JP2014500874A - 抗igf抗体を用いた治療レジメン - Google Patents

抗igf抗体を用いた治療レジメン Download PDF

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JP2014500874A
JP2014500874A JP2013538999A JP2013538999A JP2014500874A JP 2014500874 A JP2014500874 A JP 2014500874A JP 2013538999 A JP2013538999 A JP 2013538999A JP 2013538999 A JP2013538999 A JP 2013538999A JP 2014500874 A JP2014500874 A JP 2014500874A
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igf
cancer
antibody
dose
antigen
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Japanese (ja)
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JP2014500874A5 (enExample
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ヴィナー,ジャヤ
チャン,ヨン
マクデヴィット,ジェニファー
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メディミューン,エルエルシー
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/80Immunoglobulins specific features remaining in the (producing) cell, i.e. intracellular antibodies or intrabodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2013538999A 2010-11-16 2011-11-15 抗igf抗体を用いた治療レジメン Pending JP2014500874A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41431810P 2010-11-16 2010-11-16
US61/414,318 2010-11-16
US201161529614P 2011-08-31 2011-08-31
US61/529,614 2011-08-31
PCT/US2011/060839 WO2012068148A1 (en) 2010-11-16 2011-11-15 Regimens for treatments using anti-igf antibodies

Publications (2)

Publication Number Publication Date
JP2014500874A true JP2014500874A (ja) 2014-01-16
JP2014500874A5 JP2014500874A5 (enExample) 2015-01-08

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013538999A Pending JP2014500874A (ja) 2010-11-16 2011-11-15 抗igf抗体を用いた治療レジメン

Country Status (6)

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US (2) US20130330353A1 (enExample)
EP (1) EP2640421A4 (enExample)
JP (1) JP2014500874A (enExample)
AU (1) AU2011329067A1 (enExample)
CA (1) CA2818561A1 (enExample)
WO (1) WO2012068148A1 (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2925351A4 (en) * 2012-11-29 2016-08-24 Bayer Healthcare Llc MONOCLONAL ANTIBODIES DIRECTED AGAINST ACTIVATED PROTEIN C (APC)
CN107106676A (zh) * 2013-12-19 2017-08-29 免疫医疗有限责任公司 用于治疗肉瘤的组合物和方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005018671A1 (ja) * 2003-08-21 2005-03-03 Kyowa Hakko Kogyo Co., Ltd. 癌転移阻害剤
JP2009519711A (ja) * 2005-12-13 2009-05-21 アストラゼネカ アクチボラグ インスリン様増殖因子に特異的な結合タンパク質およびその使用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090029184A (ko) * 2006-04-07 2009-03-20 더 가브먼트 오브 더 유나이티드 스테이츠 오브 아메리카, 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 항체 조성물 및 신생물성 질병의 치료 방법
ES2556353T3 (es) * 2008-02-21 2016-01-15 Merck Sharp & Dohme Corp. Compuestos que son inhibidores de las ERK
MY150984A (en) * 2008-12-12 2014-03-31 Boehringer Ingelheim Int Anti-agf antibodies

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005018671A1 (ja) * 2003-08-21 2005-03-03 Kyowa Hakko Kogyo Co., Ltd. 癌転移阻害剤
JP2009519711A (ja) * 2005-12-13 2009-05-21 アストラゼネカ アクチボラグ インスリン様増殖因子に特異的な結合タンパク質およびその使用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN6015038085; Cancer Research Vol.69,No.9 Suppl., 2009, Abstract No.2802 *
JPN6015038087; Cancer Research Vol.69,No.9 Suppl., 2009, Abstract No.2803 *
JPN6015038088; Cancer Research Vol.64,No.17, 2004, p6252-6258 *
JPN6015038090; International Journal of Cancer Vol.118,No.10, 2006, p2602-2608 *

Also Published As

Publication number Publication date
WO2012068148A1 (en) 2012-05-24
US20150183860A1 (en) 2015-07-02
AU2011329067A1 (en) 2013-05-30
CA2818561A1 (en) 2012-05-24
US20130330353A1 (en) 2013-12-12
EP2640421A1 (en) 2013-09-25
EP2640421A4 (en) 2014-05-28

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