JP2014503482A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2014503482A5 JP2014503482A5 JP2013537154A JP2013537154A JP2014503482A5 JP 2014503482 A5 JP2014503482 A5 JP 2014503482A5 JP 2013537154 A JP2013537154 A JP 2013537154A JP 2013537154 A JP2013537154 A JP 2013537154A JP 2014503482 A5 JP2014503482 A5 JP 2014503482A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- antibody
- domain
- immunoglobulin
- hypervariable regions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000013691 Interleukin-17 Human genes 0.000 claims 22
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 10
- 108010074051 C-Reactive Protein Proteins 0.000 claims 8
- 102100032752 C-reactive protein Human genes 0.000 claims 7
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 7
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 7
- 101001090860 Homo sapiens Myeloblastin Proteins 0.000 claims 4
- 102100034681 Myeloblastin Human genes 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 4
- GLGAUBPACOBAMV-DOFZRALJSA-N arachidonylcyclopropylamide Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NC1CC1 GLGAUBPACOBAMV-DOFZRALJSA-N 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 210000003743 erythrocyte Anatomy 0.000 claims 2
- 239000000710 homodimer Substances 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 238000004062 sedimentation Methods 0.000 claims 2
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 108060003951 Immunoglobulin Proteins 0.000 claims 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
- 102000013463 Immunoglobulin Light Chains Human genes 0.000 claims 1
- 108010065825 Immunoglobulin Light Chains Proteins 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 239000005557 antagonist Substances 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 102000018358 immunoglobulin Human genes 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 229960004540 secukinumab Drugs 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
- 230000003442 weekly effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41053310P | 2010-11-05 | 2010-11-05 | |
| US61/410,533 | 2010-11-05 | ||
| PCT/EP2011/069476 WO2012059598A2 (en) | 2010-11-05 | 2011-11-04 | Methods of treating rheumatoid arthritis using il-17 antagonists |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015232562A Division JP6049843B2 (ja) | 2010-11-05 | 2015-11-30 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014503482A JP2014503482A (ja) | 2014-02-13 |
| JP2014503482A5 true JP2014503482A5 (OSRAM) | 2014-12-18 |
Family
ID=44906168
Family Applications (8)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537154A Pending JP2014503482A (ja) | 2010-11-05 | 2011-11-04 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2015232562A Active JP6049843B2 (ja) | 2010-11-05 | 2015-11-30 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2016139469A Active JP6250109B2 (ja) | 2010-11-05 | 2016-07-14 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2017223669A Active JP6515168B2 (ja) | 2010-11-05 | 2017-11-21 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2019076324A Pending JP2019142912A (ja) | 2010-11-05 | 2019-04-12 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2021031383A Pending JP2021104995A (ja) | 2010-11-05 | 2021-03-01 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2023084472A Pending JP2023109910A (ja) | 2010-11-05 | 2023-05-23 | Ｉｌ－１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2025034128A Pending JP2025102772A (ja) | 2010-11-05 | 2025-03-04 | Ｉｌ－１７アンタゴニストを用いて関節リウマチを治療する方法 |
Family Applications After (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015232562A Active JP6049843B2 (ja) | 2010-11-05 | 2015-11-30 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2016139469A Active JP6250109B2 (ja) | 2010-11-05 | 2016-07-14 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2017223669A Active JP6515168B2 (ja) | 2010-11-05 | 2017-11-21 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2019076324A Pending JP2019142912A (ja) | 2010-11-05 | 2019-04-12 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2021031383A Pending JP2021104995A (ja) | 2010-11-05 | 2021-03-01 | Ｉｌ−１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2023084472A Pending JP2023109910A (ja) | 2010-11-05 | 2023-05-23 | Ｉｌ－１７アンタゴニストを用いて関節リウマチを治療する方法 |
| JP2025034128A Pending JP2025102772A (ja) | 2010-11-05 | 2025-03-04 | Ｉｌ－１７アンタゴニストを用いて関節リウマチを治療する方法 |
Country Status (30)
| Country | Link |
|---|---|
| US (10) | US9744234B2 (OSRAM) |
| EP (6) | EP4116325A1 (OSRAM) |
| JP (8) | JP2014503482A (OSRAM) |
| KR (5) | KR20180019247A (OSRAM) |
| CN (2) | CN104800844A (OSRAM) |
| AU (1) | AU2011325134B2 (OSRAM) |
| BR (1) | BR112013011176A2 (OSRAM) |
| CA (2) | CA2813849C (OSRAM) |
| CL (1) | CL2013001213A1 (OSRAM) |
| CY (1) | CY1121802T1 (OSRAM) |
| DE (1) | DE20187001T1 (OSRAM) |
| DK (2) | DK3111954T3 (OSRAM) |
| ES (3) | ES2804624T1 (OSRAM) |
| FI (1) | FI3757126T3 (OSRAM) |
| HR (2) | HRP20251174T1 (OSRAM) |
| HU (1) | HUE044038T2 (OSRAM) |
| IL (4) | IL311014A (OSRAM) |
| LT (2) | LT3757126T (OSRAM) |
| MA (1) | MA34647B1 (OSRAM) |
| MX (1) | MX362591B (OSRAM) |
| PH (1) | PH12013500890A1 (OSRAM) |
| PL (1) | PL3111954T3 (OSRAM) |
| PT (2) | PT3757126T (OSRAM) |
| RS (1) | RS67377B1 (OSRAM) |
| RU (1) | RU2582937C2 (OSRAM) |
| SG (2) | SG189138A1 (OSRAM) |
| SI (1) | SI3111954T1 (OSRAM) |
| TR (1) | TR201909531T4 (OSRAM) |
| TW (3) | TWI604851B (OSRAM) |
| WO (1) | WO2012059598A2 (OSRAM) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011254557B2 (en) | 2010-05-20 | 2015-09-03 | Ablynx Nv | Biological materials related to HER3 |
| HUE044038T2 (hu) | 2010-11-05 | 2019-09-30 | Novartis Ag | Spondilitisz ankilopoetika kezelési eljárásai anti-IL-17 alkalmazásával |
| UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
| WO2013055745A2 (en) | 2011-10-11 | 2013-04-18 | Medimmune, Llc | Cd40l-specific tn3-derived scaffolds and methods of use thereof |
| US9284283B2 (en) | 2012-02-02 | 2016-03-15 | Ensemble Therapeutics Corporation | Macrocyclic compounds for modulating IL-17 |
| US20140004131A1 (en) | 2012-05-04 | 2014-01-02 | Novartis Ag | Antibody formulation |
| WO2014155278A2 (en) | 2013-03-26 | 2014-10-02 | Novartis Ag | Methods of treating autoimmune diseases using il-17 antagonists |
| US9688769B2 (en) | 2013-10-22 | 2017-06-27 | Novimmune S.A. | Methods and compositions for diagnosis and treatment of disorders in patients with elevated levels of TLR4 ligands and other biomarkers |
| CN105916883B (zh) * | 2014-01-28 | 2019-12-03 | 北京韩美药品有限公司 | 双功能融合蛋白及其制备方法和用途 |
| SMT201900544T1 (it) | 2014-05-13 | 2019-11-13 | Medimmune Ltd | Anticorpi anti-b7-h1 e anti-ctla-4 per trattare il cancro del polmone non a piccole cellule |
| US11548940B2 (en) | 2014-05-15 | 2023-01-10 | Rani Therapeutics, Llc | Anti-interleukin antibody preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device |
| AU2015258859B2 (en) | 2014-05-15 | 2020-07-23 | Rani Therapeutics, Llc | Pharmaceutical compositions and methods for fabrication of solid masses comprising polypeptides and/or proteins |
| FR3021976B1 (fr) * | 2014-06-06 | 2018-11-02 | Hospices Civils De Lyon | Marqueur biologique permettant d'evaluer le niveau pro-inflammatoire dependant de la contribution fonctionnelle de l'il-17 chez un individu |
| WO2015191760A2 (en) * | 2014-06-10 | 2015-12-17 | Abbvie, Inc. | Compositions and methods for treating rheumatoid arthritis |
| NL2013007B1 (en) * | 2014-06-16 | 2016-07-05 | Ablynx Nv | Methods of treating TTP with immunoglobulin single variable domains and uses thereof. |
| KR20230170796A (ko) * | 2014-09-10 | 2023-12-19 | 노파르티스 아게 | 건선성 관절염 환자에서 구조적 손상의 진행을 억제하기 위한 il-17 길항제의 용도 |
| MX2017004983A (es) * | 2014-10-22 | 2017-11-13 | Armo Biosciences Inc | Metodos para usar interleucina 10 para tratar enfermedades y trastornos. |
| AR103173A1 (es) * | 2014-12-22 | 2017-04-19 | Novarits Ag | Productos farmacéuticos y composiciones líquidas estables de anticuerpos il-17 |
| AR103172A1 (es) * | 2014-12-22 | 2017-04-19 | Novartis Ag | Reducción selectiva de residuos de cisteina en anticuerpos il-17 |
| EP3265493B1 (en) | 2015-03-02 | 2024-01-10 | 180 Therapeutics LP | Method of treating a localized fibrotic disorder using an il-33 antagonist |
| EP3167892A1 (en) | 2015-11-10 | 2017-05-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for preventing or treating imflammatory bowel diseases |
| JP6858766B2 (ja) * | 2015-10-19 | 2021-04-14 | ノバルティス アーゲー | インターロイキン１７（ｉｌ−１７）アンタゴニストを用いてｘ線陰性体軸性脊椎関節炎を治療する方法 |
| AU2017316513A1 (en) * | 2016-08-23 | 2019-03-28 | Csl Behring Gmbh | Method of preventing acute attacks of hereditary angioedema associated with C1 esterase inhibitor deficiency |
| WO2019087133A1 (en) * | 2017-11-02 | 2019-05-09 | Novartis Ag | Method of treating tendinopathy using interleukin-17 (il-17) |
| GB201719447D0 (en) * | 2017-11-23 | 2018-01-10 | Ucb Biopharma Sprl | Pharmaceutical composition |
| CN112584857A (zh) * | 2018-05-09 | 2021-03-30 | 诺华股份有限公司 | 卡那吉努单抗的用途 |
| US20210340200A1 (en) * | 2018-09-26 | 2021-11-04 | Viela Bio, Inc. | Cd40l antagonist and uses thereof |
| WO2020154252A1 (en) * | 2019-01-22 | 2020-07-30 | Genentech, Inc. | Methods of treating rheumatoid arthritis, chronic spontaneous urticaria, and systemic lupus erythematosis using an inhibitor of bruton's tyrosine kinase |
| CN120241997A (zh) | 2019-02-18 | 2025-07-04 | 伊莱利利公司 | 治疗性抗体制剂 |
| KR102169901B1 (ko) * | 2019-05-17 | 2020-10-26 | 연세대학교 산학협력단 | Dna 메틸화를 이용한 면역 항암 요법의 치료 반응에 관한 정보 제공 방법 및 이를 이용한 키트 |
| CN110179746A (zh) | 2019-05-17 | 2019-08-30 | 通化东宝生物科技有限公司 | 一种稳定的苏金单抗注射剂及其制备方法 |
| BR112022002150A2 (pt) * | 2019-08-05 | 2022-06-07 | Evelo Biosciences Inc | Composições e métodos para tratar psoríase e dermatite atópica com o uso de prevotella histicola |
| BR112022004941A2 (pt) * | 2019-09-20 | 2022-06-28 | Novartis Ag | Métodos para tratar doenças autoimunes com o uso de antagonistas de interleucina-17 (il-17) |
| AU2020386669A1 (en) | 2019-11-19 | 2022-06-02 | Novartis Ag | Methods of treating Lupus Nephritis using interleukin-17 (IL-17) antagonists |
| CN112915201B (zh) * | 2019-12-06 | 2023-06-27 | 珠海市丽珠单抗生物技术有限公司 | 包含抗il-17抗体的液体制剂 |
| WO2021146850A1 (en) * | 2020-01-20 | 2021-07-29 | Tsinghua University | A critical role of febrile temperature in regulating interleukin (il) -17 producing cells via smad4 |
| WO2022113105A1 (en) * | 2020-11-25 | 2022-06-02 | Dr. Reddy's Laboratories Limited | Stable therapeutic protein formulation and methods of making the same |
| TW202241505A (zh) * | 2021-01-04 | 2022-11-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 抗il-17抗體治療自體免疫性疾病和炎症的方法 |
| TW202246329A (zh) * | 2021-03-03 | 2022-12-01 | 大陸商蘇州盛迪亞生物醫藥有限公司 | 抗il-17抗體治療自體免疫性疾病和炎症的方法 |
| KR102339377B1 (ko) * | 2021-03-29 | 2021-12-13 | 김지혜 | 사용자 맞춤형 문화 예술 컨텐츠 제공 방법 및 장치 |
| KR20240024929A (ko) * | 2021-06-21 | 2024-02-26 | 브리스톨-마이어스 스큅 컴퍼니 | 고농도 동결건조 생물제제 약물 제품의 재구성 시간을 감소시키기 위한 수크로스, 만니톨 및 글리신의 용도 |
| CN114306594A (zh) * | 2021-12-21 | 2022-04-12 | 华中科技大学同济医学院附属协和医院 | 地舒单抗在制备治疗膝关节骨性关节炎的药物中的应用 |
| WO2024156841A1 (en) | 2023-01-27 | 2024-08-02 | Fresenius Kabi Deutschland Gmbh | Biopharmaceutical composition |
| EP4406553A1 (en) | 2023-01-27 | 2024-07-31 | Fresenius Kabi Deutschland GmbH | Stable secukinumab biopharmaceutical composition |
| WO2025071335A1 (ko) * | 2023-09-27 | 2025-04-03 | 삼성바이오에피스 주식회사 | 항-il-17 항체의 안정한 액상 제형 |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0565233A (ja) | 1991-03-08 | 1993-03-19 | Mitsui Toatsu Chem Inc | モノクローナル抗体含有凍結乾燥製剤 |
| US5250442A (en) * | 1993-04-08 | 1993-10-05 | Orestes Cabezas | Method of treating rheumatoid arthritis using tetracycline |
| US6309636B1 (en) * | 1995-09-14 | 2001-10-30 | Cancer Research Institute Of Contra Costa | Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides |
| EP0852951A1 (de) | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
| US20050147609A1 (en) | 1998-05-15 | 2005-07-07 | Genentech, Inc. | Use of anti-IL-17 antibody for the treatment of cartilage damaged by osteoarthritis |
| JP2000186046A (ja) | 1998-10-14 | 2000-07-04 | Snow Brand Milk Prod Co Ltd | 慢性関節リウマチ治療剤及び診断方法 |
| US20040009535A1 (en) | 1998-11-27 | 2004-01-15 | Celltech R&D, Inc. | Compositions and methods for increasing bone mineralization |
| US6395511B1 (en) | 1998-11-27 | 2002-05-28 | Darwin Discovery, Ltd. | Nucleic acids encoding a novel family of TGF-β binding proteins from humans |
| JP4159682B2 (ja) | 1998-12-22 | 2008-10-01 | 株式会社クラレ | 止血材 |
| CA2454587C (en) | 2001-07-25 | 2012-11-13 | Protein Design Labs, Inc. | Stable lyophilized pharmaceutical formulation of igg antibodies |
| MXPA04004459A (es) | 2001-11-09 | 2005-05-16 | Johnson & Johnson | Composiciones liofilizadas de anticuerpo monoclonal. |
| WO2003073991A2 (en) | 2002-03-01 | 2003-09-12 | Celltech R & D, Inc. | Methods to increase or decrease bone density |
| WO2003106657A2 (en) | 2002-06-14 | 2003-12-24 | Stowers Institute For Medical Research | Wise/sost nucleic acid sequences and amino acid sequences |
| US6974701B2 (en) | 2003-03-21 | 2005-12-13 | Hemovations, Llc | Erythrocyte sedimentation rate (ESR) test measurement instrument of unitary design and method of using the same |
| EA015166B1 (ru) | 2003-06-16 | 2011-06-30 | Ю-Си-Би Мэньюфэкчуринг, Инк. | Иммуногенные пептиды склеростина (sost), индуцирующие образование специфических антител |
| US8461155B2 (en) | 2003-09-22 | 2013-06-11 | University Of Connecticut | Sclerostin and the inhibition of WNT signaling and bone formation |
| US8039642B2 (en) | 2003-12-09 | 2011-10-18 | Life Technologies Corporation | Pyrenyloxysulfonic acid fluorescent agents |
| GB0417487D0 (en) * | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
| JP3936365B2 (ja) | 2004-09-14 | 2007-06-27 | ソニーケミカル＆インフォメーションデバイス株式会社 | 機能素子実装モジュール及びその製造方法 |
| KR100996801B1 (ko) | 2005-03-08 | 2010-11-25 | 파마시아 앤드 업존 캄파니 엘엘씨 | 항-ＭＡｄＣＡＭ 항체 조성물 |
| US8003108B2 (en) | 2005-05-03 | 2011-08-23 | Amgen Inc. | Sclerostin epitopes |
| US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
| EP1957474A4 (en) | 2005-11-04 | 2011-08-24 | Harvard College | SYNTHESIS OF FTSZ HEMMERN |
| MY149159A (en) | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
| US9084777B2 (en) | 2005-12-28 | 2015-07-21 | Chugai Seiyaku Kabushiki Kaisha | Stabilized antibody-containing formulations |
| CN101374864A (zh) * | 2006-01-31 | 2009-02-25 | 诺瓦提斯公司 | 用于靶向癌症的il-17拮抗性抗体 |
| TW200815469A (en) | 2006-06-23 | 2008-04-01 | Astrazeneca Ab | Compounds |
| JP2010502220A (ja) | 2006-09-05 | 2010-01-28 | メダレックス インコーポレーティッド | 骨形態形成タンパク質およびその受容体に対する抗体ならびにその使用方法 |
| JPWO2008029908A1 (ja) | 2006-09-07 | 2010-01-21 | 協和発酵キリン株式会社 | 抗体を含有する安定な凍結乾燥医薬製剤 |
| UA99716C2 (ru) * | 2006-10-02 | 2012-09-25 | Кирин-Амген Инк. | Антитело, которое специфично связывает человеческий il-17 рецептор а (il-17ra) |
| US7767206B2 (en) | 2006-10-02 | 2010-08-03 | Amgen Inc. | Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto |
| WO2008061013A2 (en) | 2006-11-10 | 2008-05-22 | Amgen Inc. | Antibody-based diagnostics and therapeutics |
| EP2094731A2 (en) | 2006-11-10 | 2009-09-02 | UCB Pharma S.A. | Anti human sclerostin antibodies |
| NZ578235A (en) | 2007-02-02 | 2012-05-25 | Novartis Ag | Modulators of sclerostin binding partners for treating bone-related disorders |
| RS53157B (sr) | 2007-03-20 | 2014-06-30 | Eli Lilly And Company | Antitela na sklerostin |
| MX2009010179A (es) | 2007-03-22 | 2010-03-15 | Imclone Llc | Formulaciones estables de anticuerpo. |
| WO2008121615A2 (en) | 2007-03-30 | 2008-10-09 | Medimmune, Inc. | Antibody formulation |
| AU2008266745B2 (en) * | 2007-06-20 | 2014-04-17 | Merck Sharp & Dohme Corp. | Joint destruction biomarkers for anti-IL-17A therapy of inflammatory joint disease |
| US7720605B2 (en) | 2007-06-22 | 2010-05-18 | Weyerhaeuser Nr Company | Identifying vegetation attributes from LiDAR data |
| CL2008002775A1 (es) | 2007-09-17 | 2008-11-07 | Amgen Inc | Uso de un agente de unión a esclerostina para inhibir la resorción ósea. |
| AR068767A1 (es) | 2007-10-12 | 2009-12-02 | Novartis Ag | Anticuerpos contra esclerostina, composiciones y metodos de uso de estos anticuerpos para tratar un trastorno patologico mediado por esclerostina |
| EP2628486A3 (en) | 2007-12-14 | 2013-10-30 | Amgen, Inc. | Method for treating bone fracture with anti-sclerostin antibodies |
| NZ589434A (en) | 2008-06-03 | 2012-11-30 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| US20090301682A1 (en) | 2008-06-05 | 2009-12-10 | Baker Hughes Incorporated | Casting furnace method and apparatus |
| MX2010014574A (es) | 2008-07-08 | 2011-04-27 | Abbott Lab | Inmunoglobulinas de dominio variable dual para prostaglandina e2 y usos de las mismas. |
| UA103499C2 (ru) | 2008-09-29 | 2013-10-25 | Рош Глікарт Аг | Антитело против интерлейкина-17 (ил-17) человека и его применение |
| BRPI0921845A2 (pt) | 2008-11-12 | 2019-09-17 | Medimmune Llc | formulação aquosa estéril estável, forma de dosagem unitária farmacêutica, seringa pré-carregada, e, métodos para tratar uma doença ou distúrbio, para tratar ou prevenir rejeição, para esgotar células t que expressam icos em um paciente humano, e para interromper arquitetura central germinal em um órgão linfóide secundário de um primata |
| FR2938547B1 (fr) | 2008-11-14 | 2012-11-16 | Total Raffinage Marketing | Liant synthetique clair |
| WO2010065491A2 (en) | 2008-12-01 | 2010-06-10 | Carolus Therapeutics, Inc. | Methods of treating inflammatory disorders |
| KR101579771B1 (ko) | 2009-03-05 | 2015-12-28 | 애브비 인코포레이티드 | Ｉｌ-17 결합 단백질 |
| CN103154031A (zh) | 2010-10-08 | 2013-06-12 | 诺华有限公司 | 利用il-17拮抗剂治疗牛皮癣的方法 |
| HUE044038T2 (hu) | 2010-11-05 | 2019-09-30 | Novartis Ag | Spondilitisz ankilopoetika kezelési eljárásai anti-IL-17 alkalmazásával |
| TW201307845A (zh) * | 2010-12-13 | 2013-02-16 | Novartis Ag | 預測方法及利用ｉｌ－１７拮抗劑治療關節炎的方法 |
| AU2012341081B2 (en) | 2011-11-21 | 2015-06-04 | Novartis Ag | Methods of treating psoriatic arthritis (PsA) using IL-17 antagonists and PsA response or non- response alleles |
| EP2838560A2 (en) | 2012-04-20 | 2015-02-25 | Novartis AG | Methods of treating ankylosing spondylitis using il-17 antagonists |
| WO2014155278A2 (en) | 2013-03-26 | 2014-10-02 | Novartis Ag | Methods of treating autoimmune diseases using il-17 antagonists |
| JP6858766B2 (ja) | 2015-10-19 | 2021-04-14 | ノバルティス アーゲー | インターロイキン１７（ｉｌ−１７）アンタゴニストを用いてｘ線陰性体軸性脊椎関節炎を治療する方法 |
| US11280479B2 (en) | 2017-10-18 | 2022-03-22 | The Sloan Company | Sign box light module |
-
2011
- 2011-11-04 HU HUE16163440A patent/HUE044038T2/hu unknown
- 2011-11-04 EP EP22180976.7A patent/EP4116325A1/en active Pending
- 2011-11-04 TW TW100140410A patent/TWI604851B/zh active
- 2011-11-04 KR KR1020187004058A patent/KR20180019247A/ko not_active Ceased
- 2011-11-04 EP EP20187001.1A patent/EP3757126B1/en active Active
- 2011-11-04 SI SI201131750T patent/SI3111954T1/sl unknown
- 2011-11-04 HR HRP20251174TT patent/HRP20251174T1/hr unknown
- 2011-11-04 IL IL311014A patent/IL311014A/en unknown
- 2011-11-04 PH PH1/2013/500890A patent/PH12013500890A1/en unknown
- 2011-11-04 JP JP2013537154A patent/JP2014503482A/ja active Pending
- 2011-11-04 CA CA2813849A patent/CA2813849C/en active Active
- 2011-11-04 ES ES20187001T patent/ES2804624T1/es active Pending
- 2011-11-04 MX MX2013005060A patent/MX362591B/es active IP Right Grant
- 2011-11-04 KR KR1020187034385A patent/KR20180129991A/ko not_active Ceased
- 2011-11-04 ES ES21180656T patent/ES3030036T3/es active Active
- 2011-11-04 PT PT201870011T patent/PT3757126T/pt unknown
- 2011-11-04 TW TW105142587A patent/TWI618543B/zh active
- 2011-11-04 DK DK16163440.7T patent/DK3111954T3/da active
- 2011-11-04 RS RS20251090A patent/RS67377B1/sr unknown
- 2011-11-04 PT PT16163440T patent/PT3111954T/pt unknown
- 2011-11-04 DE DE20187001.1T patent/DE20187001T1/de active Pending
- 2011-11-04 FI FIEP20187001.1T patent/FI3757126T3/fi active
- 2011-11-04 US US13/877,585 patent/US9744234B2/en active Active
- 2011-11-04 DK DK20187001.1T patent/DK3757126T3/da active
- 2011-11-04 TR TR2019/09531T patent/TR201909531T4/tr unknown
- 2011-11-04 EP EP16163440.7A patent/EP3111954B1/en not_active Revoked
- 2011-11-04 CN CN201510199026.8A patent/CN104800844A/zh active Pending
- 2011-11-04 BR BR112013011176-3A patent/BR112013011176A2/pt not_active IP Right Cessation
- 2011-11-04 ES ES16163440T patent/ES2733712T3/es active Active
- 2011-11-04 EP EP21180656.7A patent/EP3912640B1/en active Active
- 2011-11-04 CA CA3116725A patent/CA3116725C/en active Active
- 2011-11-04 PL PL16163440T patent/PL3111954T3/pl unknown
- 2011-11-04 KR KR1020137011539A patent/KR20140008305A/ko not_active Ceased
- 2011-11-04 RU RU2013125775/15A patent/RU2582937C2/ru active
- 2011-11-04 SG SG2013023064A patent/SG189138A1/en unknown
- 2011-11-04 KR KR1020167014431A patent/KR20160067984A/ko not_active Ceased
- 2011-11-04 LT LTEP20187001.1T patent/LT3757126T/lt unknown
- 2011-11-04 LT LTEP16163440.7T patent/LT3111954T/lt unknown
- 2011-11-04 SG SG10201505624VA patent/SG10201505624VA/en unknown
- 2011-11-04 WO PCT/EP2011/069476 patent/WO2012059598A2/en not_active Ceased
- 2011-11-04 EP EP19162707.4A patent/EP3542820A1/en not_active Withdrawn
- 2011-11-04 AU AU2011325134A patent/AU2011325134B2/en not_active Expired - Fee Related
- 2011-11-04 CN CN2011800529537A patent/CN103189074A/zh active Pending
- 2011-11-04 EP EP11778903.2A patent/EP2635303A2/en not_active Withdrawn
- 2011-11-04 TW TW104103341A patent/TWI616204B/zh active
- 2011-11-04 KR KR1020157003096A patent/KR20150020734A/ko not_active Ceased
-
2013
- 2013-03-18 IL IL225309A patent/IL225309B/en active IP Right Grant
- 2013-05-03 MA MA35873A patent/MA34647B1/fr unknown
- 2013-05-03 CL CL2013001213A patent/CL2013001213A1/es unknown
-
2015
- 2015-11-30 JP JP2015232562A patent/JP6049843B2/ja active Active
-
2016
- 2016-07-14 JP JP2016139469A patent/JP6250109B2/ja active Active
-
2017
- 2017-07-20 US US15/654,854 patent/US10363307B2/en active Active
- 2017-11-21 JP JP2017223669A patent/JP6515168B2/ja active Active
-
2018
- 2018-10-24 IL IL262559A patent/IL262559B/en unknown
-
2019
- 2019-04-12 JP JP2019076324A patent/JP2019142912A/ja active Pending
- 2019-06-12 US US16/439,423 patent/US20190307880A1/en not_active Abandoned
- 2019-06-26 HR HRP20191162TT patent/HRP20191162T1/hr unknown
- 2019-07-03 CY CY20191100708T patent/CY1121802T1/el unknown
-
2020
- 2020-03-19 US US16/824,613 patent/US11534491B2/en active Active
- 2020-12-18 US US17/127,758 patent/US20210128726A1/en not_active Abandoned
-
2021
- 2021-02-02 US US17/165,729 patent/US20210177966A1/en not_active Abandoned
- 2021-03-01 JP JP2021031383A patent/JP2021104995A/ja active Pending
- 2021-04-25 IL IL282625A patent/IL282625A/en unknown
- 2021-12-08 US US17/545,894 patent/US12465635B2/en active Active
-
2022
- 2022-10-21 US US18/048,797 patent/US20230293683A1/en active Pending
- 2022-12-02 US US18/061,221 patent/US20230346926A1/en active Pending
-
2023
- 2023-05-23 JP JP2023084472A patent/JP2023109910A/ja active Pending
-
2025
- 2025-02-24 US US19/061,831 patent/US20250205332A1/en active Pending
- 2025-03-04 JP JP2025034128A patent/JP2025102772A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2014503482A5 (OSRAM) | ||
| JP6711883B2 (ja) | Ｐｄ−１に対するヒト抗体 | |
| JP2011522832A5 (OSRAM) | ||
| JP2016065094A5 (OSRAM) | ||
| JP2018537962A5 (OSRAM) | ||
| JP2019521647A5 (OSRAM) | ||
| HRP20191162T1 (hr) | Postupci liječenja ankilozantnog spondilitisa uporabom anti-il-17 protutijela | |
| HRP20210393T1 (hr) | Anti-tfr antitijela i njihova uporaba u liječenju proliferativnih i upalnih poremećaja | |
| Semerano et al. | Targeting IL-6 for the treatment of rheumatoid arthritis: Phase II investigational drugs | |
| ES2769123T3 (es) | Anticuerpos de quimiocinas PAN ELR+ CXC | |
| FI3487882T3 (fi) | Gprc5d-vasta-aineita, bispesifisiä antigeeniä sitovia molekyylejä, jotka sitovat gprc5d:tä ja cd3:a, sekä niiden käyttötapoja | |
| JP2014114288A5 (OSRAM) | ||
| RU2015104001A (ru) | Комбинированная терапия для лечения глиобластомы | |
| US20250243268A1 (en) | Engineered anti-il-2 antibodies | |
| JP2017507650A (ja) | Ｐｄ−ｌ１に対するヒト抗体 | |
| JP2015521607A5 (OSRAM) | ||
| JP2014509510A5 (OSRAM) | ||
| JP2015007098A5 (OSRAM) | ||
| JP2012524071A5 (OSRAM) | ||
| US20140199299A1 (en) | Combination Therapies and Methods Using Anti-CD3 Modulating Agents and Anti-IL-6 Antagonists | |
| JP2013535190A5 (OSRAM) | ||
| JP2015514110A5 (OSRAM) | ||
| RU2016109448A (ru) | Комбинированная терапия для лечения глиобластомы | |
| JP2015535828A5 (OSRAM) | ||
| TWI500629B (zh) | 介白素－６抗體及其用途 |