JP2014506577A5 - - Google Patents
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- Publication number
- JP2014506577A5 JP2014506577A5 JP2013553538A JP2013553538A JP2014506577A5 JP 2014506577 A5 JP2014506577 A5 JP 2014506577A5 JP 2013553538 A JP2013553538 A JP 2013553538A JP 2013553538 A JP2013553538 A JP 2013553538A JP 2014506577 A5 JP2014506577 A5 JP 2014506577A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- compound
- acceptable salt
- indol
- pyran
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 8
- -1 2,3-dihydro-1H-indol-1-yl Chemical group 0.000 claims 4
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- YUWYELLNOWOIEC-UHFFFAOYSA-N oxane-4-carboxamide;hydrochloride Chemical compound Cl.NC(=O)C1CCOCC1 YUWYELLNOWOIEC-UHFFFAOYSA-N 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161441840P | 2011-02-11 | 2011-02-11 | |
| US61/441,840 | 2011-02-11 | ||
| PCT/US2012/024428 WO2012109415A1 (en) | 2011-02-11 | 2012-02-09 | Cathepsin c inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014506577A JP2014506577A (ja) | 2014-03-17 |
| JP2014506577A5 true JP2014506577A5 (https=) | 2015-03-05 |
| JP5931929B2 JP5931929B2 (ja) | 2016-06-08 |
Family
ID=46638952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013553538A Expired - Fee Related JP5931929B2 (ja) | 2011-02-11 | 2012-02-09 | カテプシンｃ阻害剤 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US8841463B2 (https=) |
| EP (1) | EP2672821B9 (https=) |
| JP (1) | JP5931929B2 (https=) |
| KR (1) | KR20140048857A (https=) |
| CN (1) | CN103491777B (https=) |
| AR (1) | AR085163A1 (https=) |
| AU (1) | AU2012214405B2 (https=) |
| BR (1) | BR112013020510A2 (https=) |
| CA (1) | CA2827157A1 (https=) |
| CL (1) | CL2013002325A1 (https=) |
| CO (1) | CO6741219A2 (https=) |
| DO (1) | DOP2013000182A (https=) |
| EA (1) | EA023168B1 (https=) |
| ES (1) | ES2583091T3 (https=) |
| IL (1) | IL227814A0 (https=) |
| MA (1) | MA34961B1 (https=) |
| MX (1) | MX2013009279A (https=) |
| PE (1) | PE20140999A1 (https=) |
| PH (1) | PH12013501665A1 (https=) |
| SG (1) | SG192669A1 (https=) |
| TW (1) | TW201302736A (https=) |
| UY (1) | UY33905A (https=) |
| WO (1) | WO2012109415A1 (https=) |
| ZA (1) | ZA201306074B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014091443A1 (en) | 2012-12-13 | 2014-06-19 | Glaxo Group Limited | Cathepsin c inhibitors for treating cystic fibrosis, non-cystic fibrosis bronchiectasis, and anca-associated vasculitis |
| NO2699580T3 (https=) | 2014-01-24 | 2018-02-24 | ||
| JP6849197B2 (ja) * | 2016-02-12 | 2021-03-24 | ファーマクシス リミテッド | リジルオキシダーゼのインドールおよびアザインドールハロアリルアミン誘導体阻害剤およびその使用 |
| TW202413352A (zh) | 2022-06-13 | 2024-04-01 | 日商模數探索股份有限公司 | 氮雜環烷基羰基環狀胺化合物 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2622581B1 (fr) * | 1987-11-03 | 1990-02-16 | Inorgan Sa Rech Develop Pharm | Nouveaux derives de l-proline, leur preparation et leurs applications biologiques |
| US6232299B1 (en) | 1996-05-01 | 2001-05-15 | Eli Lilly And Company | Use of protein kinase C inhibitors to enhance the clinical efficacy of oncolytic agents and radiation therapy |
| CN1240355A (zh) * | 1996-05-01 | 2000-01-05 | 伊莱利利公司 | 蛋白激酶c抑制剂增强溶癌剂和放射治疗的临床功效的用途 |
| US6214799B1 (en) | 1996-05-14 | 2001-04-10 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
| AU2002232558A1 (en) * | 2000-12-12 | 2002-06-24 | Corvas International, Inc. | Compounds, compositions and methods for treatment of parasitic infections |
| EP2195321B1 (en) | 2007-04-12 | 2016-10-19 | Pfizer Inc. | 3-amido-pyrrolo[3,4-c]pyrazole-5(1h, 4h,6h) carbaldehyde derivatives as inhibitors of protein kinase c |
| CN102574830A (zh) * | 2009-05-07 | 2012-07-11 | 阿斯利康(瑞典)有限公司 | 取代的1-氰基乙基杂环基甲酰胺化合物750 |
| UY32827A (es) * | 2009-08-12 | 2011-02-28 | Glaxo Group Ltd | Inhibidores de catepsina c |
| WO2012119941A1 (en) | 2011-03-04 | 2012-09-13 | Prozymex A/S | Peptidyl nitrilcompounds as peptidase inhibitors |
-
2012
- 2012-02-09 EP EP12744272.1A patent/EP2672821B9/en active Active
- 2012-02-09 MX MX2013009279A patent/MX2013009279A/es not_active Application Discontinuation
- 2012-02-09 AU AU2012214405A patent/AU2012214405B2/en not_active Ceased
- 2012-02-09 TW TW101104141A patent/TW201302736A/zh unknown
- 2012-02-09 CN CN201280017698.7A patent/CN103491777B/zh not_active Expired - Fee Related
- 2012-02-09 US US13/984,061 patent/US8841463B2/en not_active Expired - Fee Related
- 2012-02-09 WO PCT/US2012/024428 patent/WO2012109415A1/en not_active Ceased
- 2012-02-09 JP JP2013553538A patent/JP5931929B2/ja not_active Expired - Fee Related
- 2012-02-09 UY UY0001033905A patent/UY33905A/es unknown
- 2012-02-09 PH PH1/2013/501665A patent/PH12013501665A1/en unknown
- 2012-02-09 MA MA36229A patent/MA34961B1/fr unknown
- 2012-02-09 KR KR1020137023618A patent/KR20140048857A/ko not_active Ceased
- 2012-02-09 PE PE2013001836A patent/PE20140999A1/es not_active Application Discontinuation
- 2012-02-09 ES ES12744272.1T patent/ES2583091T3/es active Active
- 2012-02-09 EA EA201391155A patent/EA023168B1/ru not_active IP Right Cessation
- 2012-02-09 SG SG2013060165A patent/SG192669A1/en unknown
- 2012-02-09 CA CA2827157A patent/CA2827157A1/en not_active Abandoned
- 2012-02-09 BR BR112013020510A patent/BR112013020510A2/pt not_active IP Right Cessation
- 2012-02-10 AR ARP120100455A patent/AR085163A1/es unknown
-
2013
- 2013-08-05 IL IL227814A patent/IL227814A0/en unknown
- 2013-08-09 DO DO2013000182A patent/DOP2013000182A/es unknown
- 2013-08-09 CO CO13190045A patent/CO6741219A2/es unknown
- 2013-08-09 CL CL2013002325A patent/CL2013002325A1/es unknown
- 2013-08-13 ZA ZA2013/06074A patent/ZA201306074B/en unknown
-
2014
- 2014-08-21 US US14/464,734 patent/US9187461B2/en not_active Expired - Fee Related