JP2014507949A5 - - Google Patents
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- Publication number
- JP2014507949A5 JP2014507949A5 JP2013555840A JP2013555840A JP2014507949A5 JP 2014507949 A5 JP2014507949 A5 JP 2014507949A5 JP 2013555840 A JP2013555840 A JP 2013555840A JP 2013555840 A JP2013555840 A JP 2013555840A JP 2014507949 A5 JP2014507949 A5 JP 2014507949A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- tissue sample
- nanoparticles
- dna
- dna binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000523 sample Substances 0.000 claims 19
- 210000001519 tissue Anatomy 0.000 claims 13
- 239000002105 nanoparticle Substances 0.000 claims 12
- 238000000034 method Methods 0.000 claims 11
- 230000004568 DNA-binding Effects 0.000 claims 10
- 108091005804 Peptidases Proteins 0.000 claims 9
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims 9
- 239000002096 quantum dot Substances 0.000 claims 7
- 210000004940 nucleus Anatomy 0.000 claims 6
- 239000004365 Protease Substances 0.000 claims 5
- 238000003556 assay Methods 0.000 claims 3
- 239000011230 binding agent Substances 0.000 claims 3
- 238000012800 visualization Methods 0.000 claims 3
- 239000012624 DNA alkylating agent Substances 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- 238000007901 in situ hybridization Methods 0.000 claims 2
- 239000002082 metal nanoparticle Substances 0.000 claims 2
- 229910044991 metal oxide Inorganic materials 0.000 claims 2
- 150000004706 metal oxides Chemical class 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- ZCCUUQDIBDJBTK-UHFFFAOYSA-N psoralen Chemical compound C1=C2OC(=O)C=CC2=CC2=C1OC=C2 ZCCUUQDIBDJBTK-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229910052723 transition metal Inorganic materials 0.000 claims 2
- 150000003624 transition metals Chemical class 0.000 claims 2
- PRDFBSVERLRRMY-UHFFFAOYSA-N 2'-(4-ethoxyphenyl)-5-(4-methylpiperazin-1-yl)-2,5'-bibenzimidazole Chemical compound C1=CC(OCC)=CC=C1C1=NC2=CC=C(C=3NC4=CC(=CC=C4N=3)N3CCN(C)CC3)C=C2N1 PRDFBSVERLRRMY-UHFFFAOYSA-N 0.000 claims 1
- HPJFXFRNEJHDFR-UHFFFAOYSA-N 22291-04-9 Chemical compound C1=CC(C(N(CCN(C)C)C2=O)=O)=C3C2=CC=C2C(=O)N(CCN(C)C)C(=O)C1=C32 HPJFXFRNEJHDFR-UHFFFAOYSA-N 0.000 claims 1
- VXGRJERITKFWPL-UHFFFAOYSA-N 4',5'-Dihydropsoralen Natural products C1=C2OC(=O)C=CC2=CC2=C1OCC2 VXGRJERITKFWPL-UHFFFAOYSA-N 0.000 claims 1
- FWBHETKCLVMNFS-UHFFFAOYSA-N 4',6-Diamino-2-phenylindol Chemical compound C1=CC(C(=N)N)=CC=C1C1=CC2=CC=C(C(N)=N)C=C2N1 FWBHETKCLVMNFS-UHFFFAOYSA-N 0.000 claims 1
- 229940126161 DNA alkylating agent Drugs 0.000 claims 1
- 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 claims 1
- 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 claims 1
- 125000001931 aliphatic group Chemical group 0.000 claims 1
- 230000027455 binding Effects 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 210000000349 chromosome Anatomy 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000011496 digital image analysis Methods 0.000 claims 1
- 239000002905 metal composite material Substances 0.000 claims 1
- 230000002797 proteolythic effect Effects 0.000 claims 1
- 239000011535 reaction buffer Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161464217P | 2011-02-28 | 2011-02-28 | |
| US61/464,217 | 2011-02-28 | ||
| PCT/EP2012/053255 WO2012116949A1 (en) | 2011-02-28 | 2012-02-27 | Application of quantum dots for nuclear staining |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014507949A JP2014507949A (ja) | 2014-04-03 |
| JP2014507949A5 true JP2014507949A5 (cg-RX-API-DMAC10.html) | 2014-05-22 |
| JP5943943B2 JP5943943B2 (ja) | 2016-07-05 |
Family
ID=45872918
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013555840A Expired - Fee Related JP5943943B2 (ja) | 2011-02-28 | 2012-02-27 | 核染色のための量子ドットの適用 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9448231B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2681334B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP5943943B2 (cg-RX-API-DMAC10.html) |
| AU (1) | AU2012222506B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2824355C (cg-RX-API-DMAC10.html) |
| DK (1) | DK2681334T3 (cg-RX-API-DMAC10.html) |
| ES (1) | ES2588514T3 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2012116949A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9696298B2 (en) | 2003-04-03 | 2017-07-04 | Enzo Life Sciences, Inc. | Multisignal reagents for labeling analytes |
| US9156986B2 (en) * | 2003-04-03 | 2015-10-13 | Enzo Life Sciences, Inc. | Multisignal labeling reagents and processes and uses therefor |
| MX2018004838A (es) | 2015-11-06 | 2019-07-18 | Ventana Med Syst Inc | Diagnosticos representativos. |
| CN105543395B (zh) * | 2016-02-22 | 2019-03-29 | 深圳优圣康医学检验实验室 | 检测乳腺癌her2基因的纳米量子点标记分子探针及其制备方法 |
| US10747999B2 (en) * | 2017-10-18 | 2020-08-18 | The Trustees Of Columbia University In The City Of New York | Methods and systems for pattern characteristic detection |
| WO2019092269A1 (en) | 2017-11-13 | 2019-05-16 | F. Hoffmann-La Roche Ag | Devices for sample analysis using epitachophoresis |
| CN109030440B (zh) * | 2018-07-18 | 2020-12-04 | 西北农林科技大学 | 一种基于三氧化钼量子点检测单宁酸含量的方法 |
| US10908092B2 (en) | 2018-10-11 | 2021-02-02 | Baker Hughes, A Ge Company, Llc | Process for making cyano functionalized gold nanoparticles |
| EP3864403A1 (en) | 2018-10-12 | 2021-08-18 | F. Hoffmann-La Roche AG | Detection methods for epitachophoresis workflow automation |
| CN111333622B (zh) * | 2018-12-18 | 2022-08-09 | 中国科学院大连化学物理研究所 | 含活性酯的高亮度、高稳定性荧光染料及其合成和应用 |
| JP7441243B2 (ja) | 2019-05-14 | 2024-02-29 | エフ． ホフマン－ラ ロシュ アーゲー | 試料分析のための装置および方法 |
| JPWO2023127783A1 (cg-RX-API-DMAC10.html) * | 2021-12-28 | 2023-07-06 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5990479A (en) | 1997-11-25 | 1999-11-23 | Regents Of The University Of California | Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| WO2000029617A2 (en) | 1998-09-24 | 2000-05-25 | Advanced Research And Technology Institute, Inc. | Water-soluble luminescent quantum dots and bioconjugates thereof |
| CA2400379A1 (en) | 2000-02-16 | 2001-08-23 | Quantum Dot Corporation | Microarray methods utilizing semiconductor nanocrystals |
| JP4951184B2 (ja) | 2000-03-20 | 2012-06-13 | マサチューセッツ インスティテュート オブ テクノロジー | 無機粒子結合体 |
| US6649138B2 (en) | 2000-10-13 | 2003-11-18 | Quantum Dot Corporation | Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media |
| EP1215199A1 (en) * | 2000-12-08 | 2002-06-19 | Sony International (Europe) GmbH | Linker molecules for selective metallisation of nucleic acids and their uses |
| US20020083888A1 (en) | 2000-12-28 | 2002-07-04 | Zehnder Donald A. | Flow synthesis of quantum dot nanocrystals |
| US20020127224A1 (en) | 2001-03-02 | 2002-09-12 | James Chen | Use of photoluminescent nanoparticles for photodynamic therapy |
| JP2005511761A (ja) * | 2001-07-10 | 2005-04-28 | ノース・キャロライナ・ステイト・ユニヴァーシティ | ナノ粒子送達ビヒクル |
| AUPR647801A0 (en) | 2001-07-19 | 2001-08-09 | Cea Technologies Inc. | Chromatin segmentation |
| EP2218762A3 (en) | 2001-07-20 | 2010-09-29 | Life Technologies Corporation | Luminescent nanoparticles and methods for their preparation |
| JP2004065040A (ja) | 2002-08-02 | 2004-03-04 | Japan Science & Technology Corp | マウスナノス様遺伝子 |
| EP1627420B1 (en) | 2003-05-07 | 2020-07-15 | Indiana University Research and Technology Corporation | Alloyed semiconductor quantum dots and concentration-gradient alloyed quantum dots, series comprising the same and methods related thereto |
| KR100657891B1 (ko) | 2003-07-19 | 2006-12-14 | 삼성전자주식회사 | 반도체 나노결정 및 그 제조방법 |
| JP4111099B2 (ja) | 2003-08-21 | 2008-07-02 | ソニー株式会社 | 生化学分析方法及び装置 |
| US20080118941A1 (en) | 2004-09-02 | 2008-05-22 | The Regents Of The University Of California | Signal Peptide-Semiconductor Nanocrystal Conjugates |
| EP1893241A2 (en) | 2005-04-28 | 2008-03-05 | Ventana Medical Systems, Inc. | Fluorescent nanoparticles conjugated to antibodies via a peg linker |
| CN104090095B (zh) | 2005-11-23 | 2016-06-01 | 文塔纳医疗系统公司 | 分子缀合物 |
| US7498177B2 (en) | 2006-04-24 | 2009-03-03 | Jesus Martinez De La Fuente | Quantum dots and their uses |
| ES2372427T3 (es) | 2006-09-01 | 2012-01-19 | Ventana Medical Systems, Inc. | Método para producir sondas de ácido nucleico. |
| EP2116511B1 (en) | 2006-12-28 | 2018-04-18 | National Institute of Advanced Industrial Science And Technology | Method of regulating the color of prussian blue type metal complex nanoparticles, prussian blue type metal complex nanoparticle obtained by the same, dispersion of the nanoparticles, electrode and transmitted-light regulator both employing the nanoparticles |
| AU2008212820B2 (en) | 2007-02-09 | 2014-01-30 | Northwestern University | Particles for detecting intracellular targets |
| US8790877B2 (en) | 2007-07-12 | 2014-07-29 | The United States Of America As Represented By The Secretary Of The Air Force | Using DNA aptamers and quantum dots for the detection of proteins or other targets |
| KR100951719B1 (ko) | 2007-10-02 | 2010-04-07 | 재단법인서울대학교산학협력재단 | 세포투과성 펩타이드와 형광표지 자성나노입자의 복합체 및그 용도 |
| WO2011011782A1 (en) | 2009-07-24 | 2011-01-27 | Duke University | Functionalized metal-coated energy converting nanoparticles, methods for production thereof and methods for use |
-
2012
- 2012-02-22 US US13/402,567 patent/US9448231B2/en not_active Expired - Fee Related
- 2012-02-27 DK DK12709822.6T patent/DK2681334T3/en active
- 2012-02-27 WO PCT/EP2012/053255 patent/WO2012116949A1/en not_active Ceased
- 2012-02-27 AU AU2012222506A patent/AU2012222506B2/en not_active Ceased
- 2012-02-27 ES ES12709822.6T patent/ES2588514T3/es active Active
- 2012-02-27 EP EP12709822.6A patent/EP2681334B1/en not_active Not-in-force
- 2012-02-27 CA CA2824355A patent/CA2824355C/en not_active Expired - Fee Related
- 2012-02-27 JP JP2013555840A patent/JP5943943B2/ja not_active Expired - Fee Related
-
2015
- 2015-06-02 US US14/728,833 patent/US20150267262A1/en not_active Abandoned
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