JP2014511704A5 - - Google Patents
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- JP2014511704A5 JP2014511704A5 JP2014504317A JP2014504317A JP2014511704A5 JP 2014511704 A5 JP2014511704 A5 JP 2014511704A5 JP 2014504317 A JP2014504317 A JP 2014504317A JP 2014504317 A JP2014504317 A JP 2014504317A JP 2014511704 A5 JP2014511704 A5 JP 2014511704A5
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- JP
- Japan
- Prior art keywords
- cells
- antigen
- specific
- viral
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000000034 method Methods 0.000 claims 19
- 210000001744 T-lymphocyte Anatomy 0.000 claims 14
- 239000000427 antigen Substances 0.000 claims 10
- 102000036639 antigens Human genes 0.000 claims 10
- 108091007433 antigens Proteins 0.000 claims 10
- 210000004443 dendritic cell Anatomy 0.000 claims 9
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 6
- 208000036142 Viral infection Diseases 0.000 claims 5
- 230000009385 viral infection Effects 0.000 claims 5
- 241000700605 Viruses Species 0.000 claims 4
- 238000012258 culturing Methods 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 210000001616 monocyte Anatomy 0.000 claims 4
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 4
- 101000831496 Homo sapiens Toll-like receptor 3 Proteins 0.000 claims 3
- 102100024324 Toll-like receptor 3 Human genes 0.000 claims 3
- 108010067390 Viral Proteins Proteins 0.000 claims 3
- 230000000735 allogeneic effect Effects 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 210000004698 lymphocyte Anatomy 0.000 claims 3
- 239000000463 material Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 101000669447 Homo sapiens Toll-like receptor 4 Proteins 0.000 claims 2
- 102000008070 Interferon-gamma Human genes 0.000 claims 2
- 108010074328 Interferon-gamma Proteins 0.000 claims 2
- 108090000172 Interleukin-15 Proteins 0.000 claims 2
- 108010002350 Interleukin-2 Proteins 0.000 claims 2
- 108010002586 Interleukin-7 Proteins 0.000 claims 2
- 108091036414 Polyinosinic:polycytidylic acid Proteins 0.000 claims 2
- 229940124614 TLR 8 agonist Drugs 0.000 claims 2
- 102100039360 Toll-like receptor 4 Human genes 0.000 claims 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 2
- 238000004113 cell culture Methods 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 229960003130 interferon gamma Drugs 0.000 claims 2
- 239000002245 particle Substances 0.000 claims 2
- 230000037452 priming Effects 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 230000003612 virological effect Effects 0.000 claims 2
- 108090000672 Annexin A5 Proteins 0.000 claims 1
- 102000004121 Annexin A5 Human genes 0.000 claims 1
- 102100027207 CD27 antigen Human genes 0.000 claims 1
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 1
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 1
- 101000914511 Homo sapiens CD27 antigen Proteins 0.000 claims 1
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 1
- 101000669402 Homo sapiens Toll-like receptor 7 Proteins 0.000 claims 1
- -1 IL-1β Proteins 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 102000003996 Interferon-beta Human genes 0.000 claims 1
- 108090000467 Interferon-beta Proteins 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 102000043129 MHC class I family Human genes 0.000 claims 1
- 108091054437 MHC class I family Proteins 0.000 claims 1
- 102000043131 MHC class II family Human genes 0.000 claims 1
- 108091054438 MHC class II family Proteins 0.000 claims 1
- 206010070834 Sensitisation Diseases 0.000 claims 1
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 1
- 102100039390 Toll-like receptor 7 Human genes 0.000 claims 1
- 230000007416 antiviral immune response Effects 0.000 claims 1
- 230000006907 apoptotic process Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 108020004999 messenger RNA Proteins 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
- 230000008313 sensitization Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229940044616 toll-like receptor 7 agonist Drugs 0.000 claims 1
- 238000001890 transfection Methods 0.000 claims 1
- 229960004854 viral vaccine Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161474892P | 2011-04-13 | 2011-04-13 | |
| US61/474,892 | 2011-04-13 | ||
| PCT/EP2012/056658 WO2012140127A2 (en) | 2011-04-13 | 2012-04-12 | Method for priming of t cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014511704A JP2014511704A (ja) | 2014-05-19 |
| JP2014511704A5 true JP2014511704A5 (https=) | 2015-05-28 |
Family
ID=45953145
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014504317A Withdrawn JP2014511704A (ja) | 2011-04-13 | 2012-04-12 | Ｔ細胞のプライミングのための方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US9492529B2 (https=) |
| EP (1) | EP2696894B1 (https=) |
| JP (1) | JP2014511704A (https=) |
| KR (1) | KR20140043340A (https=) |
| CN (1) | CN103533955A (https=) |
| WO (1) | WO2012140127A2 (https=) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2788474T1 (sl) * | 2012-12-18 | 2016-01-29 | Immunicum Ab | Ko-diferenciacija monocitov iz alogenskih darovalcev |
| EP4282419A1 (en) | 2012-12-20 | 2023-11-29 | Purdue Research Foundation | Chimeric antigen receptor-expressing t cells as anti-cancer therapeutics |
| KR102615825B1 (ko) | 2015-03-11 | 2023-12-21 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | 전위효소 폴리펩타이드 및 이의 용도 |
| CN108289910A (zh) * | 2015-03-26 | 2018-07-17 | 宾夕法尼亚大学理事会 | 在体外人造淋巴结用于治疗和表位作图的t细胞的敏化和扩增 |
| US20180171294A1 (en) * | 2015-03-26 | 2018-06-21 | The Trustees Of The University Of Pennsylvania | In vitro artificial lymph node method for sensitization and expansion of t cells for therapy and epitope mapping |
| KR102873947B1 (ko) * | 2015-05-07 | 2025-10-22 | 베이롤 칼리지 오브 메드신 | 수지상 세포 면역요법 |
| CN113552343A (zh) * | 2015-12-16 | 2021-10-26 | Neogap治疗学公司 | T细胞反应性平台 |
| CN105543170A (zh) * | 2015-12-31 | 2016-05-04 | 中山大学 | 一种可刺激t细胞扩增的组合物 |
| WO2017139065A1 (en) | 2016-02-08 | 2017-08-17 | American Gene Technologies International Inc. | Hiv vaccination and immunotherapy |
| EP3439675A4 (en) | 2016-04-08 | 2019-12-18 | Purdue Research Foundation | METHOD AND COMPOSITIONS FOR CAR-T CELL THERAPY |
| AU2017292582C1 (en) * | 2016-07-08 | 2021-11-11 | American Gene Technologies International Inc. | HIV pre-immunization and immunotherapy |
| US11649288B2 (en) | 2017-02-07 | 2023-05-16 | Seattle Children's Hospital | Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents |
| WO2018160622A1 (en) | 2017-02-28 | 2018-09-07 | Endocyte, Inc. | Compositions and methods for car t cell therapy |
| CN111065400A (zh) * | 2017-10-03 | 2020-04-24 | 公益财团法人东京都医学总合研究所 | 抗流感药物 |
| US11311576B2 (en) | 2018-01-22 | 2022-04-26 | Seattle Children's Hospital | Methods of use for CAR T cells |
| US12312416B2 (en) | 2018-02-06 | 2025-05-27 | Seattle Children's Hospital | Fluorescein-specific cars exhibiting optimal t cell function against FL-PLE labelled tumors |
| AU2019225174B2 (en) | 2018-02-23 | 2025-11-20 | Endocyte, Inc. | Sequencing method for CAR T cell therapy |
| CN109370987A (zh) * | 2018-11-23 | 2019-02-22 | 见多视光(北京)科技有限公司 | 外周血ctl细胞改良的培养方法 |
| KR102234394B1 (ko) * | 2019-03-08 | 2021-03-31 | 신지섭 | 타가면역세포배양방법, 그 방법으로 얻어진 면역세포배양액 및 이를 포함하는 면역세포치료제 |
| WO2020219812A1 (en) | 2019-04-26 | 2020-10-29 | Allogene Therapeutics, Inc. | Methods of manufacturing allogeneic car t cells |
| WO2021006733A1 (en) * | 2019-07-08 | 2021-01-14 | Erasmus University Medical Center Rotterdam | Rapid in vitro t cell exhaustion |
| CN115210252A (zh) | 2020-02-04 | 2022-10-18 | 西雅图儿童医院（Dba西雅图儿童研究所） | 抗二硝基苯酚的嵌合抗原受体 |
| EP4259163A2 (en) * | 2020-12-09 | 2023-10-18 | Tevogen Bio Inc. | Virus specific t-cells and methods of treating and preventing viral infections |
| CN115877017B (zh) * | 2023-03-01 | 2023-05-05 | 首都医科大学附属北京地坛医院 | 预测hiv/aids患者免疫重建的产品和系统 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6821778B1 (en) | 1993-12-01 | 2004-11-23 | The Board Of Trustees Of Leland Stanford Junior University | Methods for using dendritic cells to activate gamma/delta-T cell receptor-positive T cells |
| US5827642A (en) | 1994-08-31 | 1998-10-27 | Fred Hutchinson Cancer Research Center | Rapid expansion method ("REM") for in vitro propagation of T lymphocytes |
| DE69840739D1 (de) | 1997-10-27 | 2009-05-28 | Merix Bioscience Inc | Methode und Zusammensetzung zur Herstellung von reifen dendritischen Zellen |
| EP1814580B1 (en) | 2004-11-24 | 2016-08-10 | Fred Hutchinson Cancer Research Center | Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens |
| EP1712634A1 (en) | 2005-04-13 | 2006-10-18 | Wittycell SAS | Selection of highly efficient antigen presenting cells for regulating immunity and uses thereof |
| US8476419B2 (en) | 2007-09-14 | 2013-07-02 | Vrije Universiteit Brussel | Enhancing the T-cells stimulatory capacity of human antigen presenting cells and their use in vaccination |
| EP2494038B1 (en) | 2009-10-27 | 2019-06-26 | Immunicum AB | Method for proliferation of antigen-specific t cells |
-
2012
- 2012-04-12 JP JP2014504317A patent/JP2014511704A/ja not_active Withdrawn
- 2012-04-12 US US14/110,899 patent/US9492529B2/en not_active Expired - Fee Related
- 2012-04-12 WO PCT/EP2012/056658 patent/WO2012140127A2/en not_active Ceased
- 2012-04-12 EP EP12713992.1A patent/EP2696894B1/en not_active Not-in-force
- 2012-04-12 KR KR1020137029247A patent/KR20140043340A/ko not_active Withdrawn
- 2012-04-12 CN CN201280018223.XA patent/CN103533955A/zh active Pending
-
2016
- 2016-11-14 US US15/350,124 patent/US10000736B2/en active Active
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