JP2014506231A5 - - Google Patents
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- Publication number
- JP2014506231A5 JP2014506231A5 JP2013530249A JP2013530249A JP2014506231A5 JP 2014506231 A5 JP2014506231 A5 JP 2014506231A5 JP 2013530249 A JP2013530249 A JP 2013530249A JP 2013530249 A JP2013530249 A JP 2013530249A JP 2014506231 A5 JP2014506231 A5 JP 2014506231A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cancer
- protein
- composition according
- smad7
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 18
- 102000049873 Smad7 Human genes 0.000 claims 7
- 108700031279 Smad7 Proteins 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 101700026522 SMAD7 Proteins 0.000 claims 3
- 239000013604 expression vector Substances 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 239000000546 pharmaceutical excipient Substances 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 206010052428 Wound Diseases 0.000 claims 2
- 208000027418 Wounds and injury Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000004968 inflammatory condition Effects 0.000 claims 2
- 208000003265 stomatitis Diseases 0.000 claims 2
- 238000007910 systemic administration Methods 0.000 claims 2
- 230000026683 transduction Effects 0.000 claims 2
- 238000010361 transduction Methods 0.000 claims 2
- 239000013603 viral vector Substances 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 102100030608 Mothers against decapentaplegic homolog 7 Human genes 0.000 claims 1
- 208000003445 Mouth Neoplasms Diseases 0.000 claims 1
- 206010028116 Mucosal inflammation Diseases 0.000 claims 1
- 201000010927 Mucositis Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 239000012190 activator Substances 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 201000010536 head and neck cancer Diseases 0.000 claims 1
- 208000014829 head and neck neoplasm Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 230000000968 intestinal effect Effects 0.000 claims 1
- 208000012987 lip and oral cavity carcinoma Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 239000011325 microbead Substances 0.000 claims 1
- 239000004005 microsphere Substances 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 230000001105 regulatory effect Effects 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 238000011200 topical administration Methods 0.000 claims 1
- 230000008733 trauma Effects 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38544510P | 2010-09-22 | 2010-09-22 | |
| US61/385,445 | 2010-09-22 | ||
| PCT/US2011/052499 WO2012040295A2 (en) | 2010-09-22 | 2011-09-21 | Therapeutic applications of smad7 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014506231A JP2014506231A (ja) | 2014-03-13 |
| JP2014506231A5 true JP2014506231A5 (cg-RX-API-DMAC7.html) | 2014-11-13 |
| JP6124791B2 JP6124791B2 (ja) | 2017-05-10 |
Family
ID=45874343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013530249A Active JP6124791B2 (ja) | 2010-09-22 | 2011-09-21 | Ｓｍａｄ７の治療的適用 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9084746B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2618829B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP6124791B2 (cg-RX-API-DMAC7.html) |
| CN (2) | CN103501803B (cg-RX-API-DMAC7.html) |
| CA (1) | CA2849382C (cg-RX-API-DMAC7.html) |
| IL (1) | IL225406B (cg-RX-API-DMAC7.html) |
| WO (1) | WO2012040295A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2849382C (en) | 2010-09-22 | 2021-02-16 | The Regents Of The University Of Colorado, A Body Corporate | Therapeutic applications of smad7 for the treatment of oral mucositis |
| US9422352B2 (en) | 2013-03-08 | 2016-08-23 | The Regents Of The University Of Colorado, A Body Corporate | PTD-SMAD7 therapeutics |
| WO2016172608A1 (en) * | 2015-04-23 | 2016-10-27 | Washington State University | Smad7 gene delivery as a therapeutic |
| KR101853923B1 (ko) * | 2016-01-25 | 2018-05-02 | 연세대학교 산학협력단 | Smad 단백질을 포함하는 자가 면역 질환 치료용 조성물, Smad 단백질을 포함하는 융합 단백질, 이를 제조하기 위한 벡터, 및 이의 제조 방법 |
| US10772813B2 (en) | 2016-06-03 | 2020-09-15 | Colradel, LLC | Compositions and methods of administering a colchicine based topical composition for the prevention of radiation fibrosis |
| WO2019133949A1 (en) * | 2017-12-30 | 2019-07-04 | The Regents Of The University Of Colorado, A Body Corporate | Therapeutics of ptd-smad7 fusion proteins |
| WO2019133950A1 (en) * | 2017-12-30 | 2019-07-04 | The Regents Of The University Of Colorado, A Body Corporate | Smad7 for treatment and prevention of posterior capsule opacification |
| CA3157375A1 (en) * | 2019-10-29 | 2021-05-06 | The Trustees Of The University Of Pennsylvania | Automated and precise device for dental plaque detection, monitoring and removal |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8200523A (nl) | 1982-02-11 | 1983-09-01 | Univ Leiden | Werkwijze voor het in vitro transformeren van planteprotoplasten met plasmide-dna. |
| US4879236A (en) | 1984-05-16 | 1989-11-07 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| US4952500A (en) | 1988-02-01 | 1990-08-28 | University Of Georgia Research Foundation, Inc. | Cloning systems for Rhodococcus and related bacteria |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5302523A (en) | 1989-06-21 | 1994-04-12 | Zeneca Limited | Transformation of plant cells |
| US7705215B1 (en) | 1990-04-17 | 2010-04-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5550318A (en) | 1990-04-17 | 1996-08-27 | Dekalb Genetics Corporation | Methods and compositions for the production of stably transformed, fertile monocot plants and cells thereof |
| US5322783A (en) | 1989-10-17 | 1994-06-21 | Pioneer Hi-Bred International, Inc. | Soybean transformation by microparticle bombardment |
| EP0506884B1 (en) * | 1989-12-21 | 1996-09-04 | Whitehead Institute For Biomedical Research | Method of delivering molecules into eukaryotic cells |
| US5484956A (en) | 1990-01-22 | 1996-01-16 | Dekalb Genetics Corporation | Fertile transgenic Zea mays plant comprising heterologous DNA encoding Bacillus thuringiensis endotoxin |
| US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US5610042A (en) | 1991-10-07 | 1997-03-11 | Ciba-Geigy Corporation | Methods for stable transformation of wheat |
| US5702932A (en) | 1992-07-20 | 1997-12-30 | University Of Florida | Microinjection methods to transform arthropods with exogenous DNA |
| HUT70467A (en) | 1992-07-27 | 1995-10-30 | Pioneer Hi Bred Int | An improved method of agrobactenium-mediated transformation of cultvred soyhean cells |
| ATE173016T1 (de) * | 1992-08-21 | 1998-11-15 | Biogen Inc | Von tat abgeleitete transportpolypeptide |
| GB9222888D0 (en) | 1992-10-30 | 1992-12-16 | British Tech Group | Tomography |
| US5436222A (en) | 1993-03-15 | 1995-07-25 | The Research Foundation Of State University Of New York | Use of platelet factor 4 to treat inflammatory diseases |
| US5656610A (en) | 1994-06-21 | 1997-08-12 | University Of Southern California | Producing a protein in a mammal by injection of a DNA-sequence into the tongue |
| US5871986A (en) | 1994-09-23 | 1999-02-16 | The General Hospital Corporation | Use of a baculovirus to express and exogenous gene in a mammalian cell |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| US5780448A (en) | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| US5945100A (en) | 1996-07-31 | 1999-08-31 | Fbp Corporation | Tumor delivery vehicles |
| US5981274A (en) | 1996-09-18 | 1999-11-09 | Tyrrell; D. Lorne J. | Recombinant hepatitis virus vectors |
| GB2320431B (en) | 1996-12-20 | 2000-08-30 | Johnson & Johnson Medical | Compositions for the treatment of chronic wounds |
| CA2290040A1 (en) | 1997-05-20 | 1998-11-26 | Ludwig Institute For Cancer Research | Smad7 and uses thereof |
| US6891082B2 (en) | 1997-08-01 | 2005-05-10 | The Johns Hopkins University School Of Medicine | Transgenic non-human animals expressing a truncated activintype II receptor |
| US5994624A (en) | 1997-10-20 | 1999-11-30 | Cotton Incorporated | In planta method for the production of transgenic plants |
| IL138692A0 (en) * | 1998-03-27 | 2001-10-31 | Lilly Co Eli | Treatment and prevention of vascular disease |
| US8466134B1 (en) | 1998-06-26 | 2013-06-18 | Athena Neurosciences, Inc. | Aqueous compositions containing corticosteroids for nasal and pulmonary delivery |
| US6998240B2 (en) * | 2001-06-11 | 2006-02-14 | Wisconsin Alumni Research Foundation | Screen for selective inhibitors or activators of Smad protein function |
| AUPR638101A0 (en) * | 2001-07-13 | 2001-08-09 | Bioa Pty Limited | Composition and method for treatment of disease |
| US7299801B2 (en) | 2002-09-06 | 2007-11-27 | 3M Innovative Properties Company | Metering valve for a metered dose inhaler providing consistent delivery |
| KR100472938B1 (ko) * | 2002-10-31 | 2005-03-11 | 학교법인 한림대학교 | 세포침투 효율을 향상시킨 수송도메인-목표단백질-수송도메인 융합단백질 및 그 용도 |
| EP1673444A2 (en) | 2003-10-16 | 2006-06-28 | The University Court Of The University Of Edinburgh | Control of es cell self-renewal and lineage specification, and medium therefor |
| ES2400034T3 (es) * | 2005-01-14 | 2013-04-05 | Camurus Ab | Formulaciones bioadhesivas tópicas |
| MX2007012344A (es) | 2005-04-05 | 2007-12-13 | Pioneer Hi Bred Int | Metodos y composiciones para disenar moleculas de acido nucleico para la expresion de polipeptido en plantas usando la desviacion de codon de virus de planta. |
| EP1933852B1 (en) * | 2005-09-27 | 2018-12-19 | TissueTech, Inc. | Amniotic membrane preparations and purified compositions and methods of use |
| WO2008105925A2 (en) | 2006-09-01 | 2008-09-04 | Oregon Health & Science University | COMPOUNDS AND METHODS FOR MODULATING β-CATENIN/SMAD-7 INTERACTIONS |
| US20080114287A1 (en) * | 2006-11-14 | 2008-05-15 | Kar Neng Lai | Ultrasound Microbubble Mediated Genes Delivery System |
| WO2009117439A2 (en) * | 2008-03-17 | 2009-09-24 | The Scripps Research Institute | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
| US8591961B2 (en) * | 2008-09-04 | 2013-11-26 | Allergan, Inc. | Aesthetic treatment of scars and aging skin |
| US20110152352A1 (en) * | 2008-06-10 | 2011-06-23 | Tufts University | Smad proteins control drosha-mediated mirna maturation |
| US20100184033A1 (en) * | 2008-07-16 | 2010-07-22 | West Michael D | Methods to accelerate the isolation of novel cell strains from pluripotent stem cells and cells obtained thereby |
| CA2849382C (en) | 2010-09-22 | 2021-02-16 | The Regents Of The University Of Colorado, A Body Corporate | Therapeutic applications of smad7 for the treatment of oral mucositis |
| WO2013151663A1 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of membrane proteins |
| US9422352B2 (en) | 2013-03-08 | 2016-08-23 | The Regents Of The University Of Colorado, A Body Corporate | PTD-SMAD7 therapeutics |
-
2011
- 2011-09-21 CA CA2849382A patent/CA2849382C/en active Active
- 2011-09-21 CN CN201180051033.3A patent/CN103501803B/zh not_active Expired - Fee Related
- 2011-09-21 JP JP2013530249A patent/JP6124791B2/ja active Active
- 2011-09-21 EP EP11827421.6A patent/EP2618829B1/en active Active
- 2011-09-21 CN CN201510882397.6A patent/CN105457016B/zh not_active Expired - Fee Related
- 2011-09-21 EP EP19167590.9A patent/EP3536337A1/en not_active Withdrawn
- 2011-09-21 WO PCT/US2011/052499 patent/WO2012040295A2/en not_active Ceased
- 2011-09-21 US US13/822,173 patent/US9084746B2/en active Active
-
2013
- 2013-03-21 IL IL225406A patent/IL225406B/en active IP Right Grant
-
2015
- 2015-06-25 US US14/750,557 patent/US9474784B2/en active Active
-
2016
- 2016-09-30 US US15/282,022 patent/US10350265B2/en active Active
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