JP2014509298A - アルファへリックスミメティック及びその関連の方法 - Google Patents

アルファへリックスミメティック及びその関連の方法 Download PDF

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Publication number
JP2014509298A
JP2014509298A JP2013539024A JP2013539024A JP2014509298A JP 2014509298 A JP2014509298 A JP 2014509298A JP 2013539024 A JP2013539024 A JP 2013539024A JP 2013539024 A JP2013539024 A JP 2013539024A JP 2014509298 A JP2014509298 A JP 2014509298A
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Prior art keywords
optionally substituted
substituted
methyl
pyrazino
ylmethyl
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JP2013539024A
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Japanese (ja)
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JP2014509298A5 (cg-RX-API-DMAC10.html
Inventor
弘行 小路
剛直 小田上
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PRISM Pharma
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PRISM Pharma
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Publication of JP2014509298A publication Critical patent/JP2014509298A/ja
Publication of JP2014509298A5 publication Critical patent/JP2014509298A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2013539024A 2011-02-25 2012-02-27 アルファへリックスミメティック及びその関連の方法 Pending JP2014509298A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161446801P 2011-02-25 2011-02-25
US61/446,801 2011-02-25
PCT/JP2012/055489 WO2012115286A1 (en) 2011-02-25 2012-02-27 Alpha helix mimetics and methods relating thereto

Publications (2)

Publication Number Publication Date
JP2014509298A true JP2014509298A (ja) 2014-04-17
JP2014509298A5 JP2014509298A5 (cg-RX-API-DMAC10.html) 2015-05-07

Family

ID=45878996

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013539024A Pending JP2014509298A (ja) 2011-02-25 2012-02-27 アルファへリックスミメティック及びその関連の方法

Country Status (5)

Country Link
US (1) US20140051706A1 (cg-RX-API-DMAC10.html)
EP (1) EP2678341A1 (cg-RX-API-DMAC10.html)
JP (1) JP2014509298A (cg-RX-API-DMAC10.html)
CN (1) CN103517904A (cg-RX-API-DMAC10.html)
WO (1) WO2012115286A1 (cg-RX-API-DMAC10.html)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014528445A (ja) * 2011-10-07 2014-10-27 ユニバーシティー オブ サザン カリフォルニア 体性幹細胞の非対称分裂を促進するためのｃｂｐ／カテニン拮抗剤
WO2016204193A1 (ja) * 2015-06-16 2016-12-22 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ 抗がん剤
JP2017088633A (ja) * 2010-11-16 2017-05-25 ユニバーシティー オブ サザン カリフォルニア 体性幹細胞の非対称分裂を促進するためのｃｂｐ／カテニン拮抗剤
US12303505B2 (en) 2017-02-08 2025-05-20 Eisai R&D Management Co., Ltd. Tumor-treating pharmaceutical composition

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KR102168006B1 (ko) * 2010-10-07 2020-10-20 유니버시티 오브 써던 캘리포니아 체세포 줄기 세포의 비대칭 분열을 향상시키기 위한 ｃｂｐ/카테닌 길항제
JP2015536300A (ja) * 2012-10-19 2015-12-21 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ Ｃｂｐ／カテニン阻害剤を用いる強皮症の治療
CN104902901A (zh) * 2012-10-19 2015-09-09 株式会社棱镜制药 使用cbp/连环蛋白的抑制剂治疗过度增殖性和癌前皮肤病
US9700569B2 (en) 2012-12-12 2017-07-11 Prism Pharma Co., Ltd. Prevention or treatment agent for hepatic fibrosis
CN105899211A (zh) * 2013-10-18 2016-08-24 小路弘行 使用cbp/连环蛋白的抑制剂治疗肝纤维化
US9174998B2 (en) * 2013-12-25 2015-11-03 Eisai R&D Management Co., Ltd. (6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-4,7-dioxo-8-({6-[3-(piperazin-1-yl)azetidin-1-yl]pyridin-2-yl}methyl)-2-(prop-2-en-1-yl)-octahydro-1H-pyrazino[2,1-c][1,2,4]triazine-1-carboxamide compound
KR102559211B1 (ko) 2015-06-23 2023-07-25 에자이 알앤드디 매니지먼트 가부시키가이샤 (6S,9aS)-N-벤질-8-({6-[3-(4-에틸피페라진-1-일)아제티딘-1-일]피리딘-2-일}메틸)-6-(2-플루오로-4-하이드록시벤질)-4,7-디옥소-2-(프로프-2-엔-1-일)헥사하이드로-2H-피라지노[2,1-c][1,2,4]트리아진-1(6H)-카복사마이드의 결정
CN105061315B (zh) * 2015-08-06 2017-10-24 大连理工大学 一类1,5‑二苯基吡唑‑3‑羧酸类化合物及其应用
EP3366687B1 (en) * 2015-09-18 2020-04-29 National University Corporation Tottori University Suppression and regeneration promoting effect of low molecular weight compound on cancer and fibrosis
WO2018212202A1 (en) 2017-05-16 2018-11-22 Eisai R&D Management Co., Ltd. Treatment of hepatocellular carcinoma
WO2021086909A1 (en) 2019-10-29 2021-05-06 Eisai R&D Managment Co., Ltd. Combination of a pd-1 antagonist, a vegfr/fgfr/ret tyrosine kinase inhibitor and a cbp/beta-catenin inhibitor for treating cancer
AR121544A1 (es) 2020-03-12 2022-06-15 3 2 Pharma Inhibidores de la vía de señalización por cbp / catenina y sus usos
WO2021183791A1 (en) * 2020-03-12 2021-09-16 City Of Hope Wnt/cbp/catenin signaling pathway inhibitors and uses thereof
CN116018345A (zh) * 2020-07-16 2023-04-25 株式会社棱镜生物实验室 新的杂环化合物
CN116925081A (zh) * 2022-04-11 2023-10-24 中国科学院上海药物研究所 一种环肽类化合物及其应用
JP2025515047A (ja) * 2022-05-04 2025-05-13 アティラ・ファーマ・インコーポレイテッド 線維症の治療方法

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US20050250780A1 (en) * 2002-10-17 2005-11-10 Myriad Genetics, Incorporated Reverse-turn mimetics and compositions and methods relating thereto
JP2007532674A (ja) * 2004-04-16 2007-11-15 チョンウェ ファーマ コーポレーション リバースターンミメティックおよびそれに関連した方法
WO2009148192A1 (en) * 2008-06-06 2009-12-10 Prism Biolab Corporation Alpha helix mimetics and methods relating thereto
WO2010120112A2 (en) * 2009-04-15 2010-10-21 Choongwae Pharma Corporation Novel compounds of reverse-turn mimetics, method for manufacturing the same and use thereof
JP2011500666A (ja) * 2007-10-15 2011-01-06 チュンウェ ファーマ コーポレーション リバースターン類似体の新規化合物およびその用途（３）

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ATE398129T1 (de) * 2001-10-12 2008-07-15 Choongwae Pharma Corp Reverse-turn-mimetika und diese betreffendes verfahren
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WO2005021025A2 (en) * 2003-08-28 2005-03-10 Choongwae Pharma Corporation MODULATION OF β-CATENIN/TCF ACTIVATED TRANSCRIPTION
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EP2408300B1 (en) * 2009-03-21 2016-05-11 Sunshine Lake Pharma Co., Ltd. Amino ester derivatives, salts thereof and methods of use
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US20050250780A1 (en) * 2002-10-17 2005-11-10 Myriad Genetics, Incorporated Reverse-turn mimetics and compositions and methods relating thereto
JP2007532674A (ja) * 2004-04-16 2007-11-15 チョンウェ ファーマ コーポレーション リバースターンミメティックおよびそれに関連した方法
JP2011500666A (ja) * 2007-10-15 2011-01-06 チュンウェ ファーマ コーポレーション リバースターン類似体の新規化合物およびその用途（３）
WO2009148192A1 (en) * 2008-06-06 2009-12-10 Prism Biolab Corporation Alpha helix mimetics and methods relating thereto
WO2010120112A2 (en) * 2009-04-15 2010-10-21 Choongwae Pharma Corporation Novel compounds of reverse-turn mimetics, method for manufacturing the same and use thereof

Cited By (8)

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Publication number Priority date Publication date Assignee Title
US9371330B2 (en) 2010-11-16 2016-06-21 University Of Southern California Substituted pyrazino[1,2-a]pyrimidines useful as CBP/catenin antagonists for enhancing asymmetric division of somatic stem cells
JP2017088633A (ja) * 2010-11-16 2017-05-25 ユニバーシティー オブ サザン カリフォルニア 体性幹細胞の非対称分裂を促進するためのｃｂｐ／カテニン拮抗剤
US10092568B2 (en) 2010-11-16 2018-10-09 University Of Southern California CBP/Catenin antagonists for enhancing asymmetric division of somatic stem cells
JP2014528445A (ja) * 2011-10-07 2014-10-27 ユニバーシティー オブ サザン カリフォルニア 体性幹細胞の非対称分裂を促進するためのｃｂｐ／カテニン拮抗剤
WO2016204193A1 (ja) * 2015-06-16 2016-12-22 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ 抗がん剤
JPWO2016204193A1 (ja) * 2015-06-16 2018-04-05 株式会社ＰＲＩＳＭ Ｐｈａｒｍａ 抗がん剤
US11369623B2 (en) 2015-06-16 2022-06-28 Prism Pharma Co., Ltd. Anticancer combination of a CBP/catenin inhibitor and an immune checkpoint inhibitor
US12303505B2 (en) 2017-02-08 2025-05-20 Eisai R&D Management Co., Ltd. Tumor-treating pharmaceutical composition

Also Published As

Publication number Publication date
EP2678341A1 (en) 2014-01-01
CN103517904A (zh) 2014-01-15
US20140051706A1 (en) 2014-02-20
WO2012115286A1 (en) 2012-08-30

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