JP2014168466A5 - - Google Patents

Info

Publication number

JP2014168466A5

JP2014168466A5 JP2014067990A JP2014067990A JP2014168466A5 JP 2014168466 A5 JP2014168466 A5 JP 2014168466A5 JP 2014067990 A JP2014067990 A JP 2014067990A JP 2014067990 A JP2014067990 A JP 2014067990A JP 2014168466 A5 JP2014168466 A5 JP 2014168466A5

Authority

JP

Japan

Prior art keywords

alk

pharmaceutical composition

cancer

diagnostic agent

lung cancer

Prior art date

2014-03-28

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

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• 101710168331 ALK tyrosine kinase receptor Proteins 0.000 claims 18
• 230000004927 fusion Effects 0.000 claims 18
• 229940039227 diagnostic agent Drugs 0.000 claims 12
• 239000000032 diagnostic agent Substances 0.000 claims 12
• 239000008194 pharmaceutical composition Substances 0.000 claims 12
• 206010028980 Neoplasm Diseases 0.000 claims 9
• 201000011510 cancer Diseases 0.000 claims 9
• 108091033319 polynucleotide Proteins 0.000 claims 9
• 102000040430 polynucleotide Human genes 0.000 claims 9
• 239000002157 polynucleotide Substances 0.000 claims 9
• 229920001184 polypeptide Polymers 0.000 claims 8
• 102000004196 processed proteins & peptides Human genes 0.000 claims 8
• 108090000765 processed proteins & peptides Proteins 0.000 claims 8
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims 7
• 201000005202 lung cancer Diseases 0.000 claims 7
• 208000020816 lung neoplasm Diseases 0.000 claims 7
• 239000002773 nucleotide Substances 0.000 claims 7
• 125000003729 nucleotide group Chemical group 0.000 claims 7
• 229940122531 Anaplastic lymphoma kinase inhibitor Drugs 0.000 claims 6
• 239000012472 biological sample Substances 0.000 claims 6
• 239000003153 chemical reaction reagent Substances 0.000 claims 6
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 6
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 6
• 101150023956 ALK gene Proteins 0.000 claims 4
• 108020004459 Small interfering RNA Proteins 0.000 claims 4
• 238000003556 assay Methods 0.000 claims 4
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• 239000004055 small Interfering RNA Substances 0.000 claims 4
• 238000001514 detection method Methods 0.000 claims 3
• 230000000694 effects Effects 0.000 claims 3
• 108090000623 proteins and genes Proteins 0.000 claims 3
• 102000009664 Microtubule-Associated Proteins Human genes 0.000 claims 2
• 108010020004 Microtubule-Associated Proteins Proteins 0.000 claims 2
• 108091034117 Oligonucleotide Proteins 0.000 claims 2
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• 150000003384 small molecules Chemical group 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
• 108020005187 Oligonucleotide Probes Proteins 0.000 claims 1
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• 238000007901 in situ hybridization Methods 0.000 claims 1
• 108020004999 messenger RNA Proteins 0.000 claims 1
• 238000007899 nucleic acid hybridization Methods 0.000 claims 1
• 239000002751 oligonucleotide probe Substances 0.000 claims 1