EA201491411A1 - Растворимый manf при поражениях бета-клеток поджелудочной железы - Google Patents

Растворимый manf при поражениях бета-клеток поджелудочной железы

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Publication number
EA201491411A1
EA201491411A1 EA201491411A EA201491411A EA201491411A1 EA 201491411 A1 EA201491411 A1 EA 201491411A1 EA 201491411 A EA201491411 A EA 201491411A EA 201491411 A EA201491411 A EA 201491411A EA 201491411 A1 EA201491411 A1 EA 201491411A1
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pancreatic
subject
cell
cells
lesion
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EA201491411A
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English (en)
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Фумихико Урано
Кохсуке Канекура
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Юниверсити Оф Массачусетс
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Publication of EA201491411A1 publication Critical patent/EA201491411A1/ru

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Abstract

Изобретение относится, частично, к способам диагностики поражения β-клеток поджелудочной железы, прогнозирования для субъекта риска развития поражения β-клеток поджелудочной железы, мониторинга функции β-клеток поджелудочной железы или массы β-клеток поджелудочной железы у субъекта, имеющего риск развития поражения β-клеток поджелудочной железы, мониторинга эффективности лечения поражения β-клеток поджелудочной железы у субъекта, идентификации субъекта, имеющего повышенный риск развития поражения β-клеток поджелудочной железы, выбор субъекта для лечения поражения β-клеток поджелудочной железы, выбор субъекта для участия в клиническом исследовании и обнаружения стресса эндоплазматического ретикулума в β-клетке поджелудочной железы. Данные способы включают определение по меньшей мере одного уровня растворимого мезенцефалического нейротрофического фактора астроцитов (MANF) в биологическом образце от субъекта. Также предложены фармацевтические композиции, содержащие растворимый белок MANF, и наборы, содержащие антитело или антигенсвязывающий фрагмент антитела, которые специфически связываются с растворимым MANF.
EA201491411A 2012-01-24 2013-01-23 Растворимый manf при поражениях бета-клеток поджелудочной железы EA201491411A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261590021P 2012-01-24 2012-01-24
PCT/US2013/022768 WO2013112602A1 (en) 2012-01-24 2013-01-23 Soluble manf in pancreatic beta-cell disorders

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EA201491411A1 true EA201491411A1 (ru) 2014-12-30

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US (2) US9891231B2 (ru)
EP (1) EP2820424B1 (ru)
JP (2) JP2015508155A (ru)
KR (1) KR20140121449A (ru)
CN (1) CN104204811B (ru)
AU (1) AU2013212284A1 (ru)
BR (1) BR112014018204A8 (ru)
CA (1) CA2861541C (ru)
EA (1) EA201491411A1 (ru)
HK (1) HK1204364A1 (ru)
IL (1) IL233721A0 (ru)
WO (1) WO2013112602A1 (ru)

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US9891231B2 (en) 2018-02-13
WO2013112602A1 (en) 2013-08-01
EP2820424B1 (en) 2016-12-07
EP2820424A4 (en) 2015-10-21
US20150198613A1 (en) 2015-07-16
US20180321255A1 (en) 2018-11-08
JP6465923B2 (ja) 2019-02-06
AU2013212284A1 (en) 2014-08-14
KR20140121449A (ko) 2014-10-15
EP2820424A1 (en) 2015-01-07
CN104204811B (zh) 2017-02-22
IL233721A0 (en) 2014-09-30
CA2861541A1 (en) 2013-08-01
CA2861541C (en) 2021-11-30
CN104204811A (zh) 2014-12-10
US10845371B2 (en) 2020-11-24
JP2017186342A (ja) 2017-10-12
BR112014018204A8 (pt) 2017-07-11
JP2015508155A (ja) 2015-03-16
BR112014018204A2 (ru) 2017-06-20
HK1204364A1 (en) 2015-11-13

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