JP2014506718A - 質量分析の方法、装置、及びシステム - Google Patents
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Abstract
【選択図】 図1A
Description
本出願は、2011年2月14日出願の「質量分析計」という名称の米国特許仮出願第61/442,385号の恩典を請求するものであり、この出願は、これにより引用によって本明細書に組み込まれる。
114 磁気ヨーク
170 真空フランジ
172 真空ハウジングシール
180 入口
Claims (20)
- (A)約10-5mmHg又はそれ未満の真空をサポートする真空空洞を形成する真空ハウジングと、
(B)前記真空空洞内に配置され、かつ該真空空洞を通って伝播する荷電粒子の加速を制御するために電極電位まで帯電するように構成された電極と、
(C)前記電極のための前記電極電位を供給するために前記真空空洞の外側の電源からの入力電圧を変換するように該真空空洞内に配置された変換回路と、
(D)約36V未満又はそれに等しい誘電強度を有し、前記変換回路と前記電源の間の電気接続を提供するフィードスルーと、
を含むことを特徴とする質量分析計。 - 前記荷電粒子は、電子であることを特徴とする請求項1に記載の質量分析計。
- (E)前記電子を供給するために前記真空空洞内に配置された電子源と、
(F)前記電子を反発するカソードと、
(G)分析される検体粒子に向けて前記電子を加速するために前記電子源から前記電極の反対側に配置されたアノードと、
を更に含むことを特徴とする請求項2に記載の質量分析計。 - 前記変換回路は、
(i)前記アノードのための約100Vから約5kVのアノード電位と、
(ii)前記カソードのための前記アノード電位よりも低いカソード電位約70Vと、
を供給するように更に構成され、
前記電極電位は、前記アノード電位よりも低い約0Vと約140Vの間である、
ことを特徴とする請求項3に記載の質量分析計。 - (H)前記真空空洞内に配置され、かつ前記電極電位を変えるために前記変換回路と作動可能に結合された制御電子機器、
を更に含むことを特徴とする請求項2に記載の質量分析計。 - 前記変換回路は、約1Vから約36Vの第1の値を有する前記入力電圧を約100Vから約5kVの第2の値を有する前記電極電位に変換するように構成されることを特徴とする請求項1に記載の質量分析計。
- 前記フィードスルーは、前記真空空洞の内側と外側間の唯一の電気接続であることを特徴とする請求項1に記載の質量分析計。
- (A)約10-5mmHg又はそれ未満の圧力まで排気された真空空洞を与える段階と、
(B)前記真空空洞の外側の電源から入力電圧を受電する段階と、
(C)前記真空空洞内に配置された変換回路を用いて前記入力電圧を電極電位に変換する段階と、
(D)前記真空空洞内の電極を前記電極電位まで帯電する段階と、
(E)(D)で帯電された前記電極を用いて前記真空空洞内の荷電粒子を加速する段階と、
を含むことを特徴とする質量分析方法。 - 前記入力電圧は、約3Vから約36Vであり、前記電極電位は、約100Vから約5kVであることを特徴とする請求項8に記載の方法。
- 前記荷電粒子は、電子であり、
(E)は、
(E1)前記電子の加速を制御するために前記電極電位を変える段階、
を更に含む、
ことを特徴とする請求項8に記載の方法。 - (E1)は、
前記真空空洞内に配置された電子構成要素を用いて前記電極電位を制御する段階、
を含む、
ことを特徴とする請求項9に記載の方法。 - 前記荷電粒子は、イオン化検体粒子であり、
(F)前記荷電粒子の加速に基づいて前記イオン化検体粒子の質量を判断する段階、
を更に含むことを特徴とする請求項8に記載の方法。 - (A)真空空洞を形成する真空ハウジングと、
(B)第1の領域で第1の強度及び第2の領域で第2の強度を有する磁場を発生させる磁気ヨーク内の磁石と、
(C)前記真空空洞の真空圧力を維持するために前記第1の領域にあるように位置決めされたイオンポンプと、
(D)前記真空空洞を通って伝播するイオン化検体粒子の質量を判断するために前記第2の領域にあるように位置決めされた質量分析器と、
(E)前記検体粒子をイオン化する電子の加速を制御するために前記真空空洞内に配置された制御電極と、
(F)変換された電圧を前記イオンポンプ、前記制御電極、及び/又は前記質量分析器に供給するために前記真空空洞内に配置された変換回路と、
を含むことを特徴とする質量分析計。 - 前記磁気ヨーク内の前記磁石は、前記磁場が発生した時に前記第1の強度が約0.1テスラであり、かつ前記第2の強度が約0.7テスラであるように構成されることを特徴とする請求項13に記載の質量分析計。
- 前記質量分析器は、磁気セクター分析器であることを特徴とする請求項13に記載の質量分析計。
- (G)前記真空空洞内に配置され、かつ前記制御電極の電位を変えるために前記変換回路と作動可能に結合された制御電子機器、
を更に含むことを特徴とする請求項13に記載の質量分析計。 - (H)前記真空空洞内に配置され、かつ前記質量分析器によって供給された信号を処理するために前記変換回路によって電力供給されるように構成された信号処理電子機器、
を更に含むことを特徴とする請求項13に記載の質量分析計。 - (I)前記電子を供給するために前記真空空洞内に配置された電子源と、
(J)前記電子を反発するカソードと、
(K)前記検体粒子に向けて前記電子を加速するために前記電子源から前記制御電極の反対側に配置されたアノードと、
を更に含むことを特徴とする請求項13に記載の質量分析計。 - 前記変換回路は、
(i)前記アノードのための約100Vから約5kVのアノード電位と
(ii)前記カソードのための前記アノード電位よりも低いカソード電位約70Vと、
(iii)前記制御電極のための前記アノード電位よりも低い制御電位約0V及び約140Vと、
を供給するように更に構成される、
ことを特徴とする請求項18に記載の質量分析計。 - 前記変換回路は、約1Vから約36Vの第2の値を有する入力電圧から約100Vから約5kVの第1の値を有する前記変換電圧を供給するように構成されることを特徴とする請求項18に記載の質量分析計。
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