JP2014221064A5 - - Google Patents
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- JP2014221064A5 JP2014221064A5 JP2014137893A JP2014137893A JP2014221064A5 JP 2014221064 A5 JP2014221064 A5 JP 2014221064A5 JP 2014137893 A JP2014137893 A JP 2014137893A JP 2014137893 A JP2014137893 A JP 2014137893A JP 2014221064 A5 JP2014221064 A5 JP 2014221064A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- isolated
- functional fragment
- mesothelin
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 102000003735 Mesothelin Human genes 0.000 claims description 9
- 108090000015 Mesothelin Proteins 0.000 claims description 9
- 239000012634 fragment Substances 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 4
- 239000000427 antigen Substances 0.000 claims 3
- 102000036639 antigens Human genes 0.000 claims 3
- 108091007433 antigens Proteins 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 101000623901 Homo sapiens Mucin-16 Proteins 0.000 claims 2
- 102100023123 Mucin-16 Human genes 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 230000001580 bacterial effect Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000004962 mammalian cell Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- HOGDNTQCSIKEEV-UHFFFAOYSA-N n'-hydroxybutanediamide Chemical compound NC(=O)CCC(=O)NO HOGDNTQCSIKEEV-UHFFFAOYSA-N 0.000 description 2
- 239000004471 Glycine Substances 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 150000003141 primary amines Chemical class 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US437807P | 2007-11-26 | 2007-11-26 | |
| US61/004,378 | 2007-11-26 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010535269A Division JP5608091B2 (ja) | 2007-11-26 | 2008-11-19 | 抗メソセリン抗体およびその使用 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018038254A Division JP6717869B2 (ja) | 2007-11-26 | 2018-03-05 | 抗メソセリン抗体およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014221064A JP2014221064A (ja) | 2014-11-27 |
| JP2014221064A5 true JP2014221064A5 (cg-RX-API-DMAC7.html) | 2016-03-31 |
Family
ID=40351874
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010535269A Expired - Fee Related JP5608091B2 (ja) | 2007-11-26 | 2008-11-19 | 抗メソセリン抗体およびその使用 |
| JP2014137893A Pending JP2014221064A (ja) | 2007-11-26 | 2014-07-03 | 抗メソセリン抗体およびその使用 |
| JP2018038254A Active JP6717869B2 (ja) | 2007-11-26 | 2018-03-05 | 抗メソセリン抗体およびその使用 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010535269A Expired - Fee Related JP5608091B2 (ja) | 2007-11-26 | 2008-11-19 | 抗メソセリン抗体およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018038254A Active JP6717869B2 (ja) | 2007-11-26 | 2018-03-05 | 抗メソセリン抗体およびその使用 |
Country Status (30)
Families Citing this family (90)
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| US8268970B2 (en) * | 2007-10-01 | 2012-09-18 | Bristol-Myers Squibb Company | Human antibodies that bind mesothelin, and uses thereof |
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| UY32560A (es) * | 2009-04-29 | 2010-11-30 | Bayer Schering Pharma Ag | Inmunoconjugados de antimesotelina y usos de los mismos |
| TWI589589B (zh) * | 2010-12-20 | 2017-07-01 | 建南德克公司 | 抗間皮素（ｍｅｓｏｔｈｅｌｉｎ）抗體及免疫接合物 |
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| US9527925B2 (en) | 2011-04-01 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Bispecific binding molecules binding to VEGF and ANG2 |
| JP2014515753A (ja) | 2011-04-21 | 2014-07-03 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 新規な結合剤−薬物複合体（ａｄｃ）およびそれらの使用 |
| US20140004121A1 (en) * | 2012-06-27 | 2014-01-02 | Amgen Inc. | Anti-mesothelin binding proteins |
| EP2900695B1 (en) * | 2012-09-27 | 2018-01-17 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Mesothelin antibodies and methods for eliciting potent antitumor activity |
| CN103819559B (zh) * | 2013-12-10 | 2016-02-24 | 中国科学院武汉病毒研究所 | 一种抗间皮素纳米抗体及其编码基因和该纳米抗体的用途 |
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| CN108064248B (zh) | 2014-09-30 | 2022-03-15 | 生物控股有限公司 | 人源抗二肽重复(dpr)抗体 |
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| WO2017032293A1 (zh) * | 2015-08-21 | 2017-03-02 | 科济生物医药（上海）有限公司 | 抗间皮素全人抗体以及靶向间皮素的免疫效应细胞 |
| KR101782487B1 (ko) * | 2015-09-24 | 2017-09-27 | 재단법인 목암생명과학연구소 | 신규 항-메소텔린 항체 및 이를 포함하는 조성물 |
| WO2017060322A2 (en) | 2015-10-10 | 2017-04-13 | Bayer Pharma Aktiengesellschaft | Ptefb-inhibitor-adc |
| MA44140A (fr) | 2015-12-22 | 2021-05-19 | Dana Farber Cancer Inst Inc | Récepteur d'antigène chimérique (car) contre la mésothéline et anticorps contre l'inhibiteur de pd-l1 pour une utilisation combinée dans une thérapie anticancéreuse |
| CA3009709A1 (en) | 2015-12-30 | 2017-07-06 | Novartis Ag | Immune effector cell therapies with enhanced efficacy |
| JP6859498B2 (ja) * | 2016-02-15 | 2021-04-14 | 地方独立行政法人神奈川県立病院機構 | 膜型ムチン様タンパク質の認識とその医療応用 |
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| CA3027302A1 (en) | 2016-06-20 | 2017-12-28 | F-Star Beta Limited | Binding members(1) |
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| IL292551B2 (en) | 2016-10-07 | 2023-10-01 | Tcr2 Therapeutics Inc | Preparations and methods for reprogramming T-cell receptors using fusion proteins |
| AU2017363311A1 (en) | 2016-11-22 | 2019-06-13 | TCR2 Therapeutics Inc. | Compositions and methods for TCR reprogramming using fusion proteins |
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| JP6339283B1 (ja) | 2017-10-31 | 2018-06-06 | 国立大学法人 岡山大学 | Ｄｎａ、ポリペプチド、抗メソセリン抗体、腫瘍イメージング剤及び複合体 |
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| MX2020006666A (es) * | 2017-12-24 | 2020-08-31 | Noile Immune Biotech Inc | Celula inmunocompetente que expresa una molecula de superficie celular que reconoce especificamente la mesotelina humana, il-7 y ccl19. |
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| AU760120B2 (en) * | 1997-12-01 | 2003-05-08 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Antibodies, including Fv molecules, and immunoconjugates having high binding affinity for mesothelin and methods for their use |
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-
2008
- 2008-11-19 EP EP16170412.7A patent/EP3103814A1/en not_active Withdrawn
- 2008-11-19 SI SI200831603A patent/SI2215121T1/sl unknown
- 2008-11-19 CN CN201410396441.8A patent/CN104151429B/zh not_active Expired - Fee Related
- 2008-11-19 EP EP13168583.6A patent/EP2634196A1/en not_active Ceased
- 2008-11-19 AU AU2008329221A patent/AU2008329221B2/en not_active Ceased
- 2008-11-19 BR BRPI0819909A patent/BRPI0819909B8/pt not_active IP Right Cessation
- 2008-11-19 EP EP08855189.0A patent/EP2215121B1/en active Active
- 2008-11-19 MY MYPI2010002379A patent/MY157164A/en unknown
- 2008-11-19 CN CN200880125390.8A patent/CN101952319B/zh not_active Expired - Fee Related
- 2008-11-19 ES ES08855189.0T patent/ES2569513T3/es active Active
- 2008-11-19 MX MX2010005603A patent/MX2010005603A/es active IP Right Grant
- 2008-11-19 WO PCT/EP2008/009756 patent/WO2009068204A1/en not_active Ceased
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