JP2014504593A5 - - Google Patents

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Publication number
JP2014504593A5
JP2014504593A5 JP2013548554A JP2013548554A JP2014504593A5 JP 2014504593 A5 JP2014504593 A5 JP 2014504593A5 JP 2013548554 A JP2013548554 A JP 2013548554A JP 2013548554 A JP2013548554 A JP 2013548554A JP 2014504593 A5 JP2014504593 A5 JP 2014504593A5
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Japan
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compound
formula
prepared
process according
aryl
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JP2013548554A
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Japanese (ja)
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JP6057300B2 (ja
JP2014504593A (ja
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Priority claimed from PCT/US2012/020388 external-priority patent/WO2012094540A2/en
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Publication of JP2014504593A5 publication Critical patent/JP2014504593A5/ja
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JP2013548554A 2011-01-05 2012-01-05 グリコスフィンゴ脂質の調製及びその使用の方法 Active JP6057300B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161430117P 2011-01-05 2011-01-05
US61/430,117 2011-01-05
PCT/US2012/020388 WO2012094540A2 (en) 2011-01-05 2012-01-05 Methods for preparation of glycosphingolipids and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016209071A Division JP6259887B2 (ja) 2011-01-05 2016-10-25 グリコスフィンゴ脂質の調製及びその使用の方法

Publications (3)

Publication Number Publication Date
JP2014504593A JP2014504593A (ja) 2014-02-24
JP2014504593A5 true JP2014504593A5 (enExample) 2015-02-19
JP6057300B2 JP6057300B2 (ja) 2017-01-11

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ID=45688966

Family Applications (2)

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JP2013548554A Active JP6057300B2 (ja) 2011-01-05 2012-01-05 グリコスフィンゴ脂質の調製及びその使用の方法
JP2016209071A Active JP6259887B2 (ja) 2011-01-05 2016-10-25 グリコスフィンゴ脂質の調製及びその使用の方法

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JP2016209071A Active JP6259887B2 (ja) 2011-01-05 2016-10-25 グリコスフィンゴ脂質の調製及びその使用の方法

Country Status (15)

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US (2) US9181292B2 (enExample)
EP (1) EP2661440B1 (enExample)
JP (2) JP6057300B2 (enExample)
KR (1) KR102005003B1 (enExample)
CN (1) CN103748103A (enExample)
AU (2) AU2012204336C1 (enExample)
BR (1) BR112013017382B1 (enExample)
CA (1) CA2854725C (enExample)
CO (1) CO6761397A2 (enExample)
ES (1) ES2654382T3 (enExample)
HK (1) HK1197068A1 (enExample)
IL (1) IL227333B (enExample)
MX (1) MX345764B (enExample)
RU (1) RU2636587C2 (enExample)
WO (1) WO2012094540A2 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7960139B2 (en) 2007-03-23 2011-06-14 Academia Sinica Alkynyl sugar analogs for the labeling and visualization of glycoconjugates in cells
ES2442024T3 (es) 2008-07-15 2014-02-07 Academia Sinica Matrices de glucano sobre portaobjetos de vidrio revestidos con aluminio de tipo PTFE y métodos relacionados
US10087236B2 (en) 2009-12-02 2018-10-02 Academia Sinica Methods for modifying human antibodies by glycan engineering
US11377485B2 (en) 2009-12-02 2022-07-05 Academia Sinica Methods for modifying human antibodies by glycan engineering
US10338069B2 (en) 2010-04-12 2019-07-02 Academia Sinica Glycan arrays for high throughput screening of viruses
AU2011250970B2 (en) 2010-05-10 2016-12-15 Sinica, Academia Zanamivir phosphonate congeners with anti-influenza activity and determining oseltamivir susceptibility of influenza viruses
US9181292B2 (en) * 2011-01-05 2015-11-10 Pi-Hui Liang Methods for preparation of glycosphingolipids and uses thereof
EP2811831B1 (en) * 2012-02-07 2018-04-11 The Regents Of The University Of California Glycosphingolipids for use in modulating immune responses
US10130714B2 (en) 2012-04-14 2018-11-20 Academia Sinica Enhanced anti-influenza agents conjugated with anti-inflammatory activity
WO2014031498A1 (en) 2012-08-18 2014-02-27 Academia Sinica Cell-permeable probes for identification and imaging of sialidases
AU2013305827A1 (en) 2012-08-21 2015-03-05 Academia Sinica Benzocyclooctyne compounds and uses thereof
EP2727929A1 (en) * 2012-10-30 2014-05-07 Wittycell Method of preparation of alpha galactosyl ceramides compounds
EP3013365B1 (en) 2013-06-26 2019-06-05 Academia Sinica Rm2 antigens and use thereof
EP3013347B1 (en) 2013-06-27 2019-12-11 Academia Sinica Glycan conjugates and use thereof
JP6486368B2 (ja) * 2013-09-06 2019-03-20 アカデミア シニカAcademia Sinica 改変されたグリコシル基を含む糖脂質を用いたヒトiNKT細胞の活性化
AU2015206370A1 (en) 2014-01-16 2016-07-07 Academia Sinica Compositions and methods for treatment and detection of cancers
US10150818B2 (en) 2014-01-16 2018-12-11 Academia Sinica Compositions and methods for treatment and detection of cancers
CN106415244B (zh) 2014-03-27 2020-04-24 中央研究院 反应性标记化合物及其用途
CA2950415A1 (en) 2014-05-27 2015-12-03 Academia Sinica Anti-cd20 glycoantibodies and uses thereof
JP7093612B2 (ja) 2014-05-27 2022-06-30 アカデミア シニカ Bacteroides由来のフコシダーゼおよびそれを使用する方法
US10118969B2 (en) 2014-05-27 2018-11-06 Academia Sinica Compositions and methods relating to universal glycoforms for enhanced antibody efficacy
CN106661099A (zh) 2014-05-27 2017-05-10 中央研究院 抗her2醣抗体及其用途
WO2015184001A1 (en) 2014-05-28 2015-12-03 Academia Sinica Anti-tnf-alpha glycoantibodies and uses thereof
TWI745275B (zh) * 2014-09-08 2021-11-11 中央研究院 使用醣脂激活人類iNKT細胞
US9975965B2 (en) 2015-01-16 2018-05-22 Academia Sinica Compositions and methods for treatment and detection of cancers
US10495645B2 (en) 2015-01-16 2019-12-03 Academia Sinica Cancer markers and methods of use thereof
JP6779887B2 (ja) 2015-01-24 2020-11-04 アカデミア シニカAcademia Sinica 新規なグリカンコンジュゲートおよびその使用方法
WO2017083830A1 (en) * 2015-11-13 2017-05-18 La Jolla Institute For Allergy And Immunology Sphingamide compounds and methods for binding inkt cells
US10852310B2 (en) 2015-12-11 2020-12-01 Opko Diagnostics, Llc Fluidic systems involving incubation of samples and/or reagents
CA3006882C (en) 2015-12-29 2023-11-28 Opko Diagnostics, Llc Fluid collection device and related methods
EP3426693A4 (en) 2016-03-08 2019-11-13 Academia Sinica PROCESS FOR MODULAR SYNTHESIS OF N-GLYCANES AND ARRANGEMENTS THEREOF
CA3034057A1 (en) 2016-08-22 2018-03-01 CHO Pharma Inc. Antibodies, binding fragments, and methods of use
EP3681512B1 (en) * 2017-09-13 2021-08-04 Abivax Abx196 for use in the treatment of bladder cancer
CN110835361A (zh) * 2019-10-21 2020-02-25 山东大学 一类唾液酸糖基给体及其制备方法和应用
WO2021142581A1 (zh) * 2020-01-13 2021-07-22 郑州市御合源生物科技有限公司 一种糖苷化合物及其制备方法和应用
WO2022148758A1 (en) * 2021-01-06 2022-07-14 Evonik Operations Gmbh Hydroxy-substituted sphingolipids
CN114805454B (zh) * 2021-01-21 2023-07-18 中国科学院生态环境研究中心 α-半乳糖神经酰胺类化合物及其制备方法和用途
EP4301374A4 (en) 2021-03-01 2025-09-10 Deciduous Therapeutics Inc COMPOUNDS FOR ACTIVATING INVARIANT NATURAL KILLER T CELLS AND METHODS OF USE IN ELIMINATING INFLAMMATORY SENESCENT CELLS

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0676429B2 (ja) 1987-03-09 1994-09-28 理化学研究所 ラクト系列スフィンゴ糖脂質の合成法
JP2588729B2 (ja) * 1987-10-05 1997-03-12 塩野義製薬株式会社 スフィンゴシン誘導体
AU683026B2 (en) 1992-10-22 1997-10-30 Kirin Pharma Kabushiki Kaisha Novel shingoglycolipid and use thereof
CA2142153A1 (en) * 1994-03-04 1995-09-05 Jacques Banville Sulfated .beta.-glycolipid derivatives as cell adhesion inhibitors
JPH11269189A (ja) * 1998-03-19 1999-10-05 Nissin Food Prod Co Ltd 免疫調節作用を有する化合物
CN1405172A (zh) 2001-08-13 2003-03-26 青岛海洋大学 一种乳糖胺脂及其制备方法和应用
DE10258007B4 (de) * 2002-12-12 2006-02-09 Sanofi-Aventis Deutschland Gmbh Aromatische Fluorglycosidderivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zur Herstellung dieser Arzneimittel
JP2008516194A (ja) 2004-10-04 2008-05-15 アルケミア リミティッド 選択的阻害剤
US7923013B2 (en) * 2004-12-28 2011-04-12 The Rockefeller University Glycolipids and analogues thereof as antigens for NKT cells
US7534434B2 (en) 2004-12-28 2009-05-19 The Rockefeller University Glycolipids and analogues thereof as antigens for NK T cells
HUE031643T2 (en) 2006-04-03 2017-07-28 Technion Res & Dev Foundation New aminoglycosides and their applications in the treatment of genetic disorders
US8420607B2 (en) 2006-06-30 2013-04-16 University Of Georgia Research Foundation, Inc. Anthrax carbohydrates, synthesis and uses thereof
CN101012254A (zh) 2006-08-29 2007-08-08 中国海洋大学 一种α-半乳糖鞘糖脂的2’-OH衍生物及其制备方法
KR100868959B1 (ko) 2006-12-30 2008-11-17 재단법인서울대학교산학협력재단 알파-갈락토실세라마이드 유도체, 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 함유하는면역보조용 약학적 조성물
EP2144594A4 (en) 2007-04-13 2012-12-05 Academia Sinica ALPHA-GALACTOSYL CERAMIDE ANALOGUES AND THEIR USE IN IMMUNOTHERAPIES
US20090137793A1 (en) 2007-11-19 2009-05-28 Academia Sinica Disaccharide compounds
ES2543063T3 (es) 2008-05-16 2015-08-14 Galecto Biotech Ab Nueva síntesis de inhibidores de galactósidos
US7928077B2 (en) 2008-07-11 2011-04-19 Academia Sinica Alpha-galactosyl ceramide analogs and their use as immunotherapies
US9181292B2 (en) 2011-01-05 2015-11-10 Pi-Hui Liang Methods for preparation of glycosphingolipids and uses thereof

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