnosis of als and for als progression |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013522589A JP2013522589A (ja) | 2013-06-13 |
| JP2013522589A5 true JP2013522589A5 (https=) | 2014-04-24 |
| JP5904953B2 JP5904953B2 (ja) | 2016-04-20 |
Family
ID=43971347
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012556645A Expired - Fee Related JP5904953B2 (ja) | 2010-03-10 | 2011-03-10 | Ａｌｓの早期診断およびａｌｓ進行のための細胞性血液マーカー |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US20130230499A1 (https=) |
| EP (1) | EP2545381A1 (https=) |
| JP (1) | JP5904953B2 (https=) |
| CA (1) | CA2792471A1 (https=) |
| WO (1) | WO2011111043A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013144957A1 (en) | 2012-03-26 | 2013-10-03 | Yeda Research And Development Co. Ltd. At The Weizmann Institute Of Science | Cellular markers for diagnosis of alzheimer's disease and for alzheimer's disease progression |
| CA3067416A1 (en) | 2017-06-27 | 2019-01-03 | Neuracle Science Co., Ltd. | Use of anti-fam19a5 antibodies for treating cancers |
| AU2019264996A1 (en) * | 2018-05-10 | 2020-11-26 | The Methodist Hospital | Methods for prognosis and management of disease |
| DE102019121344A1 (de) * | 2019-08-07 | 2021-02-11 | ToposNomos Ltd. | Verfahren und Durchflusszytometer zum Untersuchen einer menschlichen oder tierischen Zellprobe sowie Computerprogrammprodukt |
| CN118103710A (zh) | 2021-08-09 | 2024-05-28 | 安元有限公司 | 用于检测临床前阿兹海默氏病的组合物、试剂盒和方法 |
| EP4426295A1 (en) * | 2021-11-02 | 2024-09-11 | Tranquis Therapeutics, Inc. | Selection and treatment of subjects having a circulating myeloid cell inflammatory phenotype |
| WO2025058005A1 (ja) * | 2023-09-15 | 2025-03-20 | 国立大学法人徳島大学 | 筋萎縮性側索硬化症（ａｌｓ）と関連するバイオマーカー |
| WO2025263405A1 (ja) * | 2024-06-18 | 2025-12-26 | 慶應義塾 | 筋萎縮性側索硬化症における判定、疾患修飾薬治療効果予測および判定、モニタリング、並びに層別化のためのバイオマーカーおよび方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5426028A (en) * | 1991-07-05 | 1995-06-20 | Rush-Presbyterian-St. Lukes Medical Center | Screening method for chronic immune dysfunction syndrome |
| US7410773B2 (en) * | 1995-02-02 | 2008-08-12 | Ghazi Jaswinder Dhoot | Method of preparing an undifferentiated cell |
| JP4328050B2 (ja) * | 2000-01-20 | 2009-09-09 | イエダ リサーチ アンド デベロップメント カンパニー リミテッド | 神経保護療法のためのコポリマー１、関連ペプチド及びポリペプチドならびにそれらによって処理されたｔ細胞の使用 |
| US20020081635A1 (en) * | 2000-05-11 | 2002-06-27 | Thomas Terry E. | Novel antibody compositions for preparing enriched T cell preparations |
| US20020155511A1 (en) * | 2000-09-08 | 2002-10-24 | Carolyn Horrocks | Novel antibody compositions for the negative selection of specific rat leukocyte subsets |
| US20030077576A1 (en) * | 2001-03-20 | 2003-04-24 | Joann Trial | Use of monoclonal antibodies and functional assays for prediction of risk of opportunistic infection |
| JP2005510524A (ja) * | 2001-11-16 | 2005-04-21 | アルス・セラピー・デベロツプメント・フアンデーシヨン・インコーポレーテツド | ポリアミン経路の調節による神経変性障害の治療 |
| US7105183B2 (en) * | 2004-02-03 | 2006-09-12 | The Regents Of The University Of California | Chlorite in the treatment of neurodegenerative disease |
| CN101287465B (zh) * | 2005-09-12 | 2012-04-04 | 科学与工业研究会 | 青蓝霉素a用于制备作为免疫抑制剂的药物的用途 |
| WO2007136157A1 (en) * | 2006-05-24 | 2007-11-29 | Hee Tae Kim | Compositions and methods for treating motor neuron diseases |
| WO2008036374A2 (en) * | 2006-09-21 | 2008-03-27 | Medistem Laboratories, Inc. | Allogeneic stem cell transplants in non-conditioned recipients |
| EP2073009A1 (en) * | 2007-12-19 | 2009-06-24 | Cell Med Research GMBH | Method for T, NK and NKT cells |
| US10114012B2 (en) * | 2008-10-31 | 2018-10-30 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and assays for detecting and quantifying pure subpopulations of white blood cells in immune system disorders |
| WO2010086679A1 (en) * | 2009-01-28 | 2010-08-05 | Istituto Oncologico Veneto | Myeloid-derived suppressor cells generated in vitro |
-
2011
- 2011-03-10 WO PCT/IL2011/000227 patent/WO2011111043A1/en not_active Ceased
- 2011-03-10 EP EP11714845A patent/EP2545381A1/en not_active Withdrawn
- 2011-03-10 US US13/583,790 patent/US20130230499A1/en not_active Abandoned
- 2011-03-10 CA CA2792471A patent/CA2792471A1/en not_active Abandoned
- 2011-03-10 JP JP2012556645A patent/JP5904953B2/ja not_active Expired - Fee Related
-
2015
- 2015-04-02 US US14/677,123 patent/US20150209404A1/en not_active Abandoned
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