JP2014510114A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014510114A5 JP2014510114A5 JP2014502963A JP2014502963A JP2014510114A5 JP 2014510114 A5 JP2014510114 A5 JP 2014510114A5 JP 2014502963 A JP2014502963 A JP 2014502963A JP 2014502963 A JP2014502963 A JP 2014502963A JP 2014510114 A5 JP2014510114 A5 JP 2014510114A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- compound according
- heteroaryl
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 7
- 125000004452 carbocyclyl group Chemical group 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 150000002431 hydrogen Chemical group 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000004404 heteroalkyl group Chemical group 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000000304 alkynyl group Chemical group 0.000 claims 4
- 102000001253 Protein Kinase Human genes 0.000 claims 3
- 239000003112 inhibitor Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 108060006633 protein kinase Proteins 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims 2
- 230000005494 condensation Effects 0.000 claims 2
- 238000009833 condensation Methods 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- -1 1-ii Substances 0.000 claims 1
- REXUYBKPWIPONM-UHFFFAOYSA-N 2-bromoacetonitrile Chemical compound BrCC#N REXUYBKPWIPONM-UHFFFAOYSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 102000038012 SFKs Human genes 0.000 claims 1
- 108091008118 SFKs Proteins 0.000 claims 1
- 102000000551 Syk Kinase Human genes 0.000 claims 1
- 108010016672 Syk Kinase Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000002152 alkylating effect Effects 0.000 claims 1
- 229960002685 biotin Drugs 0.000 claims 1
- 235000020958 biotin Nutrition 0.000 claims 1
- 239000011616 biotin Substances 0.000 claims 1
- 239000013522 chelant Substances 0.000 claims 1
- 239000002872 contrast media Substances 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 230000005298 paramagnetic effect Effects 0.000 claims 1
- 230000002285 radioactive effect Effects 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 0 *C(*CC1=O)C1C#N Chemical compound *C(*CC1=O)C1C#N 0.000 description 3
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161471322P | 2011-04-04 | 2011-04-04 | |
| US61/471,322 | 2011-04-04 | ||
| CA2760174A CA2760174A1 (en) | 2011-12-01 | 2011-12-01 | Protein kinase inhibitors and uses thereof |
| CA2,760,174 | 2011-12-01 | ||
| PCT/CA2012/000333 WO2012135944A1 (en) | 2011-04-04 | 2012-04-03 | Protein kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014510114A JP2014510114A (ja) | 2014-04-24 |
| JP2014510114A5 true JP2014510114A5 (enExample) | 2015-05-21 |
| JP6001053B2 JP6001053B2 (ja) | 2016-10-05 |
Family
ID=46968500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014502963A Expired - Fee Related JP6001053B2 (ja) | 2011-04-04 | 2012-04-03 | タンパク質キナーゼ阻害剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US9624239B2 (enExample) |
| EP (1) | EP2694517A4 (enExample) |
| JP (1) | JP6001053B2 (enExample) |
| CA (2) | CA2760174A1 (enExample) |
| WO (1) | WO2012135944A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2831843A1 (en) * | 2011-04-04 | 2012-10-11 | Pharmascience Inc. | Protein kinase inhibitors |
| SI2989106T1 (sl) | 2013-04-25 | 2017-07-31 | Beigene, Ltd. | Zlite heterociklične spojine kot inhibitorji beljakovinske kinaze |
| LT3702373T (lt) | 2013-09-13 | 2022-11-10 | Beigene Switzerland Gmbh | Anti-pd1 antikūnai ir jų naudojimas terapijai ir diagnostikai |
| CA2833701A1 (en) * | 2013-11-19 | 2015-05-19 | Pharmascience Inc. | Protein kinase inhibitors |
| EA201691169A1 (ru) | 2013-12-05 | 2016-09-30 | Асерта Фарма Б.В. | Терапевтическая комбинация ингибитора pi3k и ингибитора btk |
| WO2015102990A1 (en) * | 2013-12-31 | 2015-07-09 | Bohan Jin | Novel compounds for the treatment of cancer and inflammatory diseases |
| WO2015185998A2 (en) | 2014-04-11 | 2015-12-10 | Acerta Pharma B.V. | Methods of blocking the cxcr-4/sdf-1 signaling pathway with inhibitors of bone marrow x kinase |
| WO2015181633A2 (en) | 2014-04-11 | 2015-12-03 | Acerta Pharma B.V. | Methods of blocking the cxcr-4/sdf-1 signaling pathway with inhibitors of bruton's tyrosine kinase |
| TWI726608B (zh) | 2014-07-03 | 2021-05-01 | 英屬開曼群島商百濟神州有限公司 | 抗pd-l1抗體及其作為治療及診斷之用途 |
| TW201618783A (zh) | 2014-08-07 | 2016-06-01 | 艾森塔製藥公司 | 以布魯頓(Bruton)氏酪胺酸激酶(BTK)佔據和BTK再合成速率為基礎之治療癌症、免疫和自體免疫疾病及發炎性疾病之方法 |
| RS62713B1 (sr) | 2014-08-11 | 2022-01-31 | Acerta Pharma Bv | Terapeutske kombinacije btk inhibitora i bcl-2 inhibitora |
| HRP20220738T1 (hr) | 2014-08-11 | 2022-08-19 | Acerta Pharma B.V. | Terapijske kombinacije inhibitora btk, inhibitora pd-1 i/ili inhibitora pd-l1 |
| US20170224819A1 (en) | 2014-08-11 | 2017-08-10 | Acerta Pharma B.V. | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, and/or a CDK 4/6 Inhibitor |
| TW201618774A (zh) | 2014-08-11 | 2016-06-01 | 艾森塔製藥公司 | 使用ｂｔｋ抑制劑透過調變腫瘤微環境來治療實體腫瘤及其他疾病之方法 |
| WO2016087994A1 (en) | 2014-12-05 | 2016-06-09 | Acerta Pharma B.V. | Btk inhibitors to treat solid tumors through modulation of the tumor microenvironment |
| US20190008859A1 (en) | 2015-08-21 | 2019-01-10 | Acerta Pharma B.V. | Therapeutic Combinations of a MEK Inhibitor and a BTK Inhibitor |
| US20190022092A1 (en) | 2015-09-15 | 2019-01-24 | Acerta Pharma B.V. | Therapeutic Combinations of a BTK Inhibitor and a GITR Binding Molecule, a 4-1BB Agonist, or an OX40 Agonist |
| ES2980794T3 (es) | 2015-09-15 | 2024-10-03 | Acerta Pharma Bv | Combinaciones terapéuticas de un inhibidor de CD19 y un inhibidor de BTK |
| DK3402503T3 (da) | 2016-01-13 | 2020-12-21 | Acerta Pharma Bv | Terapeutiske kombinationer af et antifolat og en btk-hæmmer |
| WO2018007885A1 (en) | 2016-07-05 | 2018-01-11 | Beigene, Ltd. | COMBINATION OF A PD-l ANTAGONIST AND A RAF INHIBITOR FOR TREATING CANCER |
| EP4509183A3 (en) | 2016-08-16 | 2025-05-21 | BeiGene Switzerland GmbH | Crystalline form of (s)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetra-hydropyrazolo[1,5-a]pyrimidine-3-carboxamide, preparation, and uses thereof |
| AU2017313085B2 (en) | 2016-08-19 | 2024-06-20 | Beone Medicines I Gmbh | Use of a combination comprising a Btk inhibitor for treating cancers |
| MX390121B (es) | 2016-09-19 | 2025-03-20 | Mei Pharma Inc | Combinaciones de un inhibidor de btk y un inhibidor de pi3k para tratar neoplasias malignas hematológicas. |
| WO2018137681A1 (en) | 2017-01-25 | 2018-08-02 | Beigene, Ltd. | Crystalline forms of (s) -7- (1- (but-2-ynoyl) piperidin-4-yl) -2- (4-phenoxyphenyl) -4, 5, 6, 7-tetrahy dropyrazolo [1, 5-a] pyrimidine-3-carboxamide, preparation, and uses thereof |
| KR102757960B1 (ko) | 2017-06-26 | 2025-01-22 | 베이진 엘티디 | 간세포암(hepatocellular carcinoma: HCC)에 대한 면역 치료 |
| US11377449B2 (en) | 2017-08-12 | 2022-07-05 | Beigene, Ltd. | BTK inhibitors with improved dual selectivity |
| CN111801334B (zh) | 2017-11-29 | 2023-06-09 | 百济神州瑞士有限责任公司 | 使用包含btk抑制剂的组合治疗惰性或侵袭性b-细胞淋巴瘤 |
| WO2020249001A1 (zh) | 2019-06-10 | 2020-12-17 | 百济神州瑞士有限责任公司 | 一种含有布鲁顿氏酪氨酸激酶抑制剂的口服固体片剂及其制备方法 |
| WO2023077216A1 (en) * | 2021-11-02 | 2023-05-11 | Bright Angel Therapeutics Inc. | Heat shock protein 90 (hsp90) inhibitors for treating fungal infections and methods of use thereof |
| US11786531B1 (en) | 2022-06-08 | 2023-10-17 | Beigene Switzerland Gmbh | Methods of treating B-cell proliferative disorder |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH643228A5 (en) * | 1979-02-02 | 1984-05-30 | Givaudan & Cie Sa | Process for the preparation of alpha-hydroxycarbonyl compounds |
| JPH06502147A (ja) | 1990-10-09 | 1994-03-10 | ニューロゲン コーポレイション | 或る種のシクロアルキルおよびアザシクロアルキルピロロピリミジン；新規な種類のｇａｂａ脳リセプタリガンド |
| JP3465827B2 (ja) * | 1993-02-24 | 2003-11-10 | 株式会社日清製粉グループ本社 | アザインドール誘導体およびこれを有効成分とする抗潰瘍薬 |
| DE59500788D1 (de) * | 1994-05-03 | 1997-11-20 | Ciba Geigy Ag | Pyrrolopyrimidinderivate mit antiproliferativer Wirkung |
| GB9524346D0 (en) * | 1995-11-29 | 1996-01-31 | Univ Strathclyde | Polycyclic compounds |
| AU3176297A (en) * | 1996-06-25 | 1998-01-14 | Novartis Ag | Substituted 7-amino-pyrrolo{3,2-d}pyrimidines and the use thereof |
| WO2005118588A1 (ja) | 2004-06-02 | 2005-12-15 | Takeda Pharmaceutical Company Limited | 縮合複素環化合物 |
| US7982035B2 (en) * | 2007-08-27 | 2011-07-19 | Duquesne University Of The Holy Spirit | Tricyclic compounds having antimitotic and/or antitumor activity and methods of use thereof |
| CA2831843A1 (en) * | 2011-04-04 | 2012-10-11 | Pharmascience Inc. | Protein kinase inhibitors |
-
2011
- 2011-12-01 CA CA2760174A patent/CA2760174A1/en not_active Abandoned
-
2012
- 2012-04-03 WO PCT/CA2012/000333 patent/WO2012135944A1/en not_active Ceased
- 2012-04-03 US US14/009,635 patent/US9624239B2/en not_active Expired - Fee Related
- 2012-04-03 CA CA2831813A patent/CA2831813A1/en not_active Abandoned
- 2012-04-03 JP JP2014502963A patent/JP6001053B2/ja not_active Expired - Fee Related
- 2012-04-03 EP EP12767413.3A patent/EP2694517A4/en not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Guillon et al. | New ferrocenic pyrrolo [1, 2-a] quinoxaline derivatives: Synthesis, and in vitro antimalarial activity–Part II | |
| JP2013508373A5 (enExample) | ||
| JP2013504593A5 (enExample) | ||
| JP2017523124A5 (enExample) | ||
| JP2015042636A5 (ja) | 有機化合物 | |
| RU2013147400A (ru) | Способ получения производных кето-бензофурана | |
| Lavrado et al. | Incorporation of basic side chains into cryptolepine scaffold: Structure− antimalarial activity relationships and mechanistic studies | |
| RU2009110413A (ru) | Способ получения производных 3-дигалогенметил-пиразол-4-карбоновой кислоты | |
| RU2014110400A (ru) | Способ и промежуточные соединения для получения макролактамов | |
| JP2010513498A5 (enExample) | ||
| JP2011037841A5 (enExample) | ||
| JP2015520143A5 (enExample) | ||
| AR058554A1 (es) | Compuestos heterociclicos nitrogenados de 6 miembros sustituidos, metodos para su preparacion, composiciones farmaceuticas que los contienen y su uso en el tratamiento de enfermedades mediadas por mglur5. | |
| JP2009538910A5 (enExample) | ||
| RU2013124812A (ru) | Зонд, визуализирующий белок тау | |
| AR079250A1 (es) | Derivados de pirazolo[1,5-a]piridina utiles en el tratamiento de enfermedades del snc y canceres, composiciones farmaceuticas que los contienen e intermediario de sintesis. | |
| RU2013125326A (ru) | Гетероциклические соединения в качестве зондов для визуализации tau-патологии | |
| RU2017145357A (ru) | Пролекарство на основе фосфамида монобензилового сложного эфира тенофовира, способ его получения и применение | |
| ES2377610B1 (es) | Preparación de compuestos pirido[2,3-d]pirimidin-7(8h)-ona sustituidos. | |
| AR072301A1 (es) | Derivados de acido fenoxicroman carboxilico 6-sustituido utiles en el tratamiento y/o prevencion de enfermedades alergicas e inflamatorias, composiciones farmaceuticas que los contienen, proceso de preparacion de los mismos y compuestos intermediarios. | |
| TWI267512B (en) | A process for preparing febrifugine and isofebrifugine | |
| Maiti et al. | Iodine/CuI-mediated alkyne–carbonyl metathesis reaction: synthesis of 1-aryl-1, 2-dihydrochromeno [2, 3-b] azepine-3, 6-dione | |
| AR045447A1 (es) | Compuestos triciclicos inhibidores de transferasa de proteina de farnesilo novedosos como agentes antitumorales | |
| JP2014522854A5 (enExample) | ||
| Ismail et al. | An Exploration of the Structure-activity Relationships of 4− Aminoquinolines: Novel Antimalarials with Activity In-vivo |