BR112014018204A8 - Método de diagnóstico de distúrbio de células beta pancreáticas em um indivíduo - Google Patents
Método de diagnóstico de distúrbio de células beta pancreáticas em um indivíduoInfo
- Publication number
- BR112014018204A8 BR112014018204A8 BR112014018204A BR112014018204A BR112014018204A8 BR 112014018204 A8 BR112014018204 A8 BR 112014018204A8 BR 112014018204 A BR112014018204 A BR 112014018204A BR 112014018204 A BR112014018204 A BR 112014018204A BR 112014018204 A8 BR112014018204 A8 BR 112014018204A8
- Authority
- BR
- Brazil
- Prior art keywords
- pancreatic
- beta
- subject
- cell disorder
- cell
- Prior art date
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/473—Quinolines; Isoquinolines ortho- or peri-condensed with carbocyclic ring systems, e.g. acridines, phenanthridines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/185—Nerve growth factor [NGF]; Brain derived neurotrophic factor [BDNF]; Ciliary neurotrophic factor [CNTF]; Glial derived neurotrophic factor [GDNF]; Neurotrophins, e.g. NT-3
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
- G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/507—Pancreatic cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/475—Assays involving growth factors
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
- G01N2500/10—Screening for compounds of potential therapeutic value involving cells
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/04—Endocrine or metabolic disorders
- G01N2800/042—Disorders of carbohydrate metabolism, e.g. diabetes, glucose metabolism
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Urology & Nephrology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Gastroenterology & Hepatology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Food Science & Technology (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Toxicology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
Abstract
MÉTODO DE DIAGNOSTICO DE DISTÚRBIO DE CÉLULAS BETA PANCREÁTICAS EM UM INDIVÍDUO, a invencão providência, em parte, métodos para diagnosticar um disturbio em celulas-(Beta) pancreáticas, prever o risco num sujeito de desenvolver um distúrbio em células-(Beta) pancreáticas, monitorizar a funcão das células-(Beta) pancreáticas ou a massa das células-(Beta) pancreáticas num sujeito em risco de desenvolver um distúrbio nas células-(Beta) pancreáticas, monitorizar a eficiência de um tratamento de um distúrbio nas células-(Beta) pancreáticas de um sujeito, identificar um sujeito tendo um risco aumentado de desenvolver um distúrbio nas células-(Beta) pancreáticas, selecionar um sujeito para tratamento de um distúrbio nas células-(Beta) pancreáticas, selecionar um sujeito para participar num estudo clínico e detectar estresse no retículo endoplasmático de células-(Beta) pancreáticas; estes métodos incluem a determinacão de pelo menos um nivel de fator mesencefálico neurotrópico derivado de astrocitos solúvel (MANF) numa amostra biológica do sujeito; estão também providenciadas composicões farmacêuticas contendo uma proteína MANF solúvel e estojos contendo um anticorpo ou fragmento de anticorpo de ligacão ao antigeno que se liga especificamente a um MANF solúvel.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261590021P | 2012-01-24 | 2012-01-24 | |
PCT/US2013/022768 WO2013112602A1 (en) | 2012-01-24 | 2013-01-23 | Soluble manf in pancreatic beta-cell disorders |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112014018204A2 BR112014018204A2 (pt) | 2017-06-20 |
BR112014018204A8 true BR112014018204A8 (pt) | 2017-07-11 |
Family
ID=48873871
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014018204A BR112014018204A8 (pt) | 2012-01-24 | 2013-01-23 | Método de diagnóstico de distúrbio de células beta pancreáticas em um indivíduo |
Country Status (12)
Country | Link |
---|---|
US (2) | US9891231B2 (pt) |
EP (1) | EP2820424B1 (pt) |
JP (2) | JP2015508155A (pt) |
KR (1) | KR20140121449A (pt) |
CN (1) | CN104204811B (pt) |
AU (1) | AU2013212284A1 (pt) |
BR (1) | BR112014018204A8 (pt) |
CA (1) | CA2861541C (pt) |
EA (1) | EA201491411A1 (pt) |
HK (1) | HK1204364A1 (pt) |
IL (1) | IL233721A0 (pt) |
WO (1) | WO2013112602A1 (pt) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201217296D0 (en) | 2012-09-27 | 2012-11-14 | Alta Innovations Ltd | Method of treatment and/or prevention |
WO2014191630A2 (en) * | 2013-05-28 | 2014-12-04 | Helsingin Yliopisto | Non-human animal model encoding a non-functional manf gene |
US20170252403A1 (en) * | 2014-10-06 | 2017-09-07 | Amarantus Bioscience Holdings, Inc. | Methods and compositions for treating retinal disorders |
CN213525944U (zh) | 2017-09-27 | 2021-06-25 | 株式会社利宝德公司 | 吸收性物品 |
WO2019157388A1 (en) * | 2018-02-09 | 2019-08-15 | City Of Hope | Doc2b as a biomarker for type 1 diabetes |
CN110499330A (zh) * | 2018-05-16 | 2019-11-26 | 上海市同济医院 | 重组腺相关病毒载体及其应用 |
CN113292656B (zh) * | 2020-02-21 | 2022-10-25 | 四川大学华西医院 | 用于防治肥胖的中脑星形胶质细胞源性神经营养因子的融合蛋白 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5994392A (en) * | 1988-02-26 | 1999-11-30 | Neuromedica, Inc. | Antipsychotic prodrugs comprising an antipsychotic agent coupled to an unsaturated fatty acid |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5574010A (en) * | 1994-11-14 | 1996-11-12 | The Regents Of The University Of California | Treatment of pancreatic tumors with peptide YY and analogs thereof |
US5716928A (en) | 1995-06-07 | 1998-02-10 | Avmax, Inc. | Use of essential oils to increase bioavailability of oral pharmaceutical compounds |
US5858401A (en) | 1996-01-22 | 1999-01-12 | Sidmak Laboratories, Inc. | Pharmaceutical composition for cyclosporines |
US6007839A (en) | 1996-02-16 | 1999-12-28 | The Liposome Company, Inc. | Preparation of pharmaceutical compositions containing etherlipid-containing multiple lipid liposomes |
US6630137B1 (en) | 1997-04-28 | 2003-10-07 | Eli Lilly And Company | Activated protein C formulations |
US6063400A (en) | 1997-07-02 | 2000-05-16 | Sdg, Inc. | Targeted liposomal constructs for diagnostic and therapeutic uses |
CA2392490A1 (en) * | 1999-11-24 | 2001-05-31 | Mcs Micro Carrier Systems Gmbh | Polypeptides comprising multimers of nuclear localization signals or of protein transduction domains and their use for transferring molecules into cells |
WO2002074956A2 (en) * | 2001-03-20 | 2002-09-26 | Prescient Neuropharma Inc. | Dopaminergic neuronal survival-promoting factors and uses thereof |
US20080200453A1 (en) * | 2002-07-29 | 2008-08-21 | Cincotta Anthony H | Methods of treating metabolic syndrome using dopamine receptor agonists |
US20040077679A1 (en) * | 2002-07-29 | 2004-04-22 | Cincotta Anthony H. | Therapeutic treatment for the metabolic syndrome and type 2 diabetes |
US9655865B2 (en) * | 2002-07-29 | 2017-05-23 | Veroscience, Llc | Therapeutic treatment for metabolic syndrome, type 2 diabetes, obesity, or prediabetes |
DE10330235A1 (de) | 2003-07-04 | 2005-01-20 | Bayer Healthcare Ag | Neues Eimeria Gen und Protein sowie deren Verwendung |
US20050215558A1 (en) * | 2004-03-25 | 2005-09-29 | Cincotta Anthony H | Methods of identifying responders to dopamine agonist therapy |
US20110212055A1 (en) * | 2008-03-25 | 2011-09-01 | Commissiong John W | Neurodegenerative disorders |
CA2719385A1 (en) | 2008-04-21 | 2009-10-29 | Merck Sharp & Dohme Corp. | Pancreatic beta-cell mass biomarker |
FI20080326A0 (fi) * | 2008-04-30 | 2008-04-30 | Licentia Oy | Neurotroofinen tekijä MANF ja sen käytöt |
ES2332169B1 (es) | 2008-07-24 | 2010-10-25 | Universidad Del Pais Vasco | Empleo de microparticulas que comprenden celulas modificadas geneticamente en el tratamiento de enfermedades neurodegenerativas. |
WO2010072383A1 (en) | 2008-12-22 | 2010-07-01 | 7Roche Diagnostics Gmbh | Armet as a marker for cancer |
WO2011069051A1 (en) * | 2009-12-04 | 2011-06-09 | Caliper Life Sciences, Inc. | Method of using dopamine reuptake inhibitors and their analogs for treating diabetes symptoms and delaying or preventing diabetes-associated pathologic conditions |
AU2010353685B2 (en) | 2010-05-17 | 2014-09-25 | Betta Pharmaceuticals Co., Ltd. | Novel glucagon like peptide analogs, composition, and method of use |
KR101208955B1 (ko) | 2010-06-01 | 2012-12-06 | 주식회사 셀트리온제약 | 피페라진 다이티옥트산염 및 글리메피리드를 포함하는 약제학적 조성물 |
EP2579876A4 (en) * | 2010-06-08 | 2013-11-27 | Veroscience Llc | THERAPEUTIC TREATMENT OF METABOLIC SYNDROME, TYPE 2 DIABETES, OBESITY OR PREDICT |
FI20115870A0 (fi) * | 2011-09-05 | 2011-09-05 | Urmas Arumaee | Neuroprotektiiviset soluihin tunkeutuvat peptidit |
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2013
- 2013-01-23 EP EP13741203.7A patent/EP2820424B1/en active Active
- 2013-01-23 WO PCT/US2013/022768 patent/WO2013112602A1/en active Application Filing
- 2013-01-23 CN CN201380016366.1A patent/CN104204811B/zh not_active Expired - Fee Related
- 2013-01-23 KR KR1020147023270A patent/KR20140121449A/ko not_active Application Discontinuation
- 2013-01-23 JP JP2014554800A patent/JP2015508155A/ja not_active Withdrawn
- 2013-01-23 EA EA201491411A patent/EA201491411A1/ru unknown
- 2013-01-23 US US14/374,190 patent/US9891231B2/en active Active
- 2013-01-23 BR BR112014018204A patent/BR112014018204A8/pt not_active IP Right Cessation
- 2013-01-23 CA CA2861541A patent/CA2861541C/en active Active
- 2013-01-23 AU AU2013212284A patent/AU2013212284A1/en not_active Abandoned
-
2014
- 2014-07-20 IL IL233721A patent/IL233721A0/en unknown
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2015
- 2015-05-25 HK HK15104933.5A patent/HK1204364A1/xx not_active IP Right Cessation
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2017
- 2017-04-25 JP JP2017086473A patent/JP6465923B2/ja not_active Expired - Fee Related
-
2018
- 2018-02-12 US US15/894,714 patent/US10845371B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
BR112014018204A2 (pt) | 2017-06-20 |
US20150198613A1 (en) | 2015-07-16 |
CA2861541C (en) | 2021-11-30 |
IL233721A0 (en) | 2014-09-30 |
CN104204811A (zh) | 2014-12-10 |
WO2013112602A1 (en) | 2013-08-01 |
JP2015508155A (ja) | 2015-03-16 |
KR20140121449A (ko) | 2014-10-15 |
JP2017186342A (ja) | 2017-10-12 |
CA2861541A1 (en) | 2013-08-01 |
EA201491411A1 (ru) | 2014-12-30 |
CN104204811B (zh) | 2017-02-22 |
US20180321255A1 (en) | 2018-11-08 |
HK1204364A1 (en) | 2015-11-13 |
JP6465923B2 (ja) | 2019-02-06 |
EP2820424B1 (en) | 2016-12-07 |
EP2820424A4 (en) | 2015-10-21 |
EP2820424A1 (en) | 2015-01-07 |
AU2013212284A1 (en) | 2014-08-14 |
US9891231B2 (en) | 2018-02-13 |
US10845371B2 (en) | 2020-11-24 |
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