BR112013025782B1 - Método de medição de uma atividade metabólica (am) de uma célula, método ex-vivo de diagnóstico de uma doença associada a uma atividade metabólica modificada em um indivíduo em necessidade respectiva, método ex-vivo de otimização do tratamento de uma doença, método ex- vivo de monitoramento do tratamento de uma doença em um indivíduo e método ex-vivo de identificação de um agente capaz de alterar uma atividade metabólica das células - Google Patents

Método de medição de uma atividade metabólica (am) de uma célula, método ex-vivo de diagnóstico de uma doença associada a uma atividade metabólica modificada em um indivíduo em necessidade respectiva, método ex-vivo de otimização do tratamento de uma doença, método ex- vivo de monitoramento do tratamento de uma doença em um indivíduo e método ex-vivo de identificação de um agente capaz de alterar uma atividade metabólica das células Download PDF

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BR112013025782B1
BR112013025782B1 BR112013025782-2A BR112013025782A BR112013025782B1 BR 112013025782 B1 BR112013025782 B1 BR 112013025782B1 BR 112013025782 A BR112013025782 A BR 112013025782A BR 112013025782 B1 BR112013025782 B1 BR 112013025782B1
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cell
metabolic activity
disease
cells
cancer
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BR112013025782-2A
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Portuguese (pt)
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BR112013025782A2 (pt
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Reuven Tirosh
Fernando Patolsky
Hagit Peretz-Soroka
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Ramot At Tel-Aviv University Ltd
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5091—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing the pathological state of an organism
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    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5023—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects on expression patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • G01N33/5038—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects involving detection of metabolites per se
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    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/84—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving inorganic compounds or pH
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BR112013025782-2A 2011-04-06 2012-04-04 Método de medição de uma atividade metabólica (am) de uma célula, método ex-vivo de diagnóstico de uma doença associada a uma atividade metabólica modificada em um indivíduo em necessidade respectiva, método ex-vivo de otimização do tratamento de uma doença, método ex- vivo de monitoramento do tratamento de uma doença em um indivíduo e método ex-vivo de identificação de um agente capaz de alterar uma atividade metabólica das células BR112013025782B1 (pt)

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US201161472213P 2011-04-06 2011-04-06
US61/472,213 2011-04-06
PCT/IL2012/050125 WO2012137207A1 (en) 2011-04-06 2012-04-04 Methods of monitoring and analyzing metabolic activity profiles diagnostic and therapeutic uses of same

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BR112013025782A2 BR112013025782A2 (pt) 2016-12-20
BR112013025782B1 true BR112013025782B1 (pt) 2022-09-06

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US (3) US8728758B2 (https=)
EP (1) EP2694962B1 (https=)
JP (1) JP5990254B2 (https=)
KR (1) KR102010600B1 (https=)
CN (1) CN103518133B (https=)
AU (1) AU2012240953B2 (https=)
BR (1) BR112013025782B1 (https=)
CA (1) CA2832031C (https=)
DK (1) DK2694962T3 (https=)
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CN106164286A (zh) 2013-10-22 2016-11-23 拉莫特特拉维夫大学有限公司 用于检测的方法和系统
ITRM20130700A1 (it) * 2013-12-19 2015-06-20 Stichting Katholieke Univ Metodo per il rilevamento di cellule tumorali circolanti
CN105303035A (zh) * 2015-09-29 2016-02-03 上海新窝信息科技有限公司 一种健康监测方法及系统
CA3007606A1 (en) 2015-12-09 2017-06-15 Ramot At Tel-Aviv University Ltd. Method and system for sensing
JP2019526794A (ja) 2016-08-22 2019-09-19 ラモット・アット・テル・アビブ・ユニバーシテイ・リミテッドＲａｍｏｔ Ａｔ Ｔｅｌ Ａｖｉｖ Ｕｎｉｖｅｒｓｉｔｙ Ｌｔｄ． 生物検体の検出のための方法およびシステム
KR20190038660A (ko) 2016-08-22 2019-04-08 라모트 앳 텔-아비브 유니버시티 리미티드 피하 센싱을 위한 방법 및 시스템
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IT202000016429A1 (it) * 2020-07-07 2022-01-07 Univ Degli Studi Udine Metodo per la valutazione dell’attivita’ metabolica di una cellula non-tumorale
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US8728758B2 (en) 2014-05-20
US20180038849A1 (en) 2018-02-08
AU2012240953A1 (en) 2013-10-17
ES2627154T3 (es) 2017-07-26
WO2012137207A1 (en) 2012-10-11
CA2832031A1 (en) 2012-10-11
KR20140024871A (ko) 2014-03-03
US20130224789A1 (en) 2013-08-29
AU2012240953B2 (en) 2017-02-23
CA2832031C (en) 2019-09-17
DK2694962T3 (en) 2017-06-12
KR102010600B1 (ko) 2019-08-13
CN103518133B (zh) 2016-08-17
JP2014512006A (ja) 2014-05-19
US9784731B2 (en) 2017-10-10
CN103518133A (zh) 2014-01-15
EP2694962A1 (en) 2014-02-12
JP5990254B2 (ja) 2016-09-07
BR112013025782A2 (pt) 2016-12-20
US20140255972A1 (en) 2014-09-11
EP2694962B1 (en) 2017-03-01

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