JP2014502617A5 - - Google Patents
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- JP2014502617A5 JP2014502617A5 JP2013547380A JP2013547380A JP2014502617A5 JP 2014502617 A5 JP2014502617 A5 JP 2014502617A5 JP 2013547380 A JP2013547380 A JP 2013547380A JP 2013547380 A JP2013547380 A JP 2013547380A JP 2014502617 A5 JP2014502617 A5 JP 2014502617A5
- Authority
- JP
- Japan
- Prior art keywords
- vitamin
- composition
- group
- uridine
- mammal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 41
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims 24
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims 14
- DJJCXFVJDGTHFX-XVFCMESISA-N uridine 5'-monophosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-XVFCMESISA-N 0.000 claims 14
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 12
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims 12
- ISAKRJDGNUQOIC-UHFFFAOYSA-N Uracil Chemical compound O=C1C=CNC(=O)N1 ISAKRJDGNUQOIC-UHFFFAOYSA-N 0.000 claims 12
- 241000124008 Mammalia Species 0.000 claims 10
- 208000024827 Alzheimer disease Diseases 0.000 claims 9
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 claims 9
- 235000016709 nutrition Nutrition 0.000 claims 9
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims 9
- 229940045145 uridine Drugs 0.000 claims 9
- 150000003904 phospholipids Chemical class 0.000 claims 8
- 229930003779 Vitamin B12 Natural products 0.000 claims 7
- 229930003761 Vitamin B9 Natural products 0.000 claims 7
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims 7
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 7
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims 7
- 235000019163 vitamin B12 Nutrition 0.000 claims 7
- 239000011715 vitamin B12 Substances 0.000 claims 7
- 235000019158 vitamin B6 Nutrition 0.000 claims 7
- 239000011726 vitamin B6 Substances 0.000 claims 7
- 235000019159 vitamin B9 Nutrition 0.000 claims 7
- 239000011727 vitamin B9 Substances 0.000 claims 7
- 229940011671 vitamin b6 Drugs 0.000 claims 7
- MXHRCPNRJAMMIM-SHYZEUOFSA-N 2'-deoxyuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-SHYZEUOFSA-N 0.000 claims 6
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims 6
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims 6
- DJJCXFVJDGTHFX-UHFFFAOYSA-N Uridinemonophosphate Natural products OC1C(O)C(COP(O)(O)=O)OC1N1C(=O)NC(=O)C=C1 DJJCXFVJDGTHFX-UHFFFAOYSA-N 0.000 claims 6
- 229930003270 Vitamin B Natural products 0.000 claims 6
- 229930003268 Vitamin C Natural products 0.000 claims 6
- 229930003427 Vitamin E Natural products 0.000 claims 6
- 239000003963 antioxidant agent Substances 0.000 claims 6
- 229960001231 choline Drugs 0.000 claims 6
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 6
- -1 dUMP Chemical compound 0.000 claims 6
- MXHRCPNRJAMMIM-UHFFFAOYSA-N desoxyuridine Natural products C1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 MXHRCPNRJAMMIM-UHFFFAOYSA-N 0.000 claims 6
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 6
- 235000020660 omega-3 fatty acid Nutrition 0.000 claims 6
- 239000011669 selenium Substances 0.000 claims 6
- 229910052711 selenium Inorganic materials 0.000 claims 6
- 235000011649 selenium Nutrition 0.000 claims 6
- 229940035893 uracil Drugs 0.000 claims 6
- 235000019156 vitamin B Nutrition 0.000 claims 6
- 239000011720 vitamin B Substances 0.000 claims 6
- 235000019154 vitamin C Nutrition 0.000 claims 6
- 239000011718 vitamin C Substances 0.000 claims 6
- 235000019165 vitamin E Nutrition 0.000 claims 6
- 239000011709 vitamin E Substances 0.000 claims 6
- 229940046009 vitamin E Drugs 0.000 claims 6
- 230000003078 antioxidant effect Effects 0.000 claims 5
- 235000006708 antioxidants Nutrition 0.000 claims 5
- 210000003205 muscle Anatomy 0.000 claims 4
- 208000036119 Frailty Diseases 0.000 claims 3
- 206010003549 asthenia Diseases 0.000 claims 3
- 239000002777 nucleoside Substances 0.000 claims 3
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 3
- TZCPCKNHXULUIY-RGULYWFUSA-N 1,2-distearoyl-sn-glycero-3-phosphoserine Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@H](COP(O)(=O)OC[C@H](N)C(O)=O)OC(=O)CCCCCCCCCCCCCCCCC TZCPCKNHXULUIY-RGULYWFUSA-N 0.000 claims 2
- 239000001763 2-hydroxyethyl(trimethyl)azanium Substances 0.000 claims 2
- 235000019743 Choline chloride Nutrition 0.000 claims 2
- JZNWSCPGTDBMEW-UHFFFAOYSA-N Glycerophosphorylethanolamin Natural products NCCOP(O)(=O)OCC(O)CO JZNWSCPGTDBMEW-UHFFFAOYSA-N 0.000 claims 2
- ZWZWYGMENQVNFU-UHFFFAOYSA-N Glycerophosphorylserin Natural products OC(=O)C(N)COP(O)(=O)OCC(O)CO ZWZWYGMENQVNFU-UHFFFAOYSA-N 0.000 claims 2
- 108010046377 Whey Proteins Proteins 0.000 claims 2
- 102000007544 Whey Proteins Human genes 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 229960003178 choline chloride Drugs 0.000 claims 2
- SGMZJAMFUVOLNK-UHFFFAOYSA-M choline chloride Chemical compound [Cl-].C[N+](C)(C)CCO SGMZJAMFUVOLNK-UHFFFAOYSA-M 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000004220 muscle function Effects 0.000 claims 2
- WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 2
- 150000008104 phosphatidylethanolamines Chemical class 0.000 claims 2
- 150000003905 phosphatidylinositols Chemical class 0.000 claims 2
- 235000021119 whey protein Nutrition 0.000 claims 2
- 206010012289 Dementia Diseases 0.000 claims 1
- 241000282412 Homo Species 0.000 claims 1
- 208000010428 Muscle Weakness Diseases 0.000 claims 1
- 206010028372 Muscular weakness Diseases 0.000 claims 1
- 208000012902 Nervous system disease Diseases 0.000 claims 1
- 208000025966 Neurological disease Diseases 0.000 claims 1
- 108010064851 Plant Proteins Proteins 0.000 claims 1
- 102000007562 Serum Albumin Human genes 0.000 claims 1
- 108010071390 Serum Albumin Proteins 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000005021 gait Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000037081 physical activity Effects 0.000 claims 1
- 235000021118 plant-derived protein Nutrition 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000004580 weight loss Effects 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/NL2010/050892 WO2012091542A1 (en) | 2010-12-28 | 2010-12-28 | Combination of components for the prevention and treatment of frailty |
| NLPCT/NL2010/050892 | 2010-12-28 | ||
| NLPCT/NL2011/050555 | 2011-08-11 | ||
| NLPCT/NL2011/050556 | 2011-08-11 | ||
| PCT/NL2011/050555 WO2012091548A1 (en) | 2010-12-28 | 2011-08-11 | Non-medical increase or maintenance of body weight of a mammal |
| PCT/NL2011/050556 WO2012091549A1 (en) | 2010-12-28 | 2011-08-11 | Combination of components for the prevention and treatment of frailty |
| PCT/NL2011/050908 WO2012091571A2 (en) | 2010-12-28 | 2011-12-28 | Combination of components for the prevention and treatment of frailty |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016199122A Division JP2017061466A (ja) | 2010-12-28 | 2016-10-07 | 組成物および栄養組成物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014502617A JP2014502617A (ja) | 2014-02-03 |
| JP2014502617A5 true JP2014502617A5 (https=) | 2015-02-05 |
Family
ID=44510082
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013547376A Pending JP2014501117A (ja) | 2010-12-28 | 2011-08-11 | 哺乳動物の体重の非医療的増加または維持 |
| JP2013547380A Pending JP2014502617A (ja) | 2010-12-28 | 2011-12-28 | 虚弱防止および治療用の成分の組み合わせ |
| JP2016199122A Pending JP2017061466A (ja) | 2010-12-28 | 2016-10-07 | 組成物および栄養組成物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013547376A Pending JP2014501117A (ja) | 2010-12-28 | 2011-08-11 | 哺乳動物の体重の非医療的増加または維持 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016199122A Pending JP2017061466A (ja) | 2010-12-28 | 2016-10-07 | 組成物および栄養組成物 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9084804B2 (https=) |
| EP (3) | EP2658391B1 (https=) |
| JP (3) | JP2014501117A (https=) |
| CN (2) | CN103402368A (https=) |
| AU (4) | AU2011353251C1 (https=) |
| BR (2) | BR112013016848A2 (https=) |
| CA (2) | CA2823280C (https=) |
| ES (3) | ES2749440T3 (https=) |
| MX (2) | MX346745B (https=) |
| RU (2) | RU2647461C2 (https=) |
| WO (4) | WO2012091542A1 (https=) |
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| ES2808406T3 (es) * | 2007-06-26 | 2021-02-26 | Nutricia Nv | Mejora de la memoria en sujetos con un mini examen del estado mental de 24-26 |
| WO2012005568A1 (en) | 2010-07-07 | 2012-01-12 | N.V. Nutricia | Nutritional composition for the stimulation of muscle protein synthesis |
| WO2012091542A1 (en) | 2010-12-28 | 2012-07-05 | N.V. Nutricia | Combination of components for the prevention and treatment of frailty |
| WO2013129914A1 (en) * | 2012-03-02 | 2013-09-06 | N.V. Nutricia | Method for improving functional synaptic connectivity |
| US20150044138A1 (en) * | 2012-03-02 | 2015-02-12 | N.V. Nutricia | Method for improving functional synaptic connectivity |
| CA2914811C (en) | 2013-06-10 | 2020-10-27 | N.V. Nutricia | Muscle preservation in overweight or obese adult during weight loss program |
| CN103651940B (zh) * | 2013-12-05 | 2015-02-04 | 刘保惠 | 一种中老年牦牛奶配方奶粉及其制备方法 |
| GB201405033D0 (en) | 2014-03-20 | 2014-05-07 | Isis Innovation | Combination therapy |
| RU2705208C2 (ru) * | 2014-04-14 | 2019-11-06 | Н.В. Нютрисиа | Способ для оценки и лечения или профилактики нарушенных уровней полярных липидов в плазме |
| WO2015160233A1 (en) * | 2014-04-14 | 2015-10-22 | N.V. Nutricia | Method for assessing and treating or preventing impaired plasma polar lipid levels |
| US9526267B2 (en) | 2014-04-17 | 2016-12-27 | Savage River, Inc. | Nutrient-dense meat structured protein products |
| WO2017069610A1 (en) * | 2015-10-23 | 2017-04-27 | N.V. Nutricia | Method for improving equilibrioception in healthy individuals and nutritional composition |
| WO2017069613A1 (en) | 2015-10-23 | 2017-04-27 | N.V. Nutricia | Method for improving recognition and/or working memory in hyperphenylalanimenia and phenylketonuria patients |
| JP6861708B2 (ja) * | 2015-12-30 | 2021-04-21 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 除脂肪体重を測定するための方法 |
| WO2017155386A1 (en) * | 2016-03-08 | 2017-09-14 | N.V. Nutricia | Method for treating brain atrophy |
| CN106107984A (zh) * | 2016-07-02 | 2016-11-16 | 威海御膳坊生物科技有限公司 | 一种肿瘤患者全营养配方食品 |
| MX385552B (es) * | 2016-09-29 | 2025-03-18 | Soc Des Produits Nestle S A Star | Ácidos grasos omega 3, compuesto que libera no y vitamina b12 como neuroprotector en pacientes sin demencia. |
| US11612578B2 (en) * | 2016-11-16 | 2023-03-28 | Fresenius Kabi Deutschland Gmbh | Nutritional composition for use in therapy of patients with sarcopenia and/or frailty or pre-sarcopenic and/or pre-frail patients |
| US11197917B2 (en) | 2017-12-01 | 2021-12-14 | ByHeart, Inc. | Formulations for nutritional support in subjects in need thereof |
| WO2020118196A1 (en) * | 2018-12-06 | 2020-06-11 | Nutrient Foods, Llc | Edible high nutrient density composite and the use for reduction and management of human hypertension |
| JOP20210296A1 (ar) * | 2019-05-06 | 2023-01-30 | Ferrer Int | صور جرعة صلبة صيدلية أو دوائية مغذية متعددة الطبقات ومشتملة على مشتقات بيريميدين و/أو بيورين وفيتامينات ب، وتحضيرها واستخداماتها |
| EP3808358A1 (en) * | 2019-10-17 | 2021-04-21 | University College Cork-National University of Ireland, Cork | Microbial compositions, strains and methods |
| RU2760685C1 (ru) * | 2020-12-25 | 2021-11-29 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Саратовский государственный аграрный университет имени Н.И. Вавилова" | Композиция для инъекционного применения на основе фосфотидилхолина, метионина, витамина Е и селенита натрия - "Гепарс", обладающая гепатопротекторными свойствами, и способ ее получения |
| US20240041910A1 (en) * | 2020-12-28 | 2024-02-08 | Yamasa Corporation | Muscular atrophy inhibitor and method for inhibiting muscular atrophy |
| WO2022145438A1 (ja) * | 2020-12-28 | 2022-07-07 | ヤマサ醤油株式会社 | ＰＧＣ－１α発現促進剤、筋肉増強剤及びミトコンドリア賦活剤 |
| CN117098462A (zh) * | 2021-03-17 | 2023-11-21 | N·V·努特里奇亚 | 适合肌肉功能的液体营养组合物 |
| CN113398144B (zh) * | 2021-07-27 | 2022-04-01 | 陈玉松 | 核苷酸混合物在制备预防或缓解老年肌少症制剂中的应用 |
| CN113577092B (zh) * | 2021-07-30 | 2022-07-01 | 陈玉松 | 一种延缓衰老的含核苷酸的组合物及其制备方法和应用 |
| AU2022345465A1 (en) | 2021-09-17 | 2024-03-21 | N.V. Nutricia | Solid composition suitable as a nutritional composition or supplement for animals that suffer from brain related disorders, decline or diseases |
| GB2628186A (en) * | 2023-03-17 | 2024-09-18 | Mjn Us Holdings Llc | Gender-specific compositions |
| WO2026008342A1 (en) * | 2024-07-01 | 2026-01-08 | N.V. Nutricia | Composition for improving sleep |
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| US6403344B1 (en) * | 2001-03-28 | 2002-06-11 | Council Of Scientific And Industrial Research | Enzymatic process for the preparation of an acetylated phospholipid |
| PT1390378E (pt) | 2001-04-30 | 2009-07-23 | Trommsdorff Arzneimittel | Ésteres de uridina farmaceuticamente activos |
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| DE602004016385D1 (de) | 2003-12-24 | 2008-10-16 | Nutricia Nv | Zusammensetzungen mit pantothensäure oder derivaten davon und ihre verwendung zur stimulierung des appetits |
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| US7090879B2 (en) * | 2004-03-18 | 2006-08-15 | Abbott Laboratories | Nutritional formula containing select carotenoid combinations |
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| US7829126B2 (en) * | 2005-10-26 | 2010-11-09 | Abbott Laboratories | Infant formulas containing docosahexaenoic acid and lutein |
| EP1800675B1 (en) | 2005-12-23 | 2011-05-18 | N.V. Nutricia | Composition comprising polyunsaturated fatty acids, proteins, manganese and/or molybden and nucleosides/nucleotides for treating dementia |
| US8685485B2 (en) * | 2006-05-19 | 2014-04-01 | Solae, Llc | Protein composition and its use in restructured meat and food products |
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| WO2009002146A1 (en) | 2007-06-26 | 2008-12-31 | N.V. Nutricia | Supporting activities of daily living |
| ES2808406T3 (es) | 2007-06-26 | 2021-02-26 | Nutricia Nv | Mejora de la memoria en sujetos con un mini examen del estado mental de 24-26 |
| US20090053309A1 (en) * | 2007-08-24 | 2009-02-26 | Axiomedic Ltd., Gibraltar | Adhesive compositions for the treatment of xerostomia |
| ES2697149T3 (es) | 2007-12-20 | 2019-01-22 | Nutricia Nv | Producto líquido que contiene nucleótidos/nucleósidos |
| CN101683138A (zh) * | 2007-12-28 | 2010-03-31 | 天津中英纳米科技发展有限公司 | 一种木糖醇黄豆酱 |
| WO2010002242A1 (en) | 2008-07-02 | 2010-01-07 | N.V. Nutricia | Nutritional composition for improving muscle function and daily activity |
| WO2011078654A1 (en) * | 2009-12-24 | 2011-06-30 | N.V. Nutricia | Low-caloric high-protein nutritional composition for the stimulation of muscle protein synthesis |
| WO2012091542A1 (en) | 2010-12-28 | 2012-07-05 | N.V. Nutricia | Combination of components for the prevention and treatment of frailty |
-
2010
- 2010-12-28 WO PCT/NL2010/050892 patent/WO2012091542A1/en not_active Ceased
-
2011
- 2011-08-11 ES ES11751660T patent/ES2749440T3/es active Active
- 2011-08-11 WO PCT/NL2011/050556 patent/WO2012091549A1/en not_active Ceased
- 2011-08-11 MX MX2013007612A patent/MX346745B/es active IP Right Grant
- 2011-08-11 EP EP11751660.9A patent/EP2658391B1/en not_active Revoked
- 2011-08-11 RU RU2013135312A patent/RU2647461C2/ru not_active IP Right Cessation
- 2011-08-11 US US13/977,162 patent/US9084804B2/en not_active Expired - Fee Related
- 2011-08-11 CA CA2823280A patent/CA2823280C/en not_active Expired - Fee Related
- 2011-08-11 WO PCT/NL2011/050555 patent/WO2012091548A1/en not_active Ceased
- 2011-08-11 CN CN2011800686025A patent/CN103402368A/zh active Pending
- 2011-08-11 JP JP2013547376A patent/JP2014501117A/ja active Pending
- 2011-08-11 AU AU2011353251A patent/AU2011353251C1/en not_active Ceased
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