ES2588514T3 - Aplicación de puntos cuánticos para la tinción nuclear - Google Patents

Aplicación de puntos cuánticos para la tinción nuclear Download PDF

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Publication number
ES2588514T3
ES2588514T3 ES12709822.6T ES12709822T ES2588514T3 ES 2588514 T3 ES2588514 T3 ES 2588514T3 ES 12709822 T ES12709822 T ES 12709822T ES 2588514 T3 ES2588514 T3 ES 2588514T3
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ES
Spain
Prior art keywords
conjugate
dna
nanoparticle
dna binding
tissue sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12709822.6T
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English (en)
Spanish (es)
Inventor
Chol S. YUN
Brian D. KELLY
Julia Ashworth-Sharpe
Christopher Bieniarz
Pascal Bamford
Adrian E. Murillo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ventana Medical Systems Inc
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Ventana Medical Systems Inc
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Filing date
Publication date
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Publication of ES2588514T3 publication Critical patent/ES2588514T3/es
Active legal-status Critical Current
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/08—Naphthalimide dyes; Phthalimide dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B69/00—Dyes not provided for by a single group of this subclass
    • C09B69/10—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds
    • C09B69/109—Polymeric dyes; Reaction products of dyes with monomers or with macromolecular compounds containing other specific dyes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/588—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with semiconductor nanocrystal label, e.g. quantum dots
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Pathology (AREA)
  • Wood Science & Technology (AREA)
  • Nanotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Materials Engineering (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
ES12709822.6T 2011-02-28 2012-02-27 Aplicación de puntos cuánticos para la tinción nuclear Active ES2588514T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161464217P 2011-02-28 2011-02-28
US201161464217P 2011-02-28
PCT/EP2012/053255 WO2012116949A1 (en) 2011-02-28 2012-02-27 Application of quantum dots for nuclear staining

Publications (1)

Publication Number Publication Date
ES2588514T3 true ES2588514T3 (es) 2016-11-03

Family

ID=45872918

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12709822.6T Active ES2588514T3 (es) 2011-02-28 2012-02-27 Aplicación de puntos cuánticos para la tinción nuclear

Country Status (8)

Country Link
US (2) US9448231B2 (cg-RX-API-DMAC10.html)
EP (1) EP2681334B1 (cg-RX-API-DMAC10.html)
JP (1) JP5943943B2 (cg-RX-API-DMAC10.html)
AU (1) AU2012222506B2 (cg-RX-API-DMAC10.html)
CA (1) CA2824355C (cg-RX-API-DMAC10.html)
DK (1) DK2681334T3 (cg-RX-API-DMAC10.html)
ES (1) ES2588514T3 (cg-RX-API-DMAC10.html)
WO (1) WO2012116949A1 (cg-RX-API-DMAC10.html)

Families Citing this family (12)

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US9696298B2 (en) 2003-04-03 2017-07-04 Enzo Life Sciences, Inc. Multisignal reagents for labeling analytes
US9156986B2 (en) * 2003-04-03 2015-10-13 Enzo Life Sciences, Inc. Multisignal labeling reagents and processes and uses therefor
MX2018004838A (es) 2015-11-06 2019-07-18 Ventana Med Syst Inc Diagnosticos representativos.
CN105543395B (zh) * 2016-02-22 2019-03-29 深圳优圣康医学检验实验室 检测乳腺癌her2基因的纳米量子点标记分子探针及其制备方法
US10747999B2 (en) * 2017-10-18 2020-08-18 The Trustees Of Columbia University In The City Of New York Methods and systems for pattern characteristic detection
WO2019092269A1 (en) 2017-11-13 2019-05-16 F. Hoffmann-La Roche Ag Devices for sample analysis using epitachophoresis
CN109030440B (zh) * 2018-07-18 2020-12-04 西北农林科技大学 一种基于三氧化钼量子点检测单宁酸含量的方法
US10908092B2 (en) 2018-10-11 2021-02-02 Baker Hughes, A Ge Company, Llc Process for making cyano functionalized gold nanoparticles
EP3864403A1 (en) 2018-10-12 2021-08-18 F. Hoffmann-La Roche AG Detection methods for epitachophoresis workflow automation
CN111333622B (zh) * 2018-12-18 2022-08-09 中国科学院大连化学物理研究所 含活性酯的高亮度、高稳定性荧光染料及其合成和应用
JP7441243B2 (ja) 2019-05-14 2024-02-29 エフ． ホフマン－ラ ロシュ アーゲー 試料分析のための装置および方法
JPWO2023127783A1 (cg-RX-API-DMAC10.html) * 2021-12-28 2023-07-06

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US5990479A (en) 1997-11-25 1999-11-23 Regents Of The University Of California Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes
WO2000029617A2 (en) 1998-09-24 2000-05-25 Advanced Research And Technology Institute, Inc. Water-soluble luminescent quantum dots and bioconjugates thereof
CA2400379A1 (en) 2000-02-16 2001-08-23 Quantum Dot Corporation Microarray methods utilizing semiconductor nanocrystals
JP4951184B2 (ja) 2000-03-20 2012-06-13 マサチューセッツ インスティテュート オブ テクノロジー 無機粒子結合体
US6649138B2 (en) 2000-10-13 2003-11-18 Quantum Dot Corporation Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media
EP1215199A1 (en) * 2000-12-08 2002-06-19 Sony International (Europe) GmbH Linker molecules for selective metallisation of nucleic acids and their uses
US20020083888A1 (en) 2000-12-28 2002-07-04 Zehnder Donald A. Flow synthesis of quantum dot nanocrystals
US20020127224A1 (en) 2001-03-02 2002-09-12 James Chen Use of photoluminescent nanoparticles for photodynamic therapy
JP2005511761A (ja) * 2001-07-10 2005-04-28 ノース・キャロライナ・ステイト・ユニヴァーシティ ナノ粒子送達ビヒクル
AUPR647801A0 (en) 2001-07-19 2001-08-09 Cea Technologies Inc. Chromatin segmentation
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EP1627420B1 (en) 2003-05-07 2020-07-15 Indiana University Research and Technology Corporation Alloyed semiconductor quantum dots and concentration-gradient alloyed quantum dots, series comprising the same and methods related thereto
KR100657891B1 (ko) 2003-07-19 2006-12-14 삼성전자주식회사 반도체 나노결정 및 그 제조방법
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WO2011011782A1 (en) 2009-07-24 2011-01-27 Duke University Functionalized metal-coated energy converting nanoparticles, methods for production thereof and methods for use

Also Published As

Publication number Publication date
JP5943943B2 (ja) 2016-07-05
EP2681334B1 (en) 2016-06-15
JP2014507949A (ja) 2014-04-03
US20150267262A1 (en) 2015-09-24
AU2012222506A1 (en) 2013-07-25
WO2012116949A1 (en) 2012-09-07
EP2681334A1 (en) 2014-01-08
CA2824355C (en) 2020-03-31
AU2012222506B2 (en) 2015-08-20
US20120219948A1 (en) 2012-08-30
US9448231B2 (en) 2016-09-20
DK2681334T3 (en) 2016-08-22
CA2824355A1 (en) 2012-09-07

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